KR102738936B1 - 골수증식 장애의 치료 방법 - Google Patents

골수증식 장애의 치료 방법 Download PDF

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Publication number
KR102738936B1
KR102738936B1 KR1020217019508A KR20217019508A KR102738936B1 KR 102738936 B1 KR102738936 B1 KR 102738936B1 KR 1020217019508 A KR1020217019508 A KR 1020217019508A KR 20217019508 A KR20217019508 A KR 20217019508A KR 102738936 B1 KR102738936 B1 KR 102738936B1
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pharmaceutical composition
composition according
ruxolitinib
compound
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Korean (ko)
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KR20210095904A (ko
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아드리안 센더로비츠
마이클 쿠퍼
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콘스텔레이션 파마슈티칼스, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020217019508A 2018-11-27 2018-11-27 골수증식 장애의 치료 방법 Active KR102738936B1 (ko)

Priority Applications (1)

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KR1020247040010A KR20250004357A (ko) 2018-11-27 2018-11-27 골수증식 장애의 치료 방법

Applications Claiming Priority (1)

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PCT/US2018/062534 WO2020112086A1 (en) 2018-11-27 2018-11-27 Methods of treating myeloproliferative disorders

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KR1020247040010A Division KR20250004357A (ko) 2018-11-27 2018-11-27 골수증식 장애의 치료 방법

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KR20210095904A KR20210095904A (ko) 2021-08-03
KR102738936B1 true KR102738936B1 (ko) 2024-12-06

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KR1020217019508A Active KR102738936B1 (ko) 2018-11-27 2018-11-27 골수증식 장애의 치료 방법
KR1020247040010A Pending KR20250004357A (ko) 2018-11-27 2018-11-27 골수증식 장애의 치료 방법

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JP (2) JP7453230B2 (https=)
KR (2) KR102738936B1 (https=)
AU (1) AU2018451360B2 (https=)
BR (1) BR112021010134A2 (https=)
CA (1) CA3120973A1 (https=)
EA (1) EA202191489A1 (https=)
SG (1) SG11202105279SA (https=)
WO (1) WO2020112086A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021006205A (es) 2018-11-27 2021-10-13 Constellation Pharmaceuticals Inc Metodos de tratamiento de trastornos mieloproliferativos.
KR102738936B1 (ko) * 2018-11-27 2024-12-06 콘스텔레이션 파마슈티칼스, 인크. 골수증식 장애의 치료 방법
US20220372135A1 (en) 2019-09-27 2022-11-24 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
US20230302010A1 (en) * 2020-08-04 2023-09-28 Constellation Pharmaceuticals, Inc. 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide for treating thrombocythemia
WO2025155120A1 (ko) 2024-01-18 2025-07-24 주식회사 엘지에너지솔루션 전극조립체, 이차 전지 및 배터리 유닛

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR084070A1 (es) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
PL3157928T3 (pl) 2014-06-20 2019-07-31 Constellation Pharmaceuticals, Inc. Krystaliczne postacie 2-((4S)-6-(4-chlorofenylo)-1-metylo-4H-benzo[ c]izoksazolo-[4,5-e]azepin-4-ylo)acetamidu
KR102738936B1 (ko) * 2018-11-27 2024-12-06 콘스텔레이션 파마슈티칼스, 인크. 골수증식 장애의 치료 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cancer cell, 2018, 33(1), 29-43*
Journal of Medicinal Chemistry, 2016, 59, 1330-1339*

Also Published As

Publication number Publication date
CA3120973A1 (en) 2020-06-04
SG11202105279SA (en) 2021-06-29
AU2018451360B2 (en) 2022-05-26
EA202191489A1 (ru) 2021-09-10
AU2018451360A1 (en) 2021-06-10
BR112021010134A2 (pt) 2021-08-24
JP7453230B2 (ja) 2024-03-19
JP2024063214A (ja) 2024-05-10
JP2022519425A (ja) 2022-03-24
WO2020112086A1 (en) 2020-06-04
KR20210095904A (ko) 2021-08-03
KR20250004357A (ko) 2025-01-07

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