KR102727229B1 - Cd73 억제제 - Google Patents

Cd73 억제제 Download PDF

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Publication number
KR102727229B1
KR102727229B1 KR1020247010203A KR20247010203A KR102727229B1 KR 102727229 B1 KR102727229 B1 KR 102727229B1 KR 1020247010203 A KR1020247010203 A KR 1020247010203A KR 20247010203 A KR20247010203 A KR 20247010203A KR 102727229 B1 KR102727229 B1 KR 102727229B1
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alkyl
cycloalkyl
heterocycloalkyl
heteroaryl
aryl
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KR20240042573A (ko
Inventor
시아오후이 두
존 엑스터오비츠
발레리아 알 팬틴
다칭 순
치우핑 예
자레드 무어
타티아나 자보로틴스카야
브라이언 알 블랑크
요섭 레우
케지아 우
리우셩 주
조니 팜
히로유키 가와이
치엔-훙 예
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오릭 파마슈티칼스, 인크.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020247010203A 2019-10-30 2020-10-29 Cd73 억제제 Active KR102727229B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201962928138P 2019-10-30 2019-10-30
US62/928,138 2019-10-30
US202062987806P 2020-03-10 2020-03-10
US62/987,806 2020-03-10
US202063088646P 2020-10-07 2020-10-07
US63/088,646 2020-10-07
PCT/US2020/057996 WO2021087136A1 (en) 2019-10-30 2020-10-29 Cd73 inhibitors
KR1020227018155A KR102653726B1 (ko) 2019-10-30 2020-10-29 Cd73 억제제

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020227018155A Division KR102653726B1 (ko) 2019-10-30 2020-10-29 Cd73 억제제

Publications (2)

Publication Number Publication Date
KR20240042573A KR20240042573A (ko) 2024-04-02
KR102727229B1 true KR102727229B1 (ko) 2024-11-06

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KR1020247010203A Active KR102727229B1 (ko) 2019-10-30 2020-10-29 Cd73 억제제
KR1020227018155A Active KR102653726B1 (ko) 2019-10-30 2020-10-29 Cd73 억제제

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Country Link
US (7) US12577272B2 (https=)
EP (2) EP4596048A3 (https=)
JP (2) JP7544815B2 (https=)
KR (2) KR102727229B1 (https=)
CN (2) CN114929721B (https=)
AU (1) AU2020375914B2 (https=)
CA (1) CA3159248C (https=)
DK (1) DK4051688T3 (https=)
ES (1) ES3034168T3 (https=)
FI (1) FI4051688T3 (https=)
HU (1) HUE072504T2 (https=)
IL (2) IL292570B2 (https=)
MX (1) MX2022005256A (https=)
PL (1) PL4051688T3 (https=)
PT (1) PT4051688T (https=)
SI (1) SI4051688T1 (https=)
TW (1) TWI830962B (https=)
WO (1) WO2021087136A1 (https=)
ZA (1) ZA202204941B (https=)

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WO2018208980A1 (en) 2017-05-10 2018-11-15 Oric Pharmaceuticals, Inc. Cd73 inhibitors
US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
IL304348B2 (en) 2018-04-30 2024-08-01 Oric Pharmaceuticals Inc CD73 inhibitors
JP7557522B2 (ja) 2019-07-16 2024-09-27 オリック ファーマシューティカルズ,インク. Cd73阻害剤
PL4051688T3 (pl) * 2019-10-30 2025-09-22 Oric Pharmaceuticals, Inc. Inhibitory cd73
JP2025512384A (ja) 2022-04-13 2025-04-17 ギリアード サイエンシーズ, インコーポレイテッド Trop-2発現がんを治療するための併用療法
CN120202181A (zh) * 2022-09-14 2025-06-24 欧瑞克制药公司 Cd73抑制剂的药物形式
WO2024076873A1 (en) * 2022-10-03 2024-04-11 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
WO2024076872A1 (en) * 2022-10-03 2024-04-11 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
WO2025111247A1 (en) * 2023-11-20 2025-05-30 Oric Pharmaceuticals, Inc. Treatment of refractory multiple myeloma
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025233264A1 (en) 2024-05-07 2025-11-13 Innate Pharma Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers

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WO2019090111A1 (en) 2017-11-03 2019-05-09 Oric Pharmaceuticals, Inc. Cd73 inhibitors

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BR122023021184A2 (pt) 2024-02-27
NZ788133A (en) 2024-03-22
CA3159248C (en) 2024-05-28
FI4051688T3 (fi) 2025-06-27
EP4596048A3 (en) 2025-11-19
ES3034168T3 (en) 2025-08-13
CN114929721B (zh) 2023-07-18
US20230131747A1 (en) 2023-04-27
ZA202204941B (en) 2024-10-30
PL4051688T3 (pl) 2025-09-22
US20210130390A1 (en) 2021-05-06
US11130778B2 (en) 2021-09-28
US12018043B2 (en) 2024-06-25
KR20240042573A (ko) 2024-04-02
KR102653726B1 (ko) 2024-04-01
MX2022005256A (es) 2022-08-25
WO2021087136A1 (en) 2021-05-06
SI4051688T1 (sl) 2025-08-29
CN114929721A (zh) 2022-08-19
IL292570B1 (en) 2023-12-01
US11530236B2 (en) 2022-12-20
US20220411459A1 (en) 2022-12-29
JP2024164093A (ja) 2024-11-26
JP7688769B2 (ja) 2025-06-04
DK4051688T3 (da) 2025-06-30
IL308293A (en) 2024-01-01
EP4051688A1 (en) 2022-09-07
KR20220088786A (ko) 2022-06-28
US11028120B2 (en) 2021-06-08
US20210214387A1 (en) 2021-07-15
AU2020375914A1 (en) 2022-06-02
EP4596048A2 (en) 2025-08-06
PT4051688T (pt) 2025-06-30
JP7544815B2 (ja) 2024-09-03
EP4051688A4 (en) 2024-03-06
AU2020375914B2 (en) 2024-05-23
CN116854758A (zh) 2023-10-10
IL292570A (en) 2022-06-01
HUE072504T2 (hu) 2025-11-28
IL308293B1 (en) 2025-08-01
BR112022008365A2 (pt) 2023-03-28
IL292570B2 (en) 2024-04-01
IL308293B2 (en) 2025-12-01
US12577272B2 (en) 2026-03-17
TWI830962B (zh) 2024-02-01
EP4051688B1 (en) 2025-04-23
US12454544B2 (en) 2025-10-28
JP2023500483A (ja) 2023-01-06
US20260042794A1 (en) 2026-02-12
US20210130389A1 (en) 2021-05-06
CA3159248A1 (en) 2021-05-06
US20250034198A1 (en) 2025-01-30
TW202130353A (zh) 2021-08-16

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