KR102723194B1 - Cftr 조절제 및 이의 사용 방법 - Google Patents

Cftr 조절제 및 이의 사용 방법 Download PDF

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Publication number
KR102723194B1
KR102723194B1 KR1020187021185A KR20187021185A KR102723194B1 KR 102723194 B1 KR102723194 B1 KR 102723194B1 KR 1020187021185 A KR1020187021185 A KR 1020187021185A KR 20187021185 A KR20187021185 A KR 20187021185A KR 102723194 B1 KR102723194 B1 KR 102723194B1
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nhnh
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KR20180101415A (ko
Inventor
앨런 버크만
마크 에이치. 레빈
오누르 실
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더 리젠츠 오브 더 유니버시티 오브 캘리포니아
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
KR1020187021185A 2015-12-24 2016-12-23 Cftr 조절제 및 이의 사용 방법 Active KR102723194B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562387591P 2015-12-24 2015-12-24
US62/387,591 2015-12-24
PCT/US2016/068561 WO2017112947A1 (en) 2015-12-24 2016-12-23 Cftr regulators and methods of use thereof

Publications (2)

Publication Number Publication Date
KR20180101415A KR20180101415A (ko) 2018-09-12
KR102723194B1 true KR102723194B1 (ko) 2024-10-28

Family

ID=59091233

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187021185A Active KR102723194B1 (ko) 2015-12-24 2016-12-23 Cftr 조절제 및 이의 사용 방법

Country Status (15)

Country Link
US (2) US20190031630A1 (OSRAM)
EP (1) EP3394083B9 (OSRAM)
JP (1) JP6894902B2 (OSRAM)
KR (1) KR102723194B1 (OSRAM)
CN (1) CN108699107B (OSRAM)
AU (2) AU2016377782B2 (OSRAM)
CL (1) CL2018001714A1 (OSRAM)
CO (1) CO2018007239A2 (OSRAM)
ES (1) ES2901002T3 (OSRAM)
IL (2) IL299924B2 (OSRAM)
PL (1) PL3394083T3 (OSRAM)
PT (1) PT3394083T (OSRAM)
RU (1) RU2742934C2 (OSRAM)
WO (1) WO2017112947A1 (OSRAM)
ZA (1) ZA201804228B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3066112T3 (en) 2015-12-24 2026-05-11 The Regents Of The Univ Of California Cftr regulators and methods of use thereof
IT201700085714A1 (it) * 2017-07-26 2019-01-26 Luigi Maiuri Approccio terapeutico per il trattamento e/o prevenzione di condizioni di sensibilità al glutine.
EP3672598A4 (en) * 2017-08-24 2021-04-28 The Regents of The University of California OCULAR PHARMACEUTICAL COMPOSITIONS
FR3096890B1 (fr) * 2019-06-07 2021-05-14 H4 Orphan Pharma Utilisation d’une molécule opioïde pour traiter l’œil sec et l’œil allergique.
US20220071549A1 (en) * 2020-09-08 2022-03-10 The Regents Of The University Of California Apparatus, systems and methods of use for ocular surface potential difference measurement
PY2193067A (es) 2020-10-23 2022-06-20 Ildong Pharmaceutical Co Ltd Compuestos moduladores del cftr, composiciones y usos de estos
CN113527225B (zh) * 2021-07-15 2022-11-18 南昌大学 一种丙烯酰噻二唑衍生物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140080825A1 (en) 2004-01-30 2014-03-20 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
WO2015196071A1 (en) 2014-06-19 2015-12-23 Proteostasis Therapeutics, Inc. Compounds, compositions and methods of increasing cftr activity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1917999A (en) 1998-03-31 1999-10-18 Warner-Lambert Company Quinoxalinones as serine protease inhibitors such as factor xa and thrombin
AP2005003292A0 (en) * 2002-09-30 2005-06-30 Univ California Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
WO2005075435A1 (en) * 2004-01-30 2005-08-18 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
US20090105240A1 (en) * 2007-10-17 2009-04-23 Tomas Mustelin Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same
AU2009221327B2 (en) 2008-03-05 2014-03-27 Merck Patent Gmbh Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes
US8314239B2 (en) 2008-10-23 2012-11-20 Vertex Pharmaceutical Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2010073011A2 (en) * 2008-12-23 2010-07-01 Betagenon Ab Compounds useful as medicaments
TWI450891B (zh) * 2010-12-29 2014-09-01 Dev Center Biotechnology 新穎微管蛋白抑制劑
AU2015229188A1 (en) * 2014-03-13 2016-09-29 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing CFTR activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140080825A1 (en) 2004-01-30 2014-03-20 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
WO2015196071A1 (en) 2014-06-19 2015-12-23 Proteostasis Therapeutics, Inc. Compounds, compositions and methods of increasing cftr activity

Also Published As

Publication number Publication date
RU2742934C2 (ru) 2021-02-11
ES2901002T3 (es) 2022-03-21
RU2018126959A (ru) 2020-01-24
PL3394083T3 (pl) 2022-01-17
PT3394083T (pt) 2021-12-07
CO2018007239A2 (es) 2018-07-19
JP6894902B2 (ja) 2021-06-30
NZ743720A (en) 2024-08-30
EP3394083B1 (en) 2021-09-01
CN108699107A (zh) 2018-10-23
CA3009531A1 (en) 2017-06-29
US20200140402A1 (en) 2020-05-07
WO2017112947A1 (en) 2017-06-29
AU2021257948A1 (en) 2021-11-25
CN108699107B (zh) 2022-05-10
AU2016377782B2 (en) 2021-07-29
KR20180101415A (ko) 2018-09-12
RU2018126959A3 (OSRAM) 2020-08-20
CL2018001714A1 (es) 2018-10-26
IL260210A (en) 2018-07-31
AU2016377782A1 (en) 2018-07-12
ES2901002T9 (es) 2022-06-20
AU2021257948B2 (en) 2023-11-30
IL260210B2 (en) 2023-06-01
IL299924B1 (en) 2024-09-01
EP3394083B9 (en) 2022-04-27
IL299924A (en) 2023-03-01
EP3394083A4 (en) 2019-09-04
US20190031630A1 (en) 2019-01-31
BR112018012927A2 (en) 2018-12-11
ZA201804228B (en) 2020-09-30
EP3394083A1 (en) 2018-10-31
IL299924B2 (en) 2025-01-01
US11192869B2 (en) 2021-12-07
JP2018538354A (ja) 2018-12-27

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