KR102687412B1 - 인터루킨-33(il-33)-매개된 질환과 관련된 바이오마커 및 이의 용도 - Google Patents

인터루킨-33(il-33)-매개된 질환과 관련된 바이오마커 및 이의 용도 Download PDF

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KR102687412B1
KR102687412B1 KR1020187009724A KR20187009724A KR102687412B1 KR 102687412 B1 KR102687412 B1 KR 102687412B1 KR 1020187009724 A KR1020187009724 A KR 1020187009724A KR 20187009724 A KR20187009724 A KR 20187009724A KR 102687412 B1 KR102687412 B1 KR 102687412B1
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제이미 엠. 오렌고
진 알린
웬 퓨어리
유 베이
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리제너론 파아마슈티컬스, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C07K2319/00—Fusion polypeptide
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/575—Hormones
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KR1020187009724A 2015-10-06 2016-10-05 인터루킨-33(il-33)-매개된 질환과 관련된 바이오마커 및 이의 용도 Active KR102687412B1 (ko)

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Application Number Priority Date Filing Date Title
US201562237624P 2015-10-06 2015-10-06
US62/237,624 2015-10-06
PCT/US2016/055502 WO2017062456A2 (en) 2015-10-06 2016-10-05 Biomarkers related to interleukin-33 (il-33)-mediated diseases and uses thereof

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KR20180053682A KR20180053682A (ko) 2018-05-23
KR102687412B1 true KR102687412B1 (ko) 2024-07-24

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US (2) US10005834B2 (https=)
EP (1) EP3359567A2 (https=)
JP (1) JP6858182B2 (https=)
KR (1) KR102687412B1 (https=)
CN (1) CN108137682B (https=)
AU (1) AU2016333903B2 (https=)
CA (1) CA3000725A1 (https=)
EA (1) EA201890891A1 (https=)
HK (2) HK1259386A1 (https=)
MA (1) MA50638A (https=)
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BR112016013347B1 (pt) 2013-12-26 2023-12-12 Mitsubishi Tanabe Pharma Corporation Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos
SG11201605580RA (en) 2014-01-10 2016-10-28 Anaptysbio Inc Antibodies directed against interleukin-33 (il-33)
TWI705976B (zh) 2014-11-10 2020-10-01 美商建南德克公司 抗介白素-33抗體及其用途
CN107109494B (zh) 2014-11-10 2023-10-27 豪夫迈·罗氏有限公司 Il-33介导型疾病的治疗方法和诊断方法
EA201890891A1 (ru) 2015-10-06 2018-09-28 Ридженерон Фармасьютикалз, Инк. Биомаркеры, связанные с заболеваниями, опосредованными интерлейкином-33 (ил-33), и их применение
JP2019516362A (ja) 2016-04-27 2019-06-20 ファイザー・インク 抗ｉｌ−３３抗体、その組成物、方法および使用
KR102460040B1 (ko) 2016-04-27 2022-11-01 애브비 인코포레이티드 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법
ES3052989T3 (en) * 2017-04-13 2026-01-16 Regeneron Pharma Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1
CA3066918A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
MY199245A (en) * 2017-08-31 2023-10-23 Hyogo College Medicine Il-33 antagonist-containing therapeutic agent for endometriosis
CN109061139A (zh) * 2018-06-19 2018-12-21 温州医科大学附属第医院 血清炎性生物标志物在防治急性缺血性脑梗死中的应用
TW202519263A (zh) * 2019-03-21 2025-05-16 美商再生元醫藥公司 含有抗il-33抗體之穩定調配物
US20230099101A1 (en) * 2020-03-06 2023-03-30 The Regents Of The University Of Michigan Serine protease inhibitors for suppressing or preventing anaphylactic reaction
AU2021236306A1 (en) 2020-03-13 2022-09-15 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
JP7578943B2 (ja) * 2020-07-13 2024-11-07 学校法人自治医科大学 褥瘡治療剤
CN114814242B (zh) * 2022-06-10 2025-04-01 中日友好医院(中日友好临床医学研究所) 一种诊断慢性阻塞性肺疾病患者肌肉减少症的血液学标志物
EP4658247A1 (en) * 2023-01-31 2025-12-10 Vivacelle Bio, Inc. Compositions and methods for treating hyperprocalcitonemia
KR102834740B1 (ko) * 2023-04-10 2025-07-17 아주대학교산학협력단 Hsp10 또는 이의 항체를 유효성분으로 포함하는 만성 자발적 두드러기의 진단을 위한 바이오마커 조성물
WO2026007411A1 (zh) * 2025-02-11 2026-01-08 广州医科大学 抗IL1RL1/IL-33/NF-kB抗体和使用其治疗急性髓性白血病的方法

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US20140271658A1 (en) * 2013-03-13 2014-09-18 Regeneron Pharmaceuticals, Inc. Anti-il-33 antibodies and uses thereof
US20140271642A1 (en) 2013-03-15 2014-09-18 Regeneron Pharmaceuticals, Inc. Il-33 antagonists and uses thereof
WO2015061441A1 (en) 2013-10-23 2015-04-30 Genentech, Inc. Methods of diagnosing and treating eosinophilic disorders

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WO2017062456A2 (en) 2017-04-13
US10005834B2 (en) 2018-06-26
JP6858182B2 (ja) 2021-04-14
EA201890891A1 (ru) 2018-09-28
JP2018533557A (ja) 2018-11-15
HK1259386A1 (zh) 2019-11-29
EP3359567A2 (en) 2018-08-15
HK1255972A1 (zh) 2019-09-06
CN108137682B (zh) 2026-03-17
US10851158B2 (en) 2020-12-01
MA50638A (fr) 2020-08-05
CN108137682A (zh) 2018-06-08
MX2018004170A (es) 2018-06-06
US20180258164A1 (en) 2018-09-13
KR20180053682A (ko) 2018-05-23
CA3000725A1 (en) 2017-04-13
US20170096483A1 (en) 2017-04-06
AU2016333903A1 (en) 2018-04-26
WO2017062456A3 (en) 2017-05-18
AU2016333903B2 (en) 2021-07-08

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