KR102651348B1 - Food composition for maintaining erection and improving prostate health - Google Patents

Abstract

The present invention contains 16-18 parts by weight of black goat extract powder, 14-16 parts by weight of eel extract powder, 3-5 parts by weight of guarana extract powder, 12-14 parts by weight of tribulus extract powder, and 16-18 parts by weight of fenugreek seed extract powder. parts, L-arginine 14-16 parts by weight, black maca powder 4-6 parts by weight, nicotinic acid amide 0.4-0.6 parts by weight, calcium pantothenate 0.4-0.6 parts by weight, vitamin B1 hydrochloride 0.4-0.6 parts by weight, vitamin B6 hydrochloride 0.4 -Provides a food composition for maintaining erection and improving prostate health, comprising 0.6 parts by weight and 11-13 parts by weight of dextrin.

Description

Food composition for maintaining erection and improving prostate health {Food composition for maintaining erection and improving prostate health}

The present invention relates to a food composition for promoting and maintaining erection and improving prostate health.

In modern living environments, overwork, drinking, stress, and environmental pollution disrupt biological rhythms and increase the frequency of adult diseases such as high blood pressure, diabetes, and obesity. As a result, people in their 20s and 30s, when they should be at their peak, experience decreased energy and aging. It often causes symptoms such as sexual dysfunction and sexual dysfunction, and it appears to be very serious in people over 40 years of age.

Accordingly, in order to treat male erectile dysfunction, it is treated with exercise or medication. Exercise must be done regularly, but since it is not easy to manage it regularly while living a social life, it usually relies on drug treatment.

Male sexual function consists of sexual desire, penile erection, ejaculation, and orgasm. This is determined by complex physiological responses of the nervous, endocrine, and vascular systems, and abnormalities in any one of these can cause sexual dysfunction. Until about 10 years ago, most of these sexual dysfunctions were considered to be psychogenic, but with the development of modern medicine, more than 50% of patients with sexual dysfunctions suffer from various causes such as vascular, nervous, and endocrine diseases, diabetes, high blood pressure, and drug use. It turns out that it is. Recently, sildenafil, a phosphodiesterase V inhibitor, has been attracting a lot of attention in the treatment of sexual dysfunction. However, this treatment uses chemicals to induce temporary erections, is expensive, and causes headaches and increased blood pressure. There are many side effects, such as heart attack. In particular, there are quite a few reported cases of death due to aggravated heart disease. Therefore, there is a need to develop a safe and effective treatment for sexual dysfunction that enhances the body's instinctive erectile function, and the recent trend is to increase the production of nitric oxide and cGMP, signaling substances that have a strong relaxing effect in the smooth muscle of the corpus cavernosum, thereby increasing the production of nitric oxide and cGMP in the smooth muscle of the penis. There is growing interest in developing treatments to improve sexual function that promote erection in the corpus cavernosum.

In addition, existing erectile dysfunction drugs are developed with a focus only on temporarily inducing erections without improving physical disorders related to blood circulation and endocrine function that cause erectile dysfunction, and as they are used, tolerance gradually develops or various side effects appear. You can. Accordingly, research is currently being actively conducted to search for erectile dysfunction treatments without side effects from natural products and herbal medicines.

Patent Document 1: Republic of Korea Patent 10-1030608

The present invention was made to solve the above problems, and the purpose of the present invention is to provide a food composition for improving prostate health and promoting and maintaining erection.

In addition, another object of the present invention is to provide a food composition that significantly increases the content of flavonoids and free amino acids contained in natural raw materials and improves the absorption rate in the body, thereby significantly improving the effects of improving prostate health and maintaining erection. It is provided.

The object of the present invention is not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

In order to achieve the above object, the present invention

Black goat extract powder 16-18 parts by weight, eel extract powder 14-16 parts by weight, guarana extract powder 3-5 parts by weight, tribulus extract powder 12-14 parts by weight, fenugreek seed extract powder 16-18 parts by weight, L -Arginine 14-16 parts by weight, black maca powder 4-6 parts by weight, nicotinic acid amide 0.4-0.6 parts by weight, calcium pantothenate 0.4-0.6 parts by weight, vitamin B1 hydrochloride 0.4-0.6 parts by weight, vitamin B6 hydrochloride 0.4-0.6 parts by weight Provided is a food composition for maintaining erection and improving prostate health, comprising 11 to 13 parts by weight of dextrin.

In addition, the food composition for maintaining erection and improving prostate health includes 3-7 parts by weight of a complex fermented extract in which fermented Awi mushroom extract, fermented Corydalis extract, and fermented Cupressa leaf extract are mixed in a weight ratio of 1:1:1. ,

The complex fermentation extract is,

Washing Awi mushroom, Corydalis and Arborvitae leaves and freeze-drying them at a temperature of -48-52℃; Preparing a composite powder by grinding freeze-dried Awi mushroom, Corydalis and Arborvitae leaves and mixing them at a weight ratio of 1:1:1; 48-52 parts by weight of the composite powder and 48-52 parts by weight of ginseng fermentation extract are mixed, and Bacillus repens and Saccharomyces bayanus are mixed at a weight ratio of 1:1. Adding 0.8-1.2 parts by weight and fermenting at a temperature of 30-34°C for 5-7 days; After fermentation, heating to a temperature of 88-92°C and cooling to a temperature of 23-27°C; After cooling, adding 0.3-0.7 parts by weight of β-glucosidase and performing an enzyme reaction at a temperature of 32-36°C for 10-14 hours; After the enzyme reaction, adding 48-52 parts by weight of purified water and extracting at a temperature of 98-102°C for 5-7 hours to prepare an extract; and concentrating and freeze-drying the extract under reduced pressure.

The ginseng fermentation extract is,

Mixing ginseng and purified water at a weight ratio of 1:1 and immersing at a temperature of 3-7°C for 22-26 hours; After soaking, adding Aspergillus oryzae and fermenting at a temperature of 30-34°C for 2-4 days; After fermentation, heating to a temperature of 88-92°C and boiling for 46-50 hours; and boiling and then filtering to obtain a filtrate.

In addition, the food composition for maintaining erection and improving prostate health is a complex fermented extract mixed with Awi mushroom fermented extract, Corydalis fermented extract, and Arborvitae leaf fermented extract in a weight ratio of 1:1:1, vitamin tree fruit fermented oil, and It contains 8-12 parts by weight of a complex composition containing complex fermented oil mixed with safflower seed fermented oil at a weight ratio of 1:1,

The complex fermentation extract is,

Washing Awi mushroom, Corydalis and Arborvitae leaves and freeze-drying them at a temperature of -48-52℃; Preparing a composite powder by grinding freeze-dried Awi mushroom, Corydalis and Arborvitae leaves and mixing them at a weight ratio of 1:1:1; 48-52 parts by weight of the composite powder and 48-52 parts by weight of ginseng fermentation extract are mixed, and Bacillus repens and Saccharomyces bayanus are mixed at a weight ratio of 1:1. Adding 0.8-1.2 parts by weight and fermenting at a temperature of 30-34°C for 5-7 days; After fermentation, heating to a temperature of 88-92°C and cooling to a temperature of 23-27°C; After cooling, adding 0.3-0.7 parts by weight of β-glucosidase and performing an enzyme reaction at a temperature of 32-36°C for 10-14 hours; After the enzyme reaction, adding 48-52 parts by weight of purified water and extracting at a temperature of 98-102°C for 5-7 hours to prepare an extract; and concentrating and freeze-drying the extract under reduced pressure.

The ginseng fermentation extract is,

Mixing ginseng and purified water at a weight ratio of 1:1 and immersing at a temperature of 3-7°C for 22-26 hours; After soaking, adding Aspergillus oryzae and fermenting at a temperature of 30-34°C for 2-4 days; After fermentation, heating to a temperature of 88-92°C and boiling for 46-50 hours; and boiling and then filtering to obtain a filtrate;

The complex fermented oil is,

Washing vitamin tree fruit and safflower seeds and heat treating them at a temperature of 118-122°C for 8-12 minutes; Preparing a mixed powder by freeze-drying heat-treated vitamin tree fruits and safflower seeds at a temperature of -48-52°C, pulverizing them, and mixing them at a weight ratio of 1:1; 48-52 parts by weight of the mixed powder and 48-52 parts by weight of ginseng fermentation extract are mixed, and Bacillus repens and Saccharomyces bayanus are mixed at a weight ratio of 1:1. Adding 0.8-1.2 parts by weight and fermenting at a temperature of 30-34°C for 5-7 days; After fermentation, filtering to obtain solid content, mixing 8-12 parts by weight of the solid content and 88-92 parts by weight of hexane, and stirring for 2-4 days at a temperature of 28-32° C. to prepare an extract; and filtering the extract, concentrating it under reduced pressure, centrifuging it to remove foreign substances, and distilling it under reduced pressure.

The composite composition,

Mixing 68-72 parts by weight of purified water and 28-32 parts by weight of phospholipids, and first sonicating for 28-32 minutes at a temperature of 58-62°C;

After primary ultrasonic treatment, adding 13-17 parts by weight of the complex fermentation oil and performing secondary ultrasonic treatment at a temperature of 68-72°C for 28-32 minutes; and

After the second ultrasonic treatment, 28-32 parts by weight of the complex fermentation extract is added, and the third ultrasonic treatment is performed at a temperature of 53-57° C. for 28-32 minutes.

The food composition according to the present invention has the effect of improving prostate health and maintaining erection.

In addition, the ingredients included in the food composition according to the present invention significantly increase the total flavonoid content and the total amino acid content, and improve the absorption rate in the body, thereby improving prostate health and maintaining erectile function.

Hereinafter, various embodiments will be described in more detail. The embodiments described herein may be modified in various ways. Specific embodiments may be described in detail in the detailed description. However, the specific embodiments disclosed are only intended to facilitate understanding of the various embodiments. Accordingly, the technical idea is not limited to the specific embodiments disclosed, and should be understood to include all equivalents or substitutes included in the spirit and technical scope of the invention.

Terms containing ordinal numbers, such as primary, secondary, first, second, etc., may be used to describe various components, but these components are not limited by the above-mentioned terms. The above-mentioned terms are used only for the purpose of distinguishing one component from another.

In this specification, terms such as 'include' or 'have' are intended to designate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, but are not intended to indicate the presence of one or more other features. It should be understood that this does not exclude in advance the possibility of the existence or addition of elements, numbers, steps, operations, components, parts, or combinations thereof. When a component is said to be 'connected' or 'connected' to another component, it is understood that it may be directly connected or connected to the other component, but that other components may exist in between. It should be. On the other hand, when a component is mentioned as being 'directly connected' or 'directly connected' to another component, it should be understood that there are no other components in between.

In addition, when describing the present invention, if it is determined that a detailed description of a related known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof is abbreviated or omitted.

This invention

Black goat extract powder 16-18 parts by weight, eel extract powder 14-16 parts by weight, guarana extract powder 3-5 parts by weight, tribulus extract powder 12-14 parts by weight, fenugreek seed extract powder 16-18 parts by weight, L -Arginine 14-16 parts by weight, black maca powder 4-6 parts by weight, nicotinic acid amide 0.4-0.6 parts by weight, calcium pantothenate 0.4-0.6 parts by weight, vitamin B1 hydrochloride 0.4-0.6 parts by weight, vitamin B6 hydrochloride 0.4-0.6 parts by weight Provided is a food composition for maintaining erection and improving prostate health, comprising 11 to 13 parts by weight of dextrin.

Hereinafter, the food composition for maintaining erection and improving prostate health according to the present invention will be described in detail.

The black goat extract powder is extracted from black goat, has a low fat content, contains a large amount of minerals such as calcium, phosphorus, and iron, and contains more unsaturated fatty acids than pork and beef. The black goat essence extract powder is prepared by cutting and processing carcass from which a black goat has been slaughtered and the intestines removed, washing the processed carcass, soaking the washed carcass in purified water to remove blood, and immersing the carcass from which blood has been removed in purified water. , heated at a temperature of 118-122℃ for 28-32 minutes, added purified water and heated at a temperature of 138-142℃ for 8-10 hours, filtered to obtain a filtrate, concentrated under reduced pressure and frozen. Use what is prepared by drying. The black goat essence extract powder preferably contains 16-18 parts by weight, more preferably 16.5-17.5 parts by weight, and functionality can be ensured by including within the above content range.

The eel juice extract powder is extracted from eel. Eel is high in protein, high in calories, and high in unsaturated fatty acids, so it is recognized as the best food for preventing adult diseases such as high blood pressure, weak constitution, and restoring energy, so it is a stamina food, especially for men in the summer. It is very popular. The eel juice extract powder is prepared by cutting and processing the raw material from which the intestines of the eel have been removed, washing the processed raw material, immersing the washed raw material in purified water, and heating at a temperature of 118-122 ° C. for 28-32 minutes, Add purified water, heat at a temperature of 138-142°C for 8-10 hours, filter it to obtain a filtrate, and use the product prepared by concentrating the filtrate under reduced pressure and freeze-drying. The eel juice extract powder preferably contains 14-16 parts by weight, more preferably 14.5-15.5 parts by weight, and functionality can be ensured by including within the above content range.

The guarana extract powder is extracted from guarana. Guarana is a fruit similar in size to a coffee bean. Guarana seeds contain twice the concentration of caffeine as coffee beans and are used as a dietary supplement. Guarana's high caffeine concentration is protective. It acts as a toxin and plays a role in protecting guarana fruits and seeds from other pathogens. The guarana extract powder preferably contains 3-5 parts by weight, more preferably 3.5-4.5 parts by weight, and functionality can be ensured by containing it within the above content range.

The Tribulus extract powder is extracted from Tribulus, Tribulus (Tribulus terrestris L.) contains saponin in the roots and leaves, and sapogenin includes Diosgenin and Gitogenin. , Chlorogenin, etc. are contained. It is good for high blood pressure and is known to be effective in reducing fever, diuresis, constipation, liver disease, hematemesis, bloody stool, menstrual irregularities, and diarrhea. The tributary extract powder preferably contains 12-14 parts by weight, more preferably 12.5-13.5 parts by weight, and functionality can be ensured by including within the above content range.

The fenugreek seed extract powder is extracted from fenugreek seeds, and fenugreek is warm in nature and is known to have the effect of curing the weak and cold genitals, which causes the lower abdomen and sides to be as large as a spear, and the dark blue color around the eyes or face. The fenugreek seed extract powder preferably contains 16-18 parts by weight, more preferably 16.5-17.5 parts by weight, and functionality can be ensured by including the above content range.

L-Arginine is one of the conditionally essential amino acids and is an essential element used when converting ammonia in the body into urea. It plays a role in contributing to angina pectoris and nitric oxide, which contributes to the expansion of blood vessels, when there is too much nitric oxide in the body. It is also used to treat symptoms of high blood pressure. The L-arginine preferably contains 14-16 parts by weight, more preferably 14.5-15.5 parts by weight, and functionality can be ensured by including within the above content range.

The black maca powder is a powder manufactured from black maca. Black maca contains 10 types of essential amino acids such as valine, lysine, and arginine, and vitamins such as vitamins C, E, and B, especially in the case of arginine. It contains 1.5 times more iron than oysters, about 10 times more iron than deodeok, about 11 times more zinc than chives, and about 26 times more calcium than garlic. The black maca powder preferably contains 4-6 parts by weight, more preferably 4.5-5.5 parts by weight, and functionality can be ensured by containing it within the above content range.

The nicotinic acid amide preferably contains 0.4-0.6 parts by weight, more preferably 0.45-0.55 parts by weight, and functionality can be ensured by including within the above content range.

The calcium pantothenate preferably contains 0.4-0.6 parts by weight, and more preferably contains 0.45-0.55 parts by weight, and functionality can be ensured by including within the above content range.

The vitamin B1 hydrochloride preferably contains 0.4-0.6 parts by weight, more preferably 0.45-0.55 parts by weight, and functionality can be ensured by including it within the above content range.

The vitamin B6 hydrochloride preferably contains 0.4-0.6 parts by weight, more preferably 0.45-0.55 parts by weight, and functionality can be ensured by including it within the above content range.

In addition, the food composition for maintaining erection and improving prostate health contains 3-7 parts by weight of a complex fermented extract in which fermented Awi mushroom extract, fermented Corydalis extract, and fermented arborvitae leaf extract are mixed in a weight ratio of 1:1:1. It is preferable, and it is more preferable that it contains 4-6 parts by weight.

The complex fermentation extract is,

Washing Awi mushroom, Corydalis and Arborvitae leaves and freeze-drying them at a temperature of -48-52℃; Preparing a composite powder by grinding freeze-dried Awi mushroom, Corydalis and Arborvitae leaves and mixing them at a weight ratio of 1:1:1; 48-52 parts by weight of the composite powder and 48-52 parts by weight of ginseng fermentation extract are mixed, and Bacillus repens and Saccharomyces bayanus are mixed at a weight ratio of 1:1. Adding 0.8-1.2 parts by weight and fermenting at a temperature of 30-34°C for 5-7 days; After fermentation, heating to a temperature of 88-92°C and cooling to a temperature of 23-27°C; After cooling, adding 0.3-0.7 parts by weight of β-glucosidase and performing an enzyme reaction at a temperature of 32-36°C for 10-14 hours; After the enzyme reaction, adding 48-52 parts by weight of purified water and extracting at a temperature of 98-102°C for 5-7 hours to prepare an extract; and concentrating and freeze-drying the extract under reduced pressure.

Pleurotus eryngii var. ferulea (Pf.) is a variety of king oyster mushroom. Its English name is Ferula Oyster Mushroom, which means oyster mushroom. In China, it is called Baengnyeongcheui (白靈側耳). It grows wild on the Awi tree in the Xinjiang region, a dry area in China. The growing temperature is 8~20℃, making it suitable for spring and fall cultivation in Korea. The Awi mushroom, which grows naturally in China and Central Asia, is capable of loosening clogs. It is known as a medicinal plant that relieves coughing and inflammation and is effective in treating gastrointestinal diseases. It is a highly functional mushroom introduced in Oriental medicine books as being effective in discharging toxins from the human body, stopping coughing, relieving inflammation, and treating obstetric and gynecological diseases.

Corydalis turtschaninovii BESS. is a perennial plant of the Papaveraceae family that grows in mountains and fields across the country and is distributed in Japan, Manchuria, Amul, and Ussuri. The tubers are called Corydalis, and are known to be effective in relieving blood, live fish, energy, and pain relief, as well as treating heartache, yogic pain, irregular menstruation, and postpartum hemorrhage. Ingredients include Berberine, Corydaline, and dl tetrahydrocoptisine.

Thuja orientalis is an evergreen tree of the coniferous family Cupressaceae. Its leaves are obovate or ovate and both sides are green or light yellow-green. The length of the fruit is 15-20 mm, it is egg-shaped, and it is so effective for hair that it is introduced as a great medicine for preventing hair loss and promoting hair growth. The bark and branches are reddish brown (large) or green (small), and the bark is grey-brown and split lengthwise.

In the present invention, we intend to apply a complex fermented extract extracted from Awi mushroom, Corydalis and Arborvitae leaves to a food composition for maintaining erection and improving prostate health. In particular, the complex fermented extract is made into flavonoids and amino acids through fermentation technology using ginseng fermentation extract. The functionality is excellent as the content is significantly increased, extracted and applied.

The complex fermentation extract according to the present invention is extracted by increasing the amount of essential amino acids. The essential amino acids (EAA) are not synthesized in the body, or even if synthesized, the amount is very small and is not sufficient to achieve physiological functions, so it is necessary to Amino acids that must be obtained from food. The essential amino acids are isoleucine (I), leucine (L), lysine (K), methionine (M), phenylalanine (F), threonine (T), and tryptophan. , W), valine (V), histidine (H), and arginine (R).

The ginseng fermentation extract is,

Mixing ginseng and purified water at a weight ratio of 1:1 and immersing at a temperature of 3-7°C for 22-26 hours; After soaking, adding Aspergillus oryzae and fermenting at a temperature of 30-34°C for 2-4 days; After fermentation, heating to a temperature of 88-92°C and boiling for 46-50 hours; and boiling and then filtering to obtain a filtrate; use the product prepared by performing the following.

In addition, the food composition for maintaining erection and improving prostate health is a complex fermented extract mixed with Awi mushroom fermented extract, Corydalis fermented extract, and Arborvitae leaf fermented extract in a weight ratio of 1:1:1, vitamin tree fruit fermented oil, and It is preferable to include 8-12 parts by weight of the complex composition containing complex fermented oil mixed with safflower seed fermented oil at a weight ratio of 1:1, and more preferably 9-11 parts by weight.

The complex fermented oil is,

Washing vitamin tree fruit and safflower seeds and heat treating them at a temperature of 118-122°C for 8-12 minutes; Preparing a mixed powder by freeze-drying heat-treated vitamin tree fruits and safflower seeds at a temperature of -48-52°C, pulverizing them, and mixing them at a weight ratio of 1:1; 48-52 parts by weight of the mixed powder and 48-52 parts by weight of ginseng fermentation extract are mixed, and Bacillus repens and Saccharomyces bayanus are mixed at a weight ratio of 1:1. Adding 0.8-1.2 parts by weight and fermenting at a temperature of 30-34°C for 5-7 days; After fermentation, filtering to obtain solid content, mixing 8-12 parts by weight of the solid content and 88-92 parts by weight of hexane, and stirring for 2-4 days at a temperature of 28-32° C. to prepare an extract; and filtering the extract, concentrating it under reduced pressure, centrifuging it to remove foreign substances, and distilling it under reduced pressure.

Vitamin tree (Hippophae rhamnoides L.) is a shrubby tree of the Elaeagnaceae family, native to China and Mongolia. It grows widely in Europe and Central Asia. It can grow in poor soil and has excellent nitrogen fixation ability to prevent soil loss. It is also used for soil reclamation purposes. The fruit of the vitamin tree has a very high content of vitamins and amino acids, and is known to have excellent physiological activities such as immunity, anti-inflammatory, and antioxidant properties. It also has a very high content of proteins such as globulins and albumins and fatty acids such as linoleic acids and linolenic acids. It is known to be rich in antioxidant bioactive substances such as polyphenols, tocopherols, carotenoids, and flavonoids.

Safflower (Carthamus Tinctorius), also called safflower, is also used as a raw material for red rouge. Safflower is the flower of safflower, an annual herb belonging to the Asteraceae family. It helps blood circulation and has been known since ancient times as a good flower for women. In particular, it has been reported that it promotes blood circulation and that safflower seeds are rich in vitamin E, which has antioxidant effects and has various effects such as anti-aging. In addition, it contains flavonoids, glycosides, alkaloids, polyacetylline glycosides and other ingredients.

In the present invention, the complex fermented oil extracted from the vitamin tree fruit and safflower seed is intended to be applied to a food composition for maintaining erection and improving prostate health, and by applying the complex fermented oil, superior functionality can be secured.

In addition, the composite composition,

Mixing 68-72 parts by weight of purified water and 28-32 parts by weight of phospholipids, and first sonicating for 28-32 minutes at a temperature of 58-62°C;

After primary ultrasonic treatment, adding 13-17 parts by weight of the complex fermentation oil and performing secondary ultrasonic treatment at a temperature of 68-72°C for 28-32 minutes; and

After the second sonication, add 28-32 parts by weight of the complex fermentation extract and perform the third sonication for 28-32 minutes at a temperature of 53-57°C.

The phospholipid may be one or more selected from the group consisting of phosphatidylcholine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, phosphatidylethanolamine, phosphatidyl acid, phosphatidyl serum, phosphatidyl glycerol, and phosphatidyl inosirol, and preferably phosphatidylethanolamine is used. do.

The complex composition obtained by complexing the complex fermentation extract and the complex fermentation oil is applied to a food composition for maintaining erection and improving prostate health, and the complex composition is complexed with the complex fermentation extract extracted by significantly increasing the content of flavonoids and amino acids. It contains complex fermented oil and has excellent absorption of active ingredients, which can significantly improve functionality.

Hereinafter, the present invention will be explained in more detail by the following examples.

However, the following examples only illustrate the content of the present invention and the scope of the invention is not limited by the examples and experimental examples.

<Preparation Example 1> Preparation of complex fermentation extract-1

Ginseng and purified water were mixed at a weight ratio of 1:1, soaked at a temperature of 5°C for 24 hours, then Aspergillus oryzae was added and fermented at a temperature of 32°C for 3 days. . After fermentation, it was heated to a temperature of 90°C, boiled for 48 hours, filtered, and the filtrate was obtained to prepare a ginseng fermentation extract.

A composite powder was prepared by washing the Awi mushroom, Corydalis, and Arborvitae leaves, freeze-drying them at a temperature of -50°C, pulverizing them, and mixing them at a weight ratio of 1:1:1. 50 parts by weight of the composite powder and 50 parts by weight of the ginseng fermentation extract are mixed, and 1 part by weight of a mixed strain of Bacillus repens and Saccharomyces bayanus is mixed in a weight ratio of 1:1. After addition, it was fermented at a temperature of 32°C for 6 days. After fermentation, the fermentation was stopped by heating to a temperature of 90°C and cooled to a temperature of 25°C. After cooling, 0.5 parts by weight of β-glucosidase was added, enzymatic reaction was performed at 34°C for 12 hours, 50 parts by weight of purified water was added, and extraction was performed at 100°C for 6 hours to prepare an extract. The extract was concentrated under reduced pressure and freeze-dried to prepare a complex fermentation extract.

<Preparation Example 2> Preparation of complex fermentation extract-2

A complex fermented extract was prepared in the same manner as in Preparation Example 1, except that purified water was used instead of ginseng fermentation extract, and no enzymatic reaction was performed.

<Preparation Example 3> Preparation of complex fermentation extract-3

A complex fermentation extract was prepared in the same manner as Preparation Example 1, except that the enzyme reaction was not performed in Preparation Example 1.

<Preparation Example 4> Preparation of complex fermented oil

The vitamin tree fruit and safflower seeds were washed, heat treated at 120°C for 10 minutes, freeze-dried at -50°C, ground, and mixed at a weight ratio of 1:1 to prepare a mixed powder. 50 parts by weight of the mixed powder and 50 parts by weight of the ginseng fermentation extract are mixed, and 1 part by weight of a mixed strain of Bacillus repens and Saccharomyces bayanus mixed at a weight ratio of 1:1 After addition, it was fermented at a temperature of 32°C for 6 days. After fermentation, solid content was obtained by filtration, and 10 parts by weight of the solid content and 90 parts by weight of hexane were mixed and stirred for 3 days at a temperature of 30° C. to prepare an extract. The extract was filtered, concentrated under reduced pressure, centrifuged to remove foreign substances, and then distilled under reduced pressure to prepare complex fermented oil.

<Preparation Example 5> Preparation of composite composition

70 parts by weight of purified water and 30 parts by weight of phosphatidylethanolamine were mixed with phospholipids, and first sonicated at a temperature of 60°C for 30 minutes. After the first ultrasonic treatment, 15 parts by weight of the complex fermentation oil prepared in Preparation Example 4 was added, and the second ultrasonic treatment was performed at a temperature of 70°C for 30 minutes. After the second ultrasonic treatment, 30 parts by weight of the complex fermentation extract prepared in Preparation Example 1 was added, and a third ultrasonic treatment was performed at a temperature of 55° C. for 30 minutes to prepare a composite composition.

<Example 1> Preparation of food composition-1

17 parts by weight of black goat extract powder, 15 parts by weight of eel extract powder, 4 parts by weight of guarana extract powder, 13 parts by weight of tribulus extract powder, 17 parts by weight of fenugreek seed extract powder, 15 parts by weight of L-arginine, black maca powder A food composition was prepared by mixing 5 parts by weight, 0.5 parts by weight of nicotinic acid amide, 0.5 parts by weight of calcium pantothenate, 0.5 parts by weight of vitamin B1 hydrochloride, 0.5 parts by weight of vitamin B6 hydrochloride, and 12 parts by weight of dextrin.

<Example 2> Preparation of food composition-2

A food composition was prepared by adding 5 parts by weight of the complex fermentation extract prepared in Preparation Example 1 to the food composition of Example 1 and mixing it.

<Example 3> Preparation of food composition-3

A food composition was prepared by adding 10 parts by weight of the composite composition prepared in Preparation Example 4 to the food composition of Example 1 and mixing it.

<Experimental Example 1> Ingredient analysis

In order to analyze the flavonoid content and amino acid content of the complex fermentation extract prepared in Preparation Example 1-3, analysis was performed using high performance liquid chromatography (HPLC) analysis and an amino acid analyzer (Amino acid analyzer biochrom 30, Biochrom, UK). The total flavonoid content, total amino acid content, and essential amino acid content were analyzed, and the results are shown in Table 1 below.

Total flavonoid content
(mg/g) Total amino acid content
(mg/g) Essential amino acid content
(mg/kg) Manufacturing Example 1 56.68 10485.60 3385.12 Production example 2 30.61 5058.86 1580.16 Production example 3 38.57 7123.35 2248.67

As shown in Table 1, it was confirmed that the complex fermentation extract according to the present invention had high total flavonoid content, total amino acid content, and essential amino acid content.

<Experimental Example 2> Antioxidant functionality analysis

Using the complex fermentation extract prepared in Preparation Example 1-3 as a sample, the antioxidant power was measured by DPPH (2,2-Diphenyl-1-picryl-hydrazyl) radical scavenging activity. DPPH radical scavenging ability was determined by referring to the method of Mensor et al. 80 ㎕ of 0.2mM DPPH ethanol solution was added to each sample, stirred for 1 minute, reacted in a 25°C incubator for 10 minutes, and absorbance was measured at 517 nm using an ELISA reader. DPPH radical scavenging activity was expressed as a percentage according to the following calculation formula 1, and the results are shown in Table 2 below.

<Calculation 1>

Sample name Antioxidant effect (DPPH scavenging activity rate, %) Manufacturing Example 1 55.8 Production example 2 48.9 Production example 3 51.2

A high level of DPPH radical scavenging activity means high antioxidant effect, and as shown in Table 2 above, the complex fermentation extract according to the present invention has a high DPPH radical scavenging activity value measured and has excellent antioxidant functionality. You can check it.

<Experimental Example 3> Prostate improvement functional analysis

A clinical experiment was conducted on the food composition prepared in Examples 1-3 above to confirm its functionality in improving the prostate.

For the experiment, 30 men in their 50s and 60s were selected, and 10 people were divided into experimental group 1, experimental group 2, and experimental group 3 so that the average age was the same. Experimental group 1 was given the food composition of Example 1, and experimental group 2 was given the food composition of Example 2. The food composition of Example 3 was administered to experimental group 3. In the experiment, 3 g of the sample was taken twice a day, in the morning and evening, for 6 months. The PSA index was measured every month after taking the drug, and the average value was calculated for each experimental group, which is shown in Table 3 below.

The Prostate Specific Antigen (PSA) index is a substance that is normally produced in the prostate and is used to diagnose cancer due to elevated blood levels in diseases such as prostate carcinoma. In this experimental example, if the PSA index increases, prostate inflammation and It can be seen that diseases such as hypertrophy and prostate cancer are increasing.

In general, the normal value of the PSA index is 0-4 ng/ml, and if the PSA index is more than 4 ng/ml, there is a possibility of prostate cancer. Also, in cases of prostatitis, severe benign prostatic hyperplasia, or severe urination difficulty, PSA The index value increases.

period PSA index (ng/ml) Experimental group 1 Experimental group 2 Experimental group 3 Before intake 24.06 23.87 24.10 1 month 20.57 17.49 17.31 2 months 16.42 12.68 12.30 3 months 13.23 7.23 6.10 4 months 10.57 5.30 4.78 5 months 8.57 3.21 2.89 6 months 6.88 1.02 0.87

As shown in Table 3, it was confirmed that the PSA index was significantly reduced when the food composition according to the present invention was applied.

<Experimental Example 4> Functional analysis for improving erection promotion and maintenance

The erection-promoting effect of the food composition prepared in Examples 1-3 was measured in vivo to confirm its functionality in improving sexual function. At this time, sildenafil citrate was used as a positive control.

Specifically, male SPF New Zealand albino rabbits (weighing approximately 3.0-4.0 kg) were used as test animals, 6 each in each test group, and were kept in cages under the same conditions for at least 3 days with a certain amount of regular rabbit solid feed and water. were supplied and raised. Rabbits were used for testing after fasting for more than 48 hours, and were allowed to drink water freely during fasting.

Each of the above samples was administered orally to the rabbits prepared as above in an amount of 50 mg/kg per animal. Meanwhile, sildenafil citrate, the positive control group, was orally administered in an amount of 20 mg/kg. In this way, the onset time and duration of erection after administration were measured, and the results are shown in Table 4 below.

control group Example 1 Example 2 Example 3 Erection start time (minutes) 6.8 7.7 7.2 6.8 Maximum erection time (minutes) 18.6 15.4 17.2 18.4 Erection maintenance time (minutes) 120.7 100.5 109.5 120.6

As shown in Table 4, it was confirmed that excellent erection performance was achieved when the food composition according to the present invention was applied.

Claims (3)

Black goat extract powder 16-18 parts by weight, eel extract powder 14-16 parts by weight, guarana extract powder 3-5 parts by weight, tribulus extract powder 12-14 parts by weight, fenugreek seed extract powder 16-18 parts by weight, L -Arginine 14-16 parts by weight, black maca powder 4-6 parts by weight, nicotinic acid amide 0.4-0.6 parts by weight, calcium pantothenate 0.4-0.6 parts by weight, vitamin B1 hydrochloride 0.4-0.6 parts by weight, vitamin B6 hydrochloride 0.4-0.6 parts by weight parts, 3-7 parts by weight of complex fermentation extract and 11-13 parts by weight of dextrin,
The complex fermentation extract is,
Washing Awi mushroom, Corydalis and Arborvitae leaves and freeze-drying them at a temperature of -48-52℃; Preparing a composite powder by grinding freeze-dried Awi mushroom, Corydalis and Arborvitae leaves and mixing them at a weight ratio of 1:1:1; 48-52 parts by weight of the composite powder and 48-52 parts by weight of ginseng fermentation extract are mixed, and Bacillus repens and Saccharomyces bayanus are mixed at a weight ratio of 1:1. Adding 0.8-1.2 parts by weight and fermenting at a temperature of 30-34°C for 5-7 days; After fermentation, heating to a temperature of 88-92°C and cooling to a temperature of 23-27°C; After cooling, adding 0.3-0.7 parts by weight of β-glucosidase and performing an enzyme reaction at a temperature of 32-36°C for 10-14 hours; After the enzyme reaction, adding 48-52 parts by weight of purified water and extracting at a temperature of 98-102°C for 5-7 hours to prepare an extract; and concentrating and freeze-drying the extract under reduced pressure.
The ginseng fermentation extract is,
Mixing ginseng and purified water at a weight ratio of 1:1 and immersing at a temperature of 3-7°C for 22-26 hours; After soaking, adding Aspergillus oryzae and fermenting at a temperature of 30-34°C for 2-4 days; After fermentation, heating to a temperature of 88-92°C and boiling for 46-50 hours; A food composition for maintaining erection and improving prostate health, which is prepared by boiling and then filtering to obtain a filtrate. delete delete