KR102640198B1 - Actrii 리간드 트랩을 사용한 베타-탈라세미아의 치료 - Google Patents

Actrii 리간드 트랩을 사용한 베타-탈라세미아의 치료 Download PDF

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KR102640198B1
KR102640198B1 KR1020177035838A KR20177035838A KR102640198B1 KR 102640198 B1 KR102640198 B1 KR 102640198B1 KR 1020177035838 A KR1020177035838 A KR 1020177035838A KR 20177035838 A KR20177035838 A KR 20177035838A KR 102640198 B1 KR102640198 B1 KR 102640198B1
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certain embodiments
actriib
delete delete
signaling inhibitor
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KR20180006437A (ko
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케네스 엠. 아티에
아브데라만 라아뎀
라제쉬 쵸프라
제이 백스트롬
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셀진 코포레이션
악셀레론 파마 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020177035838A 2015-05-13 2016-05-12 Actrii 리간드 트랩을 사용한 베타-탈라세미아의 치료 Active KR102640198B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562161136P 2015-05-13 2015-05-13
US62/161,136 2015-05-13
US201562173836P 2015-06-10 2015-06-10
US62/173,836 2015-06-10
US201562243457P 2015-10-19 2015-10-19
US62/243,457 2015-10-19
PCT/US2016/031999 WO2016183280A1 (en) 2015-05-13 2016-05-12 Treatment of beta-thalassemia using actrii ligand traps

Publications (2)

Publication Number Publication Date
KR20180006437A KR20180006437A (ko) 2018-01-17
KR102640198B1 true KR102640198B1 (ko) 2024-02-23

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KR1020177035838A Active KR102640198B1 (ko) 2015-05-13 2016-05-12 Actrii 리간드 트랩을 사용한 베타-탈라세미아의 치료

Country Status (15)

Country Link
US (1) US20180125928A1 (cg-RX-API-DMAC10.html)
EP (1) EP3294320A4 (cg-RX-API-DMAC10.html)
JP (2) JP6976859B2 (cg-RX-API-DMAC10.html)
KR (1) KR102640198B1 (cg-RX-API-DMAC10.html)
CN (3) CN122399028A (cg-RX-API-DMAC10.html)
AU (2) AU2016261913B2 (cg-RX-API-DMAC10.html)
CA (1) CA2985777A1 (cg-RX-API-DMAC10.html)
HK (1) HK1251157A1 (cg-RX-API-DMAC10.html)
IL (2) IL284686B2 (cg-RX-API-DMAC10.html)
JO (1) JOP20160092B1 (cg-RX-API-DMAC10.html)
MY (1) MY189601A (cg-RX-API-DMAC10.html)
PH (1) PH12017502079A1 (cg-RX-API-DMAC10.html)
TN (1) TN2017000468A1 (cg-RX-API-DMAC10.html)
TW (2) TWI814187B (cg-RX-API-DMAC10.html)
WO (1) WO2016183280A1 (cg-RX-API-DMAC10.html)

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US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
RU2678117C2 (ru) 2012-11-02 2019-01-23 Селджин Корпорейшн Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений
CN114699529A (zh) 2014-06-13 2022-07-05 阿塞勒隆制药公司 用于治疗溃疡的方法和组合物
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
EP3227675B1 (en) 2014-12-03 2023-03-15 Celgene Corporation Activin-actrii antagonists and uses for treating myelodysplastic syndrome
MA41119A (fr) 2014-12-03 2017-10-10 Acceleron Pharma Inc Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
EP3298034A4 (en) 2015-05-20 2019-02-13 Celgene Corporation IN VITRO CELL CULTURE PROCEDURE FOR BETA THALASSEMIA BY MEANS OF ACTIVIN TYPE II RECEPTOR LIGANDS
EP3370754B1 (en) 2015-11-04 2026-04-29 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating ineffective erythropoiesis
JP7072507B2 (ja) 2015-11-23 2022-05-20 アクセルロン ファーマ インコーポレイテッド 眼の障害を処置するための方法
AU2017296040C1 (en) 2016-07-15 2023-06-22 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
LT3490582T (lt) 2016-07-27 2024-07-25 Acceleron Pharma Inc. Kompozicijos, skirtos naudoti gydant mielofibrozę
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CN114302882A (zh) 2019-07-19 2022-04-08 威佛（国际）股份公司 用于治疗输血依赖型β-地中海贫血（tdt）的膜铁转运蛋白抑制剂
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US20230174620A1 (en) 2020-04-28 2023-06-08 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
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US20230270821A1 (en) * 2020-11-06 2023-08-31 Acceleron Pharma Inc. Formulations comprising actrii polypeptide variants
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Publication number Publication date
US20180125928A1 (en) 2018-05-10
TWI814187B (zh) 2023-09-01
AU2016261913B2 (en) 2021-08-12
CA2985777A1 (en) 2016-11-17
HK1251157A1 (zh) 2019-01-25
KR20180006437A (ko) 2018-01-17
MY189601A (en) 2022-02-18
AU2021258087B2 (en) 2023-04-27
EP3294320A1 (en) 2018-03-21
JOP20160092B1 (ar) 2023-03-28
IL255527A (en) 2018-01-31
CN122537533A (zh) 2026-08-11
TWI762444B (zh) 2022-05-01
TN2017000468A1 (en) 2019-04-12
IL284686B2 (en) 2023-05-01
TW202231294A (zh) 2022-08-16
NZ737043A (en) 2025-02-28
CN122399028A (zh) 2026-07-17
TW201709927A (zh) 2017-03-16
PH12017502079A1 (en) 2018-06-11
IL255527B (en) 2021-07-29
IL284686B (en) 2023-01-01
JP6976859B2 (ja) 2021-12-08
JP2018520094A (ja) 2018-07-26
CN107847562A (zh) 2018-03-27
JP2021191755A (ja) 2021-12-16
IL284686A (en) 2021-08-31
EP3294320A4 (en) 2018-12-26
WO2016183280A1 (en) 2016-11-17
AU2021258087A1 (en) 2021-11-25
AU2016261913A1 (en) 2017-11-30

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