KR102625842B1 - 안전성 및 항암효과가 개선된 항암바이러스 - Google Patents

안전성 및 항암효과가 개선된 항암바이러스 Download PDF

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KR102625842B1
KR102625842B1 KR1020200079617A KR20200079617A KR102625842B1 KR 102625842 B1 KR102625842 B1 KR 102625842B1 KR 1020200079617 A KR1020200079617 A KR 1020200079617A KR 20200079617 A KR20200079617 A KR 20200079617A KR 102625842 B1 KR102625842 B1 KR 102625842B1
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cancer
amino acid
virus
acid sequence
ala
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KR20210002056A (ko
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황태호
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주식회사 바이오녹스
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K35/761—Adenovirus
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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KR1020200079617A 2019-06-27 2020-06-29 안전성 및 항암효과가 개선된 항암바이러스 Active KR102625842B1 (ko)

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EP (1) EP3992281A4 (enExample)
JP (1) JP7704419B2 (enExample)
KR (1) KR102625842B1 (enExample)
CN (1) CN114096661B (enExample)
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CA (1) CA3139643A1 (enExample)
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CN120037270A (zh) * 2019-08-26 2025-05-27 拜耳诺克斯有限公司 包含痘苗病毒和羟基脲作为活性成分的用于治疗癌症的药物组合物

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2014153258A2 (en) * 2013-03-14 2014-09-25 Epeius Biotechnologies Corporation Improved thymidine kinase gene

Family Cites Families (11)

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FR2699191B1 (fr) * 1992-12-16 1995-02-10 Univ Paris Curie Nouveaux vecteurs rétroviraux, lignées cellulaires les contenant, et leur utilisation dans le traitement des tumeurs.
BR9707483A (pt) 1996-02-09 1999-04-06 Rhone Poulenc Rorer Sa Sequência de ácidos nucléicos que codificam para uma timidina quinase variante de uma timidina quinase selvagem variante de uma timidina quinase do vírus do herpes simplex de tipo 1 veículo de expressão vetor e composição farmacêutica
GB0008966D0 (en) * 2000-04-13 2000-05-31 Imp College Innovations Ltd Vectors for gene therapy
WO2002042468A2 (en) * 2000-11-27 2002-05-30 Geron Corporation Glycosyltransferase vectors for treating cancer
US20040053836A1 (en) 2002-04-22 2004-03-18 Philipp Mayer-Kuckuk Method for modulating the production of a selected protein in vivo
GB0413702D0 (en) * 2004-06-18 2004-07-21 Molmed Spa Thymidine kinase
CN105407902A (zh) * 2013-03-05 2016-03-16 贝勒医学院 溶瘤病毒
KR20190059421A (ko) * 2017-11-23 2019-05-31 주식회사 바이오녹스 항암바이러스의 간동맥 투여를 이용한 간암 치료방법
WO2019108777A1 (en) * 2017-11-29 2019-06-06 Research Development Foundation Elimination of proliferating cells from stem cell-derived grafts
AU2018395012B2 (en) * 2017-12-28 2022-03-10 Bionoxx Inc. Oncolytic virus improved in safety and anticancer effect
CN114630683A (zh) * 2019-08-29 2022-06-14 拜耳诺克斯有限公司 包含痘苗病毒和粒细胞生成抑制剂作为活性成分的用于治疗癌症的药物组合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014153258A2 (en) * 2013-03-14 2014-09-25 Epeius Biotechnologies Corporation Improved thymidine kinase gene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Proc. Natd Acad. Sci. USA, 1982, Vol. 79, pp. 4927-4931.*

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CA3139643A1 (en) 2020-12-30
EP3992281A1 (en) 2022-05-04
AU2020306544B2 (en) 2025-10-16
EP3992281A4 (en) 2023-07-26
JP7704419B2 (ja) 2025-07-08
AU2020306544A1 (en) 2021-12-02
WO2020263059A1 (ko) 2020-12-30
CN114096661B (zh) 2024-10-25
US20220202885A1 (en) 2022-06-30
CN114096661A (zh) 2022-02-25
JP2022539016A (ja) 2022-09-07
KR20210002056A (ko) 2021-01-06

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