KR102587894B1 - 릴루졸 전구약물 및 그의 용도 - Google Patents

릴루졸 전구약물 및 그의 용도 Download PDF

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KR102587894B1
KR102587894B1 KR1020177027618A KR20177027618A KR102587894B1 KR 102587894 B1 KR102587894 B1 KR 102587894B1 KR 1020177027618 A KR1020177027618 A KR 1020177027618A KR 20177027618 A KR20177027618 A KR 20177027618A KR 102587894 B1 KR102587894 B1 KR 102587894B1
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amino
trifluoromethoxy
benzo
thiazol
oxo
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KR20180008402A (ko
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제이 에드워드 로벨
앨런 비. 라이츠
제프리 클로드 펠레티에
개리 로버트 스미스
하이얀 비안
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바이오하벤 파마슈티컬 홀딩 컴퍼니 엘티디.
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    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
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KR1020177027618A 2015-03-03 2016-02-26 릴루졸 전구약물 및 그의 용도 Active KR102587894B1 (ko)

Priority Applications (1)

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KR1020237034132A KR20230147746A (ko) 2015-03-03 2016-02-26 릴루졸 전구약물 및 그의 용도

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562127684P 2015-03-03 2015-03-03
US62/127,684 2015-03-03
PCT/US2016/019787 WO2016140879A1 (en) 2015-03-03 2016-02-26 Riluzole prodrugs and their use

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KR102587894B1 true KR102587894B1 (ko) 2023-10-12

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US (9) US10485791B2 (OSRAM)
EP (2) EP3265448B1 (OSRAM)
JP (2) JP6700293B2 (OSRAM)
KR (2) KR102587894B1 (OSRAM)
CN (1) CN107567438B (OSRAM)
AU (3) AU2016226463B2 (OSRAM)
BR (1) BR112017018832B1 (OSRAM)
CA (1) CA2978158C (OSRAM)
CY (1) CY1125112T1 (OSRAM)
DK (1) DK3265448T3 (OSRAM)
EA (1) EA034759B1 (OSRAM)
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HR (1) HRP20220208T1 (OSRAM)
HU (1) HUE058204T2 (OSRAM)
IL (2) IL253989B (OSRAM)
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US9725427B2 (en) * 2012-03-16 2017-08-08 Biohaven Pharmaceutical Holding Company Limited Prodrugs of riluzole and their method of use
HUE046869T2 (hu) * 2014-11-21 2020-04-28 Biohaven Therapeutics Ltd Riluzol szublingvális formulációja
HUE058204T2 (hu) 2015-03-03 2022-07-28 Biohaven Therapeutics Ltd Riluzol prodrugok és felhasználásuk
US11911369B2 (en) 2015-03-03 2024-02-27 Biohaven Therapeutics Ltd. Prodrugs of riluzole and their method of use
US12295942B2 (en) * 2015-03-03 2025-05-13 Biohaven Therapeutics Ltd. Riluzole prodrugs and their use
JP2017061430A (ja) * 2015-09-25 2017-03-30 芳男 ▲浜▼田 新規なプロドラッグ
PL3458053T3 (pl) * 2016-05-20 2022-04-25 Biohaven Therapeutics Ltd. Stosowanie riluzolu, proleków riluzolu lub analogów riluzolu z immunoterapiami w leczeniu nowotworów
US12029731B2 (en) 2016-08-10 2024-07-09 Biohaven Therapeutics Ltd. Acyl benzo[d]thiazol-2-amine and their methods of use
ES2848720T3 (es) * 2016-11-25 2021-08-11 Genuv Inc Composición para promover la diferenciación y la protección de células madre neurales y método para inducir la regeneración neural utilizando la misma
JP7300394B2 (ja) 2017-01-17 2023-06-29 ヘパリジェニックス ゲーエムベーハー 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
WO2020023324A1 (en) * 2018-07-22 2020-01-30 Biohaven Therapeutics Ltd. Use of riluzole prodrugs to treat alzheimer's disease
US12201618B2 (en) * 2017-01-18 2025-01-21 Biohaven Therapeutics Ltd. Use of riluzole prodrugs to treat Alzheimer's disease
US20180207138A1 (en) 2017-01-23 2018-07-26 Cadent Therapeutics, Inc. Methods for the treatment of tremors by positive modulation of sk channels
CN113061144A (zh) * 2017-02-28 2021-07-02 正大天晴药业集团股份有限公司 氮杂环丁烷衍生物
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