KR102579485B1 - 5-아자사이티딘류의 당 부분(糖部) 실릴에테르 유도체 - Google Patents

5-아자사이티딘류의 당 부분(糖部) 실릴에테르 유도체 Download PDF

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KR102579485B1
KR102579485B1 KR1020187018429A KR20187018429A KR102579485B1 KR 102579485 B1 KR102579485 B1 KR 102579485B1 KR 1020187018429 A KR1020187018429 A KR 1020187018429A KR 20187018429 A KR20187018429 A KR 20187018429A KR 102579485 B1 KR102579485 B1 KR 102579485B1
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azacytidine
compound
formula
substituted
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Korean (ko)
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KR20180134835A (ko
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마고이치 사코
신페이 스기야먀
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오하라 야꾸힝 고교 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187018429A 2016-04-21 2016-07-27 5-아자사이티딘류의 당 부분(糖部) 실릴에테르 유도체 Active KR102579485B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JPJP-P-2016-085145 2016-04-21
JP2016085145 2016-04-21
JPPCT/JP2016/065660 2016-05-27
PCT/JP2016/065660 WO2017183215A1 (ja) 2016-04-21 2016-05-27 ５－アザシチジン類の糖部シリルエーテル誘導体
PCT/JP2016/072010 WO2017183217A1 (ja) 2016-04-21 2016-07-27 ５－アザシチジン類の糖部シリルエーテル誘導体

Publications (2)

Publication Number Publication Date
KR20180134835A KR20180134835A (ko) 2018-12-19
KR102579485B1 true KR102579485B1 (ko) 2023-09-20

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KR1020187018429A Active KR102579485B1 (ko) 2016-04-21 2016-07-27 5-아자사이티딘류의 당 부분(糖部) 실릴에테르 유도체

Country Status (5)

Country Link
EP (2) EP3252067B1 (https=)
JP (1) JP2017197539A (https=)
KR (1) KR102579485B1 (https=)
CN (1) CN108368148B (https=)
WO (2) WO2017183215A1 (https=)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
JP6956937B2 (ja) * 2018-02-19 2021-11-02 大原薬品工業株式会社 Ｄｎｍｔ阻害剤の用途
WO2020090698A1 (ja) * 2018-10-30 2020-05-07 大原薬品工業株式会社 医薬組成物
US12472196B2 (en) 2019-09-26 2025-11-18 Ohara Pharmaceutical Co., Ltd. Use of DNMT inhibitor
WO2022031759A1 (en) * 2020-08-04 2022-02-10 Herophilus, Inc. Decitabine induced mecp2 expression and uses thereof
US20240091247A1 (en) * 2021-02-23 2024-03-21 Ohara Pharmaceutical Co., Ltd. Inhibitor for chronic myeloid leukemia stem cells
WO2025263591A1 (ja) * 2024-06-21 2025-12-26 大原薬品工業株式会社 経口用ｄｎｍｔ阻害剤の結晶形態

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050665A1 (en) 2002-11-29 2004-06-17 Amedis Pharmaceuticals Ltd. Silicon compounds

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US3816619A (en) 1965-08-25 1974-06-11 Upjohn Co Ladakamycin and process for preparing same
CH527207A (de) 1968-05-08 1972-08-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen
GB0227906D0 (en) * 2002-11-29 2003-01-08 Amedis Pharm Ltd Compounds and their use
KR100866399B1 (ko) 2002-12-10 2008-11-03 엘지엔시스(주) 매체자동지급기의 모듈부 스톱퍼장치
KR100897924B1 (ko) 2002-12-10 2009-05-18 엘지엔시스(주) 금융통합단말기 프린터부의 용지가이드 장치
US7700567B2 (en) * 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
CN102010455B (zh) * 2009-09-05 2012-07-11 山东新时代药业有限公司 一种地西他滨的制备方法
MX2013010945A (es) * 2011-03-31 2014-03-12 Celgene Internat Sarl Sintesis de 5 - azacitidina.
WO2013036846A2 (en) * 2011-09-09 2013-03-14 Koronis Pharmaceuticals, Incorporated N4 derivatives of deoxycytidine prodrugs
EP3204121B1 (en) * 2014-10-08 2019-06-19 Epigenetics Pharma LLC Silylated 5-aza-pyrimidine prodrugs useful for treating cancer
KR101922702B1 (ko) 2016-05-10 2018-11-29 주식회사 씨엔제이 기판용 필름의 재활용 칩 제작방법 및 장치

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050665A1 (en) 2002-11-29 2004-06-17 Amedis Pharmaceuticals Ltd. Silicon compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Oncology, 1974, 30, 405-422.

Also Published As

Publication number Publication date
EP3252067A4 (en) 2017-12-06
EP3252067B1 (en) 2019-05-29
JP2017197539A (ja) 2017-11-02
EP3252067A1 (en) 2017-12-06
EP3543249A1 (en) 2019-09-25
KR20180134835A (ko) 2018-12-19
CN108368148A (zh) 2018-08-03
CN108368148B (zh) 2021-11-05
WO2017183217A1 (ja) 2017-10-26
WO2017183215A1 (ja) 2017-10-26

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