KR102579306B1 - Cosmetics composition for anti-alopecia - Google Patents

Abstract

The hair cosmetic composition for preventing hair loss according to an embodiment of the present invention includes menthol, panthenol, brewer's yeast extract, sabal palm fruit extract, copper tripeptide-1, caffeine, SH-polypeptide-9, SH-polypeptide-7, Includes tocopherol, SH-oligopeptide-1 and SH-polypeptide-71. Therefore, the present invention has the advantage of being able to soothe scalp heat, scalp inflammation, and suppress itching, which can cause hair loss, by using menthol, which soothes scalp heat and suppresses inflammation and itching. In addition, the present invention has the advantage of being able to help alleviate hair loss symptoms by improving wound healing by using panthenol, which is used as an auxiliary treatment for hair loss in the over-the-counter market.

Description

Hair cosmetic composition for preventing hair loss {COSMETICS COMPOSITION FOR ANTI-ALOPECIA}

The present invention relates to a hair cosmetic composition for preventing hair loss.

There are about 100,000 to 150,000 hairs in the human body, and they are formed in “hair follicles.” There is a papilla in the hair follicle, and small blood vessels are distributed in this area to supply nutrients necessary for hair growth. Next to the papilla, there is a seborrheic gland that supplies oil that gives hair shine.

Hair follicles are made up of different epithelial cells and dermal papilla cells (DPCs). DPCs are mesenchymally-derived fibroblasts located at the base of hair follicles and play an important role in hair growth.

In particular, minoxidil has been reported to have proliferative and anti-apoptotic effects on DPCs. Similarly, several reports have shown increased hair growth through proliferation of DPCs.

Each hair has a different cycle and grows and falls out through anagen, catagen, and telogen stages. This cycle repeats over 3 to 6 years, with an average of 50 to 100 hairs falling out normally per day. In general, alopecia refers to an abnormally large number of hairs falling out during this cycle as the ratio of hairs in the growth phase becomes shorter and the number of hairs in the catagen or telogen phase increases.

Currently, the prevention and treatment of alopecia are divided into medical approaches and oriental medicine approaches. Medical approaches include drug therapy, surgical methods, nutritional therapy, and diet therapy. Drugs that promote hair growth include minoxidil (MXD) and finasteride, which are approved by the U.S. Food and Drug Administration (FDA).

However, it has been reported that minoxidil and finasteride have problems in that hair loss continues as usual when treatment is stopped, and side effects such as dermatitis occur when used for a long time.

Therefore, there is a need to overcome the above-mentioned problems with hair loss prevention and treatment, and to study hair loss prevention and treatment foods or medicines containing natural products that have no side effects and are highly stable.

The purpose of the present invention is to provide a hair cosmetic composition for preventing hair loss that can soothe heat in the scalp and suppress scalp inflammation and itchiness, which can cause hair loss, by using menthol, which soothes scalp heat and suppresses inflammation and itchiness. do.

In addition, the purpose of the present invention is to provide a hair cosmetic composition for preventing hair loss that can help alleviate hair loss symptoms by improving wound healing by using panthenol, which is used as an auxiliary treatment for hair loss in the general drug market.

In addition, the present invention stimulates lipid metabolism and blood flow by using brewer's yeast extract, which has an effect on scalp blood circulation, hair growth, and hair loss prevention and contains biotin (i.e., vitamin B7), thereby helping blood circulation in the scalp, hair growth, and hair growth. The purpose is to provide a hair cosmetic composition for preventing hair loss that can prevent hair loss.

In addition, the present invention is a hair loss prevention hair product that prevents hair loss by preventing conversion of testosterone to dihydrotestosterone (DHT) by using sabalpalm fruit extract, which can inhibit enzyme (i.e., 5α-Reductase) activation. The purpose is to provide a cosmetic composition.

In addition, the present invention promotes the creation of new capillaries by using copper tripeptide-1, which can promote the creation of new capillaries and inhibit enzyme (i.e. 5α-Reductase) activation, thereby supplying blood, oxygen, and nutrients to the hair follicles. The purpose is to provide a hair cosmetic composition for preventing hair loss that can improve hair loss by supplying and prevent hair loss by preventing conversion of testosterone to dihydrotestosterone (DHT).

In addition, the purpose of the present invention is to provide a hair cosmetic composition for preventing hair loss that strengthens hair roots by using caffeine, which strengthens hair, and promotes the proliferation of hair keratinocytes, thereby helping hair follicles to produce hair well. Do it as

In addition, the present invention provides a hair cosmetic composition for preventing hair loss that can inhibit the oxidation of unsaturated fatty acids constituting the cell membrane as an oxygen scavenger by using vitamin E and tocopherol, which performs an antioxidant effect, thereby reducing hair follicle oxidative stress. The purpose is to provide

In addition, the present invention uses SH-polypeptide-9, which prevents hair loss and promotes hair growth, to promote the division of vascular endothelial cells and participate in the creation of new blood vessels to improve hair loss by supplying blood, oxygen, and nutrients. The purpose is to provide a hair cosmetic composition for preventing hair loss.

In addition, the present invention uses SH-polypeptide-7, which can promote hair growth by improving cell proliferation and differentiation of hair follicles and inducing proliferation of endothelial cells and neovascularization, making it a protein with the same functionality as human growth hormone. The purpose is to provide a hair cosmetic composition for preventing hair loss that can be used.

In addition, the present invention uses SH-oligopeptide-1, which can promote hair growth by improving cell proliferation and differentiation of hair follicles and inducing endothelial cell proliferation and neovascularization, so that it can be used as an indicator growth factor. The purpose is to provide a hair cosmetic composition for preventing hair loss.

In addition, the present invention uses SH-polypeptide-71, which can promote hair growth by improving cell proliferation and differentiation of hair follicles and inducing endothelial cell proliferation and neovascularization, so that it can be used as a vascular activation peptide. The purpose is to provide a hair cosmetic composition for preventing hair loss.

The objects of the present invention are not limited to the objects mentioned above, and other objects and advantages of the present invention that are not mentioned can be understood by the following description and will be more clearly understood by the examples of the present invention. Additionally, it will be readily apparent that the objects and advantages of the present invention can be realized by the means and combinations thereof indicated in the patent claims.

Hair cosmetic compositions for preventing hair loss to achieve this purpose include menthol, panthenol, brewer's yeast extract, sabal palm fruit extract, copper tripeptide-1, caffeine, SH-polypeptide-9, SH-polypeptide-7, tocopherol, Includes SH-oligopeptide-1 and SH-polypeptide-71.

According to the present invention, there is an advantage of being able to soothe scalp heat, scalp inflammation, and suppress itching, which can cause hair loss, by using menthol, which soothes scalp heat and suppresses inflammation and itching.

In addition, according to the present invention, there is an advantage in that panthenol, which is used as an auxiliary treatment for hair loss in the over-the-counter market, can be used to improve wound healing and help alleviate hair loss symptoms.

In addition, according to the present invention, by using brewer's yeast extract, which has effects on scalp blood circulation, hair growth, and hair loss prevention and contains biotin (i.e. vitamin B7), it stimulates lipid metabolism and blood flow to help blood circulation in the scalp and hair growth. It has the advantage of preventing hair loss.

In addition, according to the present invention, there is an advantage in that hair loss can be prevented by preventing conversion of testosterone into dihydrotestosterone (DHT) by using sabalpalm fruit extract, which can inhibit enzyme (i.e., 5α-Reductase) activation.

In addition, according to the present invention, by using copper tripeptide-1, which can promote the creation of new capillaries and inhibit the activation of enzymes (i.e. 5α-Reductase), the creation of new capillaries is promoted to supply blood, oxygen, and oxygen to the hair follicles. It has the advantage of improving hair loss by providing nutrition and preventing hair loss by preventing the conversion of testosterone to dihydrotestosterone (DHT).

In addition, according to the present invention, there is an advantage that by using caffeine, which strengthens hair, it can strengthen hair roots and promote the proliferation of hair keratinocytes, thereby helping hair follicles to produce hair well.

In addition, according to the present invention, by using vitamin E and tocopherol, which has an antioxidant effect, there is an advantage that oxidation of unsaturated fatty acids constituting the cell membrane can be suppressed as an oxygen scavenger, thereby reducing hair follicle oxidative stress.

In addition, according to the present invention, by using SH-polypeptide-9, which prevents hair loss and promotes hair growth, it promotes the division of vascular endothelial cells and participates in the creation of new blood vessels, thereby improving hair loss by supplying blood, oxygen, and nutrients. There is an advantage to having it.

In addition, according to the present invention, by using SH-polypeptide-7, which can promote hair growth by improving cell proliferation and differentiation of hair follicles and inducing proliferation of endothelial cells and neovascularization, a protein with the same functionality as human growth hormone is obtained. It has the advantage of being able to be used as a .

In addition, according to the present invention, it can be used as an indicator growth factor by using SH-oligopeptide-1, which can promote hair growth by improving cell proliferation and differentiation of hair follicles and inducing endothelial cell proliferation and neovascularization. There is an advantage.

In addition, according to the present invention, it can be used as a vascular activation peptide by using SH-polypeptide-71, which can promote hair growth by improving cell proliferation and differentiation of hair follicles and inducing proliferation of endothelial cells and neovascularization. There is an advantage to having it.

The above-mentioned objects, features, and advantages will be described in detail later with reference to the attached drawings, so that those skilled in the art will be able to easily implement the technical idea of the present invention. In describing the present invention, if it is determined that a detailed description of known technologies related to the present invention may unnecessarily obscure the gist of the present invention, the detailed description will be omitted. Hereinafter, preferred embodiments according to the present invention will be described in detail with reference to the attached drawings. In the drawings, identical reference numerals are used to indicate identical or similar components.

In this specification, “hair loss” refers to the phenomenon of hair falling out from the scalp or a condition in which hair becomes sparse or thin, and “prevention of hair loss” refers to preventing and suppressing the hair loss phenomenon as described above, and “hair growth “Promotion” means not only promoting the creation of new hair, but also allowing existing hair to grow healthily. Generally, “hair growth” occurs in the growth phase and is promoted by inducing the telogen phase to the growth phase and delaying the growth phase to the catagen phase.

The hair cycle can be divided into three main phases known as the anagen phase, catagen phase, and telogen phase. During the growth phase, hair formation occurs as hair follicles grow deeper into the skin along with rapid proliferation of cells. The next phenomenon is the catagen phase, which is a transitional phase in which the cessation of cell division is noticeable. During this process, the hair follicles gradually degenerate and hair growth stops. In the next phase, the telogen phase, the degenerated hair follicle contains a germ containing densely packed dermal papilla cells. The initiation of new anagen events in the telogen phase is induced by rapid cell proliferation in the embryo, expansion of the dermal papilla, and synthesis of basement membrane elements.

Therefore, it is necessary to prevent hair loss, i.e., prevent hair loss, or induce hair regrowth, i.e., promote hair growth, by promoting or extending the growth phase, and the composition according to the present invention has the effect of preventing hair that already exists from falling out. , an effect of improving existing hair, such as thickening it, and an effect of generating new hair.

Dermal papilla cells are mesoderm-derived fibroblasts located at the base of hair follicles, and are thought to play an important role in hair growth through interaction with the hair matrix cells of the hair follicle (Jahoda CA, et al., 1984; Oliver R.F., et al., 1986). In addition, minoxidil, which is used as a hair loss treatment, is a KATP-channel opener and has been shown to increase growth in NIH3T3 fibroblasts (Sanders, et al., 1996).

Additionally, in this specification, “Alopecia” may include all hair loss classified as hair loss in the art, excluding scarring (recurrent) alopecia. For example, it may mean hair loss of one or more of the following: alopecia areata, male pattern baldness, alopecia areata, female alopecia, childhood alopecia, adolescent alopecia, hair loss caused by drugs, and seborrheic alopecia accompanying scalp skin diseases such as seborrheic dermatitis or psoriasis. .

Below, various aspects and various implementation examples of the present invention will be described in more detail.

The hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include menthol.

The menthol is an ingredient used for stomach pain, toothache, etc. It is good for pain and inflammation, and has a cooling effect on the scalp, so it can add a refreshing feeling to the scalp.

Therefore, the hair cosmetic composition for preventing hair loss according to an embodiment of the present invention can soothe scalp heat, scalp inflammation, and suppress itching, which can cause hair loss, by using menthol, which soothes scalp heat and suppresses inflammation and itching. There is an advantage to having it.

It is desirable to contain 0.3% by weight of menthol. For this reason, if the menthol content is less than 0.05% by weight, the efficacy and effect are minimal.

The hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include pantherol.

Pantherol is known to be used as an auxiliary treatment for hair loss in the OTC market. Pantherol, also known as vitamin B5, is a functional ingredient that helps alleviate hair loss symptoms by improving the wound healing power of medicines and cosmetics. It is preferable to contain 0.2% by weight of pantherol.

Therefore, the present invention has the advantage of being able to help alleviate hair loss symptoms by improving wound healing by using panthenol, which is used as an auxiliary treatment for hair loss in the over-the-counter market.

The hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include brewer's yeast extract.

This brewer's yeast extract is effective in improving scalp blood circulation, hair growth, and preventing hair loss. It is desirable to contain 0.025% by weight of this brewer's yeast extract.

Therefore, the present invention stimulates lipid metabolism and blood flow by using brewer's yeast extract, which has an effect on scalp blood circulation, hair growth, and hair loss prevention and contains biotin (i.e., vitamin B7), thereby helping blood circulation in the scalp, hair growth, and hair growth. It has the advantage of preventing hair loss.

The hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include sabal palm fruit extract.

This sabal palm fruit extract has the effect of preventing hair loss by inhibiting enzyme (i.e. 5α-Reductase) activation. It is preferable that the sabal palm fruit extract contains 0.005% by weight.

Therefore, the present invention has the advantage of preventing hair loss by preventing conversion of testosterone into dihydrotestosterone (DHT) by using sabalpalm fruit extract, which can inhibit enzyme (i.e., 5α-Reductase) activation.

A hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include copper tripeptide-1. It is preferable to contain 0.001% by weight of copper tripeptide-1.

Copper tripeptide-1 has the effect of preventing hair loss by promoting the creation of new capillaries and inhibiting the activation of enzymes (i.e., 5α-Reductase).

Therefore, the present invention promotes the creation of new capillaries by using copper tripeptide-1, which can promote the creation of new capillaries and inhibit the activation of enzymes (i.e., 5α-Reductase), thereby supplying blood, oxygen, and nutrients to the hair follicles. It has the advantage of improving hair loss by supplying and preventing hair loss by preventing the conversion of testosterone into dihydrotestosterone (DHT).

The hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may contain caffeine. It is preferable to contain 0.0005% by weight of caffeine.

This caffeine has hair strengthening effects. Therefore, the present invention has the advantage of using caffeine, which strengthens hair, to strengthen hair roots and promote the proliferation of hair keratinocytes, thereby helping hair follicles to produce hair well.

The hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include tocopherol. It is desirable to contain 0.00004% by weight of tocopherol.

These tocopherols have vitamin E and antioxidant effects. Therefore, the present invention has the advantage of being able to suppress oxidation of unsaturated fatty acids constituting the cell membrane as an oxygen scavenger by using vitamin E and tocopherol, which performs an antioxidant effect, thereby reducing hair follicle oxidative stress.

A hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include SH-polypeptide-9. It is preferable to contain 0.0001% by weight of SH-polypeptide-9.

This SH-polypeptide-9 has the effect of preventing hair loss and promoting hair growth.

Therefore, the present invention promotes the division of vascular endothelial cells by using SH-polypeptide-9, which prevents hair loss and promotes hair growth, participates in the creation of new blood vessels, and improves hair loss by supplying blood, oxygen, and nutrients. There is an advantage.

A hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include SH-polypeptide-7. It is preferable to contain 0.00005% by weight of SH-polypeptide-7.

This SH-polypeptide-7 has the effect of promoting hair growth by improving cell proliferation and differentiation of hair follicles and inducing proliferation of endothelial cells and creation of new blood vessels.

Therefore, the present invention uses SH-polypeptide-7, which can promote hair growth by improving cell proliferation and differentiation of hair follicles and inducing endothelial cell proliferation and neovascularization, making it a protein with the same functionality as human growth hormone. It has the advantage of being usable.

A hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include SH-oligopeptide-1. It is preferable to contain 0.00001% by weight of SH-Oligopeptide-1.

This SH-oligopeptide-1 has the effect of promoting hair growth by improving cell proliferation and differentiation of hair follicles and inducing proliferation of endothelial cells and creation of new blood vessels.

Therefore, the present invention has the advantage that it can be used as an indicator growth factor by using SH-oligopeptide-1, which can promote hair growth by improving cell proliferation and differentiation of hair follicles and inducing endothelial cell proliferation and neovascularization. There is.

A hair cosmetic composition for preventing hair loss according to an embodiment of the present invention may include SH-polypeptide-71. It is preferable to contain 0.000005% by weight of SH-polypeptide-71.

This SH-polypeptide-71 has the effect of promoting hair growth by improving cell proliferation and differentiation of hair follicles and inducing proliferation of endothelial cells and creation of new blood vessels.

Therefore, the present invention can be used as a vascular activation peptide by using SH-polypeptide-71, which can promote hair growth by improving cell proliferation and differentiation of hair follicles and inducing proliferation of endothelial cells and neovascularization. There is an advantage.

Considering the above results, the hair cosmetic composition for preventing hair loss according to the present invention not only has excellent efficacy as an anti-hair loss agent, but also prevents, alleviates and prevents scalp aging, thereby alleviating and improving hair loss that may be accelerated by this. It will be self-evident that it is possible.

In addition, the hair loss prevention agent composition is manufactured in the form of cream, lotion, essence, serum, toner, tonic, mist, etc., and is applied to the scalp to keep the scalp healthy. In particular, it is an anti-hair loss agent that can prevent, alleviate, and prevent scalp aging. can be used

Hereinafter, the present invention will be further explained through manufacturing examples and test examples. These examples are for illustrating the present invention in more detail, and the scope of the present invention is not limited to these examples.

Manufacturing example

Preparation of Examples 1-4

Purified water, denatured alcohol, ethoxydiglycol, dipropylene glycol, 1,2-hexanediol, PEG-60 hydrogenated castor oil according to the composition ratio of Preparation Examples 1-4 shown in Table 1 below. And sodium citrate was dissolved and heated to about 70°C to prepare Solution 1, containing salicylic acid, hydroxyethyl cellulose, glycerin, allantoin, green water seed extract, cornmint leaf extract, citric acid, buckwheat seed extract, and red bean extract. , barley extract, ethylhexylglycerin, green tea extract, medicinal buckwheat extract, ginseng extract, black bean extract, lobule leaf extract, calamus root extract, Spanish licorice root extract, disodium EDTA, peppermint oil, lecithin, phenoxyethanol, polysol. Add Bait 60 and dipotassium glycyrrhizate and heat to about 70°C to prepare Solution 2.

The prepared solution 2 was added to solution 1, mixed, emulsified, and cooled. Then, component 3 was added and mixed uniformly to prepare a hair cosmetic composition for preventing hair loss that has the effect of alleviating scalp aging.

[Table 1]

The anti-hair loss agent prepared according to Table 1 above, which has the effect of preventing, alleviating, and preventing scalp aging, was used on 18 adult men and women in the morning and evening after washing their hair.

1) Measurement of change rate of hair loss after hair washing

The hair cosmetic composition for preventing hair loss according to an embodiment of the present invention was used on a total of 18 adult men and women with hair loss, 2 each, and the number of hairs that fell out after washing the hair before use and after a specific period of use was measured. ㅇ, it was evaluated according to the evaluation criteria shown in Table 2 below, and the results were shown in Tables 2 and 3.

[Table 2]

[Table 3]

In Example 1, the hair cosmetic composition for preventing hair loss according to an embodiment of the present invention was not used, in Example 2, 0.3% by weight of menthol and 0.2% by weight of panthenol were used, and in Example 3, 0.3% by weight of menthol, 0.2% by weight of panthenol, 0.025% by weight of brewer's yeast extract, 0.005% by weight of sabal palm fruit extract, 0.001% by weight of copper tripeptide-1, 0.0005% by weight of caffeine, and 0.0001% by weight of SH-polypeptide-9 were used, Example 4 0.3% by weight of menthol, 0.2% by weight of panthenol, 0.025% by weight of brewer's yeast extract, 0.005% by weight of sabal palm fruit extract, 0.001% by weight of copper tripeptide-1, 0.0005% by weight of caffeine, 0.0001% by weight of SH-polypeptide-9, 0.00005% by weight of SH-polypeptide-7, 0.00004% by weight of tocopherol, 0.00001% by weight of SH-oligopeptide-1, and 0.000005% by weight of SH-polypeptide-71 were used.

As can be seen in Table 3, it can be seen that the number of hair fallouts decreased significantly as the hair cosmetic composition for preventing hair loss according to an embodiment of the present invention was used.

That is, in Example 1, where the hair cosmetic composition for preventing hair loss according to an embodiment of the present invention was not used, the amount of hair loss increased, in Example 2, the amount of hair loss decreased by less than 10%, and in Example 3, the amount of hair loss increased. It can be seen that the amount of hair loss was reduced by 11-30%, and in Example 4, the amount of hair loss was reduced by more than 31%.

2) Hair thickness measurement

Hair thickness was measured using a phototrichogram, and the measuring device was Folliscope 4.0 (Lead M, Korea), an equipment that analyzes hair characteristics based on photos taken using a high-resolution digital macro camera. The test area was measured using .

[Table 4]

As shown in [Table 4], changes in hair thickness were confirmed in all test subjects, and as a result, an increase in scalp refreshing sensation was confirmed in all test subjects.

Hair loss usually begins as the hair becomes thinner, and as a result of the above experiment, an increase in hair thickness was confirmed, which means that there is an effect in preventing hair loss.

As described above, although the present invention has been described with reference to limited embodiments and drawings, the present invention is not limited to the above embodiments, and those skilled in the art can make various modifications and modifications from these descriptions. Change is possible. Accordingly, the spirit of the present invention should be understood only by the scope of the claims stated below, and all equivalent or equivalent changes thereof shall fall within the scope of the spirit of the present invention.

Claims (3)

In a hair cosmetic composition for preventing hair loss,
Menthol, panthenol, brewer's yeast extract, sabal palm fruit extract, copper tripeptide-1, caffeine, tocopherol, SF-polypeptide-9, SH-polypeptide-7, SH-polypeptide-71 and SH-oligopeptide-1. Characterized by including
Hair cosmetic composition for preventing hair loss. delete According to paragraph 1,
The hair cosmetic composition for preventing hair loss is
Menthol 0.3% by weight, panthenol 0.2% by weight, brewer's yeast extract 0.025% by weight, sabal palm fruit extract 0.005% by weight, copper tripeptide-1 0.001% by weight, caffeine 0.0005% by weight, SH-polypeptide-9 0.0001% by weight, SH - Characterized by comprising 0.00005% by weight of polypeptide-7, 0.00004% by weight of tocopherol, 0.00001% by weight of SH-oligopeptide-1, and 0.000005% by weight of SH-polypeptide-71.
Hair cosmetic composition for preventing hair loss.