KR102566552B1 - 종양 치료용 바이러스 - Google Patents

종양 치료용 바이러스 Download PDF

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KR102566552B1
KR102566552B1 KR1020207005067A KR20207005067A KR102566552B1 KR 102566552 B1 KR102566552 B1 KR 102566552B1 KR 1020207005067 A KR1020207005067 A KR 1020207005067A KR 20207005067 A KR20207005067 A KR 20207005067A KR 102566552 B1 KR102566552 B1 KR 102566552B1
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cancer
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nucleic acid
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KR20200045477A (ko
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통 쳉
웨이 왕
준카이 완
웬쿤 푸
시앙종 예
쥔 장
닝샤오 시아
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시아먼 유니버시티
양셍탕 컴퍼니 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
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    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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KR1020207005067A 2017-07-21 2018-07-18 종양 치료용 바이러스 Active KR102566552B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710600732.8 2017-07-21
CN201710600732.8A CN109276580B (zh) 2017-07-21 2017-07-21 一种用于治疗肿瘤的病毒
PCT/CN2018/096100 WO2019015601A1 (zh) 2017-07-21 2018-07-18 一种用于治疗肿瘤的病毒

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KR20200045477A KR20200045477A (ko) 2020-05-04
KR102566552B1 true KR102566552B1 (ko) 2023-08-10

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US (1) US11793844B2 (enExample)
EP (1) EP3656854A4 (enExample)
JP (1) JP7144915B2 (enExample)
KR (1) KR102566552B1 (enExample)
CN (2) CN109276580B (enExample)
AU (1) AU2018303064B2 (enExample)
WO (1) WO2019015601A1 (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
CN108424881B (zh) * 2018-03-23 2021-07-27 中国食品药品检定研究院 一株肠道病毒68型及其在制备ev-d68型感染动物中的应用
CN110283794B (zh) * 2019-05-30 2021-04-23 伍泽堂 重组溶瘤病毒以及制备方法、应用和药物
CN114717201A (zh) * 2021-04-17 2022-07-08 景均股份有限公司 适应vero细胞的肠道病毒D68、肠道病毒D68疫苗及其用途
CN114561358B (zh) * 2022-03-09 2023-10-03 广州源井生物科技有限公司 一种提高细胞慢病毒感染率的增强感染培养基及方法
AU2023363971A1 (en) * 2022-10-19 2025-05-01 Kalivir Immunotherapeutics, Inc. Nucleic acids encoding soluble pd-1 and il-12 and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015007788A1 (en) 2013-07-16 2015-01-22 Sia Latima Genetically stable oncolytic rna virus, method of manufacturing and use thereof
WO2016044656A1 (en) 2014-09-17 2016-03-24 Ansun Biopharma, Inc. Treatment of infection by human enterovirus d68
US20160312314A1 (en) 2015-04-24 2016-10-27 Washington University Methods and compositions for detection of enterovirus d68

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200608222B (en) * 2004-03-11 2008-07-30 Viralytics Ltd Modified oncolytic viruses
CN101065144B (zh) * 2004-08-20 2012-06-13 溶瘤病毒有限公司 治疗血液癌症的方法和组合物
EP2125032A4 (en) 2007-02-20 2011-02-23 Mayo Foundation CANCER TREATMENT WITH VIRAL NUCLEIC ACID
US20160030497A1 (en) 2012-11-21 2016-02-04 Duke University Oncolytic poliovirus for human tumors
WO2014171526A1 (ja) 2013-04-17 2014-10-23 国立大学法人九州大学 遺伝子改変コクサッキーウイルス
FI3461491T3 (fi) 2013-04-18 2025-02-20 Tilt Biotherapeutics Oy Tehostettu adoptiivinen soluterapia
AU2014352749A1 (en) 2013-11-22 2016-06-09 Dnatrix, Inc. Adenovirus expressing immune cell stimulatory receptor agonist(s)
US9938588B2 (en) 2015-06-05 2018-04-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for detecting Enterovirus D68

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015007788A1 (en) 2013-07-16 2015-01-22 Sia Latima Genetically stable oncolytic rna virus, method of manufacturing and use thereof
WO2016044656A1 (en) 2014-09-17 2016-03-24 Ansun Biopharma, Inc. Treatment of infection by human enterovirus d68
US20160312314A1 (en) 2015-04-24 2016-10-27 Washington University Methods and compositions for detection of enterovirus d68

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Biomedical and environmental sciences, 2016, 29(9), pages 675-677.*

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Publication number Publication date
US20200254036A1 (en) 2020-08-13
CA3070628A1 (en) 2019-01-24
JP7144915B2 (ja) 2022-09-30
EP3656854A4 (en) 2021-04-28
CN110996980B (zh) 2022-06-07
US11793844B2 (en) 2023-10-24
AU2018303064B2 (en) 2024-11-14
KR20200045477A (ko) 2020-05-04
CN110996980A (zh) 2020-04-10
AU2018303064A1 (en) 2020-03-05
EP3656854A1 (en) 2020-05-27
CN109276580A (zh) 2019-01-29
CN109276580B (zh) 2021-08-24
WO2019015601A1 (zh) 2019-01-24
JP2020528890A (ja) 2020-10-01

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