KR102563568B1 - 렙틴 수용체에 길항하는 항원-결합 단백질 - Google Patents

렙틴 수용체에 길항하는 항원-결합 단백질 Download PDF

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Publication number
KR102563568B1
KR102563568B1 KR1020197016377A KR20197016377A KR102563568B1 KR 102563568 B1 KR102563568 B1 KR 102563568B1 KR 1020197016377 A KR1020197016377 A KR 1020197016377A KR 20197016377 A KR20197016377 A KR 20197016377A KR 102563568 B1 KR102563568 B1 KR 102563568B1
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antibody
lepr
amino acid
seq
acid sequence
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KR20190075133A (ko
Inventor
제스퍼 그로마다
파나이이오티스 스테비스
주디스 알타레요스
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리제너론 파마슈티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020197016377A 2016-11-08 2017-11-08 렙틴 수용체에 길항하는 항원-결합 단백질 Active KR102563568B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662419062P 2016-11-08 2016-11-08
US62/419,062 2016-11-08
PCT/US2017/060690 WO2018089532A1 (en) 2016-11-08 2017-11-08 Antigen-binding proteins that antagonize leptin receptor

Publications (2)

Publication Number Publication Date
KR20190075133A KR20190075133A (ko) 2019-06-28
KR102563568B1 true KR102563568B1 (ko) 2023-08-04

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Country Status (29)

Country Link
US (3) US10550192B2 (https=)
EP (2) EP4613772A3 (https=)
JP (4) JP7042816B2 (https=)
KR (1) KR102563568B1 (https=)
CN (1) CN110167965A (https=)
AU (2) AU2017359439B2 (https=)
CA (1) CA3043365A1 (https=)
CL (3) CL2019001263A1 (https=)
CO (1) CO2019004672A2 (https=)
DK (1) DK3538554T3 (https=)
EA (1) EA201991075A1 (https=)
ES (1) ES3040144T3 (https=)
FI (1) FI3538554T3 (https=)
HR (1) HRP20251165T1 (https=)
HU (1) HUE073276T2 (https=)
IL (2) IL266426B (https=)
LT (1) LT3538554T (https=)
MA (1) MA45801B1 (https=)
MX (2) MX2019005397A (https=)
MY (2) MY203682A (https=)
PH (1) PH12019500988A1 (https=)
PL (1) PL3538554T3 (https=)
PT (1) PT3538554T (https=)
RS (1) RS67214B1 (https=)
SG (1) SG10201913470SA (https=)
SI (1) SI3538554T1 (https=)
SM (1) SMT202500327T1 (https=)
UA (1) UA127678C2 (https=)
WO (1) WO2018089532A1 (https=)

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TW202417497A (zh) 2015-10-12 2024-05-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
LT3538554T (lt) 2016-11-08 2025-10-10 Antigeną surišantys baltymai, antagonizuojantys leptino receptorius
SG11202005146VA (en) 2017-12-18 2020-06-29 Regeneron Pharma Bispecific antigen binding molecules that bind leptin receptor and/or gp130, and methods of use thereof
PT3773713T (pt) 2018-04-06 2025-07-29 Regeneron Pharma Anticorpo agonista do recetor de leptina para usar no aumento da massa óssea num sujeito que sofre de disfunção metabólica ou de hipoleptinemia
WO2020016160A1 (en) * 2018-07-16 2020-01-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to treat neurological diseases
KR20210104744A (ko) * 2018-12-18 2021-08-25 리제너론 파마슈티칼스 인코포레이티드 렙틴 수용체, gdf8 및 액티빈 a에 대한 길항제를 사용하여 체중 및 제지방 근육량을 향상시키기 위한 조성물 및 방법
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
KR20230069969A (ko) * 2020-09-15 2023-05-19 리제너론 파마슈티칼스 인코포레이티드 통증에 대한 lepr 아고니스트의 사용
CN118436632B (zh) * 2024-07-05 2024-08-30 四川大学华西第二医院 Teriflunomide在制备预防和/或治疗原发性纤毛不动综合征的药物中的用途

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LT3538554T (lt) 2016-11-08 2025-10-10 Antigeną surišantys baltymai, antagonizuojantys leptino receptorius

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WO1997026335A1 (en) 1996-01-16 1997-07-24 The Rockefeller University Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof

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RS67214B1 (sr) 2025-10-31
IL266426B (en) 2020-11-30
FI3538554T3 (fi) 2025-09-24
HUE073276T2 (hu) 2026-01-28
IL266426A (en) 2019-06-30
AU2025201454A1 (en) 2025-04-10
EP3538554B1 (en) 2025-08-13
JP7611292B2 (ja) 2025-01-09
MA45801B1 (fr) 2021-11-30
MX2019005397A (es) 2019-10-09
US20200123264A1 (en) 2020-04-23
JP2023093753A (ja) 2023-07-04
CN110167965A (zh) 2019-08-23
AU2017359439B2 (en) 2024-11-28
JP2022031969A (ja) 2022-02-22
US20230235068A1 (en) 2023-07-27
IL272358B (en) 2022-02-01
PH12019500988A1 (en) 2019-08-19
SI3538554T1 (sl) 2025-10-30
PT3538554T (pt) 2025-09-01
JP2020504078A (ja) 2020-02-06
EP3538554A1 (en) 2019-09-18
CL2020000549A1 (es) 2020-08-28
CA3043365A1 (en) 2018-05-17
PL3538554T3 (pl) 2025-10-27
HRP20251165T1 (hr) 2025-11-21
EP4613772A3 (en) 2025-12-24
CO2019004672A2 (es) 2019-07-31
JP7042816B2 (ja) 2022-03-28
AU2017359439A1 (en) 2019-05-23
US10550192B2 (en) 2020-02-04
US20180127508A1 (en) 2018-05-10
ES3040144T3 (en) 2025-10-28
IL272358A (en) 2020-03-31
CL2020001023A1 (es) 2020-10-09
KR20190075133A (ko) 2019-06-28
JP2024109952A (ja) 2024-08-14
EP4613772A2 (en) 2025-09-10
LT3538554T (lt) 2025-10-10
SMT202500327T1 (it) 2025-11-10
MA45801A1 (fr) 2020-07-29
DK3538554T3 (da) 2025-09-08
MY191256A (en) 2022-06-10
MY203682A (en) 2024-07-12
MX2023011233A (es) 2023-10-03
EA201991075A1 (ru) 2019-10-31
CL2019001263A1 (es) 2019-09-27
US11535675B2 (en) 2022-12-27
WO2018089532A1 (en) 2018-05-17
SG10201913470SA (en) 2020-03-30
UA127678C2 (uk) 2023-11-29

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