CO2019004672A2 - Proteínas de unión a antígeno que antagonizan el receptor de leptina - Google Patents
Proteínas de unión a antígeno que antagonizan el receptor de leptinaInfo
- Publication number
- CO2019004672A2 CO2019004672A2 CONC2019/0004672A CO2019004672A CO2019004672A2 CO 2019004672 A2 CO2019004672 A2 CO 2019004672A2 CO 2019004672 A CO2019004672 A CO 2019004672A CO 2019004672 A2 CO2019004672 A2 CO 2019004672A2
- Authority
- CO
- Colombia
- Prior art keywords
- antibodies
- antigen
- lepr
- binding fragments
- bind
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención proporciona anticuerpos y fragmentos de unión a antígeno de anticuerpos que se unen al receptor de leptina (LEPR), y métodos para usarlos. De acuerdo con ciertas realizaciones, la invención incluye anticuerpos y fragmentos de unión a antígeno de anticuerpos que se unen a LEPR y antagonizan la señalización de LEPR. En ciertas realizaciones, la invención incluye anticuerpos y fragmentos de unión a antígeno de anticuerpos que se unen a LEPR en presencia o ausencia de leptina. En otras realizaciones, la invención incluye anticuerpos y fragmentos de unión a antígeno de anticuerpos que exhiben agonismo parcial de señalización LEPR. Los anticuerpos y fragmentos de unión a antígeno de la presente invención son útiles para el tratamiento de diversas afecciones, que incluyen, pero no se limitan a, caquexia por insuficiencia cardíaca congestiva, caquexia pulmonar y caquexia por cáncer, trastornos autoinmunes como enfermedad inflamatoria intestinal, lupus eritematoso, esclerosis múltiple, psoriasis, enfermedades cardiovasculares, presión arterial elevada, trastornos neurodegenerativos, depresión, cáncer como carcinoma hepatocelular, melanoma, cáncer de mama, y otras enfermedades y trastornos asociados con o causados por una elevada señalización de leptina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662419062P | 2016-11-08 | 2016-11-08 | |
| PCT/US2017/060690 WO2018089532A1 (en) | 2016-11-08 | 2017-11-08 | Antigen-binding proteins that antagonize leptin receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019004672A2 true CO2019004672A2 (es) | 2019-07-31 |
Family
ID=60409473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2019/0004672A CO2019004672A2 (es) | 2016-11-08 | 2019-05-07 | Proteínas de unión a antígeno que antagonizan el receptor de leptina |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10550192B2 (es) |
| EP (1) | EP3538554A1 (es) |
| JP (3) | JP7042816B2 (es) |
| KR (1) | KR102563568B1 (es) |
| CN (1) | CN110167965A (es) |
| AU (1) | AU2017359439A1 (es) |
| CA (1) | CA3043365A1 (es) |
| CL (3) | CL2019001263A1 (es) |
| CO (1) | CO2019004672A2 (es) |
| EA (1) | EA201991075A1 (es) |
| IL (2) | IL266426B (es) |
| MA (1) | MA45801B1 (es) |
| MX (2) | MX2019005397A (es) |
| MY (1) | MY191256A (es) |
| PH (1) | PH12019500988A1 (es) |
| SG (1) | SG10201913470SA (es) |
| UA (1) | UA127678C2 (es) |
| WO (1) | WO2018089532A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA45801B1 (fr) | 2016-11-08 | 2021-11-30 | Regeneron Pharma | Protéines de liaison à l'antigène qui sont des antagonistes du récepteur de leptine |
| BR112020012011A2 (pt) | 2017-12-18 | 2020-11-24 | Regeneron Pharmaceuticals, Inc. | moléculas de ligação a antígeno biespecífica isolada e de ligação a antígeno biespecífica ou cadeia de imunoglobulina, composição farmacêutica, recipiente ou dispositivo de injeção, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, métodos para tratar uma doença ou condição, para tratar uma condição de lipodistrofia em um sujeito, para produzir uma molécula de ligação a antígeno biespecífica, e, para administrar uma molécula de ligação a antígeno biespecífica isolada ou composição farmacêutica. |
| US11608381B2 (en) | 2018-04-06 | 2023-03-21 | Regeneron Pharmaceuticals, Inc. | Methods of treatment using a leptin receptor agonist antibody |
| WO2020016160A1 (en) * | 2018-07-16 | 2020-01-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to treat neurological diseases |
| KR20210104744A (ko) * | 2018-12-18 | 2021-08-25 | 리제너론 파마슈티칼스 인코포레이티드 | 렙틴 수용체, gdf8 및 액티빈 a에 대한 길항제를 사용하여 체중 및 제지방 근육량을 향상시키기 위한 조성물 및 방법 |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| BR112023004716A2 (pt) * | 2020-09-15 | 2023-05-09 | Regeneron Pharma | Uso de agonistas de lepr para dor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5643748A (en) | 1994-09-14 | 1997-07-01 | Progenitor, Inc. | HU-B1.219, a novel human hematopoietin receptor |
| US6451523B1 (en) | 1994-09-14 | 2002-09-17 | Interneuron Pharmaceuticals, Inc. | Detection of a leptin receptor variant and methods for regulating obesity |
| US5912123A (en) | 1994-09-14 | 1999-06-15 | Progenitor, Inc. | Detection of the leptin receptor in reproductive organs and methods for regulating reproductive biology |
| US5856098A (en) | 1994-09-14 | 1999-01-05 | Progenitor, Inc. | Detection of a leptin receptor variant |
| US6977240B1 (en) * | 1995-11-27 | 2005-12-20 | Millenium Pharmaceuticals, Inc. | Methods of using the OB receptor antibodies to treat bodyweight disorders |
| US6482927B1 (en) | 1995-11-27 | 2002-11-19 | Millennium Pharmaceuticals, Inc. | Chimeric proteins comprising the extracellular domain of murine Ob receptor |
| JP2000503204A (ja) | 1996-01-08 | 2000-03-21 | ジェネンテック インコーポレーテッド | Ｗｓｘレセプター及びリガンド類 |
| US20050019325A1 (en) | 1996-01-08 | 2005-01-27 | Carter Paul J. | WSX receptor agonist antibodies |
| AU2476301A (en) | 1996-01-16 | 2001-05-24 | Rockefeller University, The | DB the receptor for leptin nucleic acids encoding the receptor, and uses thereof |
| US7063958B1 (en) * | 1996-01-16 | 2006-06-20 | The Rockefeller University | Nucleic acids db, the receptor for leptin |
| AU1833197A (en) | 1996-01-18 | 1997-08-11 | Progenitor, Inc. | Detection of a leptin receptor variant and methods for regulating obesity |
| AU731685C (en) | 1996-01-23 | 2002-08-22 | Indevus Pharmaceuticals, Inc. | Methods for using the obese gene and its gene product to stimulate hematopoietic development |
| US7067472B1 (en) | 1996-06-04 | 2006-06-27 | The Scripps Research Institute | Diagnostic and therapeutic methods related to regulating energy mobilization with OB protein and OB antibodies |
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| AU767068B2 (en) | 1999-06-11 | 2003-10-30 | Baylor College Of Medicine | Methods and compositions for control of bone formation via modulation of leptin activity |
| US20040253242A1 (en) | 2000-12-05 | 2004-12-16 | Bowdish Katherine S. | Rationally designed antibodies |
| FR2852397B1 (fr) | 2003-03-10 | 2005-04-29 | Utilisation des genes leprotl 1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d'un sujet humain ou animal. | |
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| RU2013139267A (ru) | 2011-02-10 | 2015-03-20 | Рош Гликарт Аг | Улучшенная иммунотерапия |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| MY170126A (en) | 2012-09-12 | 2019-07-05 | Genzyme Corp | Fc containing polypeptides with altered glycosylation and reduced effector function |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| WO2015124588A1 (en) | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of diseases mediated by the nrp-1/obr complex signaling pathway |
| TWI752920B (zh) | 2015-10-12 | 2022-01-21 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
| MA45801B1 (fr) | 2016-11-08 | 2021-11-30 | Regeneron Pharma | Protéines de liaison à l'antigène qui sont des antagonistes du récepteur de leptine |
-
2017
- 2017-11-08 MA MA45801A patent/MA45801B1/fr unknown
- 2017-11-08 SG SG10201913470SA patent/SG10201913470SA/en unknown
- 2017-11-08 EP EP17801273.8A patent/EP3538554A1/en active Pending
- 2017-11-08 EA EA201991075A patent/EA201991075A1/ru unknown
- 2017-11-08 WO PCT/US2017/060690 patent/WO2018089532A1/en unknown
- 2017-11-08 CN CN201780082335.4A patent/CN110167965A/zh active Pending
- 2017-11-08 UA UAA201906354A patent/UA127678C2/uk unknown
- 2017-11-08 KR KR1020197016377A patent/KR102563568B1/ko active IP Right Grant
- 2017-11-08 CA CA3043365A patent/CA3043365A1/en active Pending
- 2017-11-08 AU AU2017359439A patent/AU2017359439A1/en active Pending
- 2017-11-08 MX MX2019005397A patent/MX2019005397A/es unknown
- 2017-11-08 MY MYPI2019002549A patent/MY191256A/en unknown
- 2017-11-08 JP JP2019523865A patent/JP7042816B2/ja active Active
- 2017-11-08 US US15/807,426 patent/US10550192B2/en active Active
-
2019
- 2019-05-02 IL IL266426A patent/IL266426B/en active IP Right Grant
- 2019-05-03 PH PH12019500988A patent/PH12019500988A1/en unknown
- 2019-05-07 CO CONC2019/0004672A patent/CO2019004672A2/es unknown
- 2019-05-08 CL CL2019001263A patent/CL2019001263A1/es unknown
- 2019-05-08 MX MX2023011233A patent/MX2023011233A/es unknown
-
2020
- 2020-01-07 US US16/736,760 patent/US11535675B2/en active Active
- 2020-01-30 IL IL272358A patent/IL272358B/en unknown
- 2020-03-05 CL CL2020000549A patent/CL2020000549A1/es unknown
- 2020-04-16 CL CL2020001023A patent/CL2020001023A1/es unknown
-
2021
- 2021-12-21 JP JP2021206917A patent/JP2022031969A/ja active Pending
-
2022
- 2022-11-17 US US18/056,411 patent/US20230235068A1/en active Pending
-
2023
- 2023-05-02 JP JP2023076083A patent/JP2023093753A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20230235068A1 (en) | 2023-07-27 |
| MX2019005397A (es) | 2019-10-09 |
| MA45801B1 (fr) | 2021-11-30 |
| IL272358B (en) | 2022-02-01 |
| KR20190075133A (ko) | 2019-06-28 |
| AU2017359439A1 (en) | 2019-05-23 |
| EP3538554A1 (en) | 2019-09-18 |
| WO2018089532A1 (en) | 2018-05-17 |
| UA127678C2 (uk) | 2023-11-29 |
| IL266426B (en) | 2020-11-30 |
| JP2023093753A (ja) | 2023-07-04 |
| IL272358A (en) | 2020-03-31 |
| CL2019001263A1 (es) | 2019-09-27 |
| JP7042816B2 (ja) | 2022-03-28 |
| PH12019500988A1 (en) | 2019-08-19 |
| CA3043365A1 (en) | 2018-05-17 |
| MY191256A (en) | 2022-06-10 |
| JP2022031969A (ja) | 2022-02-22 |
| EA201991075A1 (ru) | 2019-10-31 |
| US10550192B2 (en) | 2020-02-04 |
| US20200123264A1 (en) | 2020-04-23 |
| US11535675B2 (en) | 2022-12-27 |
| CL2020001023A1 (es) | 2020-10-09 |
| CN110167965A (zh) | 2019-08-23 |
| IL266426A (en) | 2019-06-30 |
| CL2020000549A1 (es) | 2020-08-28 |
| MX2023011233A (es) | 2023-10-03 |
| SG10201913470SA (en) | 2020-03-30 |
| US20180127508A1 (en) | 2018-05-10 |
| MA45801A1 (fr) | 2020-07-29 |
| JP2020504078A (ja) | 2020-02-06 |
| KR102563568B1 (ko) | 2023-08-04 |
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