KR102518838B1 - disinfectant composition for children - Google Patents

Abstract

The present invention relates to a disinfectant composition for children's products with improved odor, improved skin irritation, and improved safety.
The disinfectant for children's products provided from the present invention not only satisfies the notices of the Ministry of Environment, but also reduces irritation caused by odor or skin contact, and maintains weak acidity to minimize the risk of product corrosion or deformation, so that all tools or toys used by children , tableware, clothes, etc. can be safely used.

Description

Disinfectant composition for children's products {disinfectant composition for children}

The present invention relates to a disinfectant composition for children's products with improved odor, improved skin irritation, and improved safety.

In general, viruses such as influenza, avian influenza, swine flu, and corona, gram-positive bacteria such as staphylococci, streptococci, pneumonia, diphtheria, tetanus, anthrax, and actinomycetes, and salmonella, dysentery, typhus, Escherichia coli, and cholera, etc. Gram-negative bacteria infect the human body through respiratory, conjunctival or skin contact and cause various diseases such as pneumonia, typhoid fever, paratyphoid fever, conjunctivitis, food poisoning, cholera, and systemic organ dysfunction. It can be lethal during infection and transmission, resulting in an increase in morbidity and mortality.

Recently, as the incidence of various diseases caused by viruses and bacteria has increased, hygiene concepts for personal hygiene have emerged as important, and disinfectants and disinfectants for various purposes have been released, but most of them are synthetic chemicals such as high concentration ethanol, chlorine, and formalin It is composed of high toxicity and tolerance, which can cause harmful side effects to the human body and risks such as secondary environmental pollution.

In particular, it is important to sterilize objects used or in contact with young children, who are easily exposed to diseases due to their low immunity. However, as children often bite and suck things in their mouths, products made of highly toxic chemicals cannot be used, so most of them are hot water It is boiled or disinfected using UV. However, this is not only cumbersome, but also has the risk of corrosion, deformation, and generation of harmful substances by high temperature and UV.

As a result, the need for sterilization and disinfectant products for children with high ease of use and safety has gradually emerged, and as children-only products are indiscriminately released on the market without any safety verification, the Ministry of Environment issued Notice No. 2020-117 to Three disinfectant components were designated and specified as ethanol, citric acid, and 2-phenoxyethanol.

However, as mentioned above, high concentrations of ethanol can be toxic and can cause irritation due to its unique strong odor. Citric acid is also a strong acid when used in high concentrations and can cause product corrosion or skin and eye irritation. However, when only a low concentration is used, there is a problem that the sterilization power is significantly lowered.

As for technology related to the improved disinfectant, in Korea, Korean Patent Registration No. 10-5472752 "Method for preparing sterilizing water solution, alcohol sterilizing solution and method for manufacturing the same", Korean Patent Publication No. 10-2004-269410 Alcohol Sterilization Agent”, Korean Patent Registration No. 10-5476338, “Hydrogen Peroxide Sterilizer Containing Cyclic Carboxylic Acid and/or Aromatic Alcohol”, etc. are disclosed.

On the other hand, natural products such as calendula, sambaekcho, crown daisy, Schisandra, golden, mugwort, barberry, sancho, nut gall, green tea, etc. are materials that can be drunk as medicine or tea, and are completely harmless to the human body, but are known to have excellent antibacterial effects. Aroma oils such as grapefruit, thyme, lemongrass, tea tree, manuka, lavender, rosemary, chamomile, roman, peppermint, lime, and mugwort, which are widely used for cosmetics and massage, are harmless to the human body, but are known to have excellent antibacterial effects. is an ingredient There are cases where these natural ingredients are mixed and used as a disinfectant, but it is also difficult to expect a proper effect because the sterilization power has not been verified.

Accordingly, the inventors of the present invention completed the present invention by discovering that a disinfectant for children's products using a mixture of citric acid and ethanol in an optimal ratio within a non-irritating range can improve odor and skin irritation and increase sterilization power. I did.

Republic of Korea Patent Registration No. 10-5472752 Republic of Korea Patent Publication No. 10-2004-269410 Republic of Korea Patent Registration No. 10-5476338

An object of the present invention is to provide a disinfectant composition for children's products with improved odor, improved skin irritation and improved safety.

In order to achieve the above object, the present invention provides a disinfectant composition for children's products, characterized in that it comprises 15 to 35% by weight of ethanol and 0.0005 to 0.01% by weight of citric acid.

In the present invention, the disinfectant composition further comprises a natural antibacterial extract and aroma oil to be characterized

In the present invention, the natural antibacterial extract is at least one selected from the group consisting of golden, somok, baekduong, modanpi, green tea, gold silver flower, barberry, grapefruit, red pine, plum and lion balm. to be characterized

In the present invention, the natural antibacterial extract is characterized in that it is extracted by ethanol or hot water extraction method.

In the present invention, the aroma oil is at least one selected from the group consisting of thyme, lemongrass, tea tree, chamomile roman, manuka, eucalyptus, stevia, rosemary, lavender, peppermint, lime, lemon and mugwort. to be characterized

In the present invention, the natural antibacterial extract and aroma oil include 1 to 10% by weight of natural antibacterial extract and 0.01 to 1.0% by weight of aroma oil based on the total weight of the disinfectant composition. to be characterized

The disinfectant for children's products provided by the present invention reduces irritation caused by smell or skin contact, and maintains weak acidity to minimize the risk of product corrosion or deformation, so that it can be safely used for all utensils, toys, tableware, clothes, etc. used by children. can

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclatures used herein are those well known and commonly used in the art.

Throughout the present specification, when a certain component is said to "include", it means that it may further include other components without excluding other components unless otherwise stated.

When ethanol and citric acid, which are components notified by the Ministry of Environment, are used, high content must be used for high sterilization effect, but at this time, skin irritation and toxicity may occur. Therefore, in the present invention, irritation due to odor or skin contact is reduced by mixing ethanol, which is in the range where there is little irritation due to odor, and citric acid, which is in the weakly acidic (pH 3.50-5.50) range, where there is little stimulation due to pH, in an optimal ratio. and to provide a disinfectant composition for children's products that can exhibit 99.9% sterilization power.

According to one embodiment of the present invention, the present invention relates to a disinfectant composition for children's products, characterized in that it comprises 15 to 35% by weight of ethanol and 0.0005 to 0.01% by weight of citric acid.

The ethanol is preferably included in an amount of 15 to 35% by weight based on the total weight of the disinfectant composition because there is little stimulation due to odor. If less than 15% by weight of ethanol is used with respect to the total weight of the disinfectant composition, the content is too insignificant to obtain a sufficient sterilization effect against all bacteria or viruses, and if it exceeds 35% by weight, high concentration of ethanol Since it contains, it may be toxic and cause irritation due to its characteristic strong odor, which is undesirable because it is not suitable for disinfectants exclusively for children's products.

In addition, it is preferable to include 0.0005 to 0.01% by weight of the citric acid based on the total weight of the disinfectant composition because it is within the weak acidity (pH 3.50-5.50) range with little stimulation due to pH. If less than 0.0005% by weight of citric acid is used with respect to the total weight of the disinfectant composition, the content is too insignificant and the pH value is close to neutral, making it impossible to obtain a sufficient sterilization effect. It is undesirable because it can cause corrosion of the product or irritation to the skin and eyes.

Therefore, in the present invention, odor and skin irritation are improved by controlling ethanol and citric acid in various ratios, and optimal contents capable of increasing sterilization power are used, and the mixing ratio of ethanol and citric acid can be said to be the most important feature.

According to one embodiment of the present invention, the disinfectant composition may be used to additionally include a natural antibacterial extract and an aroma oil.

Even when ethanol and citric acid are used together as described above, odor improvement, skin irritation improvement, and safety are improved, but when natural extracts known to have antibacterial effects and aroma oil are added together, ethanol and citric acid By reducing the content, the pH is maintained at 5.00, which is slightly acidic, similar to healthy skin, and the sterilizing power can be 99.9%. can be granted

The natural antibacterial extract is safe to use at least one selected from the group consisting of gold, somok, baekduong, mokdanpi, green tea, gold silver flower, barberry, grapefruit, red pine, plum and lion's hair, and synergistic action to help increase bactericidal power. preferred in terms of giving.

The natural antibacterial extract may be extracted by ethanol or hot water extraction method.

In addition, the aroma oil is sterilizing power by using at least one selected from the group consisting of thyme, lemongrass, tea tree, chamomile roman, manuka, eucalyptus, stevia, rosemary, lavender, peppermint, lime, lemon and mugwort. It is desirable in terms of not only helping increase but also masking the stimulating ethanol smell and amplifying the aesthetic effect with a fragrance that stabilizes the mind and body.

According to one embodiment of the present invention, the natural antibacterial extract and the aroma oil preferably include 1 to 10% by weight of the natural antibacterial extract and 0.01 to 1.0% by weight of the aroma oil based on the total weight of the disinfectant composition.

If less than 1% by weight of the natural antibacterial extract is used relative to the total weight of the disinfectant composition, the amount is so insignificant that it is difficult to expect the effect of increasing the bactericidal power. It is undesirable because it can affect long-term stability due to temperature, and problems such as precipitation of natural components can occur when an excessive amount of extract is used.

In addition, when less than 0.01% by weight of aroma oil is used relative to the total weight of the disinfectant composition, the amount is so insignificant that it is difficult to expect an effect on increasing the sterilization power, and the fragrance is buried in the ethanol odor rather than masking the ethanol odor to enhance the unique fragrance It is difficult to expect an effect on the product, and if it exceeds 1.0% by weight, irritation due to the aroma may occur due to the strong fragrance, and it is difficult to dissolve transparently in the disinfectant and may leave marks when spraying on the product. don't

The disinfectant for children's products obtained from the above method has problems of irritation and toxicity due to skin contact caused by using high content for high sterilization effect when using ethanol and citric acid, which are components notified by the Ministry of Environment, respectively. By mixing the two components of citric acid in an optimal ratio, there is an effect of improving skin irritation and odor and improving sterilization power.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for explaining the present invention in more detail, and it is to those of ordinary skill in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. It will be self-explanatory.

<Examples 1 to 6 and Comparative Examples 1 to 4> Preparation of sterilization disinfectant

Sterilizers for children's products of Examples 1 to 6 and Comparative Examples 1 to 4 were prepared by mixing in the contents (% by weight) shown in Table 1 below.

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 ethanol 70 - 30 - 35 35 30 30 25 25 citric acid - One - 0.01 0.01 0.001 0.01 0.001 0.01 0.001 water 30 99 70 99.99 64.99 64.999 69.99 69.999 74.99 74.999

<Experimental Example 1> pH measurement

The pH of the disinfectants for children's products of Examples 1 to 6 and Comparative Examples 1 to 4 was measured and shown in Table 2 below.

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 pH - 2.09 - 3.57 3.72 5.07 3.72 5.19 3.60 4.88

As a result, as shown in Table 2, Comparative Example 2 having a citric acid content of 1% by weight has a pH of 2 and exhibits very strong acidity, and has a sterilizing power of 10% or more and less than 50% in both cells, indicating that it has some sterilizing power. However, Comparative Example 4 having a citric acid content of 0.01% by weight showed weak acidity at a pH of 3.5, reducing irritation due to acidity, but showing very low sterilization power of less than 10%.

On the other hand, in the case of Examples 1 to 6, the pH was weakly acidic and similar to or higher than that of Comparative Example 4, and it was confirmed that ethanol was applied together, resulting in high sterilization power due to the synergistic effect.

<Experimental Example 2> Evaluation of irritation to the skin

In order to check the degree of irritation to the skin using the disinfectants for children's products of Examples 1 to 6 and Comparative Examples 1 to 4, the disinfectant prepared in Comparative Example 1 was applied to the right side of one group of subjects using a patch for patch test. Attached to the inside of the arm, and the disinfectant prepared in Comparative Example 2 was attached to the inside of the left arm of one group of subjects using a patch test patch, and Comparative Examples 3 to 4 and Examples 1 to 6 were also subjected to the same method. It was attached to the inside of the right and left arms of groups 1 and 2 and removed after 6 hours, respectively. The subjects were female subjects in their 20s and 30s, and 20 subjects were divided into 2 groups of 10 persons each to perform the experiment.

Table 3 shows the results of the sensory test for the change in skin redness after the test and the extent felt by the subjects in Table 3 based on the following criteria.

[Evaluation standard]

++: there is irritation

+: slightly irritating

-: no irritation

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Stimulation ++ ++ + + + - + - + -

As a result, as shown in Table 3, it was confirmed that Comparative Examples 3 to 4 and Examples 1 to 6 had a lower degree of irritation to the skin compared to Comparative Examples 1 to 2. In Comparative Example 3, compared to Comparative Example 1, the dryness caused by ethanol or irritation caused by it decreased due to the decrease in ethanol compared to Comparative Example 1, and in Comparative Example 4, the pH increased from strong acid to weak acid due to the decrease in citric acid compared to Comparative Example 2, resulting in irritation due to acidity. this decreased. In Examples 1, 3, and 5, the pH value increased slightly more than Comparative Example 4 due to the slight pH increase effect due to ethanol in addition to the decrease in ethanol, and the stimulation to acidity was slightly improved. Examples 2, 4, and 6 It was confirmed that the decrease in citric acid brought the pH value closer to weak acidity, and the sensation of irritation was completely improved, so that no irritation appeared.

<Experimental Example 3> Measurement of sterilizing power

In order to confirm the bactericidal power of the disinfectant for children's products of Examples 1 to 6 and Comparative Examples 1 to 4, first, each strain to be tested was inoculated into a round bottom tube containing 10 mL of sterilized TSB medium, and incubated for 18 to 24 hours. It was prepared to be 5x10 ⁵ to 5x10 ⁶ CFU/mL. After preparing 99mL of the test solution in a sterilized container, 1mL of the test strain suspension was inoculated. After inoculation, mix well at regular intervals, put 1 mL each into 2 Petri dishes, and distribute 15 mL of TSA medium cooled to 50-60 ° C. to mix and solidify. After the medium hardened, TSA medium was added and superimposed thereon, and after culturing at 36 ± 1 ° C for 20 to 24 hours, the number of colonies formed was counted and shown in Table 4 below. In this experiment, Escherichia coli (ATCC 10536) and Staphylococcus aureu s (ATCC 6538) were used as test strains, and this test method referred to the test method conducted by the authorized analysis institute and ASTM E2149.

[Measurement result]

-: Inhibition rate 99.9%

+: inhibition rate of 50% or more

++: Inhibition rate 10% or more and less than 50%

+++: inhibition rate less than 10%

turnaround time number of bacterial colonies Escherichia coli Staphylococcus aureus Comparative Example 1 1 min - - Comparative Example 2 10min ++ ++ Comparative Example 3 1 min - + Comparative Example 4 10min +++ +++ Example 1 1 min - - Example 2 1 min - - Example 3 1 min - - Example 4 1 min - - Example 5 10min - - Example 6 10min - -

As a result, as shown in Table 4, in the case of Comparative Example 1, the sterilization power was very high, but the strong smell and irritation due to the use of high concentration of ethanol were high. In the case of Comparative Example 2, high concentration of citric acid was used to show strong acidity with a very low pH value, resulting in strong irritation. appear.

In addition, when the contents of ethanol and citric acid were respectively reduced to reduce irritation, it was confirmed that the irritation was significantly reduced, but the bactericidal power was slightly reduced. In the case of Comparative Example 3, E.coli colonies were not confirmed, but S. aureus colonies were slightly formed, confirming that the bactericidal power was reduced. In the case of Comparative Example 4, a large amount of bacterial colonies were observed in both cells, and it was confirmed that there was little bactericidal activity.

On the other hand, in the case of Examples 1 to 6 in which ethanol and citric acid were mixed at the optimum content, the pH value increased slightly or a lot, so the irritation caused by acidity rather decreased. It was confirmed that the sterilization power increased than when Among them, it was confirmed that Examples 1 to 4, in which the ratio of ethanol was high, showed a high sterilization effect even in a shorter treatment time than Examples 5 to 6, in which the ratio of ethanol was relatively low.

<Experimental Example 4> Measurement of sterilization power according to the addition of natural antibacterial extract and aroma oil

A sterilizer for children's products in Example 7 in which ethane and citric acid were mixed, and a natural antibacterial extract and aroma oil (mugwort) in which a 1: 1: 1 mixture of barberry extract, golden extract and green tea extract in Example 7 were added. The pH, skin irritation, and sterilizing power of the added disinfectant for children's products in Examples 8 to 11 were measured in the same manner as in Experimental Examples 1 to 3, and are shown in Table 5 below.

At this time, the treatment time of the bactericidal power test was set to 10 minutes all the same.

In addition, the natural antibacterial extract was used by extracting barberry, gold, and green tea by type and then mixing in the same ratio. 10g of dried leaves of each material was put in 200mL of distilled water, hot water extracted at 97℃ for 2 hours, and then used with a mesh. After filtering, it was used.

Example 7 Example 8 Example 9 Example 10 Example 11 ethanol 20 20 20 20 20 citric acid 0.0008 0.0008 0.0008 0.0008 0.0008 3 natural antibacterial extracts
(Hwangryeon: Golden: Green tea = 1:1:1) - One 5 One 5 Aroma Oil (Mugwort) - 0.1 0.1 0.5 0.5 pH 5.15 4.84 5.03 4.60 4.67 Stimulation - - - - - number of bacterial colonies E. coli - - - - - S. aureus + - - - -

As a result, as shown in Table 5, in the case of Example 7, the content of ethanol and citric acid was reduced compared to Example 1 to further alleviate problems caused by irritation or intoxication, and the pH was adjusted to a level similar to that of healthy skin to improve acidity. No stimulation was felt at all. However, due to the decrease in ethanol and citric acid, the bactericidal power was also reduced, and a small amount of S. aureus bacteria was observed compared to Example 1.

In addition, in the case of Examples 8 to 11, a natural antibacterial extract and aroma oil were additionally included in Example 7, and as in Example 8, even when a very small amount of natural antibacterial extract or aroma oil was applied, colony formation was not observed in both cells. It was confirmed that the bactericidal power was improved. Even when the treatment time was reduced to 1 minute, colony formation was not observed in both cells, confirming that the sterilization effect in a short time was also excellent. In addition, not only did the aroma scent completely mask the remaining ethanol smell, but also left a subtle scent in the space, which also had an aesthetic effect. In addition, as the content of the natural antibacterial extract and the content of the aroma oil increased, the pH value tended to decrease little by little, so it was confirmed that Example 9 had the least stimulation and was most suitable for its high sterilization power.

Having described specific parts of the present invention in detail above, it will be clear to those skilled in the art that these specific descriptions are only preferred embodiments, and the scope of the present invention is not limited thereby. will be. Accordingly, the substantial scope of the invention will be defined by the appended claims and their equivalents.

Claims (6)

20% by weight of ethanol, 0.0008% by weight of citric acid, 5% by weight of natural antibacterial extract, 0.1% by weight of aroma oil and 74.8992% by weight of water,
The ethanol is to minimize the ethanol content so as not to irritate the skin,
The natural antibacterial extract is a disinfectant composition for children's products, characterized in that a mixture of barberry extract, golden extract and green tea extract in a weight ratio of 1: 1: 1.


delete delete The disinfectant composition for children's products according to claim 1, wherein the natural antibacterial extract is extracted by ethanol or hot water extraction method.
The method of claim 1, wherein the aroma oil is at least one selected from the group consisting of thyme, lemongrass, tea tree, chamomile roman, manuka, eucalyptus, stevia, rosemary, lavender, peppermint, lime, lemon and mugwort. Characterized by a disinfectant composition for children's products.












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