KR102507685B1 - 난소암의 검출 및 치료를 위한 조성물 및 방법 - Google Patents

난소암의 검출 및 치료를 위한 조성물 및 방법 Download PDF

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Publication number
KR102507685B1
KR102507685B1 KR1020227022682A KR20227022682A KR102507685B1 KR 102507685 B1 KR102507685 B1 KR 102507685B1 KR 1020227022682 A KR1020227022682 A KR 1020227022682A KR 20227022682 A KR20227022682 A KR 20227022682A KR 102507685 B1 KR102507685 B1 KR 102507685B1
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South Korea
Prior art keywords
progastrin
cdr
antibody
seq
amino acid
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Korean (ko)
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KR20220100100A (ko
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알렉산더 프뢰르
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프로가스트린 에 캔서스 에스.에이 알.엘.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • G01N33/57545—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/595—Gastrins; Cholecystokinins [CCK]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020227022682A 2015-12-31 2017-01-02 난소암의 검출 및 치료를 위한 조성물 및 방법 Active KR102507685B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP15307192.3 2015-12-31
EP15307192 2015-12-31
EP16305138.6 2016-02-05
EP16305138 2016-02-05
KR1020187020588A KR102428254B1 (ko) 2015-12-31 2017-01-02 난소암의 검출 및 치료를 위한 조성물 및 방법
PCT/EP2017/050033 WO2017114972A1 (en) 2015-12-31 2017-01-02 Compositions and methods for detecting and treating ovarian cancer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187020588A Division KR102428254B1 (ko) 2015-12-31 2017-01-02 난소암의 검출 및 치료를 위한 조성물 및 방법

Publications (2)

Publication Number Publication Date
KR20220100100A KR20220100100A (ko) 2022-07-14
KR102507685B1 true KR102507685B1 (ko) 2023-03-08

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KR1020227022682A Active KR102507685B1 (ko) 2015-12-31 2017-01-02 난소암의 검출 및 치료를 위한 조성물 및 방법
KR1020187020588A Active KR102428254B1 (ko) 2015-12-31 2017-01-02 난소암의 검출 및 치료를 위한 조성물 및 방법

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Country Status (13)

Country Link
US (1) US11760808B2 (enExample)
EP (2) EP3397964B1 (enExample)
JP (2) JP6962920B2 (enExample)
KR (2) KR102507685B1 (enExample)
CN (1) CN108780091A (enExample)
AU (2) AU2017204682B2 (enExample)
BR (1) BR112018013271A2 (enExample)
CA (2) CA3194356C (enExample)
EA (1) EA037015B1 (enExample)
ES (2) ES2901602T3 (enExample)
PL (1) PL3397964T3 (enExample)
SG (1) SG11201805605TA (enExample)
WO (1) WO2017114972A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240018264A1 (en) * 2015-12-31 2024-01-18 Progastrine Et Cancers S.À R.L. Compositions and methods for detecting and treating ovarian cancer
EP3720879B1 (en) * 2017-12-05 2022-05-11 Progastrine et Cancers S.à r.l. Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer
AU2018381046B2 (en) 2017-12-08 2025-10-02 Ecs-Biotracker Sàrl Radiolabeled progastrin in cancer diagnosis
TW201940881A (zh) 2018-01-26 2019-10-16 瑞士商Ｅｃｓ前胃泌激素公司 在癌症診斷中結合前胃泌激素檢測與其他癌症生物標記的技術
WO2019166499A1 (en) 2018-02-27 2019-09-06 Ecs-Progastrin Sa Progastrin as a biomarker for immunotherapy
JP7687224B2 (ja) * 2022-01-25 2025-06-03 株式会社三洋物産 遊技機
JP7687223B2 (ja) * 2022-01-25 2025-06-03 株式会社三洋物産 遊技機

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2011083091A2 (en) * 2010-01-08 2011-07-14 Bioréalités S.A.S. Methods for treating pancreatic cancer

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IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8924581D0 (en) 1989-11-01 1989-12-20 Pa Consulting Services Bleaching of hair
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CA2050918A1 (en) 1990-01-12 1991-07-13 Raju Kucherlapati Generation of xenogeneic antibodies
GB9014932D0 (en) 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
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JPH05244982A (ja) 1991-12-06 1993-09-24 Sumitomo Chem Co Ltd 擬人化ｂ−ｂ１０
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Also Published As

Publication number Publication date
EA201891529A1 (ru) 2019-01-31
WO2017114972A1 (en) 2017-07-06
EP3397964A1 (en) 2018-11-07
KR20180105647A (ko) 2018-09-28
JP2022009080A (ja) 2022-01-14
CA3194356A1 (en) 2017-07-06
AU2021250840A1 (en) 2021-11-04
EP3954999A1 (en) 2022-02-16
EP3397964B1 (en) 2021-09-29
AU2017204682B2 (en) 2021-07-29
SG11201805605TA (en) 2018-07-30
EP3954999B9 (en) 2025-03-12
JP6962920B2 (ja) 2021-11-05
EP3954999C0 (en) 2025-01-15
AU2021250840B2 (en) 2024-06-27
KR102428254B1 (ko) 2022-08-03
ES2901602T3 (es) 2022-03-23
AU2017204682A1 (en) 2018-07-19
CA3009751A1 (en) 2017-07-06
EA037015B1 (ru) 2021-01-27
KR20220100100A (ko) 2022-07-14
BR112018013271A2 (pt) 2018-12-11
CA3194356C (en) 2025-04-08
US11760808B2 (en) 2023-09-19
EP3954999B1 (en) 2025-01-15
JP2019502923A (ja) 2019-01-31
ES3015244T3 (en) 2025-04-30
CN108780091A (zh) 2018-11-09
PL3397964T3 (pl) 2022-02-07
JP7279761B2 (ja) 2023-05-23
US20190002582A1 (en) 2019-01-03

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