KR102492549B1 - Composition comprising collagen peptides and herbal extracts for preventing and improving anemia - Google Patents

Abstract

The present invention provides a composition for preventing and improving anemia comprising a herbal extract, collagen peptide and iron.

Description

Composition for preventing and improving anemia containing collagen peptides and herbal extracts

The present invention relates to a composition for preventing and improving anemia.

Anemia refers to a case in which the blood does not supply enough oxygen necessary for metabolism of human tissues, resulting in tissue hypoxia.

Specifically, anemia refers to a condition in which red blood cells in blood are lower than normal or hemoglobin in red blood cells is lower than normal, so that oxygen can be sufficiently supplied to human tissues through blood.

Anemia does not show symptoms at first, but if anemia persists, symptoms such as dizziness, fatigue, weakness, pale skin, shortness of breath, and nail deformity appear. Research results suggesting that it can also be reported.

According to the 2019 National Health and Nutrition Examination Survey released by the Korea Centers for Disease Control and Prevention, the prevalence of anemia in Koreans aged 10 years and older was 11.6%. And according to data from the Health Insurance Evaluation Institute in 2019, about 280,000 women and about 70,000 men had iron-deficiency anemia.

The bone marrow in the human body needs iron to make hemoglobin, but without enough iron, the body cannot produce enough hemoglobin for red blood cells, resulting in iron deficiency anemia.

Iron deficiency anemia can be caused by insufficient diet, such as dieting and fast food intake, and can cause chronic bleeding such as gastrointestinal bleeding and excessive menstruation.

Vitamin deficiency anemia is also prevalent in people who consume foods deficient in folic acid and vitamin B12, or who have digestive disorders that affect the absorption of folic acid and vitamin B12.

Collagen, also known as light protein or collagen, is widely distributed in multicellular animals such as invertebrates and vertebrates, and is the most frequently found light protein in terms of quantity. In mammals, it accounts for about 1/3 of the total protein and is a major fiber-like light protein that constitutes animal connective tissue and has a very strong tensile strength. It transmits force without loss in tendons or ligaments.

In recent years, collagen peptides have been increasingly used as health foods, surgical or ophthalmic treatments, or cosmetic additives. On the other hand, these collagen peptides are regarded as food, pharmaceutical, and cosmetic, and the stability of the product and the skin and body absorption rate are important.

The present invention provides a composition for preventing and improving anemia, including collagen peptides and herbal extracts capable of preventing and improving anemia, improving blood production and blood circulation, and increasing skin moisturization and elasticity.

The composition for preventing and improving anemia according to an embodiment of the present invention includes herbal medicine extract, collagen peptide and iron.

597 to 657 parts by weight of the crude drug extract, 2850 to 3150 parts by weight of collagen peptides, and 14 to 16 parts by weight of iron.

The crude drug extract may include at least one selected from angelica extract, cnidium extract, saccharinus extract, peony extract, astragalus extract, and licorice extract.

The composition for preventing and improving anemia may further include folic acid, vitamin B2, vitamin B12 and vitamin C.

0.5 to 0.7 parts by weight of the folic acid, 4.7 to 5.3 parts by weight of the vitamin B2, 0.09 to 0.11 parts by weight of the vitamin B12, and 47 to 53 parts by weight of the vitamin C may be included.

The composition for preventing and improving anemia, including the collagen peptide and crude drug extract of the present invention, not only prevents and improves anemia, but also improves blood production and blood circulation, can increase skin moisturization and elasticity, and is effective in promoting vitality. there is.

The composition for preventing and improving anemia containing the collagen peptide and crude drug extract of the present invention adds vitality to the skin and is effective in blood retention and blood activation.

Hereinafter, some embodiments of the present invention will be described in detail through exemplary drawings. In adding reference numerals to components of each drawing, it should be noted that the same components have the same numerals as much as possible even if they are displayed on different drawings.

And, in describing the embodiments of the present invention, if it is determined that a detailed description of a related known configuration or function interferes with understanding of the embodiment of the present invention, the detailed description will be omitted.

Also, terms such as first, second, A, B, (a), and (b) may be used to describe components of an embodiment of the present invention. These terms are only used to distinguish the component from other components, and the nature, order, or order of the corresponding component is not limited by the term.

Hereinafter, a composition for preventing and improving anemia (hereinafter, referred to as 'composition for preventing and improving anemia') containing a collagen peptide and a herbal extract according to an embodiment of the present invention will be described.

The composition for preventing and improving anemia of the present invention includes a herbal extract, collagen peptide and iron.

The composition for preventing and improving anemia includes 597 to 657 parts by weight of the crude drug extract, 2850 to 3150 parts by weight of collagen peptides, and 14 to 16 parts by weight of iron.

In addition, the composition for preventing and improving anemia may include 597 to 657 parts by weight of the crude drug extract, 1000 to 5000 parts by weight of collagen peptides, and 3.6 to 16 parts by weight of iron.

Preferably, the composition for preventing and improving anemia may include 627.6 parts by weight of the crude drug extract, 3000 parts by weight of collagen peptides, and 15 parts by weight of iron.

The crude drug extract may include at least one selected from angelica extract, cnidium extract, saccharinus extract, peony extract, astragalus extract, and licorice extract.

These crude drug extracts not only generate blood, but also have the effect of energizing the hemorrhage, supplying nutrients to the body, and facilitating blood circulation.

In the present invention, the extract refers to a material obtained by separating components from natural products, and the separation method or separated component is not limited. For example, an extract may refer to extracting a component soluble in a solvent from a natural product using water or an organic solvent. In addition, in the present invention, the extract or a fraction of the extract may be used as it is, but the use method is not limited, such as being concentrated after filtration and used in the form of an extract, concentrated and then freeze-dried and used as a freeze-dried product.

In the present invention, angelica extract, cnidium extract, perilla extract, peony extract, astragalus extract, and licorice extract are herbal medicines extracted by putting 1 kg of herbal raw materials in 6 L to 8 L of water or alcohol and heating them at 80 ° C to 95 ° C for 8 to 10 hours. An extract is prepared, the crude drug extract is filtered, concentrated under reduced pressure to make a crude drug concentrate of 60 to 65 brix, and then the crude drug concentrate is sterilized at 80 ° C to 90 ° C for 30 minutes.

The herbal extract contains 119 to 131 parts by weight of angelica extract, 83 to 91 parts by weight of Cnidium extract, 119 to 131 parts by weight of Rehmannia Root extract, 119 to 131 parts by weight of Peony extract, 119 to 131 parts by weight of Astragalus extract, and It may include 38 to 42 parts by weight of licorice extract.

Preferably, the crude drug extract may include 125 parts by weight of Angelica quail extract, 87.6 parts by weight of Cnidium extract, 125 parts by weight of Rehmannia Root extract, 125 parts by weight of Peony extract, 125 parts by weight of Astragalus extract, and 40 parts by weight of licorice extract. can

The composition for preventing and improving anemia may further include folic acid, vitamin B2, vitamin B12, and vitamin C.

Specifically, the composition for preventing and improving anemia may further include 0.5 to 0.7 parts by weight of folic acid, 4.7 to 5.3 parts by weight of vitamin B2, 0.09 to 0.11 parts by weight of vitamin B12, and 47 to 53 parts by weight of vitamin C. there is.

In addition, the composition for preventing and improving anemia may further include 0.1 to 1 part by weight of folic acid, 0.4 to 40 parts by weight of the vitamin B2, 0.01 to 2 parts by weight of the vitamin B12, and 30 to 1000 parts by weight of the vitamin C there is.

Preferably, 0.6 parts by weight of folic acid, 5 parts by weight of vitamin B2, 0.1 part by weight of vitamin B12, and 50 parts by weight of vitamin C may be included.

The collagen peptide may have an average molecular weight of 200 Da to 500 Da, preferably 330 Da to 370 Da, and a size of 0.1 nm to 10 nm, more preferably 1 nm to 3 nm.

For example, the collagen peptide may include at least one of a dipeptide and a tripeptide. Therefore, the collagen peptides can be quickly absorbed into blood or skin.

The collagen peptide is made of at least one selected from the group consisting of animal collagen such as cow skin and pork skin, vegetable collagen such as fruits, vegetables, seeds, nuts, and mushrooms, and marine collagen such as seaweed, fish, fish scales, and fish skin. can

The Angelica Quali extract means an extract from Angelica Quail.

Angelica gigas Nakai, Angelica acutiloba Kitagawa, and Chinese angelica (Angelica sinensis Diels) may be one or more selected from Angelica gigas Nakai and Angelica gigas Nakai.

Angelica quinoa contains coumarine-based substances such as decursin, decursinol angelate, decursinol, nodakenetin, umbelliferon, There are nodakenin, beta-sitosterol, and beta-eudesmol, and it is known to be rich in iron, folic acid, and B vitamins.

It is known that decursin has the effect of protecting brain cells and activates blood circulation and metabolism to help remove free radicals as well as antioxidant action.

Nodakenin is known to be effective in regulating uterine function and treating sedation, pain relief, antibacterial and vitamin E deficiency.

Beta-sitosterol (β-sitosterol) is known to reduce blood cholesterol and be effective in anticancer, antioxidant, anti-inflammatory, lowering blood sugar, and enhancing immunity.

Angelica gigas has main ingredients such as bergapten, hydropthalid, and valerophenome.

The main ingredients of Chinese donkey are butylidenephthalide, ferulic acid, Z-ligustilide, hydropthalid, and valerophenome. .

The Cnidium officinale extract means that it is extracted from Cnidium officinale.

Cnidium officinale is a perennial herbaceous plant belonging to the umbel family, and is commonly cultivated for medicinal purposes in Korea. Cnidium has effects such as blood circulation, pain suppression, and liver function activation.

The sukjihwang extract means that it is extracted from sukjihwang (Rehmanniae Radix Preparata).

Rehmannia glutinosa is a perennial herbaceous plant belonging to the Scrophulariaceae family. Rehmannia root leaves and fine roots are removed and the soil is removed.

Saengjihwang is known to be effective in blood, tonic, sedation, anemia, hematemesis, hemorrhage, uterine bleeding, and tuberculous weakness. In addition, raw rehmanniae is dried, put in alcohol such as hwangju or baekju, brewed, steamed, and then dried repeatedly. It is called Rehmanniae Radix Preparata.

Sukjihwang has the efficacy of blood and consonant sound, and is used for menstrual irregularities, weak constitutions, poor growth of children, dementia, premature ejaculation, and impotence. In addition, rehmannia glutinosa improves blood circulation to improve the peripheral microcirculation of various chronic diseases, increases superoxide dismutase and glutathione peroxidase, inhibits lipid peroxidation, increases immunity, and has anticancer effects. It has effects such as increasing the activity of the fibrinolytic system, reducing polybrene-induced erythrocyte aggregation, and increasing erythrocyte deformability and ATP content. .

The peony extract means extracted from peony.

Peony means a plant of the peony genus, and the peony genus plants include Paeonia lactiflora, Paeonia Japonica Miyabe & Takeda, Paeonia lactiflora Pall., Paeonia lactiflora Pall. var. hirta Regel, and Paeonia lactiflora Pall. var. trichocarpa (Bunge) Stern).

Plants of the genus Peony are perennial herbaceous plants of the dicotyledonous peony family, and are used as a treatment for pain, abdominal pain, dysmenorrhea, amenorrhea, hematemesis, anemia, bruises, and the like.

The astragalus extract means that extracted from astragalus (Astragali Radix).

Astragali Radix is a perennial herbaceous plant of the dicotyledonous plant Rosaceae legume, distributed in Korea, Japan, Manchuria, northeastern China, and eastern Siberia. It is often cultivated as a medicinal herb. It has effects such as physical weakness, fatigue boredom, qi and blood collapse, prolapse, uterine prolapse, visceral drainage, cold sweat, and peripheral nerves.

The licorice extract means extracted from licorice (Glycyrrhiza uralensis Fisch).

Licorice (Glycyrrhiza uralensis Fisch) is a perennial herb belonging to the leguminous family and has been widely used in oriental medicine since ancient times to treat cough, detoxification, expectoration, and diuresis. Licorice is mainly cultivated in Korea and China (Glycyrrhiza uralensis Fischer, G. uralensis) and Europe (Glycyrrhiza glabra L.).

Among the major physiologically active components of licorice, triterpene-based saponins include glycyrrhizin and glycyrrhetinic acid, and flavonoid components include liquiritin and licorice. Liquiritigenin, isoliquiritin, isoliquiritigenin, glycyrol, glycyrin, licoricidin, licoricone, etc. , phenolic substances include licopyranocumarin and glycocoumarin.

Iron is one of the essential minerals in living organisms that play an essential role in oxygen transport.

The iron is ferric citrate, ferric ammonium citrate, iron gluconate, iron phosphate, iron lactate, ferrous fumarate, ferric pyrophosphate, sodium iron pyrophosphate, ferrous sulfate, heme iron, ferric chloride, reduced iron, and other food raw materials. It may be any one or more selected from among those manufactured and processed to be replenished.

Here, heme iron is a component contained in hemoglobin, myoglobin, etc., which is prepared by isolating and refining from whole blood of animals, and means dark brown powder or granules.

Heme iron is well absorbed by the human body and is effective in preventing and improving anemia by increasing the level of hemoglobin in the blood.

The folic acid (folic acid) is one of the vitamin B complex, widely distributed in nature, and is particularly contained in fruits, vegetables, legumes, liver of animals. Folic acid is essential for the synthesis of nucleic acids and amino acids necessary for cell division and growth in the body, and is used for growth development and red blood cell production in combination with vitamin B12.

The vitamin B2 is called riboflavin and is a kind of water-soluble vitamin. Deficiency of vitamin B2 can cause angular cheilitis, cheilitis, glossitis, stomatitis, or seborrheic dermatitis on soft and thin weak skin such as the nose, mouth, scrotum, and vulva, and can cause fatigue and anemia.

Vitamin B12 is converted into a coenzyme in the body and functions as a coenzyme in DNA synthesis, fatty acid and amino acid metabolism, and plays an important role in red blood cell production in the bone marrow and normal maintenance of nerve tissue.

Vitamin C is one of the vitamins contained in almost all fruits and vegetables, and it is an essential vitamin that must be ingested with food because humans do not have the enzyme to synthesize vitamin C. Vitamin C is a strong reducing agent, has an antioxidant effect, and is a coenzyme for collagen synthesis enzymes and various enzymes involved in the energy metabolism of organisms.

Example 1_Manufacture of angelica extract

After putting 1kg of Angelica quail in 6.8L of water and heating it at 91°C to make an Angelica quail extract extracted for 9 hours, the Angelica quai extract was filtered and concentrated under reduced pressure to make a 60 brix Angelica Quai concentrate, and the prepared Angelica quai concentrate was 30% at 80°C to 90°C. Sterilize in minutes

Example 2_ Preparation of Cnidium Cnidium Extract

Cnidium 1kg was put in 7.2L of water and heated to 89℃ to make a cnidium extract extracted for 10 hours, then the cnidium extract was filtered and concentrated under reduced pressure to make a 60 brix cnidium concentrate. Sterilize in minutes

Example 3_ Preparation of Rehmannia Root Extract

Put 1kg of Rehmannia Root in 7.7L of water and heat it at 94℃ to make a 10-hour extract of Rehmannia Root. Sterilize in minutes

Example 4_ Preparation of Peony Extract

After putting 1kg of peony in 7.2L of water and heating it at 89℃ to make a peony extract extracted for 10 hours, the peony extract was filtered and concentrated under reduced pressure to make a 60 brix peony concentrate. Sterilize in minutes

Example 5_ Preparation of Astragalus Extract

Put 1kg of Astragalus in 7L of water and heat it at 90℃ to make an Astragalus extract extracted for 9 hours. After filtering the Astragalus extract, concentrate under reduced pressure to make a Astragalus concentrate of 60 brix. Sterilize.

Example 6_ preparation of licorice extract

Put 1kg of licorice in 7.2L of water and heat it at 89 ℃ to make a licorice extract extracted for 10 hours, filter the licorice extract and concentrate under reduced pressure to make a licorice concentrate of 60 brix. Sterilize in minutes

Example 7_Preparation of Herbal Medicine Extract

125 mg of Angelica gigas concentrate prepared in Example 1, 87.6 mg of Cnidium concentrate prepared in Example 2, 125 mg of Sujihwang concentrate prepared in Example 3, 125 mg peony concentrate prepared in Example 4, and prepared in Example 5 A crude drug concentrate was prepared by mixing 125 mg of astragalus concentrate and 40 mg of licorice concentrate prepared in Example 6.

Example 8_ First composition for preventing and improving anemia

The first composition for preventing and improving anemia of the present invention is prepared by mixing 627.6 mg of the crude drug extract prepared in Example 7, 3000 mg of nanonized collagen peptides having an average molecular weight of 350 Da and a size of 1 nm to 3 nm, and 15 mg of iron.

Example 9_Composition for preventing and improving second anemia

The second composition for preventing and improving anemia 2 of the present invention is prepared by further mixing 0.6 mg of folic acid, 5 mg of vitamin B2, 0.1 mg of vitamin B12, and 50 mg of vitamin C with the first composition for preventing and improving anemia in Example 8.

Comparative Example 1_ Composition for preventing and improving third anemia

The third composition for preventing and improving anemia is prepared by mixing 3000 mg of nanonized collagen peptide with an average molecular weight of 350 Da and a size of 1 nm to 3 nm and 15 mg of iron.

Experimental Example 1_ Measurement of hydroxyproline in blood

60 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A, B, and C, 20 each, and group A ingested 100 g of the composition for preventing and improving anemia of Example 8_1. , Group B ingested 5g of the composition for preventing and improving anemia of Example 9_2, and group C ingested 5g of the composition for preventing and improving anemia of Example 1_3 of Comparative Example 1_3. After 100 minutes, the average blood hydroxyproline of groups A, B, and C was measured.

Blood hydroxyproline (nmol/ml) Group A 32.566 Group B 32.6 Group C 16.06

Example 8_ the first composition for preventing and improving anemia and Example 9_ the second composition for preventing and improving anemia in body absorption rates are about twice as high as those of Comparative Example 1_ the third composition for preventing and improving anemia Confirmed.

Experimental Example 2_ Skin Moisture Measurement

60 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A, B, and C, 20 each, and group A received the composition of Example 8_1 for preventing and improving anemia at 5 g each day. 30 days of ingestion, Group B of Example 9_2 composition for preventing and improving anemia was ingested at 5g per day for 30 days, and Group C of Comparative Example 1_3 composition for preventing and improving anemia was consumed daily 5g each for 30 days. The increased moisturizing power through skin moisture measurement before intake and after intake for 30 days was confirmed as the average of %. Skin moisture was measured using a skin moisture meter (my-808s, Scala Co., Ltd. Made in Japan).

skin moisturizing effect Group A 24.3% Group B 24.9% Group C 10.3%

Example 8_first composition for preventing and improving anemia and Example 9_second composition for preventing and improving anemia had a skin moisturizing effect of about 14% higher than that of Comparative Example 1_third composition for preventing and improving anemia high was confirmed.

Experimental Example 3_ skin elasticity measurement

60 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A, B, and C, 20 each, and group A received the composition of Example 8_1 for preventing and improving anemia at 5 g each day. 30 days of ingestion, Group B of Example 9_2 composition for preventing and improving anemia was ingested at 5g per day for 30 days, and Group C of Comparative Example 1_3 composition for preventing and improving anemia was consumed daily 5g each for 30 days. Through skin elasticity measurement before intake and after intake for 30 days, the average increase in elasticity was confirmed. Skin elasticity was measured using a cutometer (SEM474, Courage+Khazaka electronic GmbH Germany).

skin elasticity effect Group A 33.2% Group B 34.2% Group C 23.2%

Example 8_first composition for preventing and improving anemia and Example 9_second composition for preventing and improving anemia had a skin elasticity effect of about 10% higher than that of Comparative Example 1_third composition for preventing and improving anemia high was confirmed.

Experimental Example 4_ Fatigue recovery degree

60 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A, B, and C, 20 each, and group A received the composition of Example 8_1 for preventing and improving anemia at 5 g each day. 30 days of ingestion, Group B of Example 9_2 composition for preventing and improving anemia was ingested at 5g per day for 30 days, and Group C of Comparative Example 1_3 composition for preventing and improving anemia was consumed daily 5g each for 30 days. Table 4 below is a table confirming fatigue recovery for each group.

very good getting better weak no change getting worse Group A 12 7 One 0 0 Group B 14 6 0 0 0 Group C 0 0 8 12 0

Example 8_Composition for preventing and improving anemia 1 and Example 9_Composition for preventing and improving anemia 2 Most of the A group and the B group ingested the fatigue recovery effect, but the 3rd anemia prevention and improvement effect was observed. In Group C, which consumed the composition for improvement, there was little or no effect of improving fatigue recovery.

Experimental Example 5_ degree of improvement in blood circulation

60 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A, B, and C, 20 each, and group A received the composition of Example 8_1 for preventing and improving anemia at 5 g each day. 30 days of ingestion, Group B of Example 9_2 composition for preventing and improving anemia was ingested at 5g per day for 30 days, and Group C of Comparative Example 1_3 composition for preventing and improving anemia was consumed daily 5g each for 30 days. The degree of blood circulation improvement was confirmed by examining numbness in the limbs and coldness in the limbs for each group.

very good getting better weak no change getting worse Group A 0 7 7 5 0 Group B 0 8 7 6 0 Group C 0 0 3 17 0

Example 8_ Composition for preventing and improving anemia 1 and Example 9_ Composition for preventing and improving anemia 2 In the A group and the B group ingesting the composition, most of the blood circulation improvement effect was shown in about 37% of the test subjects. , Comparative Example 1_In the C group that consumed the composition for preventing and improving third anemia, there was almost no effect of improving blood circulation.

Experimental Example 6_degree of skin tone improvement

60 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A, B, and C, 20 each, and group A received the composition of Example 8_1 for preventing and improving anemia at 5 g each day. 30 days of ingestion, Group B of Example 9_2 composition for preventing and improving anemia was ingested at 5g per day for 30 days, and Group C of Comparative Example 1_3 composition for preventing and improving anemia was consumed daily 5g each for 30 days. The effect of pibotone improvement was confirmed for each group.

very good getting better weak no change getting worse Group A 9 9 2 0 0 Group B 10 9 One 0 0 Group C 0 8 7 5 0

Example 8_Composition for preventing and improving anemia 1 and Example 9_Composition for preventing and improving anemia 2 Intaken group A and group B showed the effect of improving skin tone in most of the test subjects, but compared Example 1_In the C group that consumed the composition for preventing and improving the third anemia, only about 40% showed an effect of improving skin tone.

This seems to be due to collagen peptides improving skin moisturization and elasticity, and at the same time, iron and herbal extracts improve blood production and blood circulation, maintaining the oil-moisture balance of the skin and adding vitality to the skin.

Experimental Example 7_ degree of increase in serum iron concentration

60 women in their 40s with a body weight of 55 kg to 70 kg were randomly divided into groups A, B, and C, 20 each, and group A received the composition of Example 8_1 for preventing and improving anemia at 5 g each day. 30 days of ingestion, Group B of Example 9_2 composition for preventing and improving anemia was ingested at 5g per day for 30 days, and Group C of Comparative Example 1_3 composition for preventing and improving anemia was consumed daily 5g each for 30 days. The effect of increasing serum iron concentration was confirmed for each group.

before intake Day 15 day 30 Group A mean serum iron concentration 93.5 (μg/dL) 114.3 (μg/dL) 123.1 (μg/dL) Group B mean serum iron concentration 94.6 (μg/dL) 115.2 (μg/dL) 123.3 (μg/dL) Group C mean serum iron concentration 94.3 (μg/dL) 107.3 (μg/dL) 118.2 (μg/dL)

Before intake, on the 15th and 30th days, around 3:00 pm, the serum iron concentrations of Group A, Group B, and Group C were measured.

Example 8_first composition for preventing and improving anemia and Example 9_second composition for preventing and improving anemia were consumed in group A and group B, Comparative Example 1_third composition for preventing and improving anemia Compared to group C, the serum iron concentration was about 7 to 7.9 (μg/dL) higher on the 15th day, and about 4.9 to 5.1 (μg/dL) higher on the 30th day. I was able to confirm.

In the above, even though all the components constituting the embodiment of the present invention have been described as being combined or operated as one, the present invention is not necessarily limited to these embodiments. That is, within the scope of the object of the present invention, all of the components may be selectively combined with one or more to operate.

In addition, all terms including technical or scientific terms described above have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention belongs, unless otherwise defined. Commonly used terms, such as terms defined in a dictionary, should be interpreted as being consistent with the contextual meaning of the related art, and unless explicitly defined in the present invention, they are not interpreted in an ideal or excessively formal meaning.

In addition, the above description is merely an example of the technical idea of the present invention, and various modifications and variations can be made to those skilled in the art without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention, but to explain, and the scope of the technical idea of the present invention is not limited by these embodiments. The protection scope of the present invention should be construed according to the following claims, and all technical ideas within the equivalent range should be construed as being included in the scope of the present invention.

Claims (5)

597 to 657 parts by weight of crude drug extract, 2850 to 3150 parts by weight of collagen peptide, and 14 to 16 parts by weight of iron,
0.5 to 0.7 parts by weight of folic acid, 4.7 to 5.3 parts by weight of vitamin B2, 0.09 to 0.11 parts by weight of vitamin B12, and 47 to 53 parts by weight of vitamin C;
The herbal extract contains 119 to 131 parts by weight of angelica extract, 83 to 91 parts by weight of Cnidium extract, 119 to 131 parts by weight of Rehmannia Root extract, 119 to 131 parts by weight of Peony extract, 119 to 131 parts by weight of Astragalus extract, and A composition for preventing and improving anemia comprising 38 to 42 parts by weight of licorice extract.
The method of claim 1,
The collagen peptide has an average molecular weight of 200 Da to 500 Da and a size of 0.1 nm to 10 nm composition for preventing and improving anemia.
The method of claim 1,
the iron,
For preventing and improving anemia, characterized in that at least one selected from iron citrate, ferric ammonium citrate, iron gluconate, iron phosphate, iron lactate, ferrous fumarate, ferric pyrophosphate, sodium iron pyrophosphate, ferrous sulfate, ferric chloride and reduced iron composition.
The method of claim 1,
The iron is a composition for preventing and improving anemia, characterized in that heme iron (Heme Iron). delete