KR102463133B1 - Cosmetic Composition Containing High-Content of Urea - Google Patents

Abstract

The present invention relates to a cosmetic composition containing a high content of urea, and more specifically, to a composition according to the inclusion of urea by including triacetin, alpha-hydroxy acid and an alkali metal salt in a specific ratio along with a high content of urea. It relates to a cosmetic composition that exhibits an effect of improving skin condition while reducing skin irritation by reducing pH rise.

Description

Cosmetic Composition Containing High-Content of Urea

The present invention relates to a cosmetic composition containing a high content of urea, and more specifically, to a composition according to the inclusion of urea by including triacetin, alpha-hydroxy acid and an alkali metal salt in a specific ratio along with a high content of urea. It relates to a cosmetic composition that exhibits an effect of improving skin condition while reducing skin irritation by reducing pH rise.

The stratum corneum (horney layer) of the skin refers to the outermost layer of the skin composed of dead cells. Healthy skin undergoes a so-called turnover action in which the aged keratin is removed and a new cell layer is created every 28 days. Repeat. However, when the turnover function of the skin is slowed due to internal and external factors such as aging, stress, ultraviolet rays and pollution, unnecessary dead skin cells are not removed but accumulated, and the skin becomes rough and thick. lead to darkening results.

In particular, since the skin of the heel or elbow is frequently exposed to pressure or friction among body parts, it is easily deprived of moisture and becomes dry, and hyperkeratinization is more likely to occur than the skin in other parts of the body. Due to the proliferation and differentiation of abnormal keratinocytes in which hyperkeratinization occurs, the surface becomes rough and the skin loses its luster and appears dull and black.

Urea is safe for the skin and promotes skin penetration effect and water retention and water retention ability of the stratum corneum, normalization of increased cell renewal, antibacterial effect to suppress chronic eczema, penetration of other moisturizing ingredients applied to the skin It has been used in many functional cosmetic formulations as a substance that promotes In addition, as it is known that it is non-toxic to the human body as it is distributed in each organ and body fluid of the human body, it is attracting attention in the pharmaceutical world. However, when urea is included in formulated cosmetics in a particularly high content, hydrolysis occurs due to the reaction of water and urea, resulting in carbon dioxide and ammonia, causing the pH to rise over time and changing into an unstable formulation, and the cosmetic container is damaged. There was a problem with swelling.

Therefore, there is a need for a means capable of stabilizing the pH of the composition during the preparation of a cosmetic composition containing urea in a high content, which has excellent skin condition improvement effect.

Japanese Patent No. 3820805 (registered on June 30, 2006)

Accordingly, the present inventors tried to find a means to stably maintain the pH of the formulation while including a high content of urea, and triacetin (glyceryl triacetate), alpha-hydroxy acids (AHAs) and alkali metal salts When added in combination in a specific ratio, the pH of the formulation can be stabilized for a long period of time, and it was confirmed that there is an effect of improving the skin condition by acetic acid slowly released from triacetin, and completed the present invention. did it

Therefore, it is an object of the present invention to stabilize the pH of the composition while containing a high content of urea, reduce gas generation, and exhibit an excellent skin condition improvement effect, particularly skin moisturizing effect, skin irritation alleviation effect, and skin inflammation alleviation effect To provide a cosmetic composition that

In order to achieve the above object, the present invention provides a cosmetic composition comprising urea, triacetin, alpha-hydroxy acid and an alkali metal salt as active ingredients,

The composition provides a cosmetic composition, characterized in that it contains urea and triacetin in a weight ratio of 4.0 to 12.5: 0.3 to 4.5.

The present invention also provides a cosmetic composition for improving skin condition, preferably a cosmetic composition for improving skin moisturizing power, a cosmetic composition for alleviating skin irritation, or a cosmetic composition for alleviating skin inflammation, comprising the composition.

The present invention also provides a cosmetic composition for adjusting pH comprising the composition.

The present invention also provides a cosmetic composition for reducing gas generation comprising the composition.

The cosmetic composition comprising urea, triacetin, alpha-hydroxy acid and alkali metal salt in a specific ratio according to the present invention as an active ingredient inhibits the production of carbon dioxide and ammonia gas, and lowers the pH of the composition containing a high content of urea. It is stably maintained for a long time, and it can provide an excellent skin condition improvement effect by acetic acid generated by the decomposition of urea and triacetin, in particular, a skin moisturizing effect improvement effect, a skin irritation alleviation effect, and a skin inflammation alleviation effect.

1 shows a change in pH of the composition over time of the cosmetic composition having the composition of Example 1 according to the present invention.
Figure 2 shows the change in the amount of skin moisture over time after skin application of the cosmetic composition having the composition of Example 1 according to the present invention.
Figure 3 shows the change in the amount of gas generation of the composition over time of the cosmetic composition having the composition of Example 1 according to the present invention as the change in the weight of the tube containing the composition.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein is those well known and commonly used in the art.

Hereinafter, the present invention will be described in more detail.

As used herein, the term “about” used to express volume, time (period), concentration, content, area, temperature, etc. means that there is a tolerance of up to 10% in the corresponding numerical value or numerical range.

Throughout this specification, "%" used to indicate the concentration of a specific substance is (weight/weight) % for solid/solid, (weight/volume) % for solid/liquid, and Liquid/liquid is (volume/volume) %.

In one embodiment of the present invention, the pH change pattern over time of a composition comprising a high content of urea together with a mixture of triacetin, alpha-hydroxy acid, lactic acid, and alkali metal salt, sodium-lactate in a specific ratio investigated. As a result, as shown in FIG. 1 below, lactic acid and sodium-lactate were included in a composition containing about 9% by weight of urea in a combination ratio of 0.5:2.5 based on weight, and triacetin was included in an appropriate amount. In this case, the pH increase of the composition over time was low, and in particular, compared to the compositions of Comparative Examples 1 to 3, the composition of Example 1 in which the content of triacetin was increased, that is, the weight ratio of urea to triacetin was 9: The composition of 3 maintained the pH of the composition at a pH of 4.0 to 6.5 for 12 weeks, confirming that the pH change of the composition was the lowest (see Test Example 1).

In another embodiment of the present invention, the skin moisturizing effect of a composition comprising a high content of urea together with a mixture of triacetin, lactic acid and sodium-lactate in a specific ratio was evaluated. As a result, as shown in FIG. 2 below, a composition comprising about 9% by weight of urea including lactic acid and sodium-lactate in a combination ratio of 0.5:2.5 based on weight and triacetin in an appropriate amount was prepared. When applied to the skin of the subject, the amount of skin moisture loss (average skin moisture loss value of the subject group) was reduced, in particular, the composition of Example 1 in which the content of triacetin was increased compared to the compositions of Comparative Examples 1 to 3, That is, the composition in which the weight ratio of urea to triacetin is 9:3 maintains the skin moisture content at about 48% even when 8 hours have elapsed after skin application, confirming that the skin moisturizing improvement effect is high (see Test Example 2).

In another embodiment of the present invention, the efficacy of reducing gas production over time of a composition comprising a high content of urea in combination with a mixture of triacetin, lactic acid and sodium-lactate in a specific ratio was evaluated. As a result, as shown in Tables 2 and 3 below, lactic acid and sodium-lactate were included in a combination ratio of 0.5:2.5 based on weight, and about 9% by weight of urea including triacetin in an appropriate amount was included. The composition of Example 1 in which the amount of gas such as carbon dioxide and / or ammonia generated from the raw material of the composition is reduced, and in particular, the content of triacetin in the composition is increased compared to the compositions of Comparative Examples 1 to 3, that is, urea The composition having a weight ratio of to triacetin of 9:3 was confirmed to have a large effect of reducing gas production even when 12 weeks had elapsed (see Test Example 3).

Accordingly, in one aspect, the present invention provides a cosmetic composition comprising urea, triacetin, alpha-hydroxy acid and an alkali metal salt as active ingredients,

The composition relates to a cosmetic composition, characterized in that it contains urea and triacetin in a weight ratio of 4.0 to 12.5: 0.3 to 4.5.

Urea used in the present invention is a kind of Natural Moisturing Factor (NMF) present in the skin, and binds with moisture to inhibit the drying of moisture in the skin. Urea is non-toxic, non-allergenic, colorless and odorless. When urea is included in the cosmetic composition (cosmetic formulation), it is decomposed and changed to ammonia due to contact with moisture or temperature change over time.

In the present invention, the urea and triacetin are 4.0-12.5: 0.3-4.5, preferably 8.0-12.4: 0.6-4.2, more preferably 8.5-12.1: 1.0-4.1, most preferably 8.8-10.0: It may be characterized in that it is combined in a weight ratio of 2.0 to 4.0.

In the present invention, the urea is characterized in that it is included in a high content in the composition, and specifically, the content of urea is 4.0 based on the total weight of the composition, taking into account the limited amount of use based on the cosmetic safety rules. -12.5% by weight, preferably 8.0-12.4% by weight, more preferably 8.5-12.1% by weight, most preferably 8.8-10.0% by weight. If the content of urea is less than 4.0% by weight, the moisturizing effect of the skin, antibiotic effect against bacteria, fungi and viruses, and anti-inflammatory effect are insufficient, and if the content of urea exceeds 12.5% by weight, formulation stability and feeling of use may be reduced have.

The triacetin used in the present invention is known to play a role in stabilizing the pH of the cosmetic composition (cosmetic formulation) when urea is used in the formulation. It is also known that acetic acid is generated by the reaction of urea and triacetin. Acetic acid has excellent skin trouble effects, but when applied directly to the skin, it may irritate the skin due to its strong acidity. However, in the case of the reaction between urea and triacetin, acetic acid is gradually generated, so that the skin condition improvement effect can be obtained without irritating the skin. The increase in pH can be reduced by the production of the acidic substance, acetic acid.

The content of triacetin used in the present invention is 0.3 to 4.5% by weight, preferably 0.6 to 4.2% by weight, more Preferably it may be characterized in that it is included in an amount of 1.0 to 4.1 wt%, most preferably 2.0 to 4.0. If the content of triacetin is less than 0.3% by weight, the moisturizing effect of the skin, the antibiotic effect against bacteria, fungi and viruses, and the anti-inflammatory effect are insufficient, and if the content exceeds 4.5% by weight, the formulation stability and feeling of use may be reduced .

In the present invention, the alkali metal salt is added as an acidity regulator for neutralizing the low acidity (pH 2.0 to 3.0) of the alpha-hydroxy acid to a pH of 4.0 to 5.0. In one embodiment of the present invention, as a result of measuring the pH of lactic acid, which is an alpha-hydroxy acid, for each concentration, the pH changes within the range of 2.0 to 3.0, and sodium is an alkali metal salt in lactic acid having a pH of 2.0 to 3.0. When lactate is added in a specific ratio, especially when mixed so that the ratio of lactic acid/sodium-lactate, that is, lactic acid to sodium-lactate, is 0.01 to 1, preferably 0.2 to 0.3 by weight It was found that the pH was maintained at 4.0-5.0. Accordingly, in another embodiment of the present invention, a mixture of sodium-lactate and lactic acid is mixed with triacetin and high in sodium so that the mixing weight ratio of sodium-lactate to lactic acid is 2.0 to 3.0: 0.1 to 1.0, preferably 2.5: 0.5. Preparation of a cosmetic composition comprising urea, triacetin, lactic acid, and sodium-lactate, which has a lowered (reduced) effect of increasing the pH in the composition due to the high content of urea in the composition containing the urea content, as an active ingredient did.

In the present invention, the mixture of alpha-hydroxy acid and alkali metal salt included as an active ingredient in the composition maintains the pH of the composition at pH 4.0 to 6.5, preferably pH 4.0 to 5.0, and over time, urea is converted to ammonia. Even if the pH is increased by change, the pH of the composition does not deviate from the range of pH 4.0 to 8.0, preferably pH 4.0 to 7.0, so that the pH of the composition can be properly maintained (adjusted). Accordingly, the mixture of the alpha-hydroxy acid and the alkali metal salt may be included in an amount effective to maintain the pH of the composition at pH 4.0 to 8.0, preferably pH 4.0 to 7.0.

Specifically, the mixture of the alpha-hydroxy acid and the alkali metal salt is 0.1 to 1.9: 1.5 to 3.9, preferably 0.2 to 1.7: 1.7 to 3.7, more preferably 0.3 to 1.5: 1.9 of the alpha-hydroxy acid and the alkali metal salt. -3.5, most preferably 0.4-1.0: characterized in that it is combined in a weight ratio of 2.0-3.0.

The alpha-hydroxy acid used in the present invention is 0.1 to 1.9% by weight, preferably 0.2 to 1.7% by weight, more Preferably it is included in an amount of 0.3 to 1.5% by weight, most preferably 0.4 to 1.0% by weight. When the content of alpha-hydroxy acid is less than 0.1% by weight, the moisturizing effect of the skin, antibacterial effect against bacteria, fungi and viruses, and anti-inflammatory effect are insufficient, and when the content of alpha-hydroxy acid exceeds 1.9% by weight, Formulation stability and feeling of use may be reduced.

In addition, the alkali metal salt used in the present invention is 1.5 to 3.9% by weight, preferably 1.7 to 3.7% by weight, more Preferably it is included in an amount of 1.9 to 3.5% by weight, most preferably 2.0 to 3.0% by weight. When the content of alkali metal salt is less than 1.5% by weight, the moisturizing effect of the skin, antibacterial effect against bacteria, fungi and viruses, and anti-inflammatory effect are insufficient, and when the content of alkali metal salt exceeds 3.9% by weight, formulation stability and feeling of use are reduced. can do it

In the present invention, the alpha-hydroxy acid is preferably lactic acid, glycolic acid, or a mixture of lactic acid and glycolic acid, more preferably lactic acid, The present invention is not limited thereto.

In the present invention, the alkali metal salt is preferably sodium-lactate, sodium-glycolate, or a mixture of sodium-lactate and sodium-glycolate, more preferably It may be sodium-lactate, but the cation binding to lactate (lactic acid) or glycorate (glycolic acid) can be replaced with potassium, zinc, calcium, magnesium, zinc, copper, manganese, boron, or ammonium in addition to sodium. .

In the present invention, the composition may be characterized in that it reduces the increase in pH in the composition due to urea.

In the present invention, the composition may be characterized in that gas generation due to urea is reduced, and the gas may be carbon dioxide, ammonia, or a mixed gas of carbon dioxide and ammonia.

In the present invention, the composition may be characterized for improving skin condition.

In the present invention, the skin condition improvement may be characterized in that the skin moisturizing power improvement.

In the present invention, the improvement of the skin condition may be characterized in that the skin irritation relief, the skin irritation relief may be characterized by the acetic acid produced from the triacetin.

In the present invention, the improvement of the skin condition may be characterized by the relief of skin inflammation, and the relief of the skin inflammation may be characterized by the acetic acid produced from the triacetin.

In the present invention, the improvement of the skin condition may be characterized in that the antibiotic activity of the skin against bacteria, fungi or viruses is enhanced, and the antibiotic activity of the skin is improved by the antibacterial activity or antibacterial activity of acetic acid produced from triacetin. It may be characterized by viral activity.

In addition, the composition comprises a humectant (polyol, etc.), oil, wax, viscosity modifier, thickener, pH adjuster, fat, organic solvent, solubilizer, thickener, gelling agent, emollient, antioxidant, suspending agent, stabilizer, foaming agent ( foaming agent), fragrance, surfactant, water, ionic emulsifier, nonionic emulsifier, filler, sequestering agent, chelating agent, preservative, vitamin, wetting agent, dye, pigment, hydrophilic active agent, lipophilic active agent, lipid vesicle Or it may include adjuvants commonly used in the field of cosmetology or dermatology, such as any other ingredients commonly used in cosmetics. The adjuvant is introduced in an amount generally used in the field of cosmetology or dermatology. In addition, the composition of the present invention may include a skin absorption promoting material to increase the skin condition improvement effect.

In the present invention, the 'polyol' may refer to a polyhydric alcohol, that is, an aliphatic compound having two or more hydroxyl groups (-OH). One having two hydroxyl groups is called glycol or diol, one having three hydroxyl groups is called glycerol, and one having four hydroxyl groups is called pentaerythritol.

According to a preferred embodiment of the present invention, the polyol is sorbitol, polyethylene glycol, polypropylene glycol, dipropylene glycol, propylene glycol, 1,3- Butylene glycol (1,3-butylene glycol), glycerin (glycerin, glycerol), propanediol, ethyl hexanediol, 1,2-hexanediol (1,2-hexanediol), PEG / sebum/polybutylene glycol-8/5/3 glycerin (peg/ppg/polybutylene glycol-8/5/3 glycerin) and pentylene glycol (pentylene glycol), more preferably glycerin , propylene glycol, ethyl hexanediol, propanediol, 1,3-butylene glycol, sorbitol and polyethylene glycol, most preferably glycerin, propylene glycol, butylene glycol, dipropylene glycol and polyethylene glycol It may be selected from the group comprising

The polyol included in the cosmetic composition is included in an amount of 1 to 20% by weight, and when the content of the polyol component is less than 1% by weight, the emulsifying power and moisturizing power are deteriorated, and when the content of the polyol component exceeds 20% by weight, the feeling of use This can fall.

In the present invention, the oil may be one or more selected from the group consisting of hydrocarbon-based oil, higher fatty acid-based oil, ester-based oil, and glyceride-based oil, but is not limited thereto.

The oil is, for example, a hydrocarbon-based oil selected from squalane, polybutene, polyisobutene, polydecene, and hydrogenated polydecene; higher fatty acid-based oils selected from cetyl alcohol, stearyl alcohol, behenyl alcohol, 2-octyldodecanol and isocetyl alcohol; Isopropyl palmitate, 2-octyldodecyl myristate, isopropyl myristate, butyl octyl salicylate, cetyl octanoate, cetyl octyl hexanoate, cococaprylate/caprate, decyl cocoate, isoste ester oil selected from aryl isostearate, pentaerythrityl tetraethyl hexanoate, and dicaprylyl carbonate; and a glyceride-based oil selected from caprylic/capric triglyceride and the like; It may be one or more selected from the like.

The oil is included in 5 to 10% by weight based on the total weight of the cosmetic composition, and if the content is less than or exceeding the above range, the stability of the composition is lowered, making it difficult to manufacture various cosmetic products.

The wax is used in cosmetics such as ozokerite, beeswax, candelilla wax, ceresin, carnauba wax, paraffin wax, montan wax, Jeffen wax, rice wax, microcrystalline wax, synthetic wax, polyethylene wax, and various silicone waxes. Any suitable wax may be used. The wax is used in an amount of 1 to 20% by weight, preferably 5 to 15% by weight, based on the total weight of the cosmetic composition in consideration of the stability and feeling of use of the formulation.

In the present invention, the viscosity modifier acts to increase the viscosity of the cosmetic to facilitate application by further enhancing the effect of tension, adhesion, and taut feeling on the skin.

The viscosity modifier used in the present invention is, for example, polyvinyl alcohol, hydroxyethyl acrylate-sodium acryloyldimethyltaurate copolymer, carboxyvinyl polymer, pectin, sodium alginate, carboxymethyl cellulose, hydroxyethyl cellulose , polyacrylic acid, alkyl acrylic acid-acrylic acid copolymer, and at least one compound selected from the group consisting of xanthan gum, but is not limited thereto.

The thickener used in the present invention refers to a substance that increases viscosity, and among them, the oil thickener refers to a thickener whose main component is oil. The oil thickener includes sucrose esters, alkyl rosinates, dextrin esters, or polyglyceryl esters. More specifically, the oil thickener is dimer dilinoleyl hydrogenated rosinate, phytosteryl / isosteryl / cetyl / stearyl / benyl dimer dilinoleate (pytosteryl / isosteary / cetyl / stearyl) /behenyl dimer dilinoleate, polyglyceryl-10-dodecabehenate, sucrose oleate, sucrose tetrastearate triacetate, glyceryl/polyglyceryl -6-isostearate/behenate esters (glyceryl/polyglyceryl-6-isostearate/behenate esters), dextrin palmitate/ethylhexanoate, dextrin myristate, glyceryl behenate / Eicosadioate (glyceryl behenate/eicosadioate), and hydrogenated rosin (hydrogenated rosine) contains one or more selected from the group consisting of.

The composition may further include powder to improve the sticky feeling of the polyol and increase the stability of the formulation. The powder is silica, talc, mica, silicon powder, titanium oxide, titanium dioxide, zinc oxide, tin oxide, chromium oxide, kaolin, alumina, barium silicate, barium sulfate, magnesium carbonate, magnesium oxide, which are commonly used in cosmetic compositions, And it may be one or more selected from the group consisting of iron oxide and the like, but is not limited thereto. Preferably, when a mixture of HDI/Trimethylol hexyllactone crosspolymer and silica is used as the powder, the sticky feeling of the polyol is improved and the stability of the formulation is remarkably excellent. The mixture of the HDI/Trimethylol hexyllactone crosspolymer and silica has a weight ratio of 99:1 to 95:5, more preferably 99:1 to 97:3, most preferably 98:2. (HDI/trimethylol hexyllactone crosspolymer:silica) mixed powder can be used.

The powder may be included in an amount of 10 to 50% by weight, preferably 15 to 45% by weight, more preferably 20 to 40% by weight, and most preferably 25 to 35% by weight, based on the total weight of the cosmetic composition. . When the powder is less than 10% by weight, the effect of improving the feeling of use and stabilizing the formulation is weak. may occur.

In the present invention, the surfactant may be a PEG-based surfactant or an ionic surfactant.

In the present invention, among the chelating agents, Disodium EDTA binds to metal ions and serves to prevent them from catalyzing, and is highly likely to be incorporated in the manufacturing process with ingredients used in the manufacture of cosmetics. It blocks the activity of metal ions to prevent deterioration of cosmetic quality and rancidity. In addition, it acts as an accelerator to help effective skin absorption of active ingredients. The disodium EDIT is preferably included in the range of 0.01 to 0.5% by weight in the cosmetic composition.

In the present invention, in order to impart useful functionality to the skin, the composition contains a moisturizing component such as glycerin, an antioxidant/anti-aging component such as an antioxidant, a whitening component such as a tyrosinase inhibitor, a keratin regeneration accelerator, and a sunscreen. Functions such as moisturizing, anti-aging, whitening, protection, and wound healing can be imparted to the skin by including protective ingredients, wound healing ingredients such as hyaluronic acid, collagen and elastin, and salt-containing ingredients such as anti-inflammatory agents in an appropriate amount, The present invention is not limited thereto.

In the present invention, the composition is a flexible lotion, nourishing lotion, essence, spray type, mist, gel, sun cream, makeup base, foundation, BB cream, concealer, lipstick, lip gloss, lip liner, powder, two-way cake, primer, pact , powder, eye shadow, blush, eye liner, eye mascara, lotion, eye cream, nourishing cream, massage cream and cleansing cream may be formulated in any one selected from the group consisting of, but is not limited thereto.

On the other hand, the cosmetic composition of the present invention may be formulated in a cream formulation, but a surfactant is used for emulsification and stabilization of the cream formulation, and a thickener is also added to stabilize the cream formulation, and a thickener (polyethylene glycol (PEG) etc.) is weak to acid, and when included with the lactic acid and urea of the present invention, which exhibit a low pH, the activity of the thickener may decrease, resulting in instability of the formulation. Therefore, when the composition of the present invention is formulated in a cream formulation, it is preferable to maintain the thickening effect only with a surfactant and fatty alcohol without adding a thickener. Therefore, it is advantageous for the composition of the present invention to be formulated in a solubilizing formulation containing a small amount of surfactant and thickening agent rather than a cream formulation. In addition, it may be formulated as a liquid crystal formulation capable of stabilizing high hardness without including a thickener, but is not necessarily limited thereto.

In the present invention, the cosmetic composition may be prepared as an oil in water (O/W emulsion) or a water in oil (W/O emulsion), preferably by an oil-in-water emulsion method. do.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not to be construed as being limited by these examples.

[ production example One] high content urea containing cosmetics Preparation of the composition

The compositions of Example 1 and Comparative Examples 1 to 3 were prepared according to the composition of Table 1 below (unit: wt%).

composition comparative example One comparative example 2 comparative example 3 Example One urea 9 9 9 9 triacetin 0 One 2 3 lactic acid 0.5 0.5 0.5 0.5 Sodium-lactate 2.5 2.5 2.5 2.5 polyol 15 15 15 15 Surfactants and Waxes 8 8 8 8 Disodium EDIT 0.05 0.05 0.05 0.05 thickener One One One One oil 10 10 10 10 antiseptic 0.2 0.2 0.2 0.2 Spices 0.3 0.3 0.3 0.3 Purified water remaining amount remaining amount remaining amount remaining amount

A brief look at the manufacturing process of the oil in water (O/W) cosmetic composition according to the present invention is as follows. First, an aqueous phase containing a moisturizing agent (polyol, etc.), a thickener, purified water, and the like, and an oil phase containing an oil, etc. were dissolved by heating to 80°C, respectively. Then, the oil phase was added to the aqueous phase in a warm state, and emulsified while stirring at a speed of 3500 to 4500 rpm for 6 minutes, thereby preparing a stable cosmetic composition.

[ test example One] in a certain proportion triacetin , lactic acid and sodium- of lactate with the mixture high content urea Investigation of changes in pH over time of the composition comprising

Emulsification was performed with the compositions of Example 1 and Comparative Examples 1 to 3 prepared in Preparation Example 1, and each composition of Examples 1 and Comparative Examples 1 to 3 was left at room temperature for 1, 3, 6, 9 and 12 weeks. After (incubation), the pH of each composition was measured with a pH meter.

As a result, as shown in FIG. 1 below, lactic acid and sodium-lactate were included in a composition containing about 9% by weight of urea in a combination ratio of 0.5:2.5 based on weight, and triacetin was included in an appropriate amount. In this case, the pH increase of the composition over time was low, and in particular, compared to the compositions of Comparative Examples 1 to 3, the composition of Example 1 in which the content of triacetin was increased, that is, the weight ratio of urea to triacetin was 9: The composition of 3 maintained the pH of the composition at pH 4.0 to 6.5 for 12 weeks, confirming that the pH change of the composition was the lowest.

[ test example 2] in a certain proportion triacetin , lactic acid and sodium- of lactate Evaluation of skin moisturizing effect improvement effect of a composition containing a high content of urea together with a mixture

Emulsification was carried out with the compositions of Example 1 and Comparative Examples 1 to 3 prepared in Preparation Example 1, and the skin moisture content of the composition was evaluated using a TEWL (Transepidermal waterloss) measurement method for a group of 20 subjects. was confirmed by the loss of (Idson, J. Soc . Cosmet . Chem . , 29:573-580, 1978).

As a result, as shown in FIG. 2 below, a composition comprising about 9% by weight of urea including lactic acid and sodium-lactate in a combination ratio of 0.5:2.5 based on weight and triacetin in an appropriate amount was prepared. When applied to the skin of the subject, the amount of skin moisture loss (average skin moisture loss value of the subject group) was reduced, in particular, the composition of Example 1 in which the content of triacetin was increased compared to the compositions of Comparative Examples 1 to 3, That is, it was confirmed that the composition in which the weight ratio of urea to triacetin was 9:3 maintained the skin moisture content at about 48% even when 8 hours had elapsed after application to the skin, and thus had a high skin moisturizing improvement effect.

[ test example 3] in a certain proportion triacetin , lactic acid and sodium- of lactate with the mixture high content urea Gas generation over time of a composition comprising reduction Efficacy evaluation

In order to perform emulsification with the compositions of Examples 1 and Comparative Examples 1 to 3 prepared in Preparation Example 1, and to measure whether gas such as carbon dioxide and / or ammonia generated from the raw material of the composition is generated by a tube common system system , Example 1 and Comparative Examples 1 to 3 Each composition was filled in a tube container (weight: about 7.5 g) with a capacity of about 20 g, and then the weight of the tube container including each composition was measured (weight: about 7.5 g) 27.5 g). Then, the tube container containing the composition was left at room temperature for 12 weeks, and then weighed again.

When gas is generated from the composition included in the tube common container, the total weight of the tube common container including the composition increases, so that the amount of gas generated from the composition can be measured by the weight change. That is, it is possible to calculate the weight value changed due to gas generation by measuring the weight of the tube common container including the composition before and after leaving it alone.

As a result, as shown in Tables 2 and 3 below, lactic acid and sodium-lactate were included in a combination ratio of 0.5:2.5 based on weight, and about 9% by weight of urea including triacetin in an appropriate amount was included. The composition of Example 1 in which the amount of gas such as carbon dioxide and / or ammonia generated from the raw material of the composition is reduced, and in particular, the content of triacetin in the composition is increased compared to the compositions of Comparative Examples 1 to 3, that is, urea It was confirmed that the composition in which the weight ratio of triacetin to triacetin was 9:3 had little change in the weight of the tube containing the composition even after 12 weeks had elapsed, so that the effect of reducing the amount of gas production was large.

Example 1 or comparative example Tubes containing the composition of 1 to 3 zero Weight of container (unit: g) before neglect After 12 weeks left weight change comparative example One 27.49 27.88 0.39 comparative example 2 27.51 27.75 0.24 comparative example 3 27.48 27.61 0.13 Example One 27.50 27.53 0.03

In summary, the cosmetic composition according to the present invention reduces the increase in pH generated in a composition containing urea in a high content through a specific combination of triacetin, lactic acid and sodium-lactate, thereby maintaining the pH of the composition stably for a long time. , has an effect of improving skin moisturizing power, and provides an effect of increasing the feeling of use of cosmetics prepared with the composition by reducing the amount of carbon dioxide and ammonia gas produced by long-term storage of the composition.

As described above in detail a specific part of the content of the present invention, for those of ordinary skill in the art, it is clear that this specific description is only a preferred embodiment, and the scope of the present invention is not limited thereby. something to do. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (16)

As an oil-in-water cosmetic composition comprising urea, triacetin, alpha-hydroxy acid and an alkali metal salt as active ingredients,
The content of urea is 9 to 12.5% by weight based on the total weight of the composition,
The content of triacetin is 3 to 4.5% by weight based on the total weight of the composition,
The content of the alpha-hydroxy acid is 0.5 to 1.9% by weight based on the total weight of the composition,
The content of the alkali metal salt, based on the total weight of the composition, characterized in that 2.5 to 3.9% by weight, oil-in-water cosmetic composition. According to claim 1, wherein the content of the urea, based on the total weight of the composition, characterized in that 9% by weight, oil-in-water cosmetic composition. According to claim 1, wherein the content of triacetin is based on the total weight of the composition, characterized in that 3% by weight, oil-in-water cosmetic composition. According to claim 1, wherein the content of the alpha-hydroxy acid, based on the total weight of the composition, characterized in that 0.5% by weight, oil-in-water cosmetic composition. According to claim 1, wherein the content of the alkali metal salt, based on the total weight of the composition, characterized in that 2.5% by weight, oil-in-water cosmetic composition. The oil-in-water cosmetic composition according to claim 1, wherein the composition comprises urea, triacetin, alpha-hydroxy acid and an alkali metal salt in a weight ratio of 9-10: 3-4: 0.5: 2.5. The oil-in-water cosmetic composition according to claim 6, wherein the composition comprises urea, triacetin, alpha-hydroxy acid and an alkali metal salt in a weight ratio of 9:3:0.5:2.5. According to claim 1, wherein the pH of the composition is characterized in that pH 4.0 ~ 6.5, oil-in-water cosmetic composition. The oil-in-water cosmetic composition according to claim 1, wherein the alpha-hydroxy acid is lactic acid, glycolic acid, or a mixture of lactic acid and glycolic acid. The oil-in-water cosmetic composition according to claim 1, wherein the alkali metal salt is sodium-lactate, sodium-glycolate, or a mixture of sodium-lactate and sodium-glycolate. According to claim 1, wherein the composition is characterized in that to reduce the increase in pH in the composition due to urea, oil-in-water cosmetic composition. According to claim 1, wherein the composition is characterized in that to reduce the gas generation due to urea, oil-in-water cosmetic composition. According to claim 1, wherein the composition is characterized in that for improving skin condition, oil-in-water cosmetic composition. [Claim 14] The cosmetic composition according to claim 13, wherein the improvement of the skin condition is improved skin moisturizing power. The cosmetic composition according to claim 13, wherein the skin condition improvement is skin irritation relief. The cosmetic composition according to claim 13, wherein the skin condition improvement is skin inflammation relief.

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