KR102458196B1 - 항-axl 길항성 항체 - Google Patents
항-axl 길항성 항체 Download PDFInfo
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- KR102458196B1 KR102458196B1 KR1020187036968A KR20187036968A KR102458196B1 KR 102458196 B1 KR102458196 B1 KR 102458196B1 KR 1020187036968 A KR1020187036968 A KR 1020187036968A KR 20187036968 A KR20187036968 A KR 20187036968A KR 102458196 B1 KR102458196 B1 KR 102458196B1
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| GB1610902.7 | 2016-06-22 | ||
| GBGB1610902.7A GB201610902D0 (en) | 2016-06-22 | 2016-06-22 | Anti-Axl Antagonistic Antibodies |
| PCT/EP2017/065313 WO2017220695A1 (en) | 2016-06-22 | 2017-06-21 | Anti-axl antagonistic antibodies |
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| KR20190021244A KR20190021244A (ko) | 2019-03-05 |
| KR102458196B1 true KR102458196B1 (ko) | 2022-10-25 |
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| KR1020187036968A Active KR102458196B1 (ko) | 2016-06-22 | 2017-06-21 | 항-axl 길항성 항체 |
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Families Citing this family (14)
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| JP6931609B2 (ja) * | 2014-12-18 | 2021-09-08 | ベルゲン テクノロジオーヴァーフォリング エイエス | 抗Ａｘｌアンタゴニスト抗体 |
| GB201610902D0 (en) * | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
| CN110483639A (zh) | 2018-05-15 | 2019-11-22 | 复旦大学 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
| GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
| NL2024108B1 (en) * | 2019-10-26 | 2021-07-19 | Vitroscan B V | Methods and apparatus for measuring immune-cell mediated anti-tumoroid responses |
| CN115210263A (zh) * | 2020-02-28 | 2022-10-18 | 西福根有限公司 | 抗axl抗体和组合物 |
| GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
| JP2023521753A (ja) | 2020-04-08 | 2023-05-25 | ベルゲンビオ アーエスアー | 抗ウイルス療法 |
| GB202006072D0 (en) * | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
| EP4286406A4 (en) | 2021-01-29 | 2025-07-23 | Illimis Therapeutics Inc | FUSION MOLECULE WITH NON-INFLAMMATORY PHAGOCYTOSIS-INDUCING ACTIVITY |
| GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
| JP2024523436A (ja) * | 2021-06-16 | 2024-06-28 | 上海▲シン▼湾生物科技有限公司 | Ａｘｌタンパク質を標的とする抗体及びその抗原結合断片、その調製方法と使用 |
| WO2022269605A1 (en) * | 2021-06-24 | 2022-12-29 | Yeda Research And Development Co. Ltd. | Combination therapy for the treatment of cancer comprising an anti-egfr antibody and an axl-inhibitor |
| CN119968395A (zh) * | 2022-08-18 | 2025-05-09 | 百进生物科技公司 | 抗axl抗体、其抗原结合片段及其制备和使用方法 |
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| EP1382969A1 (en) | 2002-07-17 | 2004-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and prevention of cancer cell invasion |
| EP2220121B1 (en) | 2007-11-12 | 2015-08-19 | U3 Pharma GmbH | Axl antibodies |
| BRPI0820543A2 (pt) | 2007-11-15 | 2015-06-16 | Chugai Pharmaceutical Co Ltd | Anticorpo monoclonal capaz de ligar a anexelekto, e uso do mesmo |
| KR20120035145A (ko) | 2009-05-11 | 2012-04-13 | 우드라이 파마 게엠베하 | 인간화 ａｘｌ 항체 |
| MX2011012136A (es) * | 2009-05-15 | 2012-04-10 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-axl. |
| WO2011014457A1 (en) | 2009-07-27 | 2011-02-03 | Genentech, Inc. | Combination treatments |
| WO2011159980A1 (en) | 2010-06-18 | 2011-12-22 | Genentech, Inc. | Anti-axl antibodies and methods of use |
| AU2012273955A1 (en) | 2011-06-22 | 2014-01-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-Axl antibodies and uses thereof |
| WO2012175691A1 (en) | 2011-06-22 | 2012-12-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-axl antibodies and uses thereof |
| EP2589609A1 (en) | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
| CN104955842B (zh) * | 2012-11-05 | 2018-04-10 | 皮埃尔法布雷医药公司 | 抗原结合蛋白及其作为定位产品用于治疗癌症的用途 |
| US9850297B2 (en) * | 2013-03-15 | 2017-12-26 | Amgen Inc. | Secreted frizzle-related protein 5 (SFRP5) binding proteins |
| JP2016518382A (ja) | 2013-04-26 | 2016-06-23 | ピエール、ファーブル、メディカマン | Ａｘｌ抗体薬物複合体および癌の治療のためのその使用 |
| MX380864B (es) * | 2014-01-29 | 2025-03-12 | Dana Farber Cancer Inst Inc | Anticuerpos contra el dominio extracelular de muc1-c (muc1-c/ecd). |
| GB201410825D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
| GB201410826D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
| US9986723B2 (en) | 2014-10-22 | 2018-06-05 | The Board Of Regents Of The University Of Texas System | Screen and use of therapeutics for pancreatic ductal adenocarcinoma |
| ES2764299T3 (es) | 2014-12-09 | 2020-06-02 | Inst Nat Sante Rech Med | Anticuerpos monoclonales humanos contra AXL |
| JP6931609B2 (ja) | 2014-12-18 | 2021-09-08 | ベルゲン テクノロジオーヴァーフォリング エイエス | 抗Ａｘｌアンタゴニスト抗体 |
| GB201610902D0 (en) * | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
| US11159088B2 (en) * | 2019-06-19 | 2021-10-26 | Appulse Power Inc. | Dual path and mode start-up circuit |
| GB202004189D0 (en) * | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
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2016
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2017
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- 2017-06-21 EP EP17732875.4A patent/EP3475305A1/en not_active Withdrawn
- 2017-06-21 CN CN201780038590.9A patent/CN109311997B/zh not_active Expired - Fee Related
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| US20210171643A1 (en) | 2021-06-10 |
| CA3025729A1 (en) | 2017-12-28 |
| CN109311997A (zh) | 2019-02-05 |
| CN109311997B (zh) | 2023-07-18 |
| GB201610902D0 (en) | 2016-08-03 |
| MX2018016096A (es) | 2019-05-06 |
| US20220195054A1 (en) | 2022-06-23 |
| WO2017220695A1 (en) | 2017-12-28 |
| CN116903748A (zh) | 2023-10-20 |
| JP2019528677A (ja) | 2019-10-17 |
| KR20190021244A (ko) | 2019-03-05 |
| US11732048B2 (en) | 2023-08-22 |
| JP7071935B2 (ja) | 2022-05-19 |
| US20240190972A1 (en) | 2024-06-13 |
| EP3475305A1 (en) | 2019-05-01 |
| AU2017281326A1 (en) | 2018-11-15 |
| US11198734B2 (en) | 2021-12-14 |
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