KR102440737B1 - 이중특이적 항체에 대한 정제 플랫폼 - Google Patents
이중특이적 항체에 대한 정제 플랫폼 Download PDFInfo
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- KR102440737B1 KR102440737B1 KR1020177003803A KR20177003803A KR102440737B1 KR 102440737 B1 KR102440737 B1 KR 102440737B1 KR 1020177003803 A KR1020177003803 A KR 1020177003803A KR 20177003803 A KR20177003803 A KR 20177003803A KR 102440737 B1 KR102440737 B1 KR 102440737B1
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- C—CHEMISTRY; METALLURGY
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- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
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| MX2020003472A (es) | 2017-11-01 | 2020-08-03 | Chugai Pharmaceutical Co Ltd | Variante e isoforma de anticuerpos con actividad biologica reducida. |
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| CN112771379B (zh) * | 2018-08-17 | 2024-07-02 | 瑞泽恩制药公司 | 用于测定多聚体蛋白质的量和纯度的方法和色谱系统 |
| AU2019343053A1 (en) * | 2018-09-21 | 2021-04-15 | Teneobio, Inc. | Methods for purifying heterodimeric, multispecific antibodies |
| WO2020066270A1 (ja) * | 2018-09-28 | 2020-04-02 | 株式会社カネカ | κ鎖可変領域を含む抗体および／または抗体断片の製造方法 |
| AU2019369421A1 (en) | 2018-10-31 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Method and system of identifying and quantifying a protein |
| MA55134A (fr) | 2018-11-21 | 2021-09-29 | Regeneron Pharma | Anticorps anti-staphylococcus et leurs utilisations |
| CN112996801A (zh) * | 2018-11-26 | 2021-06-18 | 北卡罗来纳州大学 | 用于捕获宿主细胞蛋白的肽配体 |
| US11249089B2 (en) | 2018-12-12 | 2022-02-15 | Regeneron Pharmaceuticals, Inc. | System and method of analysis of a protein using liquid chromatography-mass spectrometry |
| SG11202106393SA (en) | 2018-12-24 | 2021-07-29 | Sanofi Sa | Pseudofab-based multispecific binding proteins |
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| AU2021268026A1 (en) | 2020-05-08 | 2023-01-19 | Regeneron Pharmaceuticals, Inc. | VEGF traps and mini-traps and methods for treating ocular disorders and cancer |
| WO2022158889A1 (en) * | 2021-01-25 | 2022-07-28 | Yuhan Corporation | Methods for purifying an anti-4-1bb/anti-her2 bispecific antibody |
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| MX2024004764A (es) * | 2021-10-19 | 2024-07-04 | Alteogen Inc | Procedimiento para purificar una proteína de fusión que tiene un dominio fc de igg. |
| KR20250028362A (ko) * | 2022-06-22 | 2025-02-28 | 씨티바 바이오프로세스 알＆디 에이비 | 카파 경쇄-결합 대류 매트릭스 |
| WO2024123698A1 (en) | 2022-12-08 | 2024-06-13 | Regeneron Pharmaceuticals, Inc. | Methods to characterizing a fragment crystallizable domain of a bispecific antibody |
| CN116769044A (zh) * | 2023-07-11 | 2023-09-19 | 康日百奥生物科技(苏州)有限公司 | 抗cd3和cd19双特异性抗体蛋白及其层析纯化方法 |
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| TW202540433A (zh) | 2023-11-21 | 2025-10-16 | 美商再生元醫藥公司 | 藉由活體外接合產生共價表面修飾之腺相關病毒及共價表面修飾的腺相關病毒之純化 |
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| EP0640094A1 (en) | 1992-04-24 | 1995-03-01 | The Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| US5945311A (en) | 1994-06-03 | 1999-08-31 | GSF--Forschungszentrumfur Umweltund Gesundheit | Method for producing heterologous bi-specific antibodies |
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| ES2169299T3 (es) | 1996-09-03 | 2002-07-01 | Gsf Forschungszentrum Umwelt | Procedimiento para la destruccion de celulas tumorales contaminantes en transplantes de celulas madre utilizando anticuerpos especificos. |
| EP0826696B1 (de) | 1996-09-03 | 2002-05-29 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Verwendung bi-und trispezifischer Antikörper zur Induktion einer Tumorimmunität |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| DE19725586C2 (de) | 1997-06-17 | 1999-06-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2012531439A (ja) | 2009-06-26 | 2012-12-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 天然の免疫グロブリン形式を有する容易に単離される二重特異性抗体 |
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