AR101262A1 - Plataforma de purificación para anticuerpos biespecíficos - Google Patents

Plataforma de purificación para anticuerpos biespecíficos

Info

Publication number
AR101262A1
AR101262A1 ARP150102301A ARP150102301A AR101262A1 AR 101262 A1 AR101262 A1 AR 101262A1 AR P150102301 A ARP150102301 A AR P150102301A AR P150102301 A ARP150102301 A AR P150102301A AR 101262 A1 AR101262 A1 AR 101262A1
Authority
AR
Argentina
Prior art keywords
protein
domain
binding
paired
ablation
Prior art date
Application number
ARP150102301A
Other languages
English (en)
Spanish (es)
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of AR101262A1 publication Critical patent/AR101262A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3819—Affinity chromatography of the nucleic acid-nucleic acid binding protein type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ARP150102301A 2014-07-26 2015-07-21 Plataforma de purificación para anticuerpos biespecíficos AR101262A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462029463P 2014-07-26 2014-07-26

Publications (1)

Publication Number Publication Date
AR101262A1 true AR101262A1 (es) 2016-12-07

Family

ID=53836215

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150102301A AR101262A1 (es) 2014-07-26 2015-07-21 Plataforma de purificación para anticuerpos biespecíficos

Country Status (19)

Country Link
US (1) US10626142B2 (enExample)
EP (2) EP3912987B9 (enExample)
JP (1) JP6702967B2 (enExample)
KR (1) KR102440737B1 (enExample)
CN (1) CN107074906B (enExample)
AR (1) AR101262A1 (enExample)
AU (1) AU2015298156B2 (enExample)
DK (2) DK3172221T3 (enExample)
EA (1) EA036154B1 (enExample)
ES (2) ES2942533T3 (enExample)
FI (1) FI3912987T3 (enExample)
IL (1) IL255198B (enExample)
MX (1) MX377558B (enExample)
MY (1) MY187051A (enExample)
PL (2) PL3172221T3 (enExample)
SG (2) SG11201700157VA (enExample)
TW (1) TWI704155B (enExample)
WO (1) WO2016018740A2 (enExample)
ZA (1) ZA201700622B (enExample)

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CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
TWI464262B (zh) 2007-09-26 2014-12-11 中外製藥股份有限公司 抗體固定區的變異
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AR101262A1 (es) 2014-07-26 2016-12-07 Regeneron Pharma Plataforma de purificación para anticuerpos biespecíficos
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JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
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HUE068564T2 (hu) * 2016-06-17 2025-01-28 Hoffmann La Roche Multispecifikus antitestek tisztítása
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WO2018038469A1 (ko) * 2016-08-20 2018-03-01 (주)아이벤트러스 목적하는 이중특이성 항체의 선택적 생산 확인 방법
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
CR20240273A (es) 2017-11-01 2024-08-27 Chugai Pharmaceutical Co Ltd Variantes e isoformas de anticuerpos con actividad biológica reducida (divisional 2020-229)
CN119881293A (zh) 2018-03-21 2025-04-25 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
GB201805142D0 (en) * 2018-03-29 2018-05-16 Ge Healthcare Bioprocess R&D Ab Separation method
SG11202101369XA (en) * 2018-08-17 2021-03-30 Regeneron Pharma Method and chromatography system for determining amount and purity of a multimeric protein
BR112021004680A2 (pt) * 2018-09-21 2021-08-31 Teneobio, Inc. Métodos para purificar anticorpos multiespecíficos heterodiméricos
JPWO2020066270A1 (ja) * 2018-09-28 2021-08-30 株式会社カネカ κ鎖可変領域を含む抗体および／または抗体断片の製造方法
SG11202103628PA (en) 2018-10-31 2021-05-28 Regeneron Pharma Method and system of identifying and quantifying a protein
KR20210093856A (ko) 2018-11-21 2021-07-28 리제너론 파마슈티칼스 인코포레이티드 항-스타필로코쿠스 항체 및 이의 사용
EP3887386A4 (en) * 2018-11-26 2022-11-30 North Carolina State University PEPTIDE LIGANDS FOR HOST CELL PROTEIN CAPTURE
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Also Published As

Publication number Publication date
PL3172221T3 (pl) 2021-12-27
US20160024147A1 (en) 2016-01-28
SG10201900661YA (en) 2019-02-27
MX2017001217A (es) 2017-05-03
JP2017524740A (ja) 2017-08-31
DK3912987T3 (da) 2023-05-01
NZ728700A (en) 2023-09-29
EA036154B1 (ru) 2020-10-06
ES2881026T3 (es) 2021-11-26
EA201790247A1 (ru) 2017-08-31
IL255198B (en) 2022-04-01
CN107074906B (zh) 2021-05-14
KR102440737B1 (ko) 2022-09-06
WO2016018740A3 (en) 2016-03-17
CN107074906A (zh) 2017-08-18
AU2015298156A1 (en) 2017-02-23
EP3912987B9 (en) 2023-05-31
MX377558B (es) 2025-03-10
EP3172221A2 (en) 2017-05-31
EP3912987B1 (en) 2023-03-22
WO2016018740A2 (en) 2016-02-04
TWI704155B (zh) 2020-09-11
ES2942533T3 (es) 2023-06-02
TW201617359A (zh) 2016-05-16
US10626142B2 (en) 2020-04-21
SG11201700157VA (en) 2017-02-27
BR112017001443A2 (pt) 2017-12-05
AU2015298156B2 (en) 2020-07-16
FI3912987T3 (fi) 2023-06-19
KR20170035941A (ko) 2017-03-31
ZA201700622B (en) 2020-05-27
CA2955618A1 (en) 2016-02-04
EP3172221B1 (en) 2021-07-07
WO2016018740A8 (en) 2021-06-10
DK3172221T3 (da) 2021-08-09
IL255198A0 (en) 2017-12-31
EP3912987A1 (en) 2021-11-24
MY187051A (en) 2021-08-27
PL3912987T3 (pl) 2023-07-24
JP6702967B2 (ja) 2020-06-03

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