KR102415259B1 - 조작된 고-친화도의 인간 t 세포 수용체 - Google Patents

조작된 고-친화도의 인간 t 세포 수용체 Download PDF

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KR102415259B1
KR102415259B1 KR1020167016131A KR20167016131A KR102415259B1 KR 102415259 B1 KR102415259 B1 KR 102415259B1 KR 1020167016131 A KR1020167016131 A KR 1020167016131A KR 20167016131 A KR20167016131 A KR 20167016131A KR 102415259 B1 KR102415259 B1 KR 102415259B1
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tcr
modified
cell receptor
antigen
amino acid
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KR20160087866A (ko
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시나 엔. 스미스
다니엘 티. 해리스
데이비드 엠. 크란츠
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더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020167016131A 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체 Active KR102415259B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361907887P 2013-11-22 2013-11-22
US61/907,887 2013-11-22
PCT/US2014/066892 WO2015077607A1 (en) 2013-11-22 2014-11-21 Engineered high-affinity human t cell receptors

Publications (2)

Publication Number Publication Date
KR20160087866A KR20160087866A (ko) 2016-07-22
KR102415259B1 true KR102415259B1 (ko) 2022-06-30

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KR1020167016131A Active KR102415259B1 (ko) 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체
KR1020167016132A Ceased KR20160085345A (ko) 2013-11-22 2014-11-21 조작된 고-친화도의 인간 t 세포 수용체

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US (4) US10023625B2 (OSRAM)
EP (2) EP3071593B1 (OSRAM)
JP (4) JP6476182B2 (OSRAM)
KR (2) KR102415259B1 (OSRAM)
CN (2) CN105873945B (OSRAM)
AU (4) AU2014352834B2 (OSRAM)
BR (1) BR112016011567A2 (OSRAM)
CA (2) CA2930847A1 (OSRAM)
DK (1) DK3071593T3 (OSRAM)
ES (1) ES2729406T3 (OSRAM)
IL (2) IL245468B (OSRAM)
MX (3) MX371202B (OSRAM)
PL (1) PL3071593T3 (OSRAM)
PT (1) PT3071593T (OSRAM)
RU (2) RU2729383C2 (OSRAM)
SA (1) SA516371174B1 (OSRAM)
SG (2) SG10201804330YA (OSRAM)
TR (1) TR201908404T4 (OSRAM)
WO (2) WO2015077615A1 (OSRAM)
ZA (2) ZA201603116B (OSRAM)

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DK3071593T3 (da) 2013-11-22 2019-06-11 The Board Of Trustees Of The Univ Of Illionis Modificerede humane t-celle-receptorer med høj affinitet
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AU2021202274A1 (en) 2021-05-06
KR20160087866A (ko) 2016-07-22
CA2930847A1 (en) 2015-05-28
AU2014352834A1 (en) 2016-05-26
ZA201603169B (en) 2020-05-27
BR112016011567A2 (pt) 2017-10-24
TR201908404T4 (tr) 2019-07-22
SG10201804335QA (en) 2018-06-28
IL245467A0 (en) 2016-06-30
IL245467B (en) 2020-04-30
EP3071594A1 (en) 2016-09-28
ZA201603116B (en) 2018-12-19
JP6970724B2 (ja) 2021-11-24
SA516371174B1 (ar) 2019-04-14
RU2016124163A (ru) 2017-12-27
IL245468A0 (en) 2016-06-30
EP3071593A1 (en) 2016-09-28
JP6697386B2 (ja) 2020-05-20
RU2016124179A (ru) 2017-12-27
MX383471B (es) 2025-03-14
JP2017501129A (ja) 2017-01-12
US10344075B2 (en) 2019-07-09
AU2014352834B2 (en) 2019-08-29
US20220396606A1 (en) 2022-12-15
CN105873945B (zh) 2020-07-17
US20190055298A1 (en) 2019-02-21
DK3071593T3 (da) 2019-06-11
PL3071593T3 (pl) 2019-11-29
EP3071593B1 (en) 2019-03-13
US20160280755A1 (en) 2016-09-29
RU2740648C2 (ru) 2021-01-19
JP6476182B2 (ja) 2019-02-27
WO2015077607A1 (en) 2015-05-28
MX2016006625A (es) 2016-12-02
US10023625B2 (en) 2018-07-17
US20160280756A1 (en) 2016-09-29
MX2021006932A (es) 2021-07-07
RU2729383C2 (ru) 2020-08-06
CA2930852C (en) 2024-01-23
KR20160085345A (ko) 2016-07-15
PT3071593T (pt) 2019-06-27
CN105899530B (zh) 2020-05-08
AU2019272003A1 (en) 2019-12-19
NZ719707A (en) 2020-09-25
JP2022023196A (ja) 2022-02-07
AU2019272003B2 (en) 2021-05-06
CN105899530A (zh) 2016-08-24
SG10201804330YA (en) 2018-07-30
IL245468B (en) 2020-10-29
AU2014352826B2 (en) 2019-08-01
JP2020007374A (ja) 2020-01-16
ES2729406T3 (es) 2019-11-04
WO2015077615A1 (en) 2015-05-28
JP2017501130A (ja) 2017-01-12
CN105873945A (zh) 2016-08-17
NZ719720A (en) 2020-09-25
MX2016006620A (es) 2017-05-11
CA2930852A1 (en) 2015-05-28
AU2014352826A1 (en) 2016-05-26
EP3071594A4 (en) 2017-05-03
MX371202B (es) 2020-01-22
EP3071593A4 (en) 2017-05-03
BR112016011583A2 (pt) 2017-09-26

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