KR102384668B1 - Apj 효능제로서의 6-히드록시-5-(페닐/헤테로아릴술포닐)피리미딘-4(1h)-온 - Google Patents

Apj 효능제로서의 6-히드록시-5-(페닐/헤테로아릴술포닐)피리미딘-4(1h)-온 Download PDF

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KR102384668B1
KR102384668B1 KR1020197000800A KR20197000800A KR102384668B1 KR 102384668 B1 KR102384668 B1 KR 102384668B1 KR 1020197000800 A KR1020197000800 A KR 1020197000800A KR 20197000800 A KR20197000800 A KR 20197000800A KR 102384668 B1 KR102384668 B1 KR 102384668B1
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hydroxy
dihydropyrimidin
butyl
benzenesulfonyl
methylpyridin
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KR20190018161A (ko
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조지 오. 토라
헤더 핀레이
웬 지앙
웨이 멩
샤오준 장
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브리스톨-마이어스 스큅 컴퍼니
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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KR1020197000800A 2016-06-14 2017-06-14 Apj 효능제로서의 6-히드록시-5-(페닐/헤테로아릴술포닐)피리미딘-4(1h)-온 Active KR102384668B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662349692P 2016-06-14 2016-06-14
US62/349,692 2016-06-14
PCT/US2017/037405 WO2017218633A1 (en) 2016-06-14 2017-06-14 6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1h)-one as apj agonists

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KR20190018161A KR20190018161A (ko) 2019-02-21
KR102384668B1 true KR102384668B1 (ko) 2022-04-07

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EP (1) EP3468956B1 (https=)
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KR (1) KR102384668B1 (https=)
CN (1) CN109311821B (https=)
ES (1) ES2863903T3 (https=)
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PL3303330T3 (pl) 2015-06-03 2019-10-31 Bristol Myers Squibb Co Agoniści 4 - hydroksy - 3 - ( heteroarylo ) pirydyno - 2 - onowi receptora apj do stosowania w leczeniu zaburzeń sercowo-naczyniowych
CA3001974A1 (en) 2015-10-14 2017-04-20 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides as apj agonists
EP3383860B1 (en) 2015-12-04 2021-01-20 Bristol-Myers Squibb Company Apelin receptor agonists and methods of use
TW201725203A (zh) 2015-12-16 2017-07-16 必治妥美雅史谷比公司 作為ａｐｊ受體促效劑之雜芳基羥基嘧啶酮
SG11201808163WA (en) 2016-03-24 2018-10-30 Bristol Myers Squibb Co 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists
US9988369B2 (en) 2016-05-03 2018-06-05 Amgen Inc. Heterocyclic triazole compounds as agonists of the APJ receptor
ES2844184T3 (es) 2016-06-14 2021-07-21 Bristol Myers Squibb Co 4-hidroxi-3-sulfonilpiridin-2(1H)-onas como agonistas del receptor de APJ
CN110072850B (zh) 2016-10-14 2023-07-21 百时美施贵宝公司 3-磺酰基-5-氨基吡啶-2,4-二醇apj激动剂
US11046680B1 (en) 2016-11-16 2021-06-29 Amgen Inc. Heteroaryl-substituted triazoles as APJ receptor agonists
WO2018093576A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Alkyl substituted triazole compounds as agonists of the apj receptor
WO2018093579A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Triazole phenyl compounds as agonists of the apj receptor
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
WO2018093577A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the apj receptor
EP3541803B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
MA50509A (fr) 2017-11-03 2021-06-02 Amgen Inc Agonistes de triazole fusionnés du récepteur apj
EP3765516A2 (en) * 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
US11807624B2 (en) 2018-05-01 2023-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the APJ receptor

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PL3303330T3 (pl) 2015-06-03 2019-10-31 Bristol Myers Squibb Co Agoniści 4 - hydroksy - 3 - ( heteroarylo ) pirydyno - 2 - onowi receptora apj do stosowania w leczeniu zaburzeń sercowo-naczyniowych
CA3001974A1 (en) 2015-10-14 2017-04-20 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides as apj agonists
EP3383860B1 (en) 2015-12-04 2021-01-20 Bristol-Myers Squibb Company Apelin receptor agonists and methods of use
TW201725203A (zh) 2015-12-16 2017-07-16 必治妥美雅史谷比公司 作為ａｐｊ受體促效劑之雜芳基羥基嘧啶酮
SG11201808163WA (en) 2016-03-24 2018-10-30 Bristol Myers Squibb Co 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists
ES2844184T3 (es) 2016-06-14 2021-07-21 Bristol Myers Squibb Co 4-hidroxi-3-sulfonilpiridin-2(1H)-onas como agonistas del receptor de APJ
CN110072850B (zh) 2016-10-14 2023-07-21 百时美施贵宝公司 3-磺酰基-5-氨基吡啶-2,4-二醇apj激动剂

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US10508104B2 (en) 2019-12-17
EP3468956B1 (en) 2021-03-03
WO2017218633A1 (en) 2017-12-21
KR20190018161A (ko) 2019-02-21
JP2019518036A (ja) 2019-06-27
EP3468956A1 (en) 2019-04-17
US20190194173A1 (en) 2019-06-27
CN109311821A (zh) 2019-02-05
ES2863903T3 (es) 2021-10-13
JP6993357B2 (ja) 2022-01-13
CN109311821B (zh) 2022-10-14

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