KR102376245B1 - Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna, 이와 관련된 제제 및 용도 - Google Patents
Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna, 이와 관련된 제제 및 용도 Download PDFInfo
- Publication number
- KR102376245B1 KR102376245B1 KR1020197000227A KR20197000227A KR102376245B1 KR 102376245 B1 KR102376245 B1 KR 102376245B1 KR 1020197000227 A KR1020197000227 A KR 1020197000227A KR 20197000227 A KR20197000227 A KR 20197000227A KR 102376245 B1 KR102376245 B1 KR 102376245B1
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- South Korea
- Prior art keywords
- delete delete
- vegf
- modified rna
- composition
- saline buffer
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- Expired - Fee Related
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/515—Angiogenesic factors; Angiogenin
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- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Biophysics (AREA)
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- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020227008509A KR102494499B1 (ko) | 2016-06-07 | 2017-06-06 | Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna, 이와 관련된 제제 및 용도 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662346979P | 2016-06-07 | 2016-06-07 | |
| US62/346,979 | 2016-06-07 | ||
| US201662411091P | 2016-10-21 | 2016-10-21 | |
| US62/411,091 | 2016-10-21 | ||
| US201662432005P | 2016-12-09 | 2016-12-09 | |
| US62/432,005 | 2016-12-09 | ||
| PCT/US2017/036188 WO2017214175A1 (en) | 2016-06-07 | 2017-06-06 | Modified rna encoding vegf-a polypeptides, formulations, and uses relating thereto |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227008509A Division KR102494499B1 (ko) | 2016-06-07 | 2017-06-06 | Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna, 이와 관련된 제제 및 용도 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190039066A KR20190039066A (ko) | 2019-04-10 |
| KR102376245B1 true KR102376245B1 (ko) | 2022-03-21 |
Family
ID=59270113
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237022229A Ceased KR20230107891A (ko) | 2016-06-07 | 2017-06-06 | Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna,이와 관련된 제제 및 용도 |
| KR1020237003204A Active KR102552543B1 (ko) | 2016-06-07 | 2017-06-06 | Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna, 이와 관련된 제제 및 용도 |
| KR1020227008509A Active KR102494499B1 (ko) | 2016-06-07 | 2017-06-06 | Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna, 이와 관련된 제제 및 용도 |
| KR1020197000227A Expired - Fee Related KR102376245B1 (ko) | 2016-06-07 | 2017-06-06 | Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna, 이와 관련된 제제 및 용도 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237022229A Ceased KR20230107891A (ko) | 2016-06-07 | 2017-06-06 | Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna,이와 관련된 제제 및 용도 |
| KR1020237003204A Active KR102552543B1 (ko) | 2016-06-07 | 2017-06-06 | Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna, 이와 관련된 제제 및 용도 |
| KR1020227008509A Active KR102494499B1 (ko) | 2016-06-07 | 2017-06-06 | Vegf-a 폴리펩타이드를 인코딩하는 변형된 rna, 이와 관련된 제제 및 용도 |
Country Status (25)
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|---|---|
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| EP (2) | EP3464338B1 (enExample) |
| JP (3) | JP6859369B2 (enExample) |
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| PT (1) | PT3464338T (enExample) |
| RS (1) | RS62556B1 (enExample) |
| RU (1) | RU2756313C2 (enExample) |
| SG (2) | SG11201810816QA (enExample) |
| SI (1) | SI3464338T1 (enExample) |
| SM (1) | SMT202100586T1 (enExample) |
| TW (2) | TWI752036B (enExample) |
| WO (1) | WO2017214175A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62556B1 (sr) | 2016-06-07 | 2021-12-31 | Modernatx Inc | Modifikovana rnk koja kodira polipeptide vegf-a, njihove formulacije i upotreba |
| WO2019010304A1 (en) * | 2017-07-05 | 2019-01-10 | Wisconsin Alumni Research Foundation | MICROPARTICLES COATED WITH MINERALS FOR GENES ADMINISTRATION IN CHRONIC WOUND THERAPY |
| LT3703658T (lt) * | 2017-10-31 | 2022-07-25 | Astrazeneca Ab | Lipidų nanodalelės, skirtos modifikuotos rnr, koduojančios vegf-a polipeptidą, pristatymui |
| US20220226243A1 (en) * | 2019-05-08 | 2022-07-21 | Astrazeneca Ab | Methods of using lipid nanoparticles for delivering modified rna encoding a vegf-a polypeptide and pharmaceutical compositions comprising the same |
| JP7345888B2 (ja) * | 2021-06-17 | 2023-09-19 | 株式会社ニューギン | 遊技機 |
| WO2023061985A2 (en) * | 2021-10-12 | 2023-04-20 | Modernatx, Inc. | Compositions comprising modified rna encoding vegf-a and methods of use |
| WO2023084013A1 (en) * | 2021-11-12 | 2023-05-19 | Modernatx, Inc. | Compositions comprising modified rna encoding vegf-a and methods of use |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014511694A (ja) * | 2011-04-03 | 2014-05-19 | ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル | 修飾型rna(mod−rna)を使用する効率的なインビボタンパク質発現 |
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| DE102004035227A1 (de) * | 2004-07-21 | 2006-02-16 | Curevac Gmbh | mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen |
| AU2006211960A1 (en) | 2005-02-08 | 2006-08-17 | Board Of Regents, The University Of Texas System | Compositions and methods involving MDA-7 for the treatment of cancer |
| JP5705127B2 (ja) | 2008-12-03 | 2015-04-22 | アモーサイト インコーポレイテッド | 梗塞領域灌流改善組成物および血管損傷修復の方法 |
| CN102341498B (zh) | 2008-12-04 | 2017-12-19 | 库尔纳公司 | 通过抑制血管内皮生长因子(vegf)的天然反义转录子治疗vegf相关的疾病 |
| WO2011069529A1 (en) * | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
| AU2011358150B2 (en) | 2010-12-16 | 2016-11-03 | Sprna Gmbh | Pharmaceutical composition consisting of RNA having alkali metal as counter ion and formulated with dications |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| EP4144378A1 (en) | 2011-12-16 | 2023-03-08 | ModernaTX, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| CA2859691A1 (en) | 2011-12-21 | 2013-06-27 | Moderna Therapeutics, Inc. | Methods of increasing the viability or longevity of an organ or organ explant |
| US20140275229A1 (en) * | 2012-04-02 | 2014-09-18 | Moderna Therapeutics, Inc. | Modified polynucleotides encoding udp glucuronosyltransferase 1 family, polypeptide a1 |
| AU2013243954A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US10501513B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| US9663564B2 (en) | 2013-03-15 | 2017-05-30 | The Regents Of The University Of California | Vectors and methods to treat ischemia |
| EP2971010B1 (en) * | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| SG10201801428RA (en) | 2013-08-21 | 2018-03-28 | Curevac Ag | Method for increasing expression of rna-encoded proteins |
| CN105899534B (zh) * | 2014-01-15 | 2020-01-07 | 豪夫迈·罗氏有限公司 | 具有修饰的FCRN和保持的蛋白A结合性质的Fc区变体 |
| WO2016118725A1 (en) | 2015-01-23 | 2016-07-28 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| SMT202200178T1 (it) | 2015-09-17 | 2022-05-12 | Modernatx Inc | Composti e composizioni per il rilascio intracellulare di agenti terapeutici |
| RS62556B1 (sr) | 2016-06-07 | 2021-12-31 | Modernatx Inc | Modifikovana rnk koja kodira polipeptide vegf-a, njihove formulacije i upotreba |
| US11542490B2 (en) | 2016-12-08 | 2023-01-03 | CureVac SE | RNAs for wound healing |
| MX389934B (es) | 2016-12-09 | 2025-03-20 | Desarrolladora Y Com De Tecnologias Biomedicas Decotecbio S A De C V | Composición coadyuvante de un factor de crecimiento y un neuropéptido para acelerar la cicatrización de heridas y la repitelización de órganos. |
| LT3703658T (lt) | 2017-10-31 | 2022-07-25 | Astrazeneca Ab | Lipidų nanodalelės, skirtos modifikuotos rnr, koduojančios vegf-a polipeptidą, pristatymui |
| EP3965797A1 (en) | 2019-05-08 | 2022-03-16 | AstraZeneca AB | Compositions for skin and wounds and methods of use thereof |
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2017
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