KR102316435B1 - Injection apparatus using meedle array for liquid injection - Google Patents

Abstract

Disclosed is a liquid flow injection device using a needle array.
The liquid flow injection device may include a biopsy channel and a needle array provided in the biopsy channel for injecting a liquid flow into the target when the target of the living body is pushed.

Description

Liquid injection device using a needle array {INJECTION APPARATUS USING MEEDLE ARRAY FOR LIQUID INJECTION}

The present invention relates to a liquid injection device using a needle array.

In general, to inject liquids (drugs, various reagents for procedure or diagnosis, cell therapy agents, stem cells, etc.) into the tissue layer of a living body, insert the needle of the syringe into the tissue layer of the living body, and then apply force to the syringe. The liquid contained in the percussion syringe is injected into the tissue layer.

However, since the depth of the needle inserted into the tissue layer is controlled by the power of a person's hand operating the syringe, it may be difficult to precisely control the depth of the needle for the tissue layer.

In addition, if the injection amount of the liquid per unit time is insufficient, the injection amount of cells may be increased by increasing the diameter of the needle. However, if the diameter of the needle increases, the adjustable depth of the needle inserted into the tissue layer may be reduced.

In addition, when injecting a liquid into the tissue layer of a living body through a syringe, a needle hole by the syringe is generated in the living body, or because the length of the needle is long, it is not easy to move along the curved part of the living body, and the needle may be bent. .

In particular, various layers such as the epidermis, connective layer, muscle layer, mesothelial layer, and secretory layer (Urothelium, Lamina propria, Muscular layer, and Serosa) are distributed in the biological tissue layer within a thickness of several hundred micrometers. It is not easy to inject accurately.

Publication No. 10-2008-0009911 (published on January 30, 2008)

Embodiments of the present invention are intended to provide a liquid injection device using a needle array that can safely and accurately inject the liquid into the tissue layer.

A liquid injection device using a needle array according to an aspect of the present invention comprises: a biopsy channel; and a catheter unit provided at an end of the biopsy channel to be able to enter and exit the biopsy channel to push the target of the living body, wherein the catheter unit includes: a catheter providing a movement path of a liquid; and a needle array including a plurality of needles spaced apart on the end of the catheter and injecting the liquid into the target when the target is pushed.

At this time, the catheter may include a catheter channel unit that can enter and exit the end of the biopsy channel; And it may include a catheter extension extending from the end of the catheter channel to have a larger diameter than the catheter channel.

In addition, the catheter extension part may be eccentrically connected from one side of the catheter channel part.

In addition, the catheter unit may further include a cover agent that is applied to the end of the needle array, and melts in the living body over time when the needle array pushes the target.

In addition, the needle array may include a plurality of needles having at least one stepped portion formed in the longitudinal direction.

In addition, the present invention is a biopsy lamp provided at the end of the biopsy channel to irradiate light toward the target; and a biopsy camera configured to photograph the target at an end of the biopsy channel.

In addition, the catheter unit may be spun at the end of the biopsy channel to prevent imaging interference of the biopsy camera with the target.

In addition, the needle array may be detachable from the end of the catheter to be replaceable with a plurality of needles having different lengths.

A liquid injection device using a needle array according to an aspect of the present invention comprises: a biopsy channel; and a needle array including a plurality of needles spaced apart from each other on the end of the biopsy channel, and injecting a liquid into the target when the end of the biopsy channel is pushed to the target of the living body.

In addition, the present invention is a biopsy lamp provided at the end of the biopsy channel to irradiate light toward the target; and a biopsy camera configured to photograph the target at an end of the biopsy channel.

In addition, the present invention may further include a cover agent that is applied to the end of the needle array, and melts in the living body over time when the needle array pushes the target.

In addition, the needle array may include a plurality of needles having at least one stepped portion formed in the longitudinal direction.

In addition, the needle array is detachable from the end of the biopsy channel to be replaceable with a plurality of needles having different lengths.

Embodiments of the present invention have the advantage that the liquid can be accurately injected at the depth and position of a desired target (tissue layer) of the living body.

In addition, the embodiments of the present invention have the advantage that by increasing the area of the array needle on which the needle is disposed, the injection amount of cells or drugs injected into the target of the living body can be increased and injected into a wide target area.

In addition, in the embodiments of the present invention, by using a biopsy channel (endoscopic channel), free movement and insertion of the catheter unit is possible even for a curved portion of the living body, and the injection of liquids to the target of the living body can be rapidly progressed. There is an advantage.

1 is a block diagram illustrating a state in which a liquid injection device using a needle array according to a first embodiment of the present invention is inserted into a bystander.
FIG. 2 is an enlarged view illustrating an enlarged portion "A" of FIG. 1 .
FIG. 3 is an enlarged view illustrating an enlarged portion "B" of FIG. 2 .
4 is a state diagram showing a state in which the needle is shallowly inserted into the tissue layer of the liquid injection device using the needle array according to the first embodiment of the present invention.
5 is a state diagram showing a state in which the needle of the liquid injection device using the needle array according to the first embodiment of the present invention is deeply inserted into the tissue layer.
6 is a block diagram illustrating a liquid injection device using a needle array according to a second embodiment of the present invention.
7 is a cross-sectional view illustrating a catheter unit of a liquid injection device using a needle array according to a second embodiment of the present invention.
8 is a block diagram illustrating a liquid injection device using a needle array according to a third embodiment of the present invention.
9 is a cross-sectional view illustrating a catheter unit of a liquid injection device using a needle array according to a third embodiment of the present invention.
10 is a block diagram illustrating a liquid injection device using a needle array according to a fourth embodiment of the present invention.
11 is a block diagram illustrating a liquid injection device using a needle array according to a fifth embodiment of the present invention.
12 is a cross-sectional view illustrating a catheter unit of a liquid injection device using a needle array according to a fifth embodiment of the present invention.
13 is a perspective view illustrating a liquid injection device using a needle array according to a sixth embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings, the configuration and operation according to the embodiment of the present invention will be described in detail. The following description is one of several aspects of the present invention that is claimable, and the following description may form a part of the detailed description of the present invention. However, in describing the present invention, detailed descriptions of known configurations or functions may be omitted for clarity of the present invention.

The present invention is capable of making various changes and may include various embodiments, and specific embodiments are illustrated in the drawings and described in the detailed description. However, this is not intended to limit the present invention to a specific embodiment, it should be understood to include all modifications, equivalents and substitutes included in the spirit and scope of the present invention.

In addition, terms including an ordinal number such as 1st, 2nd, etc. may be used to describe various components, but the components are not limited by these terms. These terms are used only for the purpose of distinguishing one component from another. When it is said that a component is 'connected' or 'connected' to another component, it may be directly connected or connected to the other component, but it is understood that other components may exist in between. it should be The terms used in the present application are only used to describe specific embodiments, and are not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly dictates otherwise.

1 is a block diagram illustrating a state in which a liquid injection device using a needle array according to a first embodiment of the present invention is inserted into a bladder, and FIG. 2 is an enlarged view showing an enlarged portion "A" of FIG. , FIG. 3 is an enlarged view showing an enlarged part "B" of FIG. 2, and FIG. 4 is a state in which the needle of the liquid injection device using the needle array according to the first embodiment of the present invention is shallowly inserted into the tissue layer. It is a state diagram, and FIG. 5 is a state diagram showing a state in which the needle of the liquid injection device using the needle array according to the first embodiment of the present invention is deeply inserted into the tissue layer.

1 to 5, the liquid injection device 10 according to the first embodiment of the present invention includes a biopsy channel 100, a catheter unit 200, a biopsy lamp 300, and a biopsy camera ( 400) may be included.

Specifically, the biopsy channel 100 may be moved to a target of a living body (C: for example, bladder wall tissue). The biopsy channel 100 may include an endoscope channel used for endoscopy/procedure. Since the biopsy channel 100 corresponds to a configuration applied to a conventional endoscopic channel, a detailed description thereof will be omitted.

In the present embodiment, the biopsy channel 100 may be an endoscopic channel used for endoscopy/procedure, but is not limited thereto, and the biopsy channel 100 is for injecting a liquid into the target of the living body C. Of course, a separate channel may be used. Meanwhile, the term 'liquid' used in the present specification and claims includes drugs, various reagents for procedures or diagnosis, cell therapy agents, stem cells, etc., and includes 'liquids' as well as therapeutic agents/cells. It is defined as a comprehensive concept that includes even semi-liquids (semi-solids such as hydrogels) that enclose it.

A biopsy lamp 300 and a biopsy camera 400 may be mounted at the end of the biopsy channel 100 . In particular, the catheter unit 200 may be provided at the end of the biopsy channel 100 so as to be able to enter and exit.

The biopsy channel 100 may be provided in the form of a curved channel in which an end is curved in a “L” shape. In this embodiment, the end of the biopsy channel 100 is formed to be curved in a "L" shape, but is not limited thereto, and the end of the biopsy channel 100 may include a straight or other curved shape. Of course. Accordingly, after the catheter unit 200 is withdrawn from the end of the biopsy channel 100 , it may be pushed in a vertical direction (opposite direction) with respect to the target of the living body (C).

The catheter unit 200 may include a catheter 210 that provides a movement path of the liquid, and a needle array 220 that injects the liquid into the target when the target is pushed. The catheter 210 may be provided in the form of a pipe that can be entered and exited from the end of the biopsy channel 100 . The catheter 210 can consistently adjust the depth of insertion into the target (tissue layer) of the living body C by adjusting the length of the catheter 210 entering and leaving the end of the biopsy channel 100 .

The needle array 220 may include a plurality of needles 221 spaced apart from each other on the end of the catheter 210 . The plurality of needles 221 may be spaced apart from each other in a matrix form on the end of the catheter 210 . Since the plurality of needles 221 are spaced apart on a wide end area of the catheter 210, it is possible to increase the area of the injection path of the liquid flow to the target of the living body (C), and consequently, the injection amount of the liquid flow to the target can increase

The needle array 220 may be integrally connected to the end of the catheter 210 . Alternatively, the needle array 220 may be provided in a structure detachable from the end of the catheter (210). If the needle array 220 is detachable from the end of the catheter 210, it can be replaced with a needle array 220 having a needle 221 of a length suitable for the depth, depending on the depth of the target to be injected with the liquid flow. .

For example, as shown in FIG. 4 , when the depth of the target is a shallow position of the tissue layer, a needle array 220 having a short length of needle 221 corresponding to the depth may be used. And, as shown in FIG. 5 , when the depth of the target is a deep position of the tissue layer, a needle array 220 having a long needle 221 corresponding to the depth may be used.

Each needle 221 may be provided in the form of a pointed cone as a whole. An injection hole for injecting a liquid into the target of the living body C may be formed in the center of the needle 221 . The injection hole may be determined in consideration of the size/capacity of the liquid flow. For example, the diameter of the injection hole may be 100 μm to 150 μm.

A plurality of biopsy lamps 300 may be provided to be spaced apart from the ends of the biopsy channel 100 . Biopsy lamp 300 may provide the ability to provide photodynamic therapy using specific wavelengths. To this end, the biopsy lamp 300 may be provided with a composite device (not shown) for the purpose of phototherapy treatment. The biopsy lamp 300 irradiates light toward the target of the living body C, thereby providing illumination necessary for photographing the biopsy camera 400 .

The biopsy camera 400 may take a video image of the target of the living body C at the end of the biopsy channel 100 . The video image captured by the biopsy camera 400 may be provided to the user through a separate display (not shown). The user may accurately inject the liquid into the target of the living body C while checking the video image transmitted through the biopsy camera 400 . In addition, the user may monitor bleeding or leakage occurring in the target portion of the living body C in real time through the video image of the biopsy camera 400 .

The biopsy camera 400 may be an endoscope camera used for endoscopy/procedure. Since the biopsy channel 100 corresponds to a configuration applied to a conventional endoscopic camera, a detailed description thereof will be omitted.

6 is a block diagram illustrating a liquid flow injection device using a needle array according to a second embodiment of the present invention, and FIG. 7 is a catheter unit of the liquid flow injection device using a needle array according to the second embodiment of the present invention. is a cross-sectional view showing

6 to 7 , in the liquid flow injection device 10 according to the second embodiment, the catheter 210 may include a catheter channel part 211 and a catheter expansion part 212 .

The catheter channel unit 211 may be provided in the form of a pipe that can be entered and exited from the end of the biopsy channel 100 . The catheter extension portion 212 may extend from the end of the catheter channel portion 211 to have a larger diameter than that of the catheter channel portion 211 . Through this, the catheter extension 212 can secure a large area in which more needles 221 can be disposed.

8 is a block diagram illustrating a liquid flow injection device using a needle array according to a third embodiment of the present invention, and FIG. 9 is a catheter unit of a liquid flow injection device using a needle array according to a third embodiment of the present invention. is a cross-sectional view showing

8 to 9 , in the liquid flow injection device 10 according to the third embodiment, the catheter extension part 212 of the catheter 210 is eccentric to one side of the catheter channel part 211 . can be connected

At this time, due to the catheter extension 212 of the catheter unit 200, the view of the biopsy camera 400 is obscured, it may be difficult to photograph the target of the living body (C). To solve this problem, the catheter unit 200 may be configured to be able to spin (rotate) at the end of the biopsy channel 100 .

For example, when the photographing interference of the biopsy camera 400 is generated by the catheter expansion unit 212, the catheter is expanded by spinning (rotating) the catheter unit 200 in a direction in which the photographing interference of the biopsy camera 400 does not occur. Interference with the imaging of the biopsy camera 400 due to the unit 212 may be prevented.

10 is a block diagram illustrating a liquid injection device using a needle array according to a fourth embodiment of the present invention.

As shown in FIG. 10 , in the liquid flow injection device 10 according to the fourth embodiment, the catheter 210 may include a catheter channel part 211 , a catheter extension part 212 , and a cover agent 230 . can Hereinafter, in describing the fourth embodiment of the present invention, the differences compared with the above-described embodiments will be mainly described, and the same description and reference numerals refer to the above-described embodiments.

The cover agent 230 may be applied to the end of the needle array 220 to prevent clogging, contamination or damage of the needle 221 . The cover agent 230 may include a component that melts over time due to heat and moisture in the living body (C). Accordingly, when the needle array 220 pushes the target of the living body (C), the cover agent 230 melts by the heat and moisture of the living body (C) over time, so the needle array 220 can inject the liquid into the target of the living body (C) without clogging, contamination or damage of the needle 221 .

In this embodiment, the cover agent 230 is composed of a component that can melt in the living body (C), but is not limited thereto, and the cover agent 230 is the catheter unit 200 to the target of the living body (C). When pushing, by the pressure of the catheter unit 200, it may have a structure that can be separated from the end of the needle array 220.

11 is a block diagram illustrating a liquid flow injection device using a needle array according to a fifth embodiment of the present invention, and FIG. 12 is a catheter unit of a liquid flow injection device using a needle array according to a fifth embodiment of the present invention. is a cross-sectional view showing

11 to 12 , in the liquid injection device 10 according to the fifth embodiment, the needle array 220 includes a plurality of needles 221 having at least one step portion 221a formed therein in the longitudinal direction. ) may be included. In this embodiment, one stepped portion 221a is formed on the sidewall of the needle 221 along the circumference of the needle 221, but one or more stepped portions 221a may be formed in the needle 221, of course. am.

When the step portion 221a is formed in the plurality of needles 221 , the magnitude of the pressing force may be adjusted for each step portion 221a. As a result, when the step portion 221a is used for the needle 221, the length of insertion into the target of the living body C can be easily adjusted, and the liquid can be injected at a consistent depth of the target.

13 is a perspective view illustrating a liquid injection device using a needle array according to a sixth embodiment of the present invention.

13 , the liquid injection device according to the sixth embodiment of the present invention may include a biopsy channel 100 , a needle array 220 , a biopsy lamp 300 , and a biopsy camera 400 . have.

The biopsy channel 100 may include an endoscope channel used for endoscopy/procedure. The biopsy channel 100 may be provided in the form of a curved channel in which an end is curved in a “L” shape. In this embodiment, the end of the biopsy channel 100 is formed to be curved in a "L" shape, but is not limited thereto, and the end of the biopsy channel 100 may include a straight or other curved shape. Of course.

The biopsy channel 100 may be moved to a target of a living body (eg, bladder wall tissue). A needle array 220 , a biopsy lamp 300 and a biopsy camera 400 may be mounted at the end of the biopsy channel 100 .

The needle array 220 may include a plurality of needles 221 spaced apart from each other on the end of the biopsy channel 100 . The plurality of needles 221 may be spaced apart on the outer periphery of the end of the biopsy channel 100 . Since the plurality of needles 221 are spaced apart on the outer periphery of the end of the biopsy channel 100, it is possible to increase the area of the injection path of the liquid flow to the target of the living body (C), and consequently, the injection amount of the liquid flow to the target can increase

The needle array 220 may be integrally connected to the end of the biopsy channel 100 . Alternatively, the needle array 220 may be provided in a structure detachable from the end of the biopsy channel 100 . If the needle array 220 is detachable from the end of the catheter 210, it can be replaced with a needle array 220 having a needle 221 of a length suitable for the depth, depending on the depth of the target to be injected with the liquid flow. .

Each needle 221 may be provided in the form of a pointed cone as a whole. An injection hole for injecting a liquid flow into the target of the living body C may be formed in the center of the needle 221 . In addition, the end of the needle array 220 prevents clogging, contamination or damage of the needle 221 . A cover agent may be applied to prevent it. The cover agent may include a component that melts over time due to in vivo heat and moisture. Accordingly, when the needle array 220 pushes the target of the living body, the cover agent is melted by the heat and moisture of the living body over time, so the needle array is blocked without clogging, contamination or damage of the needle 221 . , liquids can be injected into the target of the living body.

In addition, the needle array 220 may include a plurality of needles 221 formed with at least one step in the longitudinal direction. When the step portion is formed on the plurality of needles 221 , the magnitude of the pressing force may be adjusted for each step portion. As a result, when the step portion is used for the needle 221, the length of insertion into the target of the living body can be easily adjusted, and the liquid can be injected at a consistent depth of the target.

Biopsy lamp 300 may provide the ability to provide photodynamic therapy using specific wavelengths. To this end, the biopsy lamp 300 may be provided with a composite device (not shown) for the purpose of phototherapy treatment. The biopsy lamp 300 irradiates light toward the target of the living body C, thereby providing illumination necessary for photographing the biopsy camera 400 .

The biopsy camera 400 may take a video image of the target of the living body C at the end of the biopsy channel 100 . The video image captured by the biopsy camera 400 may be provided to the user through a separate display (not shown).

As described above, the present invention can accurately inject a liquid into a desired target depth and position in a living body, and increase the area of the array needle on which the needle is disposed, thereby increasing the amount of cells injected into the target of the living body. , since the catheter unit uses the biopsy channel, it has excellent advantages such as free movement and insertion into the curved part of the living body, and the rapid injection of liquid into the target of the living body.

The embodiments described above are merely illustrative of some examples of the present technical idea, and the scope of the present technical idea is not limited to the described embodiments, and it is within the scope of the present technical idea by those skilled in the art. Various changes, modifications or substitutions will be possible, and all such implementations should be considered to fall within the scope of the present technical spirit.

100: biopsy channel 200: catheter unit
210: catheter 211: catheter channel portion
212: catheter extension 220: needle array
221: needle 221a: step part
300: biopsy lamp 400: biopsy camera

Claims (13)

biopsy channel;
a catheter unit provided so as to be able to enter and exit the end of the biopsy channel to push the target of the living body;
a biopsy lamp provided at an end of the biopsy channel to irradiate light toward the target; and
and a biopsy camera to photograph the target at the end of the biopsy channel,
The catheter unit
a catheter providing a path for the flow of liquid; and
A needle array comprising a plurality of needles spaced apart on the end of the catheter and injecting the liquid into the target when the target is pushed,
the catheter
a catheter channel unit extending in a direction parallel to the extending direction of the biopsy channel; and
Doedoe extending from the end of the catheter channel portion to have a larger diameter than the diameter of the catheter channel portion, including a catheter extension that is eccentrically connected from one side of the catheter channel portion,
The catheter unit
In a state eccentrically arranged to one side at the center of the end of the biopsy channel, the catheter channel portion is rotatably installed at the end of the biopsy channel with a rotational center to prevent interference of the biopsy camera from photographing the target,
Liquid injection device using a needle array. delete delete The method of claim 1,
The catheter unit
It is applied to the end of the needle array, further comprising a cover agent that melts in the living body over time when the needle array pushes the target,
Liquid injection device using a needle array. The method of claim 1,
The needle array is
Containing a plurality of needles formed with at least one step in the longitudinal direction,
Liquid injection device using a needle array. The method of claim 1,
the catheter
Controlling the depth of insertion of the target of the living body by adjusting the length of input and output from the end of the biopsy channel,
Liquid injection device using a needle array. The method of claim 1,
The plurality of needles
spaced apart in a matrix form on the end of the catheter,
Liquid injection device using a needle array. The method of claim 1,
The needle array is
Removable from the end of the catheter to be replaceable with a plurality of needles having different lengths,
Liquid injection device using a needle array. The method of claim 1,
The biopsy lamp is
Provided in a plurality spaced apart from the end of the biopsy channel, providing a photodynamic treatment using a specific wavelength,
Liquid injection device using a needle array. 10. The method of claim 9,
The biopsy camera
Taking a video image of the target of the living body at the end of the biopsy channel, and providing the captured video image to the user through a display,
Liquid injection device using a needle array. The method of claim 1,
When the catheter unit pushes the target of the living body, by the pressure of the catheter unit, further comprising a cover agent that can be separated from the end of the needle array,
Liquid injection device using a needle array. The method of claim 1,
The needle array is
integrally connected to the end of the catheter,
Liquid injection device using a needle array. The method of claim 1,
The needle array is
provided in a structure detachable from the end of the catheter,
Liquid injection device using a needle array.

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