KR101891398B1 - Microneedle, manufacturing method of the microneedle, and patch including the microneedle - Google Patents

Abstract

In the microneedle of the present invention, a method for producing the same, and a patch comprising the same, the microneedle of the present invention includes a swellable polymer coating layer covering at least a part of the leading edge surface.

Description

MICRONEDLE, MANUFACTURING METHOD OF THE MICRONEEDLE, AND PATCH INCLUDING THE MICRONEEDLE BACKGROUND OF THE INVENTION 1. Field of the Invention [0001]

The present invention relates to a micro needle, and more particularly to a micro needle including a coating layer, a method of manufacturing the same, and a patch including the micro needle.

In order to manufacture a micro needle, a method of filling a mold with a polymer solution is generally used. However, this method requires a vacuum or air degassing process to fill the polymer solution, and in particular, in the case of the water-soluble polymer, the needle shape of the micro needle is deformed during the process without being easily filled in the hydrophobic mold . In addition, in the case of manufacturing a drug delivery microneedle by this method, since the drug is contained in the patch portion in addition to the microneedle, it is effective to apply only the microneedle tip penetrating the tissue in order to effectively deliver the drug.

In view of this, recently, a method of applying a polymer solution to a previously prepared solid micro needle patch by dip coating or spray coating has been used. In the case of the immersion coating method, a large amount of polymer solution is required to coat the micro needle, and it is difficult to uniformly apply only to the tip. The spray coating method also has a disadvantage in that the loss of the coating solution is large.

The coated layer made by the conventional method dissolves rapidly in the body and there is a limit to the release of the drug for a long time. There is a fear of infection by the micro hole formed by attaching the micro needle, and a new type of drug delivery method using micro needle is developed .

It is an object of the present invention to provide a microneedle capable of preventing tissue damage and infection and capable of delivering drugs efficiently.

Another object of the present invention is to provide a method of manufacturing the micro needle.

Yet another object of the present invention is to provide a micro needle patch comprising the micro needle.

A microneedle for one purpose of the present invention comprises a swellable polymer coating layer which is in the form of a needle having a pointed portion and which covers at least a part of the tip portion surface.

In one embodiment, a sacrificial layer may further be provided between the tip surface of the microneedle and the coating layer. At this time, the sacrificial layer may be water-soluble. At this time, the sacrificial layer may include one or more substances selected from water-soluble polymers and saccharides. The saccharide may be selected from the group consisting of glucose, fructose, sucrose, lactose, trehalose, ribose, maltose, cellobiose, , Raffinose, mannose, galactose, xylose, and a mixture thereof. The saccharide may be at least one selected from the group consisting of raffinose, mannose, galactose, xylose, and mixtures thereof. The water-soluble polymer may be at least one selected from the group consisting of gelatin, chitosan, hyaluronic acid, alginic acid, dextran, polyethylene (ethylene oxide), polyvinylpyrrolidone Hydroxypropylmethylcellulose, hydroxypropylcellulose, polyethylene glycol, polyvinyl alcohol, xanthan gum, and mixtures thereof.

In one embodiment, the swelling polymer is selected from the group consisting of hyaluronic acid, alginic acid, pectin, carrageenan, chondroitin (sulfate), dextran (sulfate), chitosan, polylysine, collagen, gelatin, carboxymethyl chitin, (PVA), polyacrylamide (PAAm), polymethacrylic acid, polymaleic acid, polyvinyl alcohol (PVA), polyethylene oxide (polyvinyl alcohol), polyvinyl pyrrolidone PEO), poly (N-vinylpyrrolidone), poly (methyl methacrylate-co-hydroxylethyl (meth) acrylate-co-hydroxyethyl methacrylate methacrylate)), poly (acrylonitrile-aryl sulfonate), poly (glucosyloxyethyl methacrylate-sulfate) (P (GEMA)), polyethylene oxide (PEO) - Polyester oil (PEO-PPO-PEO) terpolymer, polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) ternary block copolymer, N-carboxyanhydride and copolymers of monomers forming such a polymer have.

In one embodiment, the swellable polymer may comprise a drug.

A method of manufacturing a micro needle according to another aspect of the present invention includes the steps of selectively hydrophilizing a tip end surface of a microneedle having a tip end portion and coating a swelling polymer solution on the tip end surface of the hydrophilicized micro needle, And forming a coating layer.

In one embodiment, the hydrophilization treatment may be a plasma treatment.

At this time, the plasma treatment may include exposing only the tip portion of the microneedles and selectively plasma-treating the exposed tip portions. In this case, the step of exposing only the tip portion may include placing a masking film on the microneedles except the tip portion. At this time, the plasma may be a plasma capable of hydrophilizing the tip surface of the microneedles. At this time, the plasma may be an oxygen plasma, an argon plasma, or an ammonia plasma.

In one embodiment, in the step of forming the coating layer, the swelling polymer solution may be dripped onto the leading end surface of the hydrophilicized microneedle, and the spilled swollen polymer solution may be crosslinked to form a coating layer.

In one embodiment, the step of forming the coating layer may further include coating a sacrificial layer on the tip end surface of the hydrophilicized micro needle.

A microneedle patch for another purpose of the present invention comprises a patch portion which is a flat face and a micro needle which is disposed on one face of the patch portion and which comprises a swellable polymer coating layer covering at least a part of the tip portion surface.

In one embodiment, the microneedle patch may further include a sacrificial layer between the leading end surface of the microneedle and the coating layer.

In one embodiment, the swellable polymer coating layer can be configured to be detached from the microneedles within the skin, by insertion into the skin and subsequent removal action from the skin of the patch.

In one embodiment, the microneedle patch may be a transdermal patch for drug delivery or a patch-type tissue adhesive. At this time, the tissue adhesive may be for wet surface adhesion.

According to the microneedle of the present invention, a method of manufacturing the same, and a patch including the microneedle, the present invention can easily manufacture a microneedle including a swollen polymer coating layer, and can provide a microneedle patch including the same. The microneedles of the present invention include a swellable polymer coating layer to fill holes formed by insertion by swelling of the micro-needle in the body at the time of skin insertion, thereby preventing tissue damage and secondary infection . In addition, since the micro needle according to the present invention selectively supports the drug only at the tip end portion, not including the drug in the entire micro needle, the drug can be delivered more economically and efficiently.

1 is a schematic view illustrating a microneedle according to an embodiment of the present invention.
2 is a schematic view illustrating a method of manufacturing a micro needle according to an embodiment of the present invention.
3 is a schematic view for explaining a micro needle according to an embodiment of the present invention and a method of manufacturing the same.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. The present invention is capable of various modifications and various forms, and specific embodiments are illustrated in the drawings and described in detail in the text. It is to be understood, however, that the invention is not intended to be limited to the particular forms disclosed, but on the contrary, is intended to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Like reference numerals are used for like elements in describing each drawing.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In the present application, the term "comprises" or "having ", etc. is intended to specify that there is a feature, step, operation, element, part or combination thereof described in the specification, , &Quot; an ", " an ", " an "

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the contextual meaning of the related art and are to be interpreted as either ideal or overly formal in the sense of the present application Do not.

1 is a schematic view illustrating a microneedle according to an embodiment of the present invention.

Referring to FIG. 1, a microneedle 100 of the present invention includes a swellable polymer coating layer 124 that is needle-shaped with a tip 120 and covers at least a portion of the surface of the tip 120.

The micro needle 100 means a fine needle shape. The micro needle 100 may be a micro needle 100 formed of various materials such as polymers, metals, and the like. For example, the micro needle 100 may be a micro needle 100 formed of a biocompatible polymer. The microneedle 100 of the present invention may further include a patch unit 200 that is a flat surface on which the microneedles 100 are disposed. The patch portion 200 may refer to a surface where the micro needle 100 is inserted into and contacted with the skin surface without being inserted into the skin when the micro needle 100 is inserted into the skin. The patch portion 200 may exhibit elasticity and flexibility, and thus the shape may be deformed to conform to the curved skin surface. Although not shown in the drawing, a plurality of micro needles 100 may be disposed on one side of the patch unit 200.

The microneedle 100 of the present invention includes the patch unit 200 and the microneedles 100 may be disposed on one side of the patch unit 200, have. The microneedle patch 300 of the present invention may be a transdermal patch. Transdermal patches generally refer to patches that transmit stimuli or substances through the skin. At this time, the microneedle patch 300 may be a transcutaneous patch for delivering a drug through the microneedle 100 to the body. Alternatively, the micro needle patch 300 of the present invention can be a micro needle patch-type tissue adhesive (adhesive agent). A tissue adhesive is a substance that adheres between tissues, and can be used for various purposes such as protection of a wound site and hemostasis, inter-tissue bonding and sealing. The microneedle patch 300 of the present invention can be used as a patch-type tissue adhesive, and the tissue can be quickly and easily adhered by attaching the microneedle patch 300 to the surface of the tissue requiring adhesion. In addition, tissue adhesives are materials that can be used on surfaces wetted by body fluids or blood, and in order to effectively adhere tissues in such environments, a high level of adhesion is required even in a wet environment. The microneedle 100 of the microneedle patch 300 according to the present invention absorbs fluid on the surface or tissue after it is inserted into the skin to selectively swell the tip portion to swell and thereby achieve mechanical engagement with the tissue, It is possible to effectively adhere the tissue. Therefore, the micro needle patch 300 of the present invention can be configured as a patch-type tissue adhesive that can be used not only for the skin but also for various soft tissues such as muscle, mucous membrane and the like. A more detailed description of drug delivery and tissue adhesion of the microneedle patch 300 of the present invention will be described below.

The microneedles 100 may refer to the microneedles 100 disposed on one side of the patch portion 200 of the microneedle patches 300 and may alternatively mean the microneedles 100 alone have.

The tip portion 120 of the micro needle 100 refers to a point including a pointed portion or a cutting edge of the micro needle 100 and may be referred to as a tip. The tip 120 of the microneedle of the present invention may be, for example, one in which the tip 120 surface has been plasma treated. A detailed description thereof will be given later in the method for producing a micro needle according to the present invention.

The coating layer 124 is formed of a crosslinkable swellable polymer. Swellable polymer means a polymer capable of absorbing a liquid such as water to increase its volume, that is, swellable. The swellable polymer of the present invention may be a biocompatible polymer exhibiting swellability and biodegradability. For example, the biocompatible hydrophilic polymer may be a physical, chemical, or optically crosslinked polymer. In this case, the biocompatible hydrophilic polymer may be swollen by water without being dissolved in water by crosslinking. The swelling polymer may be selected from the group consisting of hyaluronic acid, alginic acid, pectin, carrageenan, chondroitin (sulfate), dextran (sulfate), chitosan, polylysine, collagen, gelatin, carboxymethyl chitin ), Fibrin, agarose, pullulan, cellulose, polyethylene oxide, poly (N-) isopropylacrylamide (PNIPAAm), polyacrylamide (PAAm), polymethacrylic acid, polymaleic acid, polyvinyl alcohol (MMA-co-HEMA) (poly (methyl methacrylate-co (HEMA)) (poly (methyl methacrylate-co-hydroxyethyl methacrylate) hydroxyethyl methacrylate)), poly (acrylonitrile-aryl sulfonate), poly (glucosyloxyethyl methacrylate-sulfate) (PEM (glucosyloxyethyl methacrylate) sulfate), polyethylene oxide PEO) -Poly (PEO-PPO-PEO) terpolymer, polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) terpolymer, N-carboxyanhydride and copolymers of monomers forming such a polymer. . The coating layer 124 may be selectively disposed only on the surface of the tip 120 of the microneedle 100. At this time, the coating layer 124 may cover the entire surface or a part of the surface of the tip portion 120 of the microneedle.

When the micro needle 100 of the present invention is inserted into the skin, the coating layer 124 formed of the swelling polymer can swell by absorbing the body fluid in the skin tissue. Specifically, when the micro needle 100 is inserted into the skin, the coating layer 124 on the surface of the tip portion 120 of the micro needle 100 swells by absorbing the body fluid in the skin tissue, As shown in Fig. The coating layer 124 swells to fill the fine pores of the skin tissue that develop as the micro needle 100 is inserted into the skin, thereby preventing tissue damage and thereby inhibiting further infection.

The coating layer 124 may be detached from the micro needle 100 within the dermal tissue. Specifically, by inserting the swellable polymer coating layer 124 into the skin and removing the micro needle patch 300 from the skin, the swellable polymer coating layer 124 can be separated from the micro needle 100 in the skin. For example, when the swollen coating layer 124 is separated from the micro needle 100, the swollen coating layer 124 is located within the dermal tissue, and the micro needle 100 excluding the swollen coating layer 124 can be removed . Alternatively, the swollen coating layer 124 may not be separated from the micro needle 100, and the inserted micro needle 100 may be mechanically engaged more closely with the skin tissue by swelling of the coating layer 124 have.

The microneedle 100 of the present invention may further include a sacrificial layer 122 between the surface of the tip 120 and the coating layer 124. In the present invention, the sacrificial layer 122 may mean a water-soluble layer which can be dissolved by bodily fluids in skin tissue and can disappear. Specifically, when the micro needle 100 is inserted into the skin, the coating layer 124 of the micro needle 100 absorbs body fluid in the skin tissue and swells, and the sacrifice layer 122, which is a water-soluble layer, . At this time, the sacrifice layer 122 is melted to form a void space between the coating layer 124 of the micro needle 100 and the surface of the tip 120. Thus, the micro needle 100 and the swelled coating layer (124) can be easily separated. The sacrificial layer 122 may be formed of a water-soluble compound, and the water-soluble compound may be a water-soluble polymer, a water-soluble saccharide, or a mixture thereof. The water-soluble polymer may include a non-crosslinked swellable polymer. For example, the water-soluble polymer may be selected from the group consisting of gelatin, chitosan, hyaluronic acid, alginic acid, Dextran, poly (ethylene oxide), polyvinylpyrrolidone The water-soluble saccharide may be selected from the group consisting of glucose, fructose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyethylene glycol, polyvinyl alcohol, xanthan gum, , Sucrose, lactose, trehalose, ribose, maltose, cellobiose, raffinose, mannose, galactose, galactose, xylose, and a mixture thereof. The saccharide may be one or more selected from the group consisting of galactose, xylose, and a mixture thereof.

The sacrificial layer 122 of the present invention is formed between the surface of the tip 120 of the microneedle 100 and the coating layer 124 and is intimately attached to the surface of the tip 120 of the microneedle 100 The coating layer 124 can be easily separated from the micro needle 100 when the micro needle 100 is inserted into the skin by preventing direct contact between the micro needle 100 and the coating layer 124, Such as a release paper or a release paper, which can maintain the properties of the coating layer 124 from the substrate 100 or maintain the drug activity in the coating layer. In addition, the sacrificial layer 122 may be made to become a sacrificial layer.

The swellable polymer coating layer 124 may include a functional material such as a drug. In one example, if the coating layer 124 comprises a drug, the drug may be released into the tissue from the coating layer 124 that has swelled in the tissue. At this time, the swollen coating layer 124 can adjust the release amount of the loaded drug according to the degree of crosslinking of the swelling polymer. In one example, the swollen coating layer 124 may release slowly, releasing the drug slowly. That is, the coating layer 124 can deliver drugs for a long time in the body.

When the coating layer 124 comprises a drug, the micro needle 100 of the present invention can be used as a drug delivery vehicle. For example, when the micro needle 100 is separated from the swollen coating layer 124 in the skin, the micro needle 100 may be used as an implantable drug delivery device, and the micro needle 100 may be used as the swelled coating layer 124 The micro needle 100 can be used as a stationary drug delivery device. Alternatively, the microneedles 100, where the coating layer 124 does not contain a drug and are not separated from the swollen coating layer 124, may be used as a tissue adhesive. Due to this, the micro needle patch 300 including the micro needle 100 of the present invention can be used for drug delivery or tissue adhesion.

The present invention selectively processes the surface of the tip 120 of the microneedle 100 to selectively hydrophilize the microneedle to produce the microneedle.

At this time, the microneedle 100 may expose only the tip 120 of the microneedle 100 to selectively hydrophilize the surface of the exposed microneedle 120. At this time, various hydrophilic surface treatment methods can be used for the hydrophilic surface treatment method. For example, the microneedles 100 exposed only at the tip 120 of the microneedles may be contacted with a solution of a substance capable of chemically reacting with the surface of the microneedles 100, . ≪ / RTI >

Alternatively, the hydrophilizing treatment may be a plasma treatment.

Hereinafter, a method of manufacturing a microneedle according to an embodiment of the present invention will be described in more detail with reference to FIG.

2 is a schematic view illustrating a method of manufacturing a micro needle according to an embodiment of the present invention.

2 (a) is a schematic view for explaining attachment of a masking film to a micro needle, and (b) is a schematic diagram for explaining selective plasma treatment of a micro needle. (c) is a schematic diagram for explaining formation of a sacrificial layer, and (d) is a schematic diagram for explaining formation of a coating layer.

Referring to FIG. 2, the method of manufacturing the microneedle 100 of the present invention first plasma-processes the tip portion 120 surface of the microneedle 100.

At this time, in order to selectively plasma-process the microneedle 100, the exposed tip 120 of the microneedle 100 exposed only the tip 120 may be selectively plasma-treated. The tip 120 of the micro needle 100 may be exposed by placing a masking film on the surface of the overall micro needle 100 except for the tip 120 (Figures 2 (a) and 2 (b)).

The microneedles 100 are substantially the same as those described in the microneedle 100 of the present invention, and a detailed description thereof will be omitted.

The plasma may be a plasma capable of forming hydrophilic functional groups such as a hydroxyl group (-OH), a carboxyl group (-COOH) on the surface of the tip 120 of the micro needle 100. That is, the plasma may be a plasma capable of hydrophilizing the surface of the tip 120. In one example, the hydrophilically processable plasma may be an oxygen plasma, an argon plasma, or an ammonia plasma.

At this time, the time for treating the surface of the tip portion 120 of the micro needle 100 with the plasma can be controlled to adjust the adhesive force between the tip portion 120 surface of the micro needle 100 and the coating layer 124, The time may be proportional to the adhesion force between the tip portion 120 surface of the micro needle 100 and the coating layer 124. A detailed description thereof will be given later with reference to FIG.

Although the present invention has been described above with reference to specific examples using plasma for the hydrophilic treatment, the present invention is not limited thereto.

Next, in order to form micro needles, the present invention forms a coating layer 124 by coating a swelling polymer solution on the surface of the tip portion 120 of the hydrophilicized micro needle 100.

The sacrificial layer 122 may be first coated on the surface of the tip portion 120 of the hydrophilicized micro needle 100 before the coating layer 124 is formed (see FIGS. ).

The coating layer 124 and the sacrificial layer 122 are substantially the same as those described in the microneedle 100 of the present invention, so that a detailed description thereof will be omitted and differences will be mainly described.

The sacrificial layer 122 may be formed by dropping a solution of the sacrificial layer 122 on the surface of the tip 120 of the microneedle 100 selectively hydrophilized only on the tip 120 surface. For example, a dispenser can be used. At this time, the dripped swollen polymer solution may be physically, chemically, or optically crosslinked to form the coating layer 124. The present invention is characterized in that the surface of the tip 120 of the micro needle 100 is hydrophilized so that a solution containing the water soluble compound forming the sacrificial layer 122 can be easily applied to the surface of the tip 120 of the micro needle 100 To be coated.

The coating layer 124 may be formed by dropping a swellable polymer solution on the tip 120 of the microneedle 100 substantially the same as forming the sacrificial layer 122. The swelling polymer solution may be a solution containing a swelling polymer as described for the micro needle 100. At this time, the swelling polymer solution may contain a functional substance such as a drug. When the coating layer 124 is formed of a swellable polymer solution containing a drug, the drug can be released from the coating layer 124 when the micro needle 100 is inserted into the skin tissue. The amount of the released drug may be adjusted by adjusting the amount of the drug added to the swelling polymer solution or by controlling the number of times the swelling polymer is coated on the surface of the tip 120 of the microneedle 100.

The present invention is characterized in that a swellable polymer solution containing a functional material such as a drug is selectively coated only on the tip end portion 120 of the micro needle 100 so that the functional material can be contained only in the tip end portion 120 of the micro needle 100 Thus, the amount of the functional substance to be delivered can be transferred into the body without loss. Therefore, the functional material can be efficiently and economically transferred without wasting the functional material.

In the case where the surface of the tip portion 120 of the microneedle 100 is hydrophilized by the plasma, the surface of the tip portion 120 of the microneedle 100 and the swelled coating layer 124 can be adjusted. This will be described in more detail with reference to FIG.

3 is a schematic view for explaining a micro needle according to an embodiment of the present invention and a method of manufacturing the same.

FIG. 3 (a) is a schematic view for explaining microneedles subjected to a short-time plasma treatment, and FIG. 3 (b) is a schematic diagram for explaining a microneedle for a long time plasma treatment.

3, when the surface of the tip 120 of the microneedle 100 is treated with plasma for a short period of time, the adhesion between the tip 120 of the microneedle 100 and the coating layer 124 is relatively low And adhesion between the surface of the tip portion 120 of the microneedle 100 and the coating layer 124 may be high when the plasma treatment is performed for a long time. As described above, when the microneedle 100 is inserted into the skin, the coating layer 124 swells and mechanically engages with the skin tissue. At this time, the surface of the tip 120 of the microneedle 100 and the surface of the coating layer 124, The micro needle 100 and the coating layer 124 may or may not be separated from each other. Specifically, if the adhesive force between the tip 120 surface of the micro needle 100 and the coating layer 124 is greater than the interlocking force between the swollen coating layer 124 and the skin tissue, 100). ≪ / RTI > Alternatively, if the adhesive force between the tip 120 surface of the microneedle 100 and the coating layer 124 is less than the interlocking force between the swollen coating layer 124 and the skin tissue, 100, and the microneedles 100 can be removed from the skin tissue.

Thus, by adjusting the time for treating the surface of the tip portion 120 of the microneedle 100 with the plasma, the adhesive force between the tip portion 120 surface of the microneedle 100 and the coating layer 124 can be adjusted.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention as defined by the following claims. It can be understood that it is possible.

100: Micro needle
120: Micro needle tip section
122: sacrificial layer
124: Coating layer
200: patch part
300: Micro needle patch

Claims (21)

A microneedle having a cylindrical body portion and a conical tip portion disposed on the upper surface of the body portion; And
A sacrificial layer covering at least one part of the surface of the sacrificial layer, the sacrificial layer covering at least one of the water-soluble polymer and the saccharide coated on the tip portion of the micro needle and being water- And a double coating layer comprising a swollen polymer coating layer coated along the shape,
Characterized in that when exposed to moisture, the sacrificial layer is dissolved before the swellable polymer coating layer, and the swellable polymer coating layer is separated from the tip portion of the micro needle.
Micro needle for swelling polymer coating layer implantation.
delete delete delete The method according to claim 1,
The saccharide may be selected from the group consisting of glucose, fructose, sucrose, lactose, trehalose, ribose, maltose, cellobiose, raffinose, Wherein the saccharide is one or more saccharides selected from the group consisting of raffinose, mannose, galactose, xylose, and mixtures thereof.
Micro needle.
The method according to claim 1,
The water-soluble polymer may be at least one selected from the group consisting of gelatin, chitosan, hyaluronic acid, alginic acid, Dextran, poly (ethylene oxide), polyvinylpyrrolidone, Hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyethylene glycol, polyvinylalcohol, xanthan gum, and mixtures thereof.
Micro needle.
The method according to claim 1,
The swelling polymer may be selected from the group consisting of hyaluronic acid, alginic acid, pectin, carrageenan, chondroitin (sulfate), dextran (sulfate), chitosan, polylysine, collagen, gelatin, carboxymethyl chitin, fibrin, agarose, (PEO), poly (vinylidene fluoride), polyvinyl pyrrolidone, polyvinyl pyrrolidone, polyvinyl pyrrolidone, polyvinyl pyrrolidone, cellulose, polyethylene oxide, poly (N-) isopropylacrylamide (PNIPAAm), polyacrylamide Polyvinylpyrrolidone (PVP), poly (methyl methacrylate-co-hydroxylethyl methacrylate) (MMA-co-HEMA) (poly (methyl methacrylate-co-hydroxylethyl methacrylate) Poly (acrylonitrile-aryl sulfonate), poly (glucosyloxyethyl methacrylate-sulfate) (PEM), polyethylene oxide (PEO) -polyester derivatives, Polyethylene (PEO-PPO-PEO) ternary block copolymer, N-carboxyanhydride, and a copolymer of monomers forming such a polymer. ,
Micro needle.
The method according to claim 1,
Characterized in that the swelling polymer comprises a drug.
Micro needle.
Selectively hydrophilizing the apical surface of the microneedle having a cylindrical body portion and a conical tip portion disposed on the upper surface of the body portion;
A solution for forming a sacrificial layer containing at least one of a water-soluble polymer having water solubility and a saccharide is dropped and dried on the tip end surface of the hydrophilicized micro needle, Coating a sacrificial layer; And
Coating a swelling polymer coating layer on the surface of the sacrificial layer along the shape of the tip so as to cover at least a part of the surface of the sacrificial layer and form a double coating layer by dropping a swelling polymer aqueous solution on the sacrificial layer surface, ,
Characterized in that when exposed to moisture, the sacrificial layer is dissolved before the swellable polymer coating layer, and the swellable polymer coating layer is separated from the tip portion of the micro needle.
Method for manufacturing micro needle for swelling polymer coating layer implantation.
10. The method of claim 9,
Characterized in that the hydrophilization treatment is a plasma treatment.
Method of manufacturing micro needles.
11. The method of claim 10,
The plasma treatment
Only the tip of the micro needle is exposed,
And selectively treating the exposed tip with a plasma.
Method of manufacturing micro needles.
12. The method of claim 11,
Wherein the step of exposing only the tip includes positioning a masking film on the microneedles except the tip.
Method of manufacturing micro needles.
11. The method of claim 10,
Characterized in that the plasma is a plasma capable of hydrophilizing the tip surface of the microneedles,
Method of manufacturing micro needles.
14. The method of claim 13,
Wherein the plasma is an oxygen plasma, an argon plasma, or an ammonia plasma.
Method of manufacturing micro needles.
10. The method of claim 9,
In the step of coating the swellable polymer coating layer,
Characterized in that the swellable polymer aqueous solution is crosslinked on the sacrificial layer to form a swellable polymer coating layer,
Method of manufacturing micro needles. delete delete delete delete delete delete

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