KR102279629B1 - 암에 대한 멜플루펜 용량 투여 요법 - Google Patents

암에 대한 멜플루펜 용량 투여 요법 Download PDF

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KR102279629B1
KR102279629B1 KR1020187014234A KR20187014234A KR102279629B1 KR 102279629 B1 KR102279629 B1 KR 102279629B1 KR 1020187014234 A KR1020187014234 A KR 1020187014234A KR 20187014234 A KR20187014234 A KR 20187014234A KR 102279629 B1 KR102279629 B1 KR 102279629B1
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melflufen
dose
patients
administered
salt
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KR20180087254A (ko
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자콥 린드버그
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온코펩타이드즈 아베
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Assigned to 온코펩타이드즈 이노베이션 아베 reassignment 온코펩타이드즈 이노베이션 아베 권리의 전부이전등록 Assignors: 온코펩타이드즈 아베
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020187014234A 2015-12-01 2016-12-01 암에 대한 멜플루펜 용량 투여 요법 Active KR102279629B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217022171A KR20210092327A (ko) 2015-12-01 2016-12-01 암에 대한 멜플루펜 용량 투여 요법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1521217.8A GB201521217D0 (en) 2015-12-01 2015-12-01 Dosage regimens
GB1521217.8 2015-12-01
PCT/EP2016/079511 WO2017093443A1 (en) 2015-12-01 2016-12-01 Melflufen dosage regimens for cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217022171A Division KR20210092327A (ko) 2015-12-01 2016-12-01 암에 대한 멜플루펜 용량 투여 요법

Publications (2)

Publication Number Publication Date
KR20180087254A KR20180087254A (ko) 2018-08-01
KR102279629B1 true KR102279629B1 (ko) 2021-07-20

Family

ID=55177548

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020187014234A Active KR102279629B1 (ko) 2015-12-01 2016-12-01 암에 대한 멜플루펜 용량 투여 요법
KR1020217022171A Withdrawn KR20210092327A (ko) 2015-12-01 2016-12-01 암에 대한 멜플루펜 용량 투여 요법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020217022171A Withdrawn KR20210092327A (ko) 2015-12-01 2016-12-01 암에 대한 멜플루펜 용량 투여 요법

Country Status (27)

Country Link
US (3) US20180369141A1 (https=)
EP (3) EP3903777A1 (https=)
JP (2) JP6878431B2 (https=)
KR (2) KR102279629B1 (https=)
CN (1) CN108289876A (https=)
AU (2) AU2016363591B2 (https=)
BR (1) BR112018010012A8 (https=)
CA (1) CA3003102C (https=)
CY (1) CY1123469T1 (https=)
DK (1) DK3383385T4 (https=)
ES (1) ES2828033T5 (https=)
FI (1) FI3383385T4 (https=)
GB (1) GB201521217D0 (https=)
HR (1) HRP20201632T4 (https=)
HU (1) HUE051525T2 (https=)
IL (2) IL301019B2 (https=)
LT (1) LT3383385T (https=)
MX (2) MX384724B (https=)
PL (1) PL3383385T5 (https=)
PT (1) PT3383385T (https=)
RS (1) RS60986B2 (https=)
RU (2) RU2734930C2 (https=)
SG (1) SG11201803551YA (https=)
SI (1) SI3383385T2 (https=)
SM (1) SMT202000567T1 (https=)
WO (1) WO2017093443A1 (https=)
ZA (2) ZA201802816B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3866931T3 (pl) * 2018-10-18 2023-06-19 Oncopeptides Ab Związki zawierające deuter
US11939390B2 (en) * 2019-01-28 2024-03-26 Sanofi-Aventis U.S. Llc Methods of treating multiple myeloma
JP2022527532A (ja) * 2019-04-03 2022-06-02 オンコペプティデス エービー メルフルフェンによるａｌアミロイドーシスの治療
GB201905477D0 (en) * 2019-04-17 2019-05-29 Oncopeptides Ab Novel formulations
WO2021053185A1 (en) * 2019-09-20 2021-03-25 Oncopeptides Ab Melflufen formulations and their use in the treatment or prophylaxis of osteosarcoma
SE544998C2 (en) * 2021-01-13 2023-02-21 Bkmdcl Ab Peptide conjugates of melphalan for the treatment of cancer
WO2023281007A1 (en) * 2021-07-08 2023-01-12 Oncopeptides Ab Melflufen for use in the treatment of multiple myeloma

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014065751A1 (en) 2012-10-26 2014-05-01 Oncopeptides Ab Lyophilized preparations of melphalan flufenamide
US20140302014A1 (en) 2013-04-08 2014-10-09 Berg Llc Methods for the treatment of cancer using coenzyme q10 combination therapies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0002202D0 (sv) 2000-06-13 2000-06-13 Karolinska Innovations Ab New peptides
CA3024230C (en) 2011-04-28 2022-10-18 Oncopeptides Ab Lyophilized preparation of cytotoxic dipeptides
US10042382B2 (en) 2012-10-22 2018-08-07 Parker Hannifin Manufacturing Sweden Ab Joystick

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014065751A1 (en) 2012-10-26 2014-05-01 Oncopeptides Ab Lyophilized preparations of melphalan flufenamide
US20140302014A1 (en) 2013-04-08 2014-10-09 Berg Llc Methods for the treatment of cancer using coenzyme q10 combination therapies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Blood, 124(21), 2123, 2014.
Clinical Cancer Research, 19(11), 3019-3031, 2013.*

Also Published As

Publication number Publication date
CA3003102A1 (en) 2017-06-08
EP3383385B1 (en) 2020-07-29
HUE051525T2 (hu) 2021-03-01
JP6878431B2 (ja) 2021-05-26
IL301019B2 (en) 2025-12-01
GB201521217D0 (en) 2016-01-13
RS60986B2 (sr) 2023-12-29
IL301019B1 (en) 2025-08-01
EP3383385A1 (en) 2018-10-10
MX2021008738A (es) 2021-08-24
CN108289876A (zh) 2018-07-17
IL301019A (en) 2023-05-01
MX2018006706A (es) 2018-08-01
AU2016363591B2 (en) 2020-12-10
PL3383385T3 (pl) 2021-05-04
DK3383385T3 (da) 2020-10-12
EP3750534A1 (en) 2020-12-16
JP2019501881A (ja) 2019-01-24
SI3383385T2 (sl) 2024-01-31
LT3383385T (lt) 2020-12-28
KR20180087254A (ko) 2018-08-01
NZ742548A (en) 2023-10-27
PL3383385T5 (pl) 2023-12-18
EP3383385B2 (en) 2023-09-06
JP2021088560A (ja) 2021-06-10
PT3383385T (pt) 2020-10-26
RU2734930C2 (ru) 2020-10-26
DK3383385T4 (da) 2023-11-06
WO2017093443A1 (en) 2017-06-08
FI3383385T4 (fi) 2023-11-01
SMT202000567T1 (it) 2020-11-10
ZA201802816B (en) 2021-07-28
US20180369141A1 (en) 2018-12-27
CY1123469T1 (el) 2022-03-24
KR20210092327A (ko) 2021-07-23
HRP20201632T4 (hr) 2023-11-10
IL259101A (en) 2018-06-28
BR112018010012A2 (pt) 2018-11-21
EP3903777A1 (en) 2021-11-03
US20220047507A1 (en) 2022-02-17
AU2016363591A1 (en) 2018-06-28
US20250144023A1 (en) 2025-05-08
RU2018123718A3 (https=) 2020-04-02
ES2828033T3 (es) 2021-05-25
MX384724B (es) 2025-03-14
CA3003102C (en) 2022-09-13
RU2018123718A (ru) 2020-01-09
BR112018010012A8 (pt) 2019-02-26
RS60986B1 (sr) 2020-11-30
SI3383385T1 (sl) 2020-11-30
ZA202102438B (en) 2025-08-27
RU2020134307A (ru) 2020-11-27
HRP20201632T1 (hr) 2021-01-08
ES2828033T5 (es) 2024-04-04
AU2021200436A1 (en) 2021-02-25
SG11201803551YA (en) 2018-05-30

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