KR102274297B1 - Cosmetic composition containing octylgallate - Google Patents

Abstract

The present invention provides a cosmetic composition containing octyl gallate. The cosmetic composition according to the present invention is prevented from gelation by the intercellular lipid component, thereby improving formulation stability at low temperature.

Description

Cosmetic composition containing octylgallate

The present invention relates to a cosmetic composition of a solubilized formulation containing octyl gallate.

The skin is the organ that provides the primary defense against the external environment in the human body. Among them, the stratum corneum of the epidermis plays an important role through sebum and intercellular lipids, such as preventing moisture evaporation through the skin and preventing intrusion of external harmful factors.

Paying attention to the protective function of the stratum corneum, cosmetics that mimic the components of intercellular lipids have been released (Patent Document 1).

However, the intercellular lipid component had low solubility in water, so it was not easy to apply to solubilized formulations.

As an example of successful solubilization by applying an intercellular lipid component, there is a case in which poorly soluble ceramide is stabilized through an amphiphilic micelle structure (Patent Document 2). However, when stored at a low temperature of 0° C. or less, the ceramide component in micelles is precipitated as an aqueous phase, and attractive forces that cause bonding between the particles are generated due to the surface energy of the ceramide particles, resulting in a gelling phenomenon.

1. Korean Patent Publication No. 10-2005-0026778 2. Korea Patent Publication No. 10-2010-0100202

The present invention is to solve the problems of the prior art, and an object of the present invention is to provide a solubilized formulation of intercellular lipid components that does not cause gelling at low temperature.

In the present invention, the intercellular lipid component; and

It provides a cosmetic composition of a solubilized formulation comprising a compound represented by the following formula (1).

[Formula 1]

In the cosmetic composition of the solubilization formulation according to the present invention, the formation of lamellae is blocked by octyl gallate, so that the gelling phenomenon due to ceramide precipitation does not occur, thereby increasing the low-temperature stability of the formulation.

The present invention relates to an intercellular lipid component; and

It relates to a cosmetic composition of a solubilized formulation comprising a compound represented by the following formula (1).

[Formula 1]

Hereinafter, the cosmetic composition of the solubilization formulation according to the present invention will be described in more detail.

In the present invention, the intercellular lipid component serves to prevent moisture of the skin and the invasion of external harmful factors.

These intercellular lipid components may exist in the form of micelles.

A micelle is generally defined as a thermodynamically stable and uniform spherical structure formed by low molecular weight substances having amphiphilic properties, for example, both hydrophilic and hydrophobic groups.

When amphiphilic substances are dissolved in water or other solvents, due to thermodynamic stability, hydrophilicity tends to hydrate on the surface of the solvent, and the hydrophobic chains tend to align toward the outside of the surface. If the concentration is continuously increased, the surface of the solution is saturated with surfactant and the surface tension is not reduced any more. In the aqueous solution, the hydrophilic groups of the amphiphilic material are collected outside and the hydrophobic groups are gathered inside, forming micelles, which are spherical aggregates.

Since the intercellular lipid component according to the present invention has both a hydrophilic group and a hydrophobic group, which are characteristics of an amphiphilic molecule, in one molecule, it plays a role similar to that of a surfactant at a concentration below a certain concentration, but when the concentration exceeds a certain concentration, micelles are formed and suspended matter morphology, where it contains more of the intercellular lipid component, it forms a double lipid lamellae.

The lamellar structure of a bilayer such as liposomes can be used in formulations such as creams, but there is a limitation because opacification problems due to floating occur when used in solubilization formulations such as lotions, so in the present invention, intercellular lipids The component can be stably maintained in a solubilized formulation such as a lotion by forming micelles.

In addition, the micelles of the intercellular lipid component may contain cholesterol, free fatty acids, other poorly soluble substances, etc., which are components of other intercellular lipids in the micelle structure.

The average particle diameter of the micelles may be 1 to 200 nm or 100 to 150 nm. When the average particle diameter of the micelles exceeds 200 nm, there is a fear that formulation stability is inhibited.

In the present invention, the type of intercellular lipid component is not particularly limited, and ceramide type 1 to type 6, glycosphingolipid, galactosyl ceramide, sphingosine, cyphingosine, sphinganine, sphingonoid lipid, saturated lecithin , unsaturated lecithin, glycerophospholipid, cholesterol, sitosterol, cholesteryl sulfate, and mixtures thereof may be selected from the group consisting of.

In addition, the content of the intercellular lipid component may be 0.1 to 15% by weight based on the total weight of the composition. The above content is advantageous for the formation and stabilization of micelles.

In the present invention, the compound represented by Formula 1 (hereinafter, the compound of Formula 1) may be used to prevent the cosmetic composition from gelling at low temperature. When the micelles of the intercellular lipid component are stored at a low temperature of 0° C. or less, the ceramide components in the micelles are precipitated as an aqueous phase, and attractive forces that induce bonding between the particles occur due to the surface energy of the ceramide particles. This causes the ceramide to form a lamellar structure, resulting in a gelling phenomenon. On the other hand, the compound of Formula 1 has a relatively large hydrophilic head portion and a short hydrophobic carbon chain compared thereto, which has a molecular structure opposite to that of ceramide. As such, when the ceramide and structurally contradictory compounds are present together, the formation of a lamellar structure becomes difficult.

Therefore, in the present invention, by using the compound of Formula 1 together with the intercellular lipid component, the ceramide prevents the formation of a lamellar structure, so that the gelling phenomenon does not occur, thereby increasing the low-temperature stability of the formulation.

The compound of Formula 1 may be octyl gallate.

The content of the compound of Formula 1 may be 0.01 to 0.10 wt% or 0.03 to 0.05 wt% based on the total weight of the composition. It is advantageous for stabilization of the intercellular lipid component at the above content.

In the present invention, in addition to the above-described intercellular lipid component and the compound of Formula 1, a polyhydric alcohol may be further included. The polyhydric alcohol can effectively dissolve octyl gallate, and stabilizes the intercellular lipid component to maintain stability in the formulation for a longer period of time, and helps to prevent the micellar structure from growing into a lamellar structure.

The polyhydric alcohol may be selected from the group consisting of dipropylene glycol, butylene glycol, propylene glycol, glycerin, and mixtures thereof.

The polyhydric alcohol may be contained in an amount of 4 to 10% by weight based on the total weight of the composition.

In the present invention, it may also include conventional cosmetic base ingredients, for example, may further include conventional adjuvants such as stabilizers, solubilizers, vitamins, pigments and fragrances.

Hereinafter, the present invention will be described in detail by way of Examples. However, the following examples only illustrate the present invention, and the content of the present invention is not limited to the following examples.

Reference example One: octyl gallate substance information

[Formula 1]

Compound Name: OCTYL GALLATE;N-OCTYL GALLATE;Stabilizer GA-8;OCTYLGALLATE(RG);Gallic acid octyl;n-Octyl gallate, 98+%;GALLIC ACID OCTYL ESTER;Gallic Acid Octyl Eester;GALLIC ACID N-OCTYL ESTER

CAS No.: 1034-01-1

Example 1 to 2 and comparative example 1 to 2

A cosmetic composition having the composition shown in Table 1 was prepared.

Ingredients (unit: wt%) Example 1 Example 2 Comparative Example 1 Comparative Example 2 octyl gallate 0.03 0.05 - - dipropylene glycol 5.2 5.2 5.2 5.2 Glycosphingolipid 0.35 0.35 0.35 - phospholipid 0.26 0.26 0.26 - cholesterol 0.02 0.02 0.02 - Ceramide 3 0.07 0.07 0.07 - Hydroxyethyl Cellulose appropriate amount appropriate amount appropriate amount appropriate amount Acrylate/C10-30 alkyl acrylate crosspolymer appropriate amount appropriate amount appropriate amount appropriate amount Purified water To 100 To 100 To 100 To 100 chelating agent appropriate amount appropriate amount appropriate amount appropriate amount antiseptic appropriate amount appropriate amount appropriate amount appropriate amount corrector appropriate amount appropriate amount appropriate amount appropriate amount

Experimental example 1. Confirmation of stability of formulation

Formulation stability of the cosmetic compositions prepared in Examples and Comparative Examples was confirmed by the following method.

In order to test the temporal stability of the formulation, each composition was placed in a transparent plastic container and left in a fluorescent chamber at room temperature (25° C.) or high temperature (50° C.) for 2 weeks.

In addition, a cycling test and a freeze-and-thaw (F/T) test were performed.

The cycling test is to test the condition that the storage temperature changes in a 24-hour cycle, and the specific temperature change conditions are as follows: 4 hours in the first step (-10°C), 4 hours in the second step (25°C), and the third step (45 ℃) for 4 hours, 4 hours left at 25°C, and 2 hours for each step change, a total of 24 hours cycle

The F/T test is a method that repeats the process of thawing by keeping it frozen at -20℃, freezing it completely, and then leaving it at room temperature to thaw it. The stability over time of the formulation was evaluated according to the following criteria, and the results are shown in Tables 2 and 3 below.

<Evaluation criteria>

○: good

×: occurrence of gelling

Experimental items Example 1 Example 2 Comparative Example 1 Comparative Example 2 room temperature (25℃) 1 week ○ ○ ○ ○ 2 weeks ○ ○ ○ ○ high temperature (50℃) 1 week ○ ○ ○ ○ 2 weeks ○ ○ ○ ○ cycling 1 week ○ ○ ○ ○ 2 weeks ○ ○ ○ ○ F/T 1 week ○ ○ × ○ 2 weeks ○ ○ × ○ Neon 1 week ○ ○ ○ ○ 2 weeks ○ ○ ○ ○

Comparative Example 2 is a cosmetic that does not use an intercellular lipid component, and has a low water retention capacity. In order to improve this, as in Comparative Example 1, an intercellular lipid component was used to improve water retention ability, but in Comparative Example 1, gelling occurred in the F/T test as shown in Table 2 above. This is due to the intercellular lipid component including ceramide.

In the case of the example containing the intercellular lipid component and octyl gallate together, gelling did not occur at low temperature, because lamellar formation was blocked by octyl gallate, and the gelling phenomenon due to ceramide precipitation did not occur.

Experimental items Example 1 Example 2 Comparative Example 1 Comparative Example 2 F/T Viscosity (cps) 380 350 1,200 300

Table 3 is a result of measuring the F/T viscosity of the compositions according to Examples and Comparative Examples, and the occurrence of the gelling phenomenon can be confirmed by measuring the viscosity.

It can be seen that in Comparative Example 1 in which gelling occurred, there was a difference in viscosity of about 1,000 cps, unlike other examples.

Claims (7)

intercellular lipid components comprising ceramides; and
Cosmetic composition of solubilization formulation comprising a compound represented by the following formula (1)
[Formula 1]

The method of claim 1,
The intercellular lipid component consists of galactosylceramide, sphingosine, cyphingosine, sphinganine, sphingonoid lipid, saturated lecithin, unsaturated lecithin, glycerophospholipid, cholesterol, sitosterol, cholesteryl sulfate, and mixtures thereof. A cosmetic composition of solubilization formulation further comprising one or more selected from the group.
The method of claim 1,
The cosmetic composition of a solubilized formulation, wherein the intercellular lipid component is contained in an amount of 0.1 to 15% by weight based on the total weight of the composition.
The method of claim 1,
A cosmetic composition of a solubilizing formulation, wherein the compound represented by Formula 1 is contained in an amount of 0.01 to 0.10% by weight based on the total weight of the composition.
The method of claim 1,
A cosmetic composition of a solubilization formulation further comprising a polyhydric alcohol.
6. The method of claim 5,
The polyhydric alcohol is a cosmetic composition of a solubilization formulation selected from the group consisting of dipropylene glycol, butylene glycol, propylene glycol, glycerin, and mixtures thereof.
6. The method of claim 5,
The polyhydric alcohol is a cosmetic composition of a solubilized formulation containing 4 to 10% by weight based on the total weight of the composition.