KR102263760B1 - 고도 정제된 다가 불포화 지방산의 제조를 위한 크로마토그래피 방법 - Google Patents

고도 정제된 다가 불포화 지방산의 제조를 위한 크로마토그래피 방법 Download PDF

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KR102263760B1
KR102263760B1 KR1020157032878A KR20157032878A KR102263760B1 KR 102263760 B1 KR102263760 B1 KR 102263760B1 KR 1020157032878 A KR1020157032878 A KR 1020157032878A KR 20157032878 A KR20157032878 A KR 20157032878A KR 102263760 B1 KR102263760 B1 KR 102263760B1
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stream
eluent
chromatographic separation
fatty acid
depleted
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Korean (ko)
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KR20160005046A (ko
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에릭 발레리
필리페 아담
장 블레오
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그룹 노바셉
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Priority claimed from EP13305596.2A external-priority patent/EP2801604B1/en
Priority claimed from US13/897,056 external-priority patent/US8802880B1/en
Priority claimed from US14/149,420 external-priority patent/US9428711B2/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterised by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds or centrifugal chromatography
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/08—Refining

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Fats And Perfumes (AREA)
  • Liquid Carbonaceous Fuels (AREA)
KR1020157032878A 2013-05-07 2014-04-23 고도 정제된 다가 불포화 지방산의 제조를 위한 크로마토그래피 방법 Active KR102263760B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361820459P 2013-05-07 2013-05-07
EP13305596.2 2013-05-07
EP13305596.2A EP2801604B1 (en) 2013-05-07 2013-05-07 Chromatographic process for the production of highly purified polyunsaturated fatty acids
US61/820,459 2013-05-07
US13/897,056 US8802880B1 (en) 2013-05-07 2013-05-17 Chromatographic process for the production of highly purified polyunsaturated fatty acids
US13/897,056 2013-05-17
US14/149,420 US9428711B2 (en) 2013-05-07 2014-01-07 Chromatographic process for the production of highly purified polyunsaturated fatty acids
US14/149,420 2014-01-07
PCT/EP2014/058166 WO2014180654A1 (en) 2013-05-07 2014-04-23 Chromatographic process for the production of highly purified polyunsaturated fatty acids

Publications (2)

Publication Number Publication Date
KR20160005046A KR20160005046A (ko) 2016-01-13
KR102263760B1 true KR102263760B1 (ko) 2021-06-11

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KR1020157032878A Active KR102263760B1 (ko) 2013-05-07 2014-04-23 고도 정제된 다가 불포화 지방산의 제조를 위한 크로마토그래피 방법

Country Status (9)

Country Link
EP (1) EP2994523B1 (enExample)
JP (3) JP6546911B2 (enExample)
KR (1) KR102263760B1 (enExample)
CN (2) CN109679768A (enExample)
CA (1) CA2911273C (enExample)
CL (1) CL2015003247A1 (enExample)
GB (1) GB2528618B (enExample)
PE (2) PE20251531A1 (enExample)
WO (1) WO2014180654A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104529772B (zh) * 2014-12-17 2016-12-07 浙江大学 一种模拟移动床色谱制备高纯度epa酯和dha酯单体的方法
TWI648258B (zh) * 2017-07-10 2019-01-21 喬璞科技有限公司 純化不飽和脂肪酸以及二十碳五烯酸的方法
CN107556187A (zh) * 2017-08-31 2018-01-09 江苏科技大学 β‑环糊精包埋联合模拟移动床色谱分离法制备高纯度α‑亚麻酸的方法
CN112592268B (zh) * 2020-12-18 2022-12-09 江苏汉邦科技股份有限公司 一种利用连续色谱系统分离鱼油中epa的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030222024A1 (en) 2002-02-22 2003-12-04 Novasep Chromatography method and device with recovery of solvent
US20050245405A1 (en) 2004-04-09 2005-11-03 Archer-Daniels-Midland Company Method of preparing fatty acid alkyl esters from waste or recycled fatty acid stock
US20110091947A1 (en) 2008-06-20 2011-04-21 Ak Biotech Co., Ltd. High-Purity Purification Method for Omega-3 Highly Unsaturated Fatty Acids
WO2013005046A1 (en) 2011-07-06 2013-01-10 Basf Pharma (Callanish) Limited Smb process

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5598137A (en) * 1978-10-18 1980-07-25 Procter & Gamble Separation of aliphatic acid ester mixture
US4189442A (en) * 1978-10-18 1980-02-19 The Procter & Gamble Company Separation of fatty acid esters
JPS56115736A (en) * 1980-02-19 1981-09-11 Kagakuhin Kensa Kyokai Separation and purification of eicosapentaenoic acid and docosahexaenoic acid
US4797233A (en) * 1986-08-20 1989-01-10 Uop Inc. Process for separating mono-, di- and triglycerides
JPH0746097B2 (ja) 1988-05-17 1995-05-17 三菱化成エンジニアリング株式会社 クロマト分離法
US5102553A (en) 1988-12-16 1992-04-07 The Amalgamated Sugar Company Time variable simulated moving bed process
CA2159823C (en) * 1993-04-29 2004-08-31 Michel Perrut Processes for chromatographic fractionation of fatty acids and their derivatives
US5630943A (en) 1995-11-30 1997-05-20 Merck Patent Gesellschaft Mit Beschrankter Haftung Discontinuous countercurrent chromatographic process and apparatus
US6063284A (en) 1997-05-15 2000-05-16 Em Industries, Inc. Single column closed-loop recycling with periodic intra-profile injection
JP2000072713A (ja) * 1998-09-01 2000-03-07 Kanto Chem Co Inc 不飽和脂肪酸およびその類縁物質の分離剤
US6413419B1 (en) 1998-10-29 2002-07-02 Institut Francais Du Petrole Process and device for separation with variable-length chromatographic
FR2785196B1 (fr) 1998-10-29 2000-12-15 Inst Francais Du Petrole Procede et dispositif de separation avec des zones chromatographiques a longueur variable
US6375839B1 (en) 1998-10-29 2002-04-23 Institut Francais Du Petrole Process and device for separation with variable-length chromatographic zones
DE10235385B4 (de) 2002-08-02 2006-10-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur chromatographischen Trennung von Komponenten
EP1544612A1 (en) * 2003-12-09 2005-06-22 Agilent Technologies, Inc. Chromatography system and method for operating the same
FR2889077B1 (fr) 2005-07-26 2007-10-12 Novasep Soc Par Actions Simpli Procede et dispositif de separation chromatographique de fractions d'un melange
EP1982752B1 (de) 2007-04-17 2010-08-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Vorrichtung zur chromatographischen Trennung von Komponenten mit teilweiser Rückführung von Gemischfraktionen
EP2519332B1 (en) 2009-12-30 2014-03-05 BASF Pharma (Callanish) Limited Simulated moving bed chromatographic separation process for the purification of polyunsaturated fatty acids
CN102285880B (zh) * 2011-06-14 2014-07-30 国家海洋局第三海洋研究所 Epa乙酯和dha乙酯的制备方法
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
GB201111589D0 (en) * 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
CN102921192B (zh) * 2012-05-16 2014-11-12 中国计量科学研究院 一种制备高纯度单不饱和脂肪酸的方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030222024A1 (en) 2002-02-22 2003-12-04 Novasep Chromatography method and device with recovery of solvent
US20050245405A1 (en) 2004-04-09 2005-11-03 Archer-Daniels-Midland Company Method of preparing fatty acid alkyl esters from waste or recycled fatty acid stock
US20110091947A1 (en) 2008-06-20 2011-04-21 Ak Biotech Co., Ltd. High-Purity Purification Method for Omega-3 Highly Unsaturated Fatty Acids
WO2013005046A1 (en) 2011-07-06 2013-01-10 Basf Pharma (Callanish) Limited Smb process

Also Published As

Publication number Publication date
PE20200389A1 (es) 2020-02-24
CL2015003247A1 (es) 2016-05-27
WO2014180654A1 (en) 2014-11-13
GB2528618A (en) 2016-01-27
CA2911273A1 (en) 2014-11-13
CA2911273C (en) 2021-04-27
CN109679768A (zh) 2019-04-26
GB2528618B (en) 2020-12-23
JP2018141168A (ja) 2018-09-13
CN105229131A (zh) 2016-01-06
JP6546911B2 (ja) 2019-07-17
GB201520373D0 (en) 2016-01-06
JP6867524B2 (ja) 2021-04-28
JP2016523826A (ja) 2016-08-12
EP2994523B1 (en) 2024-02-21
EP2994523A1 (en) 2016-03-16
JP2020090680A (ja) 2020-06-11
PE20251531A1 (es) 2025-06-05
KR20160005046A (ko) 2016-01-13

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