KR102263673B1 - Micro needle patch and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a microneedle patch and a method for manufacturing the same, and by implementing the microneedle to have a two-layer drug structure, the drug injection effect is excellent, and the microneedle is processed using a laser rather than a casting molding method. By etching the shape, very fine microneedles can be easily formed.

Description

Micro needle patch and manufacturing method thereof

The present invention relates to a microneedle that is attached to the skin of a living body and injects a drug into the living body, and more particularly, to a large area microneedle patch and a method for manufacturing the same.

Korean Patent Laid-Open No. 10-2017-0038463 (2017.04.07) describes a method for manufacturing a microneedle. As described in this method, microneedles are mainly used for drug delivery in vivo, blood collection, and detection of analytes in the body. Unlike conventional needles, microneedles are characterized by painless skin penetration and no trauma.

The method proposed in the above publication is to manufacture a microneedle by using a circular plate formed by casting a microneedle shape in an embossed or engraved manner, and it is very difficult to form a very fine microneedle shape by the casting molding method. , because the microneedle has a single-layered drug structure, it was also not excellent in terms of drug injection effect.

Therefore, the present inventors implement the microneedle to have a two-layer drug structure, so that the drug injection effect is excellent, and the microneedle shape is etched by a wafer processing method using a laser rather than a casting method by etching a very fine microneedle. A study was conducted on a technology that can easily mold a microneedle.

Republic of Korea Patent Publication No. 10-2017-0038463 (2017.04.07)

The present invention was invented under the above purpose, and an object of the present invention is to provide a microneedle patch having an excellent drug injection effect by implementing the microneedle to have a two-layer drug structure.

Another object of the present invention is to provide a method for manufacturing a microneedle patch capable of easily forming very fine microneedles by etching the microneedle shape in a wafer processing method using a laser rather than a casting molding method. will do

According to an aspect of the present invention for achieving the above object, a method for manufacturing a micro-needle patch is to etch an acrylic wafer using a laser to produce an acrylic disk having a plurality of micro-needle shapes engraved. Acrylic disk manufacturing step; A large-area thermosetting resin disc manufacturing step of using an acrylic disc having a plurality of engraved microneedle shapes manufactured by the acrylic disc manufacturing step to prepare a large-area thermosetting resin disc having a plurality of engraved microneedle shapes; A needle layer in which a plurality of microneedles of biodegradable material is formed on one surface by dispersing and applying a biodegradable microneedle material to the large-area thermosetting resin original plate manufactured by the large-area thermosetting resin original plate manufacturing step and curing it a needle layer manufacturing step.

According to an additional aspect of the present invention, a laser beam is irradiated to the entire surface of an acrylic wafer on which a titanium (Ti) thin film is deposited through optical beam control in the acrylic disk manufacturing step to melt and etch the surface of the acrylic wafer, thereby making fine grooves on the acrylic wafer surface , and repeat the process of making fine grooves to manufacture an acrylic disk with a number of microneedle patterns engraved on the acrylic wafer.

According to an additional aspect of the present invention, when irradiating a laser beam on the surface of an acrylic wafer in the acrylic disk manufacturing step, if the laser beam is irradiated directly to the position adjacent to the position where the previous laser beam was irradiated, the boundary between the two positions is burned and irregular Therefore, in order to prevent this, the laser beam irradiation position is irradiated while jumping between the plurality of microneedle pattern formation positions.

According to an additional aspect of the present invention, the microneedle may be implemented in a horn shape of a two-layer drug structure in order to increase the effect of drug injection into the skin.

According to an additional aspect of the present invention, the microneedle may be implemented in a quadrangular pyramid shape having a rounded quadrangular surface to increase the surface area.

According to an additional aspect of the present invention, a method for manufacturing a microneedle patch includes a medical layer lamination step of laminating a medical layer made of heat-resistant, abrasion-resistant, solvent-resistant and chemical-resistant material on the other surface of the needle layer; A hydrophilic colloid layer lamination step of laminating a hydrocolloid layer (hydrocolloid layer) to prevent water leakage on the medical layer; The method further includes a pressure-sensitive adhesive sheet adhering step of adhering an adhesive sheet to the hydrophilic colloid layer.

According to another aspect of the present invention, the micro-needle patch includes a needle layer in which a plurality of micro-needles of a biodegradable material are formed on one surface; a medical layer made of heat-resistant, abrasion-resistant, solvent-resistant and chemical-resistant materials laminated on the other surface of the needle layer; a hydrocolloid layer laminated on the medical layer to prevent moisture leakage; and an adhesive sheet adhered to the hydrophilic colloid layer.

The present invention has excellent drug injection effect by implementing the microneedle to have a two-layer drug structure.

In addition, the present invention has the effect of easily forming very fine microneedles by etching the microneedle shape by a wafer processing method using a laser rather than a casting molding method.

1 is a cross-sectional view showing the configuration of an embodiment of the microneedle patch according to the present invention.
2 is a view showing an example of the shape of the microneedle of the microneedle patch according to the present invention.
Figure 3 is a flow chart showing the configuration of an embodiment of the manufacturing method of the microneedle patch according to the present invention.
Figure 4 is a view showing an example of the disk used in the manufacturing method of the microneedle patch according to the present invention.
5 is a view for explaining a laser irradiation position in the method for manufacturing a microneedle patch according to the present invention.
6 is a view illustrating a process in which a microneedle pattern is formed on the surface of an acrylic wafer by the method of manufacturing a microneedle patch according to the present invention.

Hereinafter, the present invention will be described in detail so that those skilled in the art can easily understand and reproduce it through preferred embodiments described with reference to the accompanying drawings. While specific embodiments are illustrated in the drawings and the related detailed description is set forth, they are not intended to limit the various embodiments of the present invention to a specific form.

In describing the present invention, if it is determined that a detailed description of a related well-known function or configuration may unnecessarily obscure the gist of the embodiments of the present invention, the detailed description thereof will be omitted.

When a component is referred to as being “connected” or “connected” to another component, it is understood that the other component may be directly connected or connected to the other component, but other components may exist in between. it should be

On the other hand, when it is mentioned that a certain element is "directly connected" or "directly connected" to another element, it should be understood that the other element does not exist in the middle.

1 is a cross-sectional view showing the configuration of an embodiment of the microneedle patch according to the present invention, Figure 2 is a view showing an example of the microneedle shape of the microneedle patch according to the present invention.

As shown in Figure 1, the microneedle patch 100 according to this embodiment is a needle layer 110, a medical layer 120, and a hydrocolloid layer (hydrocolloid layer) ( 130 , and an adhesive sheet 140 .

The needle layer 110 is formed with a plurality of micro needles 111 made of biodegradable material on one surface. Here, the biodegradable material refers to a drug of a material that is easily decomposed in the skin tissue of the living body when it penetrates the skin of the living body, for example, it may contain a high molecular weight hyaluronic acid and a pharmaceutical or physiological active agent mixed therewith. can

Hyaluronic acid is a powerful moisturizer that is naturally present in the skin as part of collagen and elastin. Hyaluronic acid decreases with age, causing dry skin, sagging skin and wrinkles.

On the other hand, pharmaceuticals include antipyretic analgesics, steroid anti-inflammatory drugs, vasodilators, arrhythmias, blood pressure lowering drugs, local anesthetics, hormones, antihistamines, general anesthetics, sedative analgesics, antiepileptic drugs, psychoneurotic agents, skeletal muscle relaxants, autonomic nerve agents , an antiparkinsonian agent, a diuretic, a vasoconstrictor, a respiratory stimulant, etc. may be used, but is not limited thereto.

On the other hand, as the physiological active agent, a whitening component, an anti-wrinkle component, a blood circulation promoting component, a diet component, an antibacterial component, vitamins, etc. may be used alone or in combination, but is not limited thereto.

The skin is composed of a stratum corneum of 20 μm or less from the epidermis, an epidermis of 100 μm or less, and a dermis of about 300-2,500 μm. The microneedle is smaller than the pore size in order to deliver drugs and skin beauty ingredients to a specific skin layer without pain, and may be implemented to have sufficient hardness for skin penetration. for example. The diameter of the upper end of the microneedles is about 10 μm, the length is about 300 μm, the distance between the micro needles is about 1200 μm, and the number per square centimeter is about 100.

In the case of the present invention, the microneedle 110 may be implemented in a horn shape of a two-layer drug structure as shown in FIG. 2 in order to increase the drug injection effect on the skin. On the other hand, the microneedle may be implemented in a quadrangular pyramid shape having a rounded quadrangular surface in order to increase the surface area. When the microneedle 110 is implemented in the shape of a quadrangular pyramid, the surface area is increased to increase the supporting force at the bottom of the microneedle.

For example, the two-layer drug structure means that the first surface layer of the microneedle 110 forms a layered structure to surround the inner second layer, for example, the first surface layer of the microneedle 110 is hyaluronic acid, the inner second layer Silver may be a pharmaceutical or a physiologically active agent.

The medical layer 120 is a moisture absorption layer made of a heat-resistant, abrasion-resistant, solvent-resistant and chemical-resistant material laminated on the other surface of the needle layer 110 . For example, the medical layer 120 may be a polyurethane (PolyUrethane) resin having excellent heat resistance, abrasion resistance, solvent resistance, and chemical resistance.

The hydrophilic colloidal layer 130 is laminated on the medical layer 120 to prevent moisture leakage. A hydrocolloid refers to a state or substance in which the dispersion medium is water among colloids. A substance whose diffusion and dialysis rate is significantly slow in aqueous solution is called a colloid, and refers to a generic term for gels, sols, emulsions, suspensions, creams, and foams in which liquid substances are in a dispersed state.

The adhesive sheet 140 is adhered to the hydrophilic colloid layer 130 . The adhesive sheet 140 may be a film type having an adhesive force, and the needle layer 110, the medical layer 120, and the hydrophilic colloidal layer 130 are protected from the outside to protect the needle layer 110 and the medical layer. 120 and the hydrophilic colloid layer 130 are prevented from being damaged and attached to the skin of the living body.

By implementing in this way, the present invention can provide a microneedle patch having an excellent drug injection effect by implementing the microneedle to have a two-layer drug structure.

In addition, in the conventional case, the microneedle patch was implemented only with the microneedle layer and the adhesive sheet, but in the present invention, the microneedle patch further implements a medical layer and a hydrophilic colloid layer between the microneedle layer and the adhesive sheet, so that the microneedle layer is formed. It is possible to prevent leakage of moisture contained in the biodegradable material, thereby providing a better microneedle patch.

On the other hand, according to an additional aspect of the invention, the microneedle patch 100 may further include a protection sheet (protection sheet) (150). The protective sheet 150 is for protecting the microneedles 111 and prevents the microneedles 111 formed in plurality on the microneedle layer 110 from being crushed by external pressure.

For example, the protective sheet 150 is attached to one surface of the microneedle layer 110, and a receiving groove having a depth greater than or equal to the length of the microneedle 111 is formed in the inner edge to prevent the microneedles 111 from being crushed by external pressure. It may be implemented in the form of a case made of a material that does not warp, but is not limited thereto.

When using the micro-needle patch 100, the user removes the protective sheet 150 from the micro-needle layer 110 and attaches the micro-needle 111 to the skin of the living body in a state where the micro-needle 111 is exposed.

Then, the horn-shaped microneedles 111 of the two-layer drug structure formed in plurality in the microneedle layer 110 are injected through the pores of the skin of the living body, and the biodegradable microneedles 111 in the skin tissue of the living body. ) are decomposed and a high molecular weight hyaluronic acid and a pharmaceutical or bioactive agent mixed therein are injected into the living body.

A method of manufacturing the microneedle patch as described above will be described with reference to FIGS. 3 and 4 . Figure 3 is a flow chart showing the configuration of an embodiment of the manufacturing method of the microneedle patch according to the present invention, Figure 4 is a view showing an example of the disks used in the manufacturing method of the microneedle patch according to the present invention.

As shown in FIG. 3 , the method for manufacturing a microneedle patch according to the present invention includes a step 210 for producing an acrylic disc, a step 220 for manufacturing a large-area thermosetting resin disc, and a step 230 for manufacturing a needle layer. .

First, the acrylic wafer is etched using a laser (not shown) in the acrylic disk manufacturing step 210 to produce an acrylic disk having a plurality of micro needle shapes engraved as shown in FIG. 4 (a). do.

Acrylic resin is a type of plastic and has a lower price and lower melting temperature than metals. Therefore, in the case of using an acrylic disk, the material price is lower than that of a conventional metal disk mold for electric poles.

In addition, when the microneedle shape is etched by a wafer processing method using a laser rather than a casting molding method, very fine microneedles can be easily formed at a low cost compared to a casting molding method.

For example, in the acrylic original plate manufacturing step 210, a titanium (Ti) thin film is deposited on both sides of the acrylic wafer to prevent laser reflection, and a copper (Cu) thin film is additionally deposited on the rear surface of the acrylic wafer on which the titanium (Ti) thin film is deposited. increase the rigidity.

In this state, through the optical beam control of a fine power laser (not shown), a laser beam is irradiated to the entire surface of the acrylic wafer on which the titanium (Ti) thin film is deposited, and the acrylic wafer surface is melted and etched to make a fine groove on the acrylic wafer surface. . By repeating the process of making such fine grooves, it is possible to manufacture an acrylic disk in which a plurality of micro-needle patterns are engraved on an acrylic wafer.

5 is a view for explaining a laser irradiation position in the method for manufacturing a microneedle patch according to the present invention. When irradiating the laser beam on the surface of the acrylic wafer, if the laser beam is irradiated directly to the position adjacent to the position where the previous laser beam was irradiated, the boundary between the two positions is burnt and irregular, so the intended microneedle pattern is not formed.

Therefore, as shown in FIG. 5, the laser beam irradiation position is irradiated while jumping between the plurality of microneedle pattern formation positions so that the laser beam is not directly irradiated to the position adjacent to the previous laser beam irradiated position. Prevents the location boundary from becoming irregular. The numbers in FIG. 5 indicate the laser beam irradiation order.

6 is a view illustrating a process of forming a microneedle pattern on the surface of an acrylic wafer by the method of manufacturing a microneedle patch according to the present invention. First, when the laser beam is irradiated to the surface of the acrylic wafer while jumping the laser beam irradiation position between the plurality of microneedle pattern formation positions, the microneedle pattern starts to be formed on the surface of the acrylic wafer as shown in FIG. 6(a).

If this process is repeated on the first layer of the acrylic wafer surface, the microneedle pattern is formed on the top of the acrylic wafer surface as shown in FIGS. Then, while jumping the laser beam irradiation position between the plurality of micro-needle pattern formation positions with a width smaller than the upper end of the micro-needle pattern, the micro-needle pattern forms a middle portion to form a step with the upper end of the micro-needle pattern as shown in FIG. do.

Then, while jumping the laser beam irradiation position between the plurality of microneedle pattern formation positions with a width smaller than the middle portion of the microneedle pattern, the microneedle pattern is formed at the lower end to form a step with the middle portion of the microneedle pattern as shown in (e) of FIG. to form

When the acrylic disc is manufactured by the acrylic disc manufacturing step 210, the microneedle shape manufactured by the acrylic disc manufacturing step 210 in the large-area thermosetting resin disc manufacturing step 220 is engraved using a plurality of acrylic discs. A large-area thermosetting resin disk having a plurality of microneedle-shaped arrays engraved as shown in (e) of FIG. 4 is prepared.

At this time, the large-area thermosetting resin original plate manufacturing step 220 may be implemented in the following detailed steps. First, a thermosetting resin such as UV resin is uniformly applied to a small-area acrylic plate having a plurality of microneedle shapes engraved in the acrylic disc manufacturing step 210 in the small-area embossed resin disc manufacturing step 221, and then By curing, one small-area thermosetting embossed resin plate having the same area as the acrylic plate as shown in (b) of FIG. 4 , and having a plurality of microneedle shapes embossed is prepared.

Then, after uniformly applying a thermosetting resin such as UV resin to one small-area embossed resin disc manufactured by the small-area embossed resin disc manufacturing step 221 in the small-area embossed resin disc manufacturing step 222, uniformly Repeat the curing process to produce a plurality of small-area thermosetting embossed resin discs having the same area as a small-area thermosetting embossed resin disc, but having a plurality of microneedle shapes engraved.

Then, in the small-area engraved resin disc arranging step 223, a plurality of small-area engraved resin discs manufactured by the manufacturing step 222 of the small-area engraved resin discs have a large area as shown in FIG. 4(c). arrange

Then, in the large-area embossed resin disc manufacturing step 224, a thermosetting resin such as a UV resin is uniformly applied to a plurality of small-area thermosetting engraved resin discs arranged by the small-area engraved resin disc arranging step 223. After curing, a large-area embossed resin original plate having a plurality of microneedle-shaped arrays as shown in FIG. 4(d) is embossed to prepare.

Then, in the large-area embossed resin disc manufacturing step 225, a large-area embossed resin disc having a plurality of micro-needle-shaped arrays manufactured by the large-area embossed resin disc manufacturing step 224 is embossed with a thermosetting resin such as a UV resin. After uniformly applied and cured, a large-area engraved resin original plate having a plurality of engraved microneedle-shaped arrays as shown in FIG. 4(e) is prepared.

At this time, through the acrylic disk manufacturing step 210, a plurality of acrylic disks having a plurality of microneedle shapes are manufactured, and by arranging them, a large area intaglio resin disk having a plurality of microneedle shapes intaglio is manufactured. Although the above detailed steps may be omitted, the manufacturing cost becomes high because a plurality of acrylic disks must be manufactured through wafer processing.

When a large-area thermosetting resin disc having a plurality of micro-needle-shaped arrays engraved by the manufacturing step 220 of the large-area thermosetting resin disc is manufactured, the large-area thermosetting resin disc manufacturing step 220 in the needle layer manufacturing step 230 by After dispersing and applying the biodegradable microneedle material to the prepared large-area thermosetting resin disk, it is cured to prepare a needle layer in which a plurality of biodegradable microneedles are formed on one surface.

A plurality of micro-needles made of biodegradable material are formed on one surface of the needle layer manufactured by the needle layer manufacturing step 230 . Here, the biodegradable material refers to a drug of a material that is easily decomposed in the skin tissue of the living body when it penetrates the skin of the living body, and may include, for example, a high molecular weight hyaluronic acid and a pharmaceutical agent or a bioactive agent mixed therewith. can

Hyaluronic acid is a powerful moisturizer that is naturally present in the skin as part of collagen and elastin. Hyaluronic acid decreases with age, causing dry skin, sagging skin and wrinkles.

On the other hand, pharmaceuticals include antipyretic analgesics, steroid anti-inflammatory drugs, vasodilators, arrhythmias, blood pressure lowering drugs, local anesthetics, hormones, antihistamines, general anesthetics, sedative analgesics, antiepileptic drugs, psychoneurotic agents, skeletal muscle relaxants, autonomic nerve agents , an antiparkinsonian agent, a diuretic, a vasoconstrictor, a respiratory stimulant, etc. may be used, but is not limited thereto.

On the other hand, as the physiological active agent, a whitening component, an anti-wrinkle component, a blood circulation promoting component, a diet component, an antibacterial component, vitamins, etc. may be used alone or in combination, but is not limited thereto.

The skin is composed of a stratum corneum of 20 μm or less from the epidermis, an epidermis of 100 μm or less, and a dermis of about 300-2,500 μm. The microneedle is smaller than the pore size in order to deliver drugs and skin beauty ingredients to a specific skin layer without pain, and may be implemented to have sufficient hardness for skin penetration. for example. The diameter of the upper end of the microneedles is about 10 μm, the length is about 300 μm, the spacing between the micro needles is about 1200 μm, and the number of microneedles per square centimeter may be about 100.

In the case of the present invention, the microneedle may be implemented in a horn shape of a two-layer drug structure in order to increase the effect of drug injection into the skin. On the other hand, the microneedle may be implemented in a quadrangular pyramid shape having a rounded quadrangular surface in order to increase the surface area. When the microneedle is implemented in the shape of a square pyramid, the surface area increases and the supporting force at the bottom of the microneedle increases.

For example, the two-layer drug structure means to form a layered structure so that the inner first layer of the microneedle is surrounded by the second surface layer, for example, the inner first layer of the microneedle is hyaluronic acid, and the second surface layer is pharmaceutical or physiologically active. can be the best

For example, in the needle layer manufacturing step 230, hyaluronic acid is first uniformly dispersed and applied to the large-area thermosetting resin original plate manufactured by the large-area thermosetting resin original plate manufacturing step 220, and then cured, and then a pharmaceutical agent or A two-layer drug structure microneedle can be formed by uniformly dispersing and applying a bioactive agent and then curing it.

By implementing in this way, the present invention can easily form very fine microneedles by etching the microneedle shape in a wafer processing method using a laser rather than a casting molding method.

Meanwhile, according to an additional aspect of the invention, the method for manufacturing the microneedle patch may further include a medical layer lamination step 240 , a hydrophilic colloidal layer lamination step 250 , and an adhesive sheet adhesion step 260 .

When a needle layer in which a plurality of microneedles of a biodegradable material are formed on one surface is manufactured by the needle layer manufacturing step 230 , heat resistance, abrasion resistance, solvent resistance and chemical resistance material on the other surface of the needle layer in the medical layer lamination step 240 . of the medical layer is laminated.

The medical layer is a moisture-absorbing layer made of heat-resistant, abrasion-resistant, solvent-resistant and chemical-resistant materials that are laminated on the other surface of the needle layer. For example, the medical layer may be a polyurethane (PolyUrethane) resin excellent in heat resistance, abrasion resistance, solvent resistance and chemical resistance.

Next, in the hydrophilic colloid layer stacking step 250 , a hydrocolloid layer for preventing water leakage is deposited on the medical layer. The hydrophilic colloidal layer is laminated on the medical layer to prevent moisture leakage.

A hydrocolloid refers to a state or substance in which the dispersion medium is water among colloids. A substance whose diffusion and dialysis rate is significantly slow in aqueous solution is called a colloid, and refers to a generic term for gels, sols, emulsions, suspensions, creams, and foams in which liquid substances are in a dispersed state.

Next, in the adhesive sheet adhesion step 260 , an adhesive sheet is adhered to the hydrophilic colloid layer. The adhesive sheet is adhered to the hydrophilic colloid layer. As the adhesive sheet, a film type having adhesive strength can be used, and it protects the needle layer, the medical layer, and the hydrophilic colloid layer from the outside to prevent damage to the needle layer, the medical layer, and the hydrophilic colloid layer, and at the same time protect the skin of the living body. is attached

By implementing in this way, the present invention can provide a microneedle patch having an excellent drug injection effect by implementing the microneedle to have a two-layer drug structure.

In addition, in the conventional case, the microneedle patch was implemented only with the microneedle layer and the adhesive sheet, but in the present invention, the microneedle patch further implements a medical layer and a hydrophilic colloid layer between the microneedle layer and the adhesive sheet, so that the microneedle layer is formed. It is possible to prevent leakage of moisture contained in the biodegradable material, thereby providing a better microneedle patch.

On the other hand, according to an additional aspect of the invention, the manufacturing method of the microneedle patch may further include the step of attaching a protection sheet (protection sheet) (270). The protective sheet is for protecting the microneedles, and prevents the microneedles formed in plurality on the microneedle layer from being crushed by external pressure.

For example, in the step of attaching the protective sheet 270, a receiving groove having a depth greater than or equal to the length of the microneedle is formed on the inner edge to prevent the microneedle from being crushed by external pressure. It may be attached to one surface of the microneedle layer, but is not limited thereto.

When using the microneedle patch, the user removes the protective sheet from the microneedle layer and attaches the microneedles to the skin of the living body while the microneedles are exposed.

Then, the horn-shaped microneedles of the two-layer drug structure formed in a plurality of the microneedle layer are injected through the pores of the skin of the living body, and the biodegradable microneedles are decomposed in the skin tissue of the living body, so that the high molecular weight hyaluronic acid (hyaluronic acid) and a pharmaceutical or physiologically active agent mixed therewith are added.

As described above, in the present invention, the drug injection effect is excellent by implementing the microneedle to have a two-layer drug structure.

In addition, the present invention has the effect of easily forming very fine microneedles by etching the microneedle shape by a wafer processing method using a laser rather than a casting molding method.

The various embodiments disclosed in the present specification and drawings are merely presented as specific examples to aid understanding, and are not intended to limit the scope of various embodiments of the present invention.

Accordingly, the scope of various embodiments of the present invention, in addition to the embodiments described herein, all changes or modifications derived based on the technical idea of various embodiments of the present invention are included in the scope of various embodiments of the present invention. should be interpreted as being

The present invention can be industrially used in the field of microneedle-related technology that is attached to the skin of a living body and injects a drug into the living body and its application technology.

100: microneedle patch
110: needle layer
111: micro needle
120: medical layer
130: hydrophilic colloid layer
140: adhesive sheet
150: protective sheet

Claims (8)

An acrylic plate manufacturing step of etching an acrylic wafer using a laser to produce an acrylic plate having a plurality of micro needle shapes engraved;
A large-area thermosetting resin disc manufacturing step of using an acrylic disc having a plurality of engraved microneedle shapes manufactured by the acrylic disc manufacturing step to prepare a large-area thermosetting resin disc having a plurality of engraved microneedle shape arrangements;
After dispersing and applying the biodegradable microneedle material to the large-area thermosetting resin original plate manufactured by the large-area thermosetting resin original plate manufacturing step, it is cured to produce a needle layer in which a plurality of biodegradable microneedles are formed on one surface a needle layer manufacturing step;
including,
In the manufacturing stage of the acrylic disc:
Through optical beam control, a laser beam is irradiated to the entire surface of the acrylic wafer on which a titanium (Ti) thin film is deposited, and the acrylic wafer surface is melted and etched to make fine grooves on the surface of the acrylic wafer. A method of manufacturing a micro-needle patch for manufacturing an acrylic disk on which a plurality of micro-needle patterns are engraved. delete The method of claim 1,
In the manufacturing stage of the acrylic disc:
When irradiating the laser beam on the surface of the acrylic wafer, if the laser beam is irradiated directly to the position adjacent to the previous laser beam irradiated position, the boundary between the two positions will burn and become irregular. A method of manufacturing a microneedle patch that irradiates while jumping between needle pattern formation positions. The method of claim 1,
Microneedle:
A method of manufacturing a microneedle patch implemented in the shape of a horn of a two-layer drug structure to increase the effect of drug injection into the skin The method of claim 1,
Microneedle:
A method of manufacturing a microneedle patch implemented in the shape of a quadrangular pyramid having a rounded quadrangular surface to increase the surface area. The method of claim 1,
A method of making a microneedle patch is:
A medical layer lamination step of laminating a medical layer made of heat-resistant, abrasion-resistant, solvent-resistant and chemical-resistant material on the other surface of the needle layer;
A hydrophilic colloid layer stacking step of laminating a hydrocolloid layer (hydrocolloid layer) to prevent water leakage on the medical layer;
Adhesive sheet adhesion step of adhering the adhesive sheet (adhesive sheet) to the hydrophilic colloid layer;
A method of manufacturing a microneedle patch further comprising. A microneedle patch produced by the method for producing a microneedle patch according to any one of claims 1 to 6. 8. The method of claim 7,
Microneedle patches are:
A needle layer in which a plurality of micro-needles made of biodegradable material are formed on one surface;
a medical layer made of heat-resistant, abrasion-resistant, solvent-resistant and chemical-resistant materials laminated on the other surface of the needle layer;
a hydrocolloid layer laminated on the medical layer to prevent water leakage;
an adhesive sheet adhered to the hydrophilic colloid layer;
Microneedle patch included.

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