KR101590613B1 - A constant temparature and humidiyt type microniddle patch - Google Patents
A constant temparature and humidiyt type microniddle patch Download PDFInfo
- Publication number
- KR101590613B1 KR101590613B1 KR1020150101639A KR20150101639A KR101590613B1 KR 101590613 B1 KR101590613 B1 KR 101590613B1 KR 1020150101639 A KR1020150101639 A KR 1020150101639A KR 20150101639 A KR20150101639 A KR 20150101639A KR 101590613 B1 KR101590613 B1 KR 101590613B1
- Authority
- KR
- South Korea
- Prior art keywords
- base film
- polymer material
- water
- adhesive sheet
- micro needle
- Prior art date
Links
- 239000000853 adhesive Substances 0.000 claims abstract description 33
- 230000001070 adhesive effect Effects 0.000 claims abstract description 33
- 230000004888 barrier function Effects 0.000 claims abstract description 32
- 239000002861 polymer material Substances 0.000 claims description 40
- 229920003169 water-soluble polymer Polymers 0.000 claims description 29
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 15
- 229920001600 hydrophobic polymer Polymers 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 10
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 6
- -1 polyethylene Polymers 0.000 claims description 6
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 6
- 229920002635 polyurethane Polymers 0.000 claims description 6
- 230000035699 permeability Effects 0.000 claims description 5
- 229920001083 polybutene Polymers 0.000 claims description 4
- 229920000120 polyethyl acrylate Polymers 0.000 claims description 4
- 229920002319 Poly(methyl acrylate) Polymers 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 229920005593 poly(benzyl methacrylate) Polymers 0.000 claims description 3
- 229920000205 poly(isobutyl methacrylate) Polymers 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920000129 polyhexylmethacrylate Polymers 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 229920001483 poly(ethyl methacrylate) polymer Polymers 0.000 claims description 2
- 229910052602 gypsum Inorganic materials 0.000 claims 1
- 239000010440 gypsum Substances 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 21
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 20
- 239000000416 hydrocolloid Substances 0.000 description 20
- 239000004372 Polyvinyl alcohol Substances 0.000 description 19
- 238000004519 manufacturing process Methods 0.000 description 19
- 229920002451 polyvinyl alcohol Polymers 0.000 description 19
- 239000001768 carboxy methyl cellulose Substances 0.000 description 18
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 18
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 18
- 229940105329 carboxymethylcellulose Drugs 0.000 description 18
- 230000008859 change Effects 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 239000004814 polyurethane Substances 0.000 description 14
- 239000000243 solution Substances 0.000 description 13
- 239000007788 liquid Substances 0.000 description 11
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 9
- 238000010586 diagram Methods 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 7
- 229920002674 hyaluronan Polymers 0.000 description 7
- 229960003160 hyaluronic acid Drugs 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 229920002678 cellulose Polymers 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000002253 acid Substances 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000000465 moulding Methods 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 229940023476 agar Drugs 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 239000000420 anogeissus latifolia wall. gum Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 229920003086 cellulose ether Polymers 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 235000019314 gum ghatti Nutrition 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 229920001277 pectin Polymers 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 2
- 229920001308 poly(aminoacid) Polymers 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920002689 polyvinyl acetate Polymers 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
- A61F13/0243—Adhesive bandages or dressings wound covering film layers without a fluid retention layer characterised by the properties of the skin contacting layer, e.g. air-vapor permeability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
BACKGROUND OF THE
Recently, in order to solve the problem of injecting a drug using a needle, which is a pain at the injection site, local damage of the skin, hemorrhage, and infection at the injection site, a micro needle (micro needle, microneedle) have been proposed.
The microstructure is a patch-type analgesic injection system for injecting drugs without pain with a micro needle as a structure for efficiently delivering drugs delivered through the skin.
Such microstructures must be used for a certain period of time (for example, 30 minutes to 8 hours or more) by contacting the skin surface (especially the face area) of the human body. In order to securely adhere and maintain the skin to the skin, A patch type micro needle patch is often used.
1 is a conceptual diagram of a general micro needle patch.
1, a typical micro needle patch is composed of a pressure sensitive adhesive sheet to be adhered to the skin, a base sheet which is provided on the adhesive sheet to form a micro needle, and a plurality of micro needles formed on the base sheet .
The adhesive sheet is a hydrocolloid adhesive product which is difficult to use as a general adhesive product and is a wettable dressing material which is applied as a medicine.
The base sheet is mainly made of, for example, a nonwoven fabric, a PU film, or the like as a substrate for forming microneedles.
The following technique has been known as a method of manufacturing the micro needle of the micro needle patch.
Fig. 2 is a conceptual diagram of a method of manufacturing a micro needle according to the prior art.
The method of manufacturing the microneedles disclosed in Fig. 2 is a method of producing a microneedle using a needle solution such as a hyaluronic acid (hereinafter referred to as " hyaluronic acid ") liquid or a complex polysaccharide composed of amino acid and uronic acid or a biodegradable A raw material is injected and rotated by a centrifugal separator to impart a centrifugal force so that the needle liquid is injected into the engraved mold, and then the nonwoven fabric is attached, dried, and separated from the mold.
However, in the method of injecting a liquid into the mold as described above, centrifugal force is applied to the mold by a centrifugal separator, and then a nonwoven fabric (base sheet) is adhered to the bottom surface of the needle, There is a problem that it can not be done.
In addition, the needles may be lost in the process of separating the micro needles from the mold, and the needles may be lost when the knife is cut in a certain shape because they are attached to the nonwoven fabric.
Furthermore, the method disclosed in Fig. 2 basically has a problem in that productivity is not good because a mold is used.
A technique for solving the problem of the method of manufacturing the micro needle using the mold disclosed in Fig. 2 is schematically shown in Fig.
As shown in FIG. 3, in a method of manufacturing a micro needle according to another conventional technique, a biodegradable raw material liquid such as hyaluronic acid is distributed on a base sheet formed of a PU film and faced to both sides (Fig. 3 (b)], the liquids are brought into contact with each other (Fig. 3 (B)) and slowly pulled out The micro-droplet is grounded on one surface of the application surface, and then pulled slowly to the opposite side so that the droplet has the shape of a needle.
In the advanced production method of forming the shape of the needle by spitting and pulling the microneedle solution on the base sheet of the PU film as described above, an appropriate coupling force between the needle solution and the base sheet, The contact angle (also referred to as an incident angle) when the needle liquid contacts the surface of the base sheet for forming the needle liquid is very important. This contact angle is formed by the bonding force and the repulsive force between the surface of the base sheet and the needle liquid do.
4A and 4B are diagrams for explaining the concept of the contact angle of the needle liquid. FIG. 4A shows an example in which the bonding force is too weak and the contact angle a is too large. In FIG. 4B, An example of the case where the bonding force is too strong and the contact angle b is too small is shown.
As shown in Fig. 4, the contact angle refers to the angle formed by the straight line and the solid surface when a straight line between the solid (base sheet), liquid (needle liquid) and gas (atmosphere) .
However, in the case of using the conventional PU film, there is a problem that the hydrophilic property is not matched and an optimum contact angle (and thus bonding force) can not be realized.
In order to match this, an appropriate contact angle was maintained by adjusting the hydrophilic property on the base sheet of the PU film by using a plasma processing method or the like.
However, there is a problem in that productivity is deteriorated due to the use of expensive plasma equipment, and there is also a problem in that it is difficult to maintain an appropriate contact angle of the needles.
On the other hand, the above conventional techniques have been difficult to maintain a constant water content.
In the case where the base film is made of a water soluble polymer material in a micro needle patch, moisture exchange with a wettable adhesive sheet (e.g., hydrocolloid) occurs.
That is, as shown in FIG. 5, the water moves from the water-soluble base film to the wettable adhesive sheet (hydrocolloid) or vice versa. As a result, the base film is crumpled, peeled off from the adhesive sheet, There arises a problem of warping.
Micro needle patch The entire process until the product is completed and sold, for example, the conditions of goods receipt, storage, production room, post-production storage condition, packaging condition, The water content of the water-soluble base film and the water content of the hydrocolloid, which is a hydrophilic wet dressing material, are changed in accordance with the environmental change of the external temperature and humidity. This is because the water molecules move from one side to the other .
Especially, when exporting to Europe, Americas, etc., the change of temperature and humidity becomes very severe and it is difficult to prevent the water movement due to the change of temperature even if the packaging is completely completed. As a result, the product may have wrinkles , The water-soluble base film may peel off from the wettable pressure-sensitive adhesive sheet (hydrocolloid).
The object of the present invention is to provide a constant temperature and humidity micro needle patch of the present invention,
First, by forming a barrier film on the base film, it is possible to fundamentally block the occurrence of water exchange due to the change in the ambient temperature and humidity at the contact layer between the base film and the wettable adhesive sheet (e.g., hydrocolloid) The problem of wrinkling and distortion of the base film can be solved at once,
Second, by forming a barrier film on the base film, it is possible to enhance the stability of the product by increasing the degree of reinforcement of the product,
Third, the barrier film is made of a hydrophobic polymer compound including a flexible and soft polyurethane, so that the original shape can be stably maintained even when the water content is very low.
Fourthly, the base film is configured to include a water-soluble polymer material and a gum-like hydrophilic polymer material, and the relative weight ratio of the hydrophilic polymer material to the weight of the water-soluble polymer material is adjusted, To be adjusted,
Fifth, the micro needle solution on the base film for forming the micro needles can have an optimal contact angle for microneedle formation, so that the microneedle solution maintains a proper bonding force with the base film and is stable So that it can be seated on the base film,
Sixth, by forming an optimal contact angle having an appropriate bonding force, it is possible to remarkably reduce the defective rate of the micro needle, to mold the micro needle with excellent quality,
Seventh, since it is difficult to realize a proper contact angle with a substrate (base sheet) during conventional micro needle molding, it is possible to reduce time and cost loss due to hydrophilic property imparted to a general PU film by plasma processing or the like, Temperature micro-needle patch which is suitable to be able to realize the maximization of the temperature and humidity.
To achieve the above object, the present invention provides a thermosensitive and microreactive micro needle patch comprising a pressure sensitive adhesive sheet to be adhered to the skin, a base film to be adhered to the pressure sensitive adhesive sheet, and a plurality of micro needles to be formed on the base film The microneedle patch further comprises a barrier layer formed between the adhesive sheet and the base film to block moisture from being transferred or exchanged between the adhesive sheet and the base film.
The constant temperature and humidity micro needle patch of the present invention is characterized in that the barrier layer is formed by the bottom coating or laminating of the base film.
The constant temperature and humidity micro needle patch of the present invention is characterized in that the barrier layer comprises a hydrophobic polymer material.
The constant temperature and humidity type micro needle patch of the present invention is characterized in that the hydrophobic polymer material is at least one selected from the group consisting of polyurathane, polyester, polyethylene, polypropylene, polymethylacrylate, polyethylacrylate, polyethylacrylate, polybenzylmethacrylate, polyethylmethacrylate, polyhexyl methacrylate, polyisobutyl methacrylate, polymethyl methacrylate, or poly Butenes, and poly butenes.
In the constant temperature and humidity micro needle patch of the present invention, the total thickness of the base film and the barrier layer is 20 to 2,000 μm.
In the constant temperature and humidity micro needle patch of the present invention, the barrier layer has a moisture permeability of 2,000 (g /
The constant temperature and humidity type micro needle patch of the present invention is characterized in that the base film comprises a water-soluble polymer material.
The constant temperature and humidity type micro needle patch of the present invention is characterized in that the base film further comprises a gum-like hydrophilic polymer substance in the water-soluble polymer substance.
The constant temperature and humidity type micro needle patch of the present invention is characterized in that the amount of the hydrophilic polymer to be gum is 0.1 to 10 parts by weight based on 100 parts by weight of the water soluble polymer material.
The constant temperature and humidity type micro needle patch of the present invention is characterized in that the base film has 0.1 to 10 parts by weight of a gummy hydrophilic polymer per 100 parts by weight of the water soluble polymer material.
The constant temperature and humidity type micro needle patch of the present invention is characterized in that the water soluble polymer material is at least one selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone, polyalkylene oxides, acrylamide, But are not limited to, acrylic acid, cellulose, cellulose ethers, cellulose esters, cellulose amides, polyvinyl acetates, polycarboxylic acids, And is at least one selected from the group consisting of polyaminoacids polyamides and polyacrylamides.
The constant temperature and humidity type micro needle patch of the present invention is characterized in that the gummy hydrophilic polymer substance is at least one selected from the group consisting of carboxymethyl cellulose, agar, alginate, guar gum, pectin, xanthan gum, ghatti gum, or carrageenan.
The constant temperature and humidity type micro needle patch of the present invention having the above-described structure has the following effects.
First, by forming the barrier film on the base film, it is possible to prevent water exchange due to the change in the ambient temperature and humidity at the contact layer between the base film and the wettable adhesive sheet (e.g., hydrocolloid).
As a result, the problem of peeling between the base film and the pressure-sensitive adhesive sheet and the problem of wrinkle generation and warping of the base film can be solved.
Secondly, by forming a barrier film on the base film, the degree of reinforcement of the product is increased, thereby enhancing the stability of the product.
Third, since the barrier film is made of a hydrophobic polymer compound including a soft and soft polyurethane, it is possible to maintain the original shape stably even with a slight change in moisture content.
Fourthly, the base film is constructed to include a water-soluble polymer material and a gum-like hydrophilic polymer material, and the relative weight ratio of the water-soluble polymer material to the weight of the water-soluble polymer material is adjusted, It is possible to control the contact angle of the micro needle with respect to the film.
Fifth, by adjusting the relative weight ratio of the hydrophilic polymer substance to the weight of the water-soluble polymer substance to adjust the contact angle of the micro-needle to the base film, the micro needle solution on the base film for forming the micro- An optimum contact angle can be realized.
As a result, there is an effect that the microneedle solution maintains a proper bonding force with the base film and can be stably mounted on the base film even after the microneedle is finally formed.
Sixthly, it is possible to remarkably reduce the defective rate of the micro needle by forming the optimum contact angle having an appropriate bonding force, and it is also possible to form a micro needle with excellent quality.
Seventh, since it is difficult to realize a proper contact angle with a base material (base sheet) during conventional micro needle molding, it is possible to reduce the time and cost loss due to hydrophilic property imparted to a general PU film through plasma processing or the like, The present invention has the effect of maximizing the number
1 is a conceptual diagram of a general micro needle patch.
2 is a conceptual diagram of a method for manufacturing a micro needle according to the prior art.
3 is a process conceptual diagram of a method of manufacturing a micro needle according to another conventional technique.
4A and 4B are diagrams for explaining the concept of the contact angle of the microneedles. FIG. 4A shows an example of a case where the bonding force is too weak and the contact angle a is too large. In FIG. 4B, An example of the case where the bonding force is too strong and the contact angle b is too small is shown.
Fig. 5 is a conceptual diagram showing how moisture is transferred or exchanged between a base film and an adhesive sheet when a base film is constituted of a water-soluble base film in a micro needle patch.
6 is a configuration diagram of a constant temperature and humidity type micro needle patch according to an embodiment of the present invention.
7 is a graph showing changes in the adhesive force between the base film and the hydrocolloid in which the barrier layer is formed in [Manufacturing Example 1] according to the change of time in the closed space high humidity and the adhesion force between the base film and the hydrocolloid in [Comparative Example 1] It is a change graph.
8 is an exemplary view showing a contact angle c in a constant temperature and humidity type micro needle patch according to an embodiment of the present invention.
FIG. 9 is a contact angle test example using a constant temperature and humidity type microneedle patch according to an embodiment of the present invention, and is a contact angle graph of a base film and a hyaluronic acid solution according to a relative weight ratio of CMC to 100 parts by weight of PVA.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A preferred embodiment of a constant temperature and humidity type micro needle patch of the present invention will be described in detail below with reference to the accompanying drawings.
5, the constant temperature and humidity type micro needle patch according to an embodiment of the present invention includes a pressure sensitive
According to this, it is possible to fundamentally block the occurrence of water exchange due to the change in the ambient temperature and humidity in the contact layer between the base film (in particular, the water-soluble base film) and the wettable adhesive sheet (hydrocolloid, for example) The problem of peeling between the base film and the wrinkles of the base film and the distortion problem can be solved at once.
The
In the
In the constant temperature and humidity type micro needle patch according to an embodiment of the present invention, the hydrophobic polymer material is at least one selected from the group consisting of polyurathane, polyester, polyethylene, polypropylene, polymethylacrylate Polyethylacrylate, polybenzylmethacrylate, polyethylmethaacrylate, polyhexylmethacrylate, polyisobutylmethacrylate, polymethylmethacrylate, polymethylmethacrylate, polymethylmethacrylate, polymethylmethacrylate, ) Or polybutenes (that is, any one of a plurality of the compounds described above, or a combination of two or more of the above-described plurality of compounds, which has the same meaning throughout the specification) Is used].
In this case, the hydrophobic polymer material described above is merely exemplified as a hydrophobic polymer compound. If the hydrophobic polymer compound has a hydrophobic property equivalent to that of the hydrophobic polymer compound, the hydrophobic polymer material may be substituted as an equivalent. In this case, Of course, it belongs to the scope.
As described above, the
The total thickness of the
When the thickness is less than 20 μm, each film layer (base film and barrier layer) is too thin, so that there are many defects such as occurrence of pores in molding, and thus the process becomes difficult. When the thickness is too thin, This is because, when applied to the needle patch, additional defects due to creasing occur.
If it is more than 2,000 μm, it becomes too thick and stiff, resulting in deterioration of skin adhesion, resulting in deterioration of the merchantability.
In the constant temperature and humidity micro needle patch according to an embodiment of the present invention, the
If a high polymer composite film having a water vapor permeability of 2,000 (g /
If the temperature rises or falls in the case of exporting to a remote country after sealing the product after molding the finished product, the pressure will change inside the sealed envelope accordingly, and the water soluble polymer compound Water molecules from the base film or the hydrophilic hydrocolloid adhesive sheet of PVA (for example, PVA) can move through the film having high moisture permeability in either direction due to increase or decrease of internal pressure.
[Production Example 1] A product incorporating a composite film coated with a barrier layer on a base film
PVA (polyvinyl alcohol) - CMC (carboxymethyl cellulose) film was adopted as the
The PVA - CMC film, which is a base film, was heated to constant temperature while changing the temperature in the range of 60 to 120 ° C to coat the PU resin, and the thickness of the final base film and barrier layer was 50 to 60 μm.
The composite film coated with the PU resin on the PVA - CMC film thus prepared was bonded to the hydrocolloid.
[Comparative Example 1] A product adopting a PVA-CMC film as a water-soluble film
The PVA - CMC film, which is simply a water - soluble film, was adhered to the hydrocolloid.
The products of [Manufacturing Example 1] and [Comparative Example 1] were placed in a sealed space under the conditions as shown in the following [Table 1] And the base film) was observed, and the change in the adhesive force between the base film and the hydrocolloid was measured and recorded in units of one day.
[Test Example 1]
Fig. 7 shows the change in the adhesion between the base film formed with the barrier layer in Production Example 1 and the hydrocolloid in the closed space at high humidity, and the change in the adhesion between the base film and the hydrocolloid in Comparative Example 1 A graph of the change in adhesive force with time is shown.
The change in adhesive strength was calculated assuming 100% of the initial adhesion of the base film and the hydrocolloid.
As shown in Fig. 7, it was confirmed that the adhesive force of the product produced in [Comparative Example 1] was rapidly lowered with time. On the other hand, it was confirmed that the adhesive strength of the product of [Preparation Example 1] was able to resist longer at high humidity.
The adhesive strength was measured using a Universal Testing Machine (WL2100, Withlab, Korea) with a
[Test Example 2]
Changes in the form of [Production Example 1] and [Comparative Example 1] (surface between base film and hydrocolloid) according to the change of time in the high humidity environment of the closed space were observed and compared with those of [Table 2] and [Table 3] Respectively.
1st Day / Top
11th day / upper surface
11 Day / Side
1st Day / Top
11th day / upper surface
11 Day / Side
As shown in [Table 2], in the case of [Production Example 1] according to the embodiment of the present invention, the base film on which the barrier layer was formed was adhered firmly to the surface of the hydrocolloid even on the 11th day, I could confirm.
On the other hand, as shown in [Table 3], in the case of [Comparative Example 1], the base film (PVA-CMC film) was peeled off from the hydrocolloid (see the side view) and shrunk See the picture of the upper part).
Next, a constant temperature and humidity type micro needle patch according to another embodiment of the present invention will be described.
The
In the constant temperature and humidity type micro needle patch according to another embodiment of the present invention, by adjusting the relative weight ratio of the hydrophilic polymer substance of gums to the weight of the water soluble polymer substance (compound) And the contact angle c of the
As described above, hydrophilic polymer materials such as gums are added to the water-soluble polymer material (compound) and the hydrophilic polymer material can be controlled in relative weight ratio with respect to the weight of the water-soluble polymer material, There is an advantage that the contact angle c can be adjusted (refer to FIG. 7).
Since the contact angle c of the
In general, the contact angle is preferably 30 to 80 degrees, more preferably 65 to 80 degrees.
The
In the constant temperature and humidity micro needle patch according to another embodiment of the present invention, the gummy hydrophilic polymer is 0.1 to 10 parts by weight based on 100 parts by weight of the water soluble polymer material.
If a hydrophilic polymer having a gum of less than 0.1 part by weight based on 100 parts by weight of the water-soluble polymer material is included, the rate of increase of the contact angle is remarkably low. If the water-soluble polymer material comprises more than 10 parts by weight of the gummy hydrophilic polymer , A thick film is formed on the surface of the base film to exceed the optimum contact angle value.
When a biodegradable aqueous solution such as a micro needle solution, for example, a hyaluronic acid solution, is spotted, the contact angle thereof may be about 30 to 80 °.
In the constant temperature and humidity type micro needle patch according to another embodiment of the present invention, the water soluble polymer material may be at least one selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone, polyalkylene oxides, But are not limited to, acrylamide, acrylic acid, cellulose, cellulose ethers, cellulose esters, cellulose amides, polyvinyl acetates, polycarboxylic acids, at least one selected from the group consisting of polycarboxylic acids, polyaminoacids polyamides or polyacrylamides (that is, a mixture of any one or more selected from a plurality of the above-described compounds , Which is used in the same meaning throughout the specification).
In this case, the water-soluble polymer material is only exemplarily described as an extreme hydrophilic polymer compound, and may be substituted as an equivalent substance if it is a polymer compound having an extreme value equivalent to that of the water-soluble polymer compound. In this case, Of course, it belongs to the technical scope.
In the constant temperature and humidity type micro needle patch according to another embodiment of the present invention, the gummy hydrophilic polymer material may be selected from the group consisting of carboxymethyl cellulose, agar, alginate, guar gum, at least one selected from the group consisting of pectin, xanthan gum, ghatti gum or carrageenan (that is, a mixture of any one or more selected from a plurality of compounds described above, , Which is used in the same meaning throughout the specification).
At this time, the gummy hydrophilic polymer compound is merely exemplified as a hydrophilic polymer compound, and may be substituted as an equivalent if it is a polymer compound having a hydrophilic polymer equivalent to that of the gummy hydrophilic polymer compound described above.
[Production Example 2]
As the
The
Briefly, PVA and CMC are added together in water at a ratio of 0.1 to 10 parts by weight with respect to 100 parts by weight of PVA, and the PVA and CMC are thoroughly mixed and then thinly spread in a sheet form and cured to form a film.
[Test Example 3]
The hyaluronic acid solution was used as the micro needle. The contact angle was measured while varying the weight ratio of CMC to 0 to 4 weight parts with respect to 100 parts by weight of PVA, and this was summarized in FIG. 9 and FIG. The contact angle was measured using a contact angle meter from Surface Electro Optics, and the amount of micro needle solution was shown in the contact angle photograph of Table 4.
CMC (wt%)
Figure of contact angle
0.000
5.68
0.513
32.10
0.974
35.42
2.513
68.70
3.026
76.06
3.487
78.40
4.000
79.74
As can be seen from FIG. 9 and Table 4, when the CMC was absent, the contact angle was extremely small. As the weight ratio of CMC was adjusted while controlling the relative weight ratio of CMC to 100 parts by weight of PVA, And the contact angle is about 75 to 80 degrees when the PVA is 3 to 4 parts by weight based on 100 parts by weight of PVA.
When the CMC is 4 parts by weight or more, it can be confirmed that the contact angle reaches the saturation value.
It will be apparent to those skilled in the art that the present invention may be embodied in other specific forms without departing from the spirit or scope of the invention as defined in the appended claims. It is self-evident to those who have.
Therefore, the above-described embodiments are to be considered as illustrative rather than restrictive, and the present invention is not limited to the above description, but may be modified within the scope of the appended claims and equivalents thereof.
110: adhesive sheet 120: base film
130: barrier layer 140: micro needle
Claims (4)
And a barrier layer 130 formed between the adhesive sheet 110 and the base film 120 to block moisture from moving between the adhesive sheet 110 and the base film 120,
The base film 120 includes a water-soluble polymer material and a gum-like hydrophilic polymer material,
Wherein the amount of the hydrophilic polymer is 0.1 to 10 parts by weight based on 100 parts by weight of the water-soluble polymer material,
Wherein the contact angle (c) of the micro needle (140) with respect to the base film (120) can be adjusted by controlling a relative weight ratio of the gypsum hydrophilic polymer substance to the weight of the water soluble polymer substance. Needle patch.
Wherein the barrier layer (130) comprises a hydrophobic polymer material.
The hydrophobic polymer material may be at least one selected from the group consisting of polyurathane, polyester, polyethylene, polypropylene, polymethylacrylate, polyethylacrylate, polybenzylmethacrylate, , At least one selected from the group consisting of polyethylmethacrylate, polyhexyl methacrylate, polyisobutyl methacrylate, polymethyl methacrylate, and polybutenes. Wherein the micro-needle patch is one of the two types.
Wherein the barrier layer (130) has a moisture permeability of 2,000 (g / m 2/24 hrs) or less.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150101639A KR101590613B1 (en) | 2015-07-17 | 2015-07-17 | A constant temparature and humidiyt type microniddle patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150101639A KR101590613B1 (en) | 2015-07-17 | 2015-07-17 | A constant temparature and humidiyt type microniddle patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR101590613B1 true KR101590613B1 (en) | 2016-02-02 |
Family
ID=55354670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020150101639A KR101590613B1 (en) | 2015-07-17 | 2015-07-17 | A constant temparature and humidiyt type microniddle patch |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR101590613B1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180065849A (en) * | 2016-12-08 | 2018-06-18 | 손주연 | Mask pack including two layered base and method of fabricating the same |
| KR20180079728A (en) * | 2017-01-02 | 2018-07-11 | 가천대학교 산학협력단 | Micro-needles apparatus |
| KR20200090447A (en) * | 2019-01-21 | 2020-07-29 | 주식회사 비안랩 | Micro needle patch and manufacturing method thereof |
| KR102244579B1 (en) | 2020-07-17 | 2021-04-27 | 주식회사 테라젝아시아 | Micro needle patch |
| KR102369762B1 (en) * | 2021-08-03 | 2022-03-03 | 주식회사 라파스 | Sheet for microneedle patch, microneedle patch comprising the same sheet and manufacturing method of sheet for microneedle patch |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008142183A (en) | 2006-12-07 | 2008-06-26 | Fujifilm Corp | Microneedle sheet and its production method |
| JP2011167486A (en) * | 2010-02-22 | 2011-09-01 | Kosumedei Seiyaku Kk | Microneedle patch having multilayered configuration |
-
2015
- 2015-07-17 KR KR1020150101639A patent/KR101590613B1/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008142183A (en) | 2006-12-07 | 2008-06-26 | Fujifilm Corp | Microneedle sheet and its production method |
| JP2011167486A (en) * | 2010-02-22 | 2011-09-01 | Kosumedei Seiyaku Kk | Microneedle patch having multilayered configuration |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180065849A (en) * | 2016-12-08 | 2018-06-18 | 손주연 | Mask pack including two layered base and method of fabricating the same |
| KR20180079728A (en) * | 2017-01-02 | 2018-07-11 | 가천대학교 산학협력단 | Micro-needles apparatus |
| KR101942169B1 (en) * | 2017-01-02 | 2019-01-24 | 가천대학교 산학협력단 | Micro-needles apparatus |
| KR20200090447A (en) * | 2019-01-21 | 2020-07-29 | 주식회사 비안랩 | Micro needle patch and manufacturing method thereof |
| KR102263673B1 (en) * | 2019-01-21 | 2021-06-18 | 주식회사 제이앤제이코스텍 | Micro needle patch and manufacturing method thereof |
| KR102244579B1 (en) | 2020-07-17 | 2021-04-27 | 주식회사 테라젝아시아 | Micro needle patch |
| KR102369762B1 (en) * | 2021-08-03 | 2022-03-03 | 주식회사 라파스 | Sheet for microneedle patch, microneedle patch comprising the same sheet and manufacturing method of sheet for microneedle patch |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101590613B1 (en) | A constant temparature and humidiyt type microniddle patch | |
| Wu et al. | 3D printing of microstructured and stretchable chitosan hydrogel for guided cell growth | |
| WO2010140401A1 (en) | Microneedle array using porous substrate and process for producing same | |
| CN110772661A (en) | Nontoxic environment-friendly solvent type double-layer nanofiber skin dressing and preparation method thereof | |
| KR20160121370A (en) | Microneedle patch and manufacturing mathod and machines thereof | |
| JP2016528971A (en) | Preparation process of phase transition microneedle patch | |
| KR101688645B1 (en) | Manufacturing machines and method for beauty pack by dried gel sheet and beauty pack manufactured by the same | |
| MX2011000594A (en) | Method of manufacturing cellular films directly. | |
| TW201538079A (en) | Insect control sheet | |
| EP3135315B1 (en) | Polymer laminate | |
| JP2024088790A (en) | Multi-layer microneedle patch | |
| CN112512601A (en) | Preparation method of multilayer cell membrane and multilayer cell membrane prepared by using same | |
| KR20200119936A (en) | hyaluronic acid-based melting film, METHOD FOR PREPARING THE SAME and release paper FOR THE SAME | |
| US20230211579A1 (en) | Sheet structure incorporating graphitic material, and method of manufacture | |
| KR101629007B1 (en) | A microniddle base film hanving optimal contcat angle | |
| EP3766479A1 (en) | Base composition for microneedle patch and microneedle patch comprising the same | |
| KR101873122B1 (en) | Graphene paper having high tensile strength and low sheet resistance and manufacturing method thereof | |
| KR101903036B1 (en) | Non-woven Fabric Structure for Beauty Packs and Method for Manufacturing the Same | |
| KR102570928B1 (en) | Particle attached microneedle and manufacturing method using the same | |
| WO2024078319A1 (en) | Microneedle formulation and preparation method for microneedle patch | |
| KR102703839B1 (en) | Multi-layer microneedles patch having excellent skin permeability | |
| KR102031561B1 (en) | Experimental vascular platform using porous membrane bonding technique and Manufacturing method thereof | |
| EP2948131B1 (en) | Formation of particle structures | |
| JP2023546394A (en) | Multilayer film containing nutritional substances for cell culture, its production method and its uses | |
| Song et al. | Preparation and characterization of layer structured porous chitosan scaffold for tissue engineering |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20181112 Year of fee payment: 4 |
|
| FPAY | Annual fee payment |
Payment date: 20191107 Year of fee payment: 5 |