KR102236216B1 - Method of manufacturing natural antibacterial adhesive film - Google Patents

Abstract

Disclosed is a method of manufacturing an antibacterial adhesive film. The method of manufacturing the antibacterial adhesive film includes the steps of: (a) providing an adhesive film including a base film and an adhesive layer formed on one surface of the base film; (b) coating an antibacterial solution containing an antibacterial substance and a solvent on the other side of the base film of the adhesive film; (c) forming a laminated film including an antibacterial layer/base film/adhesive layer by drying the adhesive film coated with the antibacterial solution in contact with hot air; And (d) rolling the laminated film in the form of a roll so that the antibacterial layer and the adhesive layer are in contact with each other to transfer the antibacterial layer onto the adhesive layer, thereby including a base film/adhesive layer/antibacterial layer. The antimicrobial adhesive film prepared according to the present invention includes, and the antimicrobial adhesive film manufactured according to the present invention rolls the film in the form of a roll so that the antibacterial material is transferred to the adhesive layer, so that there is no reactivity between the adhesive and the antibacterial solution. There is no limitation, the process is easy, and by including natural antibacterial substances, food or hospital (medical) waste is completely sealed to block odors, and antibacterial properties are excellent.

Description

Manufacturing method of natural antibacterial adhesive film {METHOD OF MANUFACTURING NATURAL ANTIBACTERIAL ADHESIVE FILM}

The present invention relates to a method of manufacturing an antibacterial adhesive film, and more particularly, to a method of manufacturing a natural antibacterial adhesive film having excellent antibacterial properties and blocking odor by completely sealing food or hospital (medical) waste.

Recently, as the outbreak of infectious bacteria and new infectious diseases such as swine flu, MERS, Zika virus, and super bacteria is increasing, the number of infected patients is on the rise. Accordingly, the risk of secondary infection in hospitals for medical personnel and the general public, including researchers in the laboratory, is also increasing, and thus, infectious disease treatment and vaccine research is being actively conducted. Prevention and personal hygiene are recognized as important to prevent secondary infection in hospitals or laboratories, but the most important thing is to safely dispose of medical waste to eliminate the concern of secondary infection in advance. For this reason, there is a need to improve the environment of hospitals and laboratories through safe medical waste treatment devices in order to block waste and biohazards. If such medical wastes are not disposed of safely and appropriately, they may cause secondary infections in hospitals or infections in the process of conducting research by the relevant researchers, seriously affecting the national health department and the derivation of research results. It causes social problems.

Medical waste refers to various wastes discharged from hospitals, public health centers and medical-related research institutes, including cotton wool, gauze, bandages, diapers, human extracts, syringes, needles, thermometers and test tubes, etc. There are organic solvents, and it is also called medical-related waste or hospital waste.

Due to the nature of these medical wastes, there is a high risk of contamination by various harmful substances such as pathogens, heavy metals, poisons, or blood of a specific patient, and the risk of injury due to needles and broken glass, but it is difficult to treat them immediately when such medical waste occurs in hospitals, etc. A separate medical waste collection container is mounted, and when medical waste is received in the collection container, it is incinerated through a waste treatment company or the like. However, this treatment method does not completely block the gas generated from the pollutant source, and thus, the spread of secondary infection in the hospital is a problem.

Therefore, there is a need for a method that has a completely sealing function and suppresses a pollutant source than a conventional pathogenic waste treatment method.

An object of the present invention is to solve the above problems, by rolling a film in the form of a roll and transferring the antimicrobial material to the adhesive layer, there is no reactivity between the adhesive and the antibacterial solution, so there is no limitation of the solvent, and the process is easy. It is to provide a method of manufacturing an antibacterial adhesive film.

In addition, as the antibacterial adhesive film contains a natural antibacterial substance, it is intended to provide a method of manufacturing an antibacterial adhesive film having excellent antibacterial properties and blocking odors by completely sealing food or hospital waste.

According to an aspect of the present invention, (a) providing an adhesive film comprising a base film and an adhesive layer formed on one side of the base film; (b) coating an antibacterial solution containing an antibacterial substance and a solvent on the other side of the base film of the adhesive film; (c) forming a laminated film including an antibacterial layer/substrate film/adhesive layer by drying the adhesive film coated with the antibacterial solution in contact with hot air; And (d) rolling the laminated film in the form of a roll so that the antibacterial layer and the adhesive layer are in contact with each other to transfer the antibacterial layer onto the adhesive layer, thereby including a base film/adhesive layer/antibacterial layer. A method of manufacturing an antibacterial adhesive film comprising; preparing an adhesive film is provided.

The antibacterial substance may include a natural antibacterial substance.

The natural antibacterial substance may include at least one selected from the group consisting of phytoncide, propolis, xylitol, capsaicin, curcumin, berberine, allicin, acetine, carvacrol, mastic, catechin, genton, and robinin.

The antibacterial solution may further contain an inorganic antibacterial substance.

The antibacterial solution may contain 0.01 to 50% by volume (v/v%) of the antimicrobial substance based on 100% by volume of the solvent.

The method of rolling in the form of a roll in step (d) may be a method of rolling by placing the antibacterial layer or the adhesive layer on the outermost side of the form of a roll.

The method of rolling in the form of a roll in step (d) may be a method of rolling by placing the antibacterial layer on the outermost side of the form of a roll.

Before the step (b), adjusting the concentration of the antibacterial substance in the antibacterial solution so that the antibacterial substance is uniformly distributed on the other surface of the base film of the adhesive film and formed on a part of the other surface (b') It may further include.

The base film of the step (a) is polyethylene (PE), polypropylene (PP), polyimide (PI), polyethylene terephthalate (PET), polycarbonate, and It may include at least one selected from the group consisting of polyethylene naphthalate.

The thickness of the base film in step (a) may be 10 to 100 μm.

The adhesive layer of step (a) may include at least one selected from the group consisting of rubber, acrylic polymer, adipate polymer, silicone polymer, and urethane polymer.

The thickness of the adhesive layer in step (a) may be 0.1 to 10 μm.

The coating of step (b) may be performed by one or more methods selected from the group consisting of spray spray coating, blade coating, and gravure coating.

The coating in step (b) may be performed by spray spray coating.

The solvent in step (b) may contain at least one selected from the group consisting of ethanol, methanol, n-propyl alcohol, isopropyl alcohol, sodium citrate, ionic liquid, and water. .

The antibacterial adhesive film may be for sealing at least one selected from the group consisting of medical waste, radiation waste, industrial waste, and food.

According to an aspect of the present invention, (1) preparing an antibacterial mixed solution comprising an antibacterial substance and an adhesive; (2) coating the antibacterial mixed solution on one side of a base film; And (3) drying the base film coated with the antibacterial mixture solution in contact with hot air to form an antibacterial adhesive layer including the antibacterial material and the adhesive to prepare an antibacterial adhesive film including an antibacterial adhesive layer/substrate film. A method of manufacturing an antibacterial adhesive film comprising a step is provided.

The coating of step (2) may be performed by one or more methods selected from the group consisting of spray spray coating, blade coating, and gravure coating.

The coating of step (2) may be performed by a blade and gravure coating method.

According to another aspect of the present invention, the step of providing an antibacterial adhesive film produced by the method of manufacturing the antibacterial adhesive film; Placing waste on a portion of the adhesive layer of the antibacterial adhesive film; And sealing the waste by folding the adhesive layers of the antimicrobial adhesive film so as to contact each other and bonding the other portions of the adhesive layer to each other.

The antimicrobial adhesive film manufactured according to the present invention has the effect of being easy to process, since there is no reactivity between the adhesive and the antibacterial solution, since the antimicrobial material is transferred to the adhesive layer by rolling the film in the form of a roll. .

In addition, since the antibacterial adhesive film contains a natural antibacterial substance, it completely seals food or hospital (medical) waste to block odors, and has excellent antibacterial properties.

1 is a flow chart showing a method of manufacturing an antibacterial adhesive film of the present invention (steps a to d).
2 is a structural diagram of an antibacterial adhesive film prepared according to the manufacturing method of steps (a) to (d) of the present invention.
Figure 3 is a structural diagram when the pathogenic waste is sealed with an antibacterial adhesive film prepared according to the manufacturing method of steps (a) to (d) of the present invention.
Figure 4 is a flow chart showing the manufacturing method (steps 1 to 3) of the antibacterial adhesive film of the present invention.
5 is a structural diagram of an antibacterial adhesive film prepared according to the manufacturing method of steps (1) to (3) of the present invention.
Figure 6 is a structural diagram when the pathogenic waste is sealed with an antibacterial adhesive film prepared according to the manufacturing method of steps (1) to (3) of the present invention.
7 is an FT-IR analysis result of antibacterial adhesive films, phytoncide oil, and polypropylene (PP) according to Examples 1-1 to 1-3.
Figure 8 (a) is a result of FT-IR analysis of the antibacterial adhesive film, phytoncide oil and polypropylene (PP) according to Examples 1-1 to 1-3, (b) is the characteristic peak of Figure 8 (a) It is a graph showing the relative intensity with respect to (P1, P2).
9 is an FT-IR analysis result of an antibacterial solution, phytoncide oil, and ethyl alcohol (ethanol) according to Preparation Examples 1-1 to 1-3.
10 is a thermogravimetric (TGA) analysis graph of an antibacterial mixed solution and an adhesive not containing phytoncide used in Examples 3-1 to 3-3.
11 is an antibacterial test result for E. coli of the antibacterial adhesive film according to Examples 2-1 to 2-5.
12 is an antibacterial test result for Staphylococcus aureus of the antibacterial adhesive films according to Examples 2-1 to 2-5.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those of ordinary skill in the art may easily implement the present invention.

However, the following description is not intended to limit the present invention to a specific embodiment, and in describing the present invention, when it is determined that a detailed description of a related known technology may obscure the gist of the present invention, the detailed description thereof will be omitted. .

The terms used herein are used only to describe specific embodiments, and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly indicates otherwise. In the present application, terms such as "comprise" or "have" are intended to designate the existence of features, numbers, steps, actions, elements, or combinations thereof described in the specification, but one or more other features or It is to be understood that the possibility of the presence or addition of numbers, steps, actions, elements, or combinations thereof is not preliminarily excluded.

In addition, terms including ordinal numbers such as first and second to be used hereinafter may be used to describe various elements, but the elements are not limited by the terms. The above terms are used only for the purpose of distinguishing one component from another component. For example, without departing from the scope of the present invention, a first element may be referred to as a second element, and similarly, a second element may be referred to as a first element.

In addition, when a component is referred to as being "formed" or "laminated" on another component, it may be formed or laminated by being directly attached to the front surface or one surface on the surface of the other component. It should be understood that there may be more other components in the.

1 is a flow chart showing the manufacturing method (steps a to d) of the antibacterial adhesive film of the present invention, Figure 2 is a structural diagram of the antibacterial adhesive film prepared according to the manufacturing method of steps (a) to (d) of the present invention , Figure 3 is a structural diagram when the pathogenic waste is sealed with an antibacterial adhesive film prepared according to the manufacturing method of steps (a) to (d) of the present invention.

Hereinafter, a method of manufacturing an antibacterial adhesive film of the present invention will be described with reference to FIGS. 1 to 3.

First, it provides an adhesive film including a base film and an adhesive layer formed on one side of the base film (step a).

The base film of the step (a) is polyethylene (PE), polypropylene (PP), polyimide (PI), polyethylene terephthalate (PET), It may include at least one selected from the group consisting of polycarbonate and polyethylene naphthalate.

The thickness of the base film in step (a) may be 10 to 100 μm.

The adhesive layer of step (a) may include at least one selected from the group consisting of rubber, acrylic polymer, adipate polymer, silicone polymer, and urethane polymer.

The thickness of the adhesive layer in step (a) may be 0.1 to 10 μm.

Next, an antibacterial solution containing an antibacterial substance and a solvent is coated on the other surface of the base film of the adhesive film (step b).

The antibacterial substance may include a natural antibacterial substance.

The natural antibacterial substance may include at least one selected from the group consisting of phytoncide, propolis, xylitol, capsaicin, curcumin, berberine, allicin, acetine, carvacrol, mastic, catechin, genton, and robinin, Preferably it may contain phytoncide.

The antibacterial solution may further contain an inorganic antibacterial substance, and the inorganic antibacterial substance is silver (Ag), copper (Cu), zinc (Zn), platinum (Pt), selenium (Se), titanium dioxide (TiO _{2 ).} ), zeolite, calcium phosphate, and zirconium phosphate.

The antibacterial solution may contain 0.01 to 50% by volume (v/v%) of the antimicrobial material, preferably 0.5 to 30% by volume (v/v%) of the antimicrobial material, based on 100% by volume of the solvent. It may include.

Before the step (b), adjusting the concentration of the antibacterial substance in the antibacterial solution so that the antibacterial substance is uniformly distributed on the other surface of the base film of the adhesive film and formed on a part of the other surface (b') It may further include.

The coating in step (b) may be performed by any one method selected from the group consisting of spray spray coating, blade coating, and gravure coating, and preferably spray spray coating.

The solvent in step (b) may contain at least one selected from the group consisting of ethanol, methanol, n-propyl alcohol, isopropyl alcohol, sodium citrate, ionic liquid, and water. .

Next, the adhesive film coated with the antibacterial solution is dried by contacting with hot air to form a laminated film including an antibacterial layer/substrate film/adhesive layer (step c).

Finally, by rolling the laminated film in the form of a roll so that the antibacterial layer and the adhesive layer come into contact with each other, the antibacterial layer is transferred onto the adhesive layer, thereby antibacterial adhesion including a base film/adhesive layer/antibacterial layer. Prepare a film (step d).

The method of rolling in the form of a roll in step (d) may be a method of rolling by placing the antibacterial layer or the adhesive layer on the outermost side of the roll form, and preferably, the antibacterial layer is located on the outermost side of the roll form and rolling. It could be the way.

The antibacterial adhesive film may be for sealing at least one selected from the group consisting of medical waste, radiation waste, industrial waste, and food.

Conventionally, an antimicrobial material was directly sprayed on the adhesive layer, but this has a problem in that the odor leaks as the adhesive strength decreases due to the reactivity of the adhesive and the dispersion solvent. In addition, due to the pressure-sensitive adhesive coated on the surface of the antibacterial particles, a problem such as a decrease in antibacterial activity occurred, and the optimization process design was very complicated. However, in the case of transferring after coating the antibacterial material on the other side of the base film on which the adhesive layer is formed, there is no reactivity between the adhesive and the solvent, so the range of solvents that can be used is widened, and the process design for manufacturing the antibacterial film is easy.

Figure 4 is a flow chart showing the manufacturing method (steps 1 to 3) of the antibacterial adhesive film of the present invention, Figure 5 is a structural diagram of the antibacterial adhesive film prepared according to the manufacturing method of steps (1) to (3) of the present invention , Figure 6 is a structural diagram when the pathogenic waste is sealed with an antibacterial adhesive film prepared according to the manufacturing method of steps (1) to (3) of the present invention.

Hereinafter, a method of manufacturing an antibacterial adhesive film of the present invention will be described with reference to FIGS. 4 to 6.

First, an antibacterial mixed solution containing an antibacterial substance and an adhesive is prepared (step 1).

The antibacterial substance may include a natural antibacterial substance.

The natural antibacterial substance may include at least one selected from the group consisting of phytoncide, propolis, xylitol, capsaicin, curcumin, berberine, allicin, acetine, carvacrol, mastic, catechin, genton, and robinin, Preferably it may contain phytoncide.

The antibacterial mixed solution may further contain an inorganic antibacterial material, and the inorganic antibacterial material is silver (Ag), copper (Cu), zinc (Zn), platinum (Pt), selenium (Se), titanium dioxide (TiO). ₂ ), zeolite, calcium phosphate, and zirconium phosphate.

The pressure-sensitive adhesive may include at least one selected from the group consisting of rubber, acrylic polymer, adipate polymer, silicone polymer, and urethane polymer.

Next, the antibacterial mixed solution is coated on one side of the base film (step 2).

The coating of step (2) may be performed by one or more methods selected from the group consisting of spray spray coating, blade coating, and gravure coating.

The coating of step (2) may be performed by a blade and gravure coating method.

Finally, the base film coated with the antibacterial mixture solution is dried by contacting with hot air to form an antibacterial adhesive layer including the antibacterial material and the adhesive to prepare an antibacterial adhesive film including the antibacterial adhesive layer/substrate film ( Step 3).

The base film may be the same as the base film of step (a).

The antibacterial adhesive film may be for sealing at least one selected from the group consisting of medical waste, radiation waste, industrial waste, and food.

In addition, the present invention provides an antibacterial adhesive film produced according to the method of manufacturing the antibacterial adhesive film; Placing waste on a portion of the adhesive layer of the antibacterial adhesive film; And sealing the waste by folding the adhesive layers of the antimicrobial adhesive film so as to contact each other and bonding the other portions of the adhesive layer to each other.

[Example]

Hereinafter, the present invention will be described in more detail through examples. However, this is for illustrative purposes only, and thus the scope of the present invention is not limited thereto.

Preparation Example 1: Preparation of an antibacterial solution containing a natural antibacterial substance

Manufacturing Example 1-1

Phytoncide oil (100%) as an antibacterial substance and ethanol (99.9%) as a dispersion solvent were used. An antibacterial solution was prepared by mixing 0.1 ml of phytoncide oil based on 100 ml of ethanol.

Preparation Example 1-2

An antibacterial solution was prepared in the same manner as in Preparation Example 1-1, except that 1 ml of phytoncide oil was added instead of mixing 0.1 ml of phytoncide oil in Preparation Example 1-1.

Manufacturing Example 1-3

An antibacterial solution was prepared in the same manner as in Preparation Example 1-1, except that 10 ml of phytoncide oil was added instead of mixing 0.1 ml of phytoncide oil in Preparation Example 1-1.

Preparation Example 2: Preparation of an antibacterial solution containing a natural antibacterial substance and an inorganic antibacterial substance

Manufacturing Example 2-1

Phytoncide oil (purity 99%) as a natural antibacterial substance, Ag nanoparticles (Ag NP) having a particle size of 30 nm as an inorganic antibacterial substance, Zeolite (Zeolite) having a particle size of 300 nm, and ethanol (99.9%) as a dispersion solvent were used. . Based on 100 ml of ethanol, 0.005 g of Ag nanoparticles (Ag NPs), 0.005 g of zeolite, and 1 ml of phytoncide oil were mixed, and highly dispersed through an ultrasonic pretreatment process to prepare an antibacterial solution.

Manufacturing Example 2-2

An antibacterial solution was prepared in the same manner as in Preparation Example 2-1, except that 5 ml of phytoncide oil was added instead of mixing 1 ml of phytoncide oil in Preparation Example 2-1.

Preparation Example 2-3

An antibacterial solution was prepared in the same manner as in Preparation Example 2-1, except that 10 ml of phytoncide oil was added instead of mixing 1 ml of phytoncide oil in Preparation Example 2-1.

Manufacturing Example 2-4

An antibacterial solution was prepared in the same manner as in Preparation Example 2-1, except that 15 ml of phytoncide oil was added instead of mixing 1 ml of phytoncide oil in Preparation Example 2-1.

Manufacturing Example 2-5

An antibacterial solution was prepared in the same manner as in Preparation Example 2-1, except that 20 ml of phytoncide oil was added instead of mixing 1 ml of phytoncide oil in Preparation Example 2-1.

Example 1: Preparation of an antibacterial adhesive film containing a natural antibacterial substance

Example 1-1

An adhesive film having an adhesive layer was prepared by coating a blade with poly(t-butyl acrylate) as an adhesive on one side of a polypropylene polymer base film having an area of 380 x 275 mm ^2. Then, the antibacterial solution prepared according to Preparation Example 1-1 was spray-coated on the other side of the adhesive film on which the adhesive layer was formed on a hot plate at 70°C (water pressure of spray nozzle: 0.5 MPa, air pressure of spray nozzle: 15 MPa). Then, it was dried using a hot air heater to prepare a laminated film including an antibacterial layer/substrate film/adhesive layer. Next, the antibacterial layer of the laminated film was placed on the outermost side and rolled into a roll (cylindrical) to prepare an antibacterial adhesive film. At this time, while the antibacterial layer and the adhesive layer were in contact with each other, the antibacterial layer was transferred onto the adhesive layer to prepare an antibacterial adhesive film (0.1% phytoncide oil coated film) having a structure of a base film/adhesive layer/antibacterial layer.

Example 1-2

An antibacterial adhesive film (1% phytoncide) in the same manner as in Example 1-1, except that the antibacterial solution prepared according to Preparation Example 1-2 was used instead of using the antibacterial solution prepared according to Preparation Example 1-1. oil coated film) was prepared.

Example 1-3

An antibacterial adhesive film (10% phytoncide) in the same manner as in Example 1-1, except that the antibacterial solution prepared according to Preparation Example 1-3 was used instead of using the antibacterial solution prepared according to Preparation Example 1-1. oil coated film) was prepared.

Example 2: Preparation of antibacterial adhesive film containing natural antibacterial substances and inorganic antibacterial substances

Example 2-1

An antibacterial adhesive film was prepared in the same manner as in Example 1-1, except that the antibacterial solution prepared according to Preparation Example 2-1 was used instead of using the antibacterial solution prepared according to Preparation Example 1-1.

Example 2-2

An antibacterial adhesive film was prepared in the same manner as in Example 1-1, except that the antibacterial solution prepared according to Preparation Example 2-2 was used instead of using the antibacterial solution prepared according to Preparation Example 1-1.

Example 2-3

An antibacterial adhesive film was prepared in the same manner as in Example 1-1, except that the antibacterial solution prepared according to Preparation Example 2-3 was used instead of using the antibacterial solution prepared according to Preparation Example 1-1.

Example 2-4

An antibacterial adhesive film was prepared in the same manner as in Example 1-1, except that the antibacterial solution prepared according to Preparation Example 2-4 was used instead of using the antibacterial solution prepared according to Preparation Example 1-1.

Example 2-5

An antibacterial adhesive film was prepared in the same manner as in Example 1-1, except that the antibacterial solution prepared according to Preparation Example 2-5 was used instead of using the antibacterial solution prepared according to Preparation Example 1-1.

In Table 1 below, the configurations of the antibacterial adhesive films according to Examples 1-1 to 1-3, Examples 2-1 to 2-5, and Comparative Example 1 are described.

Antibacterial adhesive film Base film Antibacterial solution solution Solvent (ml) Ag(g) Zeolite(g) Phytoncide (ml) Example 1-1 Polypropylene (PP) Manufacturing Example 1-1 Ethanol (100) - - 0.1 Example 1-2 Preparation Example 1-2 - - One Example 1-3 Manufacturing Example 1-3 - - 10 Example 2-1 Manufacturing Example 2-1 0.005 0.005 One Example 2-2 Manufacturing Example 2-2 0.005 0.005 5 Example 2-3 Preparation Example 2-3 0.005 0.005 10 Example 2-4 Manufacturing Example 2-4 0.005 0.005 15 Example 2-5 Manufacturing Example 2-5 0.005 0.005 20 Comparative Example 1 Manufacturing Comparative Example 1 Methanol (100) 0.1 - -

Example 3: Preparation of an antibacterial adhesive film using an antibacterial mixed solution containing an adhesive and an antibacterial substance

Example 3-1

An antibacterial adhesive film was prepared by coating an antibacterial mixture solution on one side of a polypropylene polymer base film having an area of 380 x 275 mm ^{2 with a blade.} The antibacterial mixed solution is a solution obtained by mixing the pressure-sensitive adhesive poly(t-butyl acrylate), the solvent ethyl acetate, and the phytoncide (antibacterial substance), wherein the mixing ratio of the pressure-sensitive adhesive and the solvent is 6:4, and the pressure-sensitive adhesive and the solvent are 0.1 ml of phytoncide oil was mixed and used based on the sum of 100 ml.

Example 3-2

An antibacterial adhesive film was prepared in the same manner as in Example 3-1, except that 1 ml of phytoncide oil was mixed and used instead of 0.1 ml of phytoncide oil in Example 3-1.

Example 3-3

An antibacterial adhesive film was prepared in the same manner as in Example 3-1, except that 10 ml of phytoncide oil was mixed and used instead of 0.1 ml of phytoncide oil in Example 3-1.

Preparation Comparative Example 1: Preparation of an antibacterial solution containing silver nanoparticles

Ag powder having a particle size of 40 nm as an antibacterial material and methanol as a dispersion solvent were used. After adding 0.1 g of Ag powder based on 100 ml of methanol, an antibacterial solution was prepared by dispersing Ag powder in methanol through an ultrasonic (Ultra-sonic) process.

Comparative Example 1: Antibacterial adhesive film containing silver nanoparticles

An antibacterial adhesive film was prepared in the same manner as in Example 1-1, except that the antibacterial solution prepared according to Preparation Comparative Example 1 was used instead of using the antibacterial solution prepared according to Preparation Example 1-1.

[Test Example]

Test Example 1: FT-IR analysis

7 is an FT-IR analysis result of antibacterial adhesive films, phytoncide oil, and polypropylene (PP) according to Examples 1-1 to 1-3.

According to FIG. 7, as a result of FT-IR analysis of the base film (PP), phytoncide oil (pure phytoncide solution), and the antibacterial adhesive film according to Examples 1-1 to 1-3, the characteristic peaks of phytoncide 1733, 1639 cm ^-1 was found only in the antibacterial adhesive film and phytoncide oil according to Examples 1-1 to 1-3. This means that the phytoncide component is present on the surface of the natural antibacterial adhesive film according to the present invention.

Test Example 2: Analysis of characteristic peaks of phytoncide

Figure 8 (a) is a result of FT-IR analysis of the antibacterial adhesive film, phytoncide oil and polypropylene (PP) according to Examples 1-1 to 1-3, (b) is the characteristic peak of Figure 8 (a) It is a graph showing the relative intensity with respect to (P1, P2).

Referring to Figure 8, the characteristic peak ^{P1 (1733 cm -1), P2} (1639cm -1) by performing characteristic peak share of the phytoncide components detected by antibiotic-sensitive adhesive film according to Examples 1-1 to 1-3 compared to the phytoncide And it was found.

Test Example 3: Characterization of antibacterial solution according to the concentration of phytoncide

9 is an FT-IR analysis result of an antibacterial solution, phytoncide oil, and ethyl alcohol (ethanol) according to Preparation Examples 1-1 to 1-3.

9, in the antibacterial solutions according to Preparation Examples 1-1 to 1-3, phytoncide components other than the ethanol component were not detected, and the antibacterial solutions according to Preparation Examples 1-1 to 1-3 were coated on a film and then dispersed. After drying the solvent, it was confirmed that the phytoncide component was detected.

Test Example 4: Thermogravimetric (TGA) analysis

10 is a thermogravimetric (TGA) analysis graph of an antibacterial mixed solution and an adhesive not containing phytoncide used in Examples 3-1 to 3-3.

According to FIG. 10, #1, #2, #3, and #4 are respectively a phytoncide-free adhesive, a 0.1 (v/v%) concentration of the adhesive (antibacterial mixed solution used in Example 3-1), and 1.0 (v /v%) concentration of the pressure-sensitive adhesive (antibacterial mixed solution used in Example 3-2) and 10 (v/v%) concentration of the pressure-sensitive adhesive (antibacterial mixed solution used in Example 3-3) different masses at different temperatures It indicates the rate of decrease. It was confirmed that the thermal decomposition temperature gradually increased as the phytoncide concentration increased at a 5% mass reduction rate. This indicates that the phytoncide component contained in the pressure-sensitive adhesive has stable thermal properties even at high temperatures.

Test Example 5: Antibacterial activity analysis

11 is an antibacterial test result for E. coli of the antibacterial adhesive film according to Examples 2-1 to 2-5, and FIG. 12 is an antibacterial test result of the antibacterial adhesive film according to Examples 2-1 to 2-5 against Staphylococcus aureus. This is the test result. The antibacterial adhesive film according to Examples 2-1 to 2-5 was cut into a size of 50 mm x 50 mm and placed on a standard film (sterilized polypropylene film), and 0.1 ml of a culture solution containing E. coli or Staphylococcus aureus was added to the antibacterial adhesive. After coating on the film, the standard film was covered and the rate of change in the concentration of the culture solution was observed after 24 hours. The control group is a sample coated with only the culture medium between the standard films. The results are shown in Table 2 below.

Antibacterial adhesive film Antibacterial solution Antibacterial activity (%) Escherichia coli Staphylococcus aureus Example 2-1 Manufacturing Example 2-1 99.9 99.9 Example 2-2 Manufacturing Example 2-2 99.9 99.9 Example 2-3 Preparation Example 2-3 99.9 99.9 Example 2-4 Manufacturing Example 2-4 99.9 99.9 Example 2-5 Manufacturing Example 2-5 99.9 99.9

11 and 12, according to Table 2, it was confirmed that the antibacterial adhesive films according to Examples 2-1 to 2-5 for the two cultures (E. coli and Staphylococcus aureus) exhibited an antimicrobial activity of 99.9%. .

Above, although the preferred embodiment of the present invention has been described in detail, the present invention is not limited to the above embodiment, and various modifications are made by those of ordinary skill in the art within the scope of the technical idea of the present invention. It is possible.

Claims (20)

(a) providing an adhesive film including a base film and an adhesive layer formed on one surface of the base film;
(b) coating an antibacterial solution containing an antibacterial substance and a solvent on the other side of the base film of the adhesive film;
(c) forming a laminated film including an antibacterial layer/substrate film/adhesive layer by drying the adhesive film coated with the antibacterial solution in contact with hot air; And
(d) antibacterial adhesion including a base film/adhesive layer/antibacterial layer by rolling the laminated film in the form of a roll so that the antibacterial layer and the adhesive layer come into contact with each other to transfer the antibacterial layer onto the adhesive layer Including; preparing a film;
A method of manufacturing an antibacterial adhesive film in which the antibacterial substance contains a natural antibacterial substance. delete The method of claim 1,
The natural antibacterial substance is characterized in that it contains at least one selected from the group consisting of phytoncide, propolis, xylitol, capsaicin, curcumin, berberine, allicin, acetine, carvacrol, mastic, catechin, genton, and robinin Method for producing an antibacterial adhesive film. The method of claim 1,
Method for producing an antibacterial adhesive film, characterized in that the antibacterial solution further comprises an inorganic antibacterial material. The method of claim 1,
The method for producing an antibacterial adhesive film, characterized in that the antibacterial solution contains 0.01 to 50% by volume (v/v%) of the antimicrobial substance based on 100% by volume of the solvent. delete delete The method of claim 1, wherein the method of manufacturing the antibacterial adhesive film
Before the step (b), adjusting the concentration of the antibacterial substance in the antibacterial solution so that the antibacterial substance is uniformly distributed on the other surface of the base film of the adhesive film and formed on a part of the other surface (b') Method for producing an antibacterial adhesive film, characterized in that it further comprises. The method of claim 1,
The base film of the step (a) is polyethylene (PE), polypropylene (PP), polyimide (PI), polyethylene terephthalate (PET), polycarbonate, And at least one selected from the group consisting of polyethylene naphthalate. The method of claim 1,
The method of manufacturing an antibacterial adhesive film, characterized in that the thickness of the base film in the step (a) is 10 to 100 μm. The method of claim 1,
The method of manufacturing an antibacterial adhesive film, wherein the adhesive layer of the step (a) comprises at least one selected from the group consisting of rubber, acrylic polymer, adipate polymer, silicone polymer, and urethane polymer. The method of claim 1,
The method for producing an antibacterial adhesive film, characterized in that the thickness of the adhesive layer in the step (a) is 0.1 to 10 μm. The method of claim 1,
The method of manufacturing an antibacterial adhesive film, characterized in that the coating of the step (b) is performed by at least one method selected from the group consisting of spray spray coating, blade coating, and gravure coating. The method of claim 1,
The method of manufacturing an antibacterial adhesive film, characterized in that the coating of the step (b) is carried out by spray coating. The method of claim 1,
The solvent in the step (b) is characterized in that it contains at least one selected from the group consisting of ethanol, methanol, n-propyl alcohol, isopropyl alcohol, sodium citrate, ionic liquid, and water. Method for producing an antibacterial adhesive film. The method of claim 1,
The antibacterial adhesive film is a method of manufacturing an antibacterial adhesive film, characterized in that for sealing at least one selected from the group consisting of medical waste, radiation waste, industrial waste, and food. delete delete delete Providing an antibacterial adhesive film produced by the method according to claim 1;
Placing waste on a portion of the adhesive layer of the antibacterial adhesive film; And
Folding the adhesive layers of the antimicrobial adhesive film to contact each other and sealing the waste by attaching the other portions of the adhesive layer;
Sealed disposal method of waste containing.

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