CN103434214B - A kind of antibiosis and self-cleaning PTP aluminium foil and preparation method thereof - Google Patents
A kind of antibiosis and self-cleaning PTP aluminium foil and preparation method thereof Download PDFInfo
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- CN103434214B CN103434214B CN201310435602.5A CN201310435602A CN103434214B CN 103434214 B CN103434214 B CN 103434214B CN 201310435602 A CN201310435602 A CN 201310435602A CN 103434214 B CN103434214 B CN 103434214B
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Abstract
The invention provides a kind of antibiosis and self-cleaning PTP aluminium foil, be double-decker, comprise, base layer, is a lamellar structure, and described base layer is made up of the hard of 20-30 micron or soft state aluminium foil; Nanometer antibacterium coating, coat on described base layer, described nanometer antibacterium coating is made up of PUR and nano antibacterial agent, the nano antibacterial agent containing 5000PPM-30000PPM concentration in described nanometer antibacterium coating; Wherein, described base layer and described nanometer antibacterium coating compound can obtain described antibiosis and self-cleaning PTP aluminium foil, and during obtained antibiosis and self-cleaning PTP In Aluminium Foil Packing medicine, described base layer is positioned at outside, and described nanometer antibacterium coating is positioned at inner side and directly contacts with medicine.This case also disclosed the preparation method of this antibiosis and self-cleaning PTP aluminium foil, and obtained PTP aluminium foil effectively can be avoided because of production and processing and pack the secondary pollution caused aluminium foil, and has certain sterilizing function to the microorganism that medicine carries.
Description
Technical field
The present invention relates to a kind of drug packing material, particularly a kind of functional form PTP aluminium foil and preparation method thereof.
Background technology
There is strict control of microorganisms standard in China for Key works Drug packing, wherein YBB10012012 Key works Drug packing aluminium foil providing as follows microbial limit: getting detected sample perforated area is 20cm
2the metal form of sterilization be pressed on inner layer surface, by aseptic cotton carrier sodium chloride injection, slightly bedew, erasing five times within the scope of plate hole, change the erasing five times again of a cotton swab, two cotton swabs erasing ten times altogether of each position, erasing five position 100cm altogether
2.Often prop up after cotton swab has been smeared and cut off immediately (or blowing), drop into and fill in the Erlenmeyer flask (or Boiling tube) of 30ml sodium chloride injection.Whole erasing cotton swab drops into after in bottle, bottle is rocked rapidly one minute, obtains need testing solution.After need testing solution carries out membrane filtration, check (Chinese Pharmacopoeia version in 2010 two annex Ⅺ J), bacterial population must not cross 1000cfu/100cm in accordance with the law
2, yeast and mold number must not cross 100cfu/100cm
2, Escherichia coli must not detect.
For meeting this requirement, the production and processing of Key works Drug packing aluminium foil and Key works Drug packing process all need complete in GMP cleaning shop.However, still inevitably there is the hidden danger of microbial contamination in Key works Drug packing aluminium foil.For reducing the probability of aluminium foil surface growth of microorganism further, the degree of purification in Production and Packaging workshop needs to improve further, is that this then needs to spend higher cost and maintenance cost.If develop the packaging material self with antibacterial functions, aluminium foil can be made from maintaining the clean of self in production and processing and packaging process, and avoid secondary pollution, the microorganism of simultaneously carrying medicine has kill bacteria effect, reduces great number cost cost.
For the problems referred to above, a kind of exploitation self with the PTP aluminium foil of antibacterial self function is by necessary property.
Summary of the invention
For above-mentioned problems of the prior art, the invention provides a kind of antibiosis and self-cleaning PTP aluminium foil, be intended to avoid because of production and processing and pack the secondary pollution caused aluminium foil; And this PTP aluminium foil also has certain sterilizing function to the microorganism that medicine carries, it is the upgraded product of typical medicine blister package.
Described a kind of antibiosis and self-cleaning PTP aluminium foil, being double-decker, comprising, base layer, is a lamellar structure, and described base layer is made up of the hard of 20-30 micron or soft state aluminium foil; Nanometer antibacterium coating, coat on described base layer, described nanometer antibacterium coating is made up of PUR and nano antibacterial agent, the nano antibacterial agent containing 5000PPM-30000PPM concentration in described nanometer antibacterium coating; Wherein, described base layer and described nanometer antibacterium coating compound can obtain described antibiosis and self-cleaning PTP aluminium foil, and during obtained antibiosis and self-cleaning PTP In Aluminium Foil Packing medicine, described base layer is positioned at outside, and described nanometer antibacterium coating is positioned at inner side and directly contacts with medicine.
Preferably, described a kind of antibiosis and self-cleaning PTP aluminium foil, wherein, described base layer outer surface is also provided with refractory coating or is coated with one deck plastics or paper material, the plastics of described refractory coating or covering or paper material are also printed on decorative pattern.
Preferably, described a kind of antibiosis and self-cleaning PTP aluminium foil, wherein, described nanometer antibacterium coating thickness is 2.5-6.5 micron.
Preferably, described a kind of antibiosis and self-cleaning PTP aluminium foil, wherein, described PUR is made by the raw material of following weight proportion: matrix resin, for plastic polyurethane resin and mylar, content is 18%-35%, and plastic polyurethane resin and mylar molecular weight are 20000-25000; Assisted resin is ethylene vinyl acetate copolymer resin, and content is 5%-12%, and molecular weight is 5000-10000; Plasticizer is diisooctyl phthalate, and content is 0.25-3%; Surface modifier is titanate coupling agent, and content is 0.5%-1%; Solvent, be the mixed solvent of butanone, butyl acetate and isopropyl alcohol, content is 50%-75%.
Preferably, described a kind of antibiosis and self-cleaning PTP aluminium foil, wherein, described nano antibacterial agent is ZnO/Ag or TiO
2/ Ag, wherein silver carrying amount is 5-15%.
This case additionally provides a kind of preparation method of antibiosis and self-cleaning PTP aluminium foil, wherein, obtains as follows, 1) be ZnO/Ag or TiO of 5-15% with coupling agents such as titanate esters to silver carrying amount
2/ Ag nano antibacterial agent carries out surface modification, obtains good anti-settling performance; 2) by 1) modified nano antibacterial agent joins in the PUR of melting, and dispersed with stirring is even, and obtained concentration is the PUR containing nano antibacterial agent of 5000-30000PPM; 3) by 2) the obtained hot-melt containing nano antibacterial agent is distributed in aluminium foil surface, and dry, rolling is also cut, obtained described antibiosis and self-cleaning PTP aluminium foil.
Preferably, the preparation method of described a kind of antibiosis and self-cleaning PTP aluminium foil, wherein, 1) be the butanone of 50%-75% by content, the mixed solvent of butyl acetate and isopropyl alcohol drops in reactor, fully stir; 2) keep stirring, the ethylene vinyl acetate copolymer of to be 5%-12% molecular weight by content be 5000-10000, content are that to be the plastic polyurethane resin of 20000-25000 and mylar, content be that the titanate coupling agent of 0.5%-1% drops into 1 successively to 18%-35% molecular weight) in described reactor, and be warmed up to more than 70 DEG C, keep temperature to stir more than 1.5 hours; 3) keeping stirring, is that the diisooctyl phthalate of 0.25-3% puts into 2 by content) in described reactor, stir 15-25 minute; 4) cool, filter, obtain described PUR.
Preferably, the preparation method of described a kind of antibiosis and self-cleaning PTP aluminium foil, wherein, during Key works Drug packing, carries out ultraviolet radiation to excite TiO in described nanometer antibacterium coating to nanometer antibacterium coating side
2or the antibacterial activity of ZnO.
Compared with prior art, beneficial effect is in the present invention: 1) described antibiosis and self-cleaning PTP aluminium foil can reduce the survival rate of aluminium foil surface microorganism in process of manufacture and Key works Drug packing process; 2) can the polyolefin sheets such as involution PE, PP, COC, the scope of application is wide; 3) can be effectively cost-saving, raise the efficiency, reduce the lifting that high standard requires the operation easier brought.
Detailed description of the invention
The present invention is described in further detail below, can implement according to this with reference to description word to make those skilled in the art.
A kind of antibiosis and self-cleaning PTP aluminium foil provided by the present invention, implemented by following concrete mode:
1) select wide spectrum and potent lasting antiseptic, this antiseptic requires the coating waste water high temperature of ability 200 DEG C.
Silver-series antibacterial agent surface in antibacterial ability, heat resistance and durability is outstanding, but the bacterium remains that silver-series antibacterial agent kills can discharge pyrogenicity and poisonous component, can cause the disease such as typhoid fever, cholera.Nano-TiO
2, ZnO can divide the organic matter being deconstructed into bacterium quickly and effectively as photocatalysis antibacterial agent, adds the synergy of other active oxidation material, can the effective poisonous compound that discharges of bacterium for degrading remains, its bactericidal effect is thorough rapidly.Nanometer Ag and photocatalytic oxide ZnO, TiO
2carry out compound, nano-ZnO, TiO during use
2the active oxy group formed and nano metal Ag are released simultaneously, thus material is not limited by illumination condition, and round-the-clock have excellent antibacterial action.ZnO/Ag or TiO has been selected in the present embodiment
2/ Ag composite nano germicide, silver carrying amount more high cost is also higher, select in the present embodiment silver carrying amount be 10% composite nano germicide.
2) surface modification of nano antibacterial agent
By ZnO/Ag, TiO
2/ Ag nano antibacterial agent puts into container, adds the titanate coupling agent solution of nano-antibacterial dosage 10%, after grinding 20min, and magnetic agitation 20min, then ultrasonic disperse 30min, stand-by.
Nanometer Zn 0/Ag after titanate coupling agent modified, TiO
2/ Ag, surface group there occurs change, and particle surface state changes thereupon, makes nano-ZnO/Ag, TiO
2affinity between/Ag particle reduces and strengthens with the affinity of solution.Modified nano-ZnO/Ag, TiO
2/ Ag reunion degree greatly reduces, and within the long duration, keep good suspension stability, decentralized photo capacitive be improved significantly.
3) the antimicrobial-coated liquid of preparation of nano, is coated with
Join in PUR coating fluid by the nano antibacterial agent suspension after surface modification, the concentration of nano antibacterial agent in coating fluid is 5000-10000PPM, after stirring, aluminium foil is coated with, and coating weight is 2.5-6.5 micron, fully dry.Through cutting the PTP aluminium foil of i.e. obtained high-efficiency antimicrobial function.Because the working concentration of PUR is usually about 30%, after coating is dry, the nano-antibacterial agent concentration on PUR surface is 15000-30000PPM, has suitable surface concentration.
4) packaging of high-efficiency antimicrobial function PTP aluminium foil uses
Unglazed according under effect, only nano Ag particles plays its antibacterial action; ZnO, TiO under ultraviolet catalytic effect
2antibacterial activity be excited, nano Ag particles and nano-ZnO, TiO
2common antibiotic and sterilizing.When Key works Drug packing, ultraviolet light irradiation process is carried out to the PUR face of PTP aluminium foil, the antibacterial activity of its maximum effect can be played.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the universal that claim and equivalency range limit, the present invention is not limited to specific details.
Claims (7)
1. an antibiosis and self-cleaning PTP aluminium foil, is characterized in that, is double-decker, comprises,
Base layer is a lamellar structure, and described base layer is made up of the hard of 20-30 micron or soft state aluminium foil;
Nanometer antibacterium coating, coat on described base layer, described nanometer antibacterium coating is made up of PUR and nano antibacterial agent, and the nano antibacterial agent containing 5000PPM-30000PPM concentration in described nanometer antibacterium coating, described nano antibacterial agent is ZnO/Ag or TiO
2/ Ag, wherein silver carrying amount is 5-15%;
Wherein, described base layer and described nanometer antibacterium coating compound can obtain described antibiosis and self-cleaning PTP aluminium foil, and during obtained antibiosis and self-cleaning PTP In Aluminium Foil Packing medicine, described base layer is positioned at outside, and described nanometer antibacterium coating is positioned at inner side and directly contacts with medicine.
2. antibiosis and self-cleaning PTP aluminium foil according to claim 1, is characterized in that, described base layer outer surface is also provided with refractory coating or is coated with one deck plastics or paper material, the plastics of described refractory coating or covering or paper material are also printed on decorative pattern.
3. antibiosis and self-cleaning PTP aluminium foil according to claim 1, is characterized in that, described nanometer antibacterium coating thickness is 2.5-6.5 micron.
4. antibiosis and self-cleaning PTP aluminium foil according to claim 1, it is characterized in that, described PUR is made by the raw material of following weight proportion:
Matrix resin, be plastic polyurethane resin and mylar, content is 18%-35%, and plastic polyurethane resin and mylar molecular weight are 20000-25000;
Assisted resin is ethylene vinyl acetate copolymer resin, and content is 5%-12%, and molecular weight is 5000-10000;
Plasticizer is diisooctyl phthalate, and content is 0.25-3%;
Surface modifier is titanate coupling agent, and content is 0.5%-1%;
Solvent, be the mixed solvent of butanone, butyl acetate and isopropyl alcohol, content is 50%-75%.
5. a preparation method for antibiosis and self-cleaning PTP aluminium foil, is characterized in that, obtains as follows,
1) be ZnO/Ag or TiO of 5-15% with titanate coupling agent to silver carrying amount
2/ Ag nano antibacterial agent carries out surface modification, obtains good anti-settling performance;
2) by 1) modified nano antibacterial agent joins in the PUR of melting, and dispersed with stirring is even, and obtained concentration is the PUR containing nano antibacterial agent of 5000-30000PPM;
3) by 2) the obtained hot-melt containing nano antibacterial agent is distributed in aluminium foil surface, and dry, rolling is also cut, obtained described antibiosis and self-cleaning PTP aluminium foil.
6. the preparation method of antibiosis and self-cleaning PTP aluminium foil according to claim 5, is characterized in that, the preparation method of described PUR is undertaken by following steps,
1) be that the mixed solvent of the butanone of 50%-75%, butyl acetate and isopropyl alcohol drops in reactor by content, fully stir;
2) keep stirring, the ethylene vinyl acetate copolymer of to be 5%-12% molecular weight by content be 5000-10000, content are that to be the plastic polyurethane resin of 20000-25000 and mylar, content be that the titanate coupling agent of 0.5%-1% drops into 1 successively to 18%-35% molecular weight) in described reactor, and be warmed up to more than 70 DEG C, keep temperature to stir more than 1.5 hours;
3) keeping stirring, is that the diisooctyl phthalate of 0.25-3% puts into 2 by content) in described reactor, stir 15-25 minute;
4) cool, filter, obtain described PUR.
7. the preparation method of antibiosis and self-cleaning PTP aluminium foil according to claim 5, is characterized in that, during Key works Drug packing, carries out ultraviolet radiation to excite TiO in described nanometer antibacterium coating to nanometer antibacterium coating side
2or the antibacterial activity of ZnO.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106183227B (en) * | 2016-07-08 | 2018-06-12 | 东莞椿田医用包装材料有限公司 | Long acting antibiotic type blister packaging materials |
| CN106189876A (en) * | 2016-07-08 | 2016-12-07 | 姚华鹏 | Antimicrobial form PUR |
| BR112020019892A2 (en) * | 2018-03-29 | 2021-01-05 | Dow Global Technologies Llc | ANTIMICROBIAL COMPOSITIONS OF HOT SEAL COATING |
| CN108705820A (en) * | 2018-06-12 | 2018-10-26 | 福建优净星环境科技有限公司 | A kind of antibacterial aluminium foil composite material and its manufacturing method |
| CN108797219B (en) * | 2018-07-25 | 2021-07-23 | 上海科茂药用包装材料有限公司 | Aluminum foil paper and preparation method thereof |
| CN112960233B (en) * | 2021-03-25 | 2023-03-24 | 宁波时代铝箔科技股份有限公司 | Antibacterial aluminum foil lunch box and preparation method thereof |
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| CN201099449Y (en) * | 2007-09-30 | 2008-08-13 | 李宝玉 | PTP aluminum foil for environment-friendly food and medicine package |
| WO2013128608A1 (en) * | 2012-03-01 | 2013-09-06 | 共同印刷株式会社 | Medicinal product package |
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Effective date of registration: 20160226 Address after: 201613, No. 18 Cai Bang Road, Jing Zhen Town, Shanghai, Songjiang District Applicant after: Shanghai Haishun New Pharmaceutical Packaging Co., Ltd. Applicant after: Suzhou Haishun Packaging Material Co., Ltd. Address before: 201613 Songjiang District, Shanghai Jing Jing Zhen Cai Bang Road, No. 18 Applicant before: Shanghai Haishun New Pharmaceutical Packaging Co., Ltd. |
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Application publication date: 20131211 Assignee: Zhejiang Haishun New Material Co., Ltd Assignor: Shanghai Haishun new pharmaceutical packaging materials Co., Ltd.|Suzhou Haishun packaging materials Co., Ltd Contract record no.: X2019980000290 Denomination of invention: Antibacterial self-cleaning PTP (Poly Terephthalic acid) aluminum foil and preparation method thereof Granted publication date: 20160316 License type: Exclusive License Record date: 20191023 |