KR102220743B1 - Cosmetic composition comprising totarol and mask pack using the same - Google Patents

Abstract

The present invention relates to a cosmetic composition containing totarol and a mask pack using the same, comprising nano-encapsulated totarol, and including nanocapsules containing the totarol inside, increasing skin permeability, so that the totarol in the skin Antibacterial, antioxidant, skin whitening and anti-wrinkle prevention effects can be enhanced.
In addition, when the functional mask pack loaded with the cosmetic composition of the present invention is attached to the face and used, the viscosity of the cosmetic composition carried on the functional mask pack decreases due to body temperature to facilitate supply to the skin. It is possible to increase the provision of the included active ingredients and increase the skin moisturizing effect.

Description

Cosmetic composition comprising totarol and mask pack using the same}

The present invention relates to a cosmetic composition comprising totarol and a mask pack using the same, and more specifically to a cosmetic composition in which totarol is nano-encapsulated to increase skin permeability, and a mask pack using the same.

There is an increasing demand for protecting the skin from yellow dust in spring, fine dust that occurs throughout the year, ultraviolet rays, skin hypersensitivity reactions or pigmentation caused by chemical cosmetics, and wrinkles caused by age.

Accordingly, mask pack products with various functions are being developed and released, and related industries are expanding. As products containing various additives, ranging from low to high prices, are pouring out, consumer complaints are also increasing.

In general, mask pack products are used in the form of sheets in the cosmetic field to protect the face or skin from external dry environments and microscopic irritation without the need for hand application.

In particular, a non-woven sheet attached to the face to obtain moisturizing and cleaning effects by impregnating a mask pack with various cosmetics or additives has become the mainstream.

Non-woven fabrics have been widely used as an excellent delivery means for various patch formulations carrying cosmetics or pharmaceuticals because they can maintain strength even when they are immersed in water or solvents, and are not dissociated, even though they are inexpensive.

In addition, the mask pack is a product impregnated with a water-soluble cosmetic solution containing a moisturizing agent, a whitening agent, an anti-wrinkle agent, and other functional cosmetic ingredients, and is attached to the user's face to provide functionality such as supplying nutrition to the face.

However, it is not optimized for consumers due to the ineffectiveness of the ingredients contained in the mask pack, decreases in skin penetration, the feeling of foreign substances remaining on the skin even after removing the mask pack, decreases in adhesion due to excess moisture, and dryness due to lack of moisture, etc. Many products that can be manufactured are also being released.

In order to solve this problem, it is necessary to develop a functional mask pack capable of showing antibacterial, antioxidant, skin whitening and anti-wrinkle effects by appropriately providing ingredients contained in the mask pack.

(Patent Document 1) KR 10-2017-0050111 A1

An object of the present invention relates to a cosmetic composition containing totarol and a mask pack using the same.

Another object of the present invention is to nanoencapsulate totarol and increase skin permeability, including nanocapsules containing the totarol inside, so that the totarol prevents antibacterial, antioxidant, skin whitening and wrinkle formation in the skin. It relates to a cosmetic composition and a mask pack using the same totarol that can increase.

Another object of the present invention is when the functional mask pack is attached to the face and used, the viscosity of the cosmetic composition supported on the skin contact layer in the functional mask pack decreases due to body temperature to facilitate supply to the skin. The present invention relates to a cosmetic composition comprising totarol and a mask pack using the same.

In order to achieve the above object, the cosmetic composition comprising totarol according to an embodiment of the present invention includes nanocapsules, solvents, capric/caprylic triglycerides, tocopherols, vitamin A, vitamin C, thickeners and glycerin. It includes, and the nanocapsule contains a totaroll inside.

The nanocapsules contain totarol inside, and the outside is in a form wrapped with lecithin.

The nanocapsules are nano-encapsulated using a microfludizer after adding and mixing totarol in a solution of lecithin and ethanol.

The thickener is selected from the group consisting of xanthan gum, cellulose, carbomer, gelatin, and mixtures thereof.

The cosmetic composition is 10,000 to 20,000 cps at 5 to 10°C, and 80 to 150 cps at 35 to 40°C.

A functional mask pack including a tota roll according to another embodiment of the present invention includes a base layer having a first open hole formed at a position corresponding to the eyes, nose, and mouth of a user; And a skin contact layer attached to one surface of the base layer and having a second open hole formed at a position corresponding to the first open hole of the base layer, wherein the skin contact layer comprises a cosmetic composition comprising the totaroll It is supported.

The cosmetic composition is 10,000 to 20,000 cps at 5 to 10°C, and 80 to 150 cps at 35 to 40°C. When the mask pack is attached to the face, the viscosity decreases due to body temperature, and the cosmetic composition contained in the skin contact layer is The supply to the skin becomes smooth.

Hereinafter, the present invention will be described in more detail.

The cosmetic composition containing totarol according to an embodiment of the present invention includes nanocapsules, solvents, capric/caprylic triglycerides, tocopherols, vitamins A, vitamins C, thickeners and glycerin, and the nanocapsules Includes a totaroll inside.

The solvent is selected from the group consisting of purified water, ethanol, and mixtures thereof, but is preferably purified water, but is not limited to the above examples.

The capric/caprylic triglyceride is a mixed tryster of glycerol, caprylic acid and capric acid. Capric/caprylic triglyceride may be artificially synthesized or natural capric/caprylic triglyceride may be used. Caprylic acid, obtained from lavender oil, lime oil and peanut oil, is a water-soluble emulsion. It is formed by oxidation of octanol. Capric acid is a crystalline fatty acid found in the fats and oils of many plants. The triglycerides of caprylic acid and caproic acid act as emollients and barriers that help moisture bind to the skin.

The tocopherol is a compound also referred to as vitamin E, and various isomers exist. Isomers of tocopherol include alpha, beta, gamma and delta-tocopherol. Tocopherol has antioxidant properties and is known to prevent oxidation of vitamin A in the body. The degree of antioxidant activity among the isomers is alpha; beta; gamma; And delta ratio of 1:1.3:1.8:2.7, it is known that delta tocopherol has the strongest antioxidant activity. On the other hand, since tocopherol itself is unstable, more stable tocopherol derivatives are used. Examples of the tocopherol derivative used in the present invention include, but are not limited to, tocopherol acetate and tocopherol palmitate.

The vitamin A (beta carotene) protects the mucous membranes of the oral cavity, nasal cavity and throat, which helps to maintain smooth and smooth disease-free skin, lowers susceptibility to infection, protects from air pollutants, improves vision, and improves night blindness. It helps prevent the formation of teeth, helps bone and teeth formation, improves skin elasticity, moisture content and smoothness, and helps reverse photoaging symptoms. When vitamin A is deficient, the skin becomes dry and hard. Vitamin A derivatives are also referred to as retinoids, and include, for example, retinol, retinyl palmitate, retinyl linoleate, and retinyl acetate. Vitamin A derivatives such as Retin A prevent and reverse sunlight damage. Vitamin A derivatives exfoliate and strengthen the skin. Vitamin A used in the present invention is preferably vitamin A palmitate, that is, retinyl palmitate.

The vitamin C is a water-soluble vitamin. In cosmetic creams, vitamin C is used as a preservative and antioxidant. Vitamin C is essential for healthy teeth, gums and bones. Vitamin C helps heal wounds and fractures, prevents scurvy, increases resistance to infections, helps preventive treatment of a swollen cold, gives strength to blood vessels, and aids in iron absorption. In addition, vitamin C is essential for the synthesis of collagen, an intracellular cement that connects tissues together. Vitamin C is one of the major antioxidant nutrients. Vitamin C prevents the conversion of nitrates (found in cigarette smoke, smog, bacon, lunch meat, and vegetables) into carcinogens. Moreover, vitamin C helps slow down the production of hyperpigments while providing some UV protection. Vitamin C used in the present invention includes vitamin C derivatives. Examples of preferred vitamin C of the present invention include, but are not limited to, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, isopalmityl ascorbate, and glucosyl ascorbate.

The thickener may be selected from the group consisting of xanthan gum, cellulose, carbomer, gelatin, and mixtures thereof, preferably using a mixture of xanthan gum and gelatin, but is not limited to the above examples.

The xanthan gum is a thickener of a natural ingredient extracted from sugar cane and has little change depending on temperature, so that it is relatively easy to gel. Since it is composed of natural ingredients, there is a disadvantage that it is easy to be contaminated with microorganisms.

The gelatin corresponds to an derived protein produced by treating collagen, a natural protein, with hot water.

In the present invention, the thickener may independently use the above-mentioned ingredients, but when a mixture in which xanthan gum and gelatin are mixed in a weight ratio of 2:1 to 3:1 is used, due to the gelation of the functional cosmetic composition, skin contact When forming a functional cosmetic composition layer on one side of the layer, it is possible to manufacture in an optimum viscosity state according to the temperature state during storage and use.

The cosmetic composition is 10,000 to 20,000 cps at 5 to 10°C, and 80 to 150 cps at 35 to 40°C.

When the cosmetic composition of the present invention is stored in a refrigerator, it is maintained in a state of 10,000 to 20,000 cps, and when applied to the skin, the viscosity decreases to 80 to 150 cps when the body temperature is transferred to the cosmetic composition, resulting in excellent application.

In order to control the viscosity as described above, preferably in the present invention, the thickener may independently use the aforementioned components, but a mixture obtained by mixing xanthan gum and gelatin in a weight ratio of 2:1 to 3:1 is used, and the average It further comprises an inorganic powder having a particle diameter of 0.01 to 5 μm.

The inorganic powder is zeolite, which ^{is mixed with a solution containing calcium ions (Ca 2+} ) and then heat-treated at 150 to 200°C for 30 to 60 minutes.

When the thickener is mixed with an inorganic powder, it is possible to adjust the viscosity range of the cosmetic composition to vary with temperature.

The cosmetic composition of the present invention is in a refrigerated state with high viscosity and little flow, but the flow improves within a temperature range similar to body temperature, thereby making it possible to provide a cosmetic composition having excellent application properties.

The glycerin has excellent moisturizing effect as a moisture-containing/moisturizing component. In addition to retaining moisture, it increases the flexibility of the skin, restores the skin's regeneration cycle, and helps maintain the function of the skin barrier. In addition, it is included in the functional cosmetic composition to enable uniform mixing between components.

The present invention is characterized in that the totarol is included in the cosmetic composition, and the totarol is nano-encapsulated and included in the functional cosmetic composition, thereby increasing skin penetration.

In the case of simply including the totaroll in the cosmetic composition, there is a problem in that it is difficult to uniformly mix the totaroll when it is manufactured as a functional cosmetic composition because the totaroll itself is a poorly soluble material.

On the other hand, as in the present invention, after nano-encapsulation and production into nano-capsules, in the case of producing a cosmetic composition, uniform mixing is possible.

The totarol is called a natural preservative and is extracted from the totara tree, an evergreen coniferous tree native to New Zealand. Totarol extracted from the totara tree protects against skin damage, and can exhibit antibacterial and antioxidant properties. In addition, due to the antioxidant action, oxidative stress that destroys skin cells, the destruction of collagen and elastin that occurs when the skin is exposed to ultraviolet rays, and wrinkle formation can be suppressed.

The nanocapsules contain totarol inside, and the outer layer is made of lecithin.

The lecithin is a natural surfactant, and a nanocapsule is formed in the form of a liposome enclosing totarol, which is a poorly soluble substance, with lecithin. Lecithin is one of the major phospholipid components that make up the animal cell membrane system and is a substance also called phosphatidyl choline. Hydrophilic components such as phosphoric acid and choline are bound to one side of glycerol, and a hydrophobic acyl group is bound to the other. Have a structure

As the lecithin, hydrogenated lecithin, unsaturated lecithin, and lyso lecithin may be used, but the present invention is not limited thereto. It is preferably hydrogenated lecithin. The lecithin of the present invention is hydrogenated lecithin containing 95% of a fatty acid-saturated phospholipid (Hydrogenated phosphatidyl choline, HPC) component through hydrogenation. Hydrogenated lecithin has good oxidation stability compared to lecithin containing unsaturated fatty acids and has decolorization and deodorization effects, so it is widely used as a raw material for cosmetic compositions requiring long-term stability. Such lecithin has a composition similar to that of skin lipids, so it has high skin affinity and can improve skin permeability in transdermal absorption of cosmetics.

The nanocapsules increase skin permeability, so that totarol directly acts in the skin, thereby increasing antibacterial activity and antioxidant effects, which are effective effects of totarol.

The nanocapsules are nano-encapsulated using a microfludizer after mixing totarol, lecithin, and ethanol.

In addition to the method of using a microfluidizer, the method of manufacturing the nanocapsule may be used without limitation, as a method that can be selected and manufactured by a person skilled in the art.

Specifically, lecithin and ethanol are put in a sealed container and a transparent lipid solution is prepared in a thermostat at 70°C. Totaroll is added and stirred to form a hydrated liquid crystal. Thereafter, Tris buffer solution (pH 4.0) was added and hydrated while rotating in a water bath maintained at about 45° C., and then stirred at a speed of 10,000 to 20,000 rpm with a homomixer. Thereafter, nanoparticles were prepared by secondary emulsification at a pressure of 3,000 to 7,000 psi using a microfluidizer.

Preferably, the cosmetic composition may further contain an Eumjigwig extract as an active ingredient.

The Eumjiguk is a fern (Sceptridium ternatum (Thunb.) Lyon), a perennial plant that grows in sunny forests or grasslands, and its thick fleshy roots spread in all directions. Leaves are divided into two, and the leaves are vegetative leaves and leaves. The leaf leaves are long petioles, split into three, and have serrated edges. The spore leaves are longer than the leaves, and the upper part is split long, and the sporangia hangs on the branch.

When Eumjigwig extract is included in the cosmetic composition in addition to the totaroll contained in the nanocapsules, the antioxidant effect, antibacterial effect, and wrinkle improvement effect are further increased by the mixing action of the totarol and Eumjigwig extract.

That is, when the Eumjigwig extract is composed of a composite composition compared to when only totarol is used in the related art, the effect is significantly increased compared to when only totarol is used according to the mixing action between the components.

More preferably, the Eumjigwang extract is a Eumjigwang methylene chloride fraction.

Specifically, the step of pulverizing the dry Eumjigwi; Leaching the pulverized product using an organic solvent; Drying the sample after leaching; Re-leaching the dried sample using an organic solvent; Drying the sample after leaching; Leaching with water; And including the step of leaching, it is possible to obtain a Eumjigwig extract.

It may further include the step of performing fractionation using an organic solvent the natural extract extracted using the organic solvent.

The method of preparing the extract may be a conventional extraction method in the art, such as an ultrasonic extraction method, a leaching method, and a reflux extraction method. Specifically, it may be an extract obtained by extracting a natural product from which foreign matter is removed by washing and drying with water, alcohol having 1 to 6 carbon atoms, or a mixed solvent thereof, or an extract extracted by sequentially applying the solvents to a sample.

The reflux extraction method is based on 100 mL of water and an alcohol having 1 to 6 carbon atoms, using 10 to 30 g of a pulverized product of a natural product, a reflux time of 1 to 3 hours, and an alcohol or water having 1 to 6 carbon atoms of 50 to 100%. More specifically, based on 100Ml of alcohol having 1 to 6 carbon atoms or 100 mL of water, 10 to 20 g of a pulverized product of a natural product, a reflux time of 1 to 2 hours, and 70 to 90% of an alcohol or water having 1 to 4 carbon atoms.

The leaching method is performed at 15 to 30° C. for 24 to 72 hours, and water or 50 to 100% alcohol having 1 to 6 carbon atoms is used as an extraction solvent. More specifically, it proceeds for 20 to 25° C. for 30 to 54 hours, and the extraction solvent is made of water or an alcohol having 1 to 6 carbon atoms of 70 to 80%.

The ultrasonic extraction method proceeds for a reaction at 30 to 50° C. for 0.5 to 2.5 hours, and the extraction solvent is water or an alcohol having 1 to 6 carbon atoms of 50 to 100%. Specifically, extraction is performed at 40 to 50° C. for 1 to 2.5 hours, and water or an alcohol having 1 to 6 carbon atoms of 70 to 80% is used as an extraction solvent.

The extraction solvent may be 2 to 50 times the weight of the sample, and more specifically 2 to 20 times. For extraction, the sample may be left for 1 to 72 hours for leaching in the extraction solvent, and more specifically, for 24 to 48 hours.

After extraction, the extract can be fractionated by sequentially applying a new fractionation solvent. The fractionation solvent used in the fractionation is at least one selected from the group consisting of water, hexane, butanol, ethyl acetic acid, ethyl acetate, methylene chloride, and mixtures thereof, and preferably methylene chloride.

A functional mask pack including a tota roll according to another embodiment of the present invention includes a base layer having a first open hole formed at a position corresponding to the eyes, nose, and mouth of a user; And a skin contact layer attached to one side of the base layer and having a second open hole formed at a position corresponding to the first open hole of the base layer, wherein the skin contact layer is supported by the cosmetic composition of the present invention. will be.

Specifically, the functional mask pack of the present invention includes a base layer having a first opening hole formed at a position corresponding to the user's eyes, nose, and leaves; And a skin contact layer attached to one surface of the base layer and having a second open hole formed at a position corresponding to the first open hole of the base layer.

The mask pack includes a skin contact layer in the base layer, and in order to increase the convenience of the mask pack user, an open hole is formed in a position corresponding to the user's eyes, nose, and leaves.

When using a mask pack, open holes are formed in the eyes to enable users to live daily life, so that they can be used as mask packs without detecting eyes. In the case of the nose, if an open hole is not formed, the mask pack There is a problem that the lifting phenomenon occurs by this nose. Accordingly, an open hole is formed to prevent the mask pack from being lifted. However, in order to deliver the functional cosmetic composition to the user's nose, a cover is additionally included in the open hole corresponding to the nose to prevent the mask pack from being lifted up, and to provide a functional cosmetic composition.

In the case of a general mask pack, since the cosmetic composition is supported on the skin contact layer, the active ingredient of the cosmetic composition is provided to the skin by using the cosmetic composition in the skin contact layer.

In this case, when the cosmetic composition is excessively supported, a problem occurs in that the degree of adhesion is deteriorated when the mask pack is used.

On the other hand, when the cosmetic composition is loaded less, there is a problem that the degree of moisturizing is provided to the skin.

In addition, it will be said that the degree of such a problem is different in the appropriate loading degree of the cosmetic composition depending on the user's environment and skin condition.

That is, when the cosmetic composition is supported on the skin contact layer and used, even if the same amount is loaded, depending on the user, it may be recognized that the cosmetic composition is excessively loaded, or it can be recognized that the skin moisturizing effect is lowered due to less loading.

Accordingly, in the present invention, in order to prevent such a problem, the viscosity is reduced by body temperature when the mask pack is attached to the face, and the viscosity is reduced by the body temperature when the mask pack is attached to the face and is 10,000 to 20,000 cps at 5 to 10 °C, Since the contained cosmetic composition is smoothly supplied to the skin, it is possible to supply a cosmetic composition having an excellent degree of adhesion between the face and the mask pack and increasing skin moisturizing power.

According to the cosmetic composition comprising totarol of the present invention, nano-encapsulation of totarol, including nanocapsules containing the totarol therein, increase skin permeability, so that totarol is antibacterial, antioxidant, and skin whitening in the skin And it is possible to increase the effect of preventing the generation of wrinkles.

In addition, when the functional mask pack loaded with the cosmetic composition of the present invention is attached to the face and used, the viscosity of the cosmetic composition carried on the functional mask pack decreases due to body temperature to facilitate supply to the skin. It is possible to increase the provision of active ingredients and increase the skin moisturizing effect.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in a number of different forms and is not limited to the embodiments described herein.

[Production Example: Preparation of cosmetic composition]

1. Preparation of nanocapsules

20% by weight of lecithin and 80% by weight of 70% ethanol are put in a sealed container, and a transparent lipid solution is prepared in a thermostat at 70°C. 100 mg of totarol is added and stirred to form a hydrated liquid crystal. Thereafter, 150 ml of 10 mM Tris buffer (pH 4.0) was added and hydrated while rotating in a water bath maintained at about 45° C., and then stirred for 5 minutes at a speed of 10,000 to 20,000 rpm with a Homomixer. Thereafter, nanoparticles were prepared by secondary emulsification at a pressure of 3,000 to 7,000 psi using a microfluidizer.

2. Preparation of Eumjigwig Extract

The Eumjigwig was washed with running water, dried with hot air at 40°C for 3 days and pulverized with a grinder. 200 g of the dried sample was immersed in 70% ethanol and stirred at room temperature for 3 days to leach. The leachate was filtered through a filter and the leaching filtration process was repeated three more times, and the filtrate was concentrated under reduced pressure to 60 g of ethanol extract were obtained.

Taking 42 g of 60 g of Eumjiguk ethanol extract (70% ethanol extract), suspended in distilled water, fractionated using methylene chloride (CH ₂ Cl ₂ ) using a separatory funnel, filtered and concentrated under reduced pressure to prepare a fraction. The powdered fraction was mixed with purified water and used.

3. Preparation of cosmetic composition

Nanocapsules prepared in Preparation Example 1 10% by weight, capric/caprylic triglyceride 5% by weight, tocopherol 1% by weight, vitamin A 1% by weight, vitamin C 1% by weight, glycerin 8% by weight, thickener 10 A cosmetic composition was prepared by mixing the weight% and the remaining water.

4. Preparation of cosmetic composition mixed with natural extract

The other ingredients were prepared in the same amount as in Preparation Example 3, except that the Eumjigwig extract was prepared by mixing as shown in Table 1 below.

IN1 IN2 IN3 IN4 IN5 Eumjigwig Extract One 3 5 10 15

(Unit weight%)

5. Preparation of cosmetic composition according to the difference in ingredients of thickener

A cosmetic composition was prepared with the same content as IN3 of Preparation Example 4, and only the composition of the thickener was different to prepare a cosmetic composition. The zeolite was mixed with a solution containing calcium ions (Ca ²⁺ ) and then heat-treated at 150 to 200° C. for 30 minutes, and ○ means that the zeolite was mixed at a weight ratio of 0.1.

IW1 IW2 IW3 IW4 IW5 Xanthan gum One 2 3 4 3 gelatin One One One One One Zeolite X X X X ○

(Unit weight ratio)

[Experimental Example 1: Viscosity Measurement]

In order to measure the viscosity according to the temperature change according to the difference of the thickener according to Preparation Example 5, the viscosity was measured using a Brookfield viscometer at 5°C to 37°C for IW1 to IW5, respectively.

IW1 IW2 IW3 IW4 IW5 5℃ 8,000 11,000 14,000 25,000 18,000 37℃ 50 90 100 300 120

(Unit cps)

According to Table 3, it has been confirmed that it maintains a high viscosity state at 5°C in IW2 and IW3, and shows a good viscosity state within the body temperature range, but IW2 and IW3 are immersed in a nonwoven fabric at 5°C. It shows the viscosity at which some flow occurs.

On the other hand, when used as a mask pack in IW5, it was confirmed that at 5°C, the flow was hardly felt even in the state of being immersed in the nonwoven fabric, and the flowability showed a high viscosity state near body temperature.

[Experimental Example 2: Skin whitening effect]

Experimental method for inhibition of intracellular melanin production

Using the B16F10 cell system, the amount of melanin production in cells was compared with that of the normal group to determine the inhibition rate. ^{1X10 5} cells were cultured for 1-3 days in a 35mm dish. To induce melanin production, the medium was treated with α-MSH or 3-isobutyl-1-methylanthine (IBMX) to promote the melanin production process.

The medium was removed, the cells were washed with PBS, and then 150 μl of 1N sodium hydroxide solution was added to the precipitated cells, dissolved in an 80°C incubator, and centrifuged. The supernatant was collected, absorbance was measured at 490 nm, and the amount of melanin was calculated using a calibration curve using synthetic melanin.

Melanogenesis inhibition rate (%) = [(A-B)/A]*100

A: the amount of melanin in the well without adding the sample

B: amount of melanin in the well to which the sample was added

Concentration (mg/ml) (-)α-MSH (ug/ml) (+)α-MSH (ug/ml) Melanin
Generation rate (%) Melanogenesis inhibition rate (%) Control 0 268.1 637.6 100 0 IN0 0.1 - 500.1 78.4 21.6 IN1 1.0 - 399.2 62.6 37.4 IN2 1.0 - 249.4 39.1 60.9 IN3 1.0 - 240.6 37.7 62.3 IN4 1.0 - 312.4 42.4 57.6 IN5 1.0 - 431.7 67.7 32.3

(IN0 is a cosmetic composition that does not contain Eumjigwig extract)

In order to confirm the skin whitening effect, as a result of measuring the inhibition rate of melanin production, it was confirmed that the skin whitening effect was excellent in IN2 to 4 compared to IN0.

[Experimental Example 3: Antioxidant Effect]

In order to check the antioxidant effect on the composition of INO-5, that is, the degree of skin aging prevention, it is applied daily in the morning and evening to the back of the hand for 15 subjects, and the hand after 5 days, 10 days and 30 days after treatment The skin aging prevention effect was compared with the sensory function of a 5-point scale (5 very good, 4 slightly excellent, 3 no difference, 2 no effect, 1 very no effect) by synthesizing the roughness and appearance of the back.

IN0 IN1 IN2 IN3 IN4 IN5 5 days 3.3 3.4 3.8 4.2 3.7 3.2 10 days 3.4 3.5 3.9 4.1 4.0 3.1 30 days 3.2 3.3 3.9 4.3 3.6 3.0

As shown in Table 5, it was confirmed that more excellent effects were exhibited in IN1 to 5 compared to IN0, and in particular, it was confirmed that more excellent effects were exhibited in IN2 to 4.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention defined in the following claims are also present. It belongs to the scope of rights of

Claims (7)

It is a cosmetic composition containing a nanocapsule containing totarol inside, a solvent, capric/caprylic triglyceride, tocopherol, vitamin A, vitamin C, thickener, glycerin, and extract of Eumjigwig,
The thickener includes xanthan gum, gelatin and zeolite,
The xanthan gum and gelatin are included in a weight ratio of 2:1 to 3:1,
The cosmetic composition has a viscosity of 10,000 to 20,000 cps at 5 to 10°C, and 80 to 150 cps at 35 to 40°C.
Cosmetic composition containing totarol. The method of claim 1,
The nanocapsules contain totaroll inside,
The outside is a form wrapped in lecithin
Cosmetic composition containing totarol. The method of claim 2,
The nanocapsules are nano-encapsulated using a microfludizer after adding and mixing totarol in a solution of lecithin and ethanol.
Cosmetic composition containing totarol. delete delete A base layer in which a first open hole is formed in a position corresponding to the user's eyes, nose, and mouth; And
A skin contact layer attached to one surface of the base layer and having a second open hole formed at a position corresponding to the first open hole of the base layer,
The skin contact layer is loaded with the cosmetic composition according to claim 1
Functional mask pack containing totaroll. The method of claim 6,
The cosmetic composition is 10,000 to 20,000 cps at 5 to 10°C,
80 to 150 cps at 35 to 40°C. When the mask pack is attached to the face, the viscosity decreases due to body temperature, so the cosmetic composition contained in the skin contact layer is smoothly supplied to the skin.
Functional mask pack containing totaroll.