KR102205259B1 - Development of antioxidant black vitamin by using vitamin C-chitosan complex and its application into cosmetic ingredients for blue light protection - Google Patents

Abstract

The present invention relates to an antioxidant carbon particle for cosmetics using a vitamin C-chitosan complex and a method for manufacturing the same, and more particularly, to an antioxidant carbon particle carbonized with vitamin C and a water-soluble amine compound, the carbon particle is 380 nm or less It has a function of absorbing more than 90% of light in the wavelength range of, and absorbing more than 50% of light in the wavelength range of more than 380 nm to 700 nm, and the carbon particles can maintain 90% or more of antioxidant activity for a long time of 2 years or more in atmospheric conditions. And, even after 30 days at moisture and 60℃, the antioxidant activity can be maintained at 50% or more, and at the same time, the antioxidant substances immobilized on the antioxidant carbon particles can continuously penetrate from the skin surface to the skin depth of 20 μm or more. It is easy to absorb blue light, which is widely emitted in everyday life such as smart device displays of computers and mobile phones, and LED lighting equipment, and can be continuously and stably absorbed by skin cells, so skin improvement effects can be expected in a short time. It relates to antioxidant carbon particles for cosmetics using vitamin C and a method for producing the same.

Description

Development of antioxidant black vitamin by using vitamin C-chitosan complex and its application into cosmetic ingredients for blue light protection}

The present invention relates to an antioxidant carbon particle (black vitamin) for cosmetics that can continuously absorb vitamin C antioxidant components into skin cells and easily absorb blue light in a wavelength range of more than 400 nm to 700 nm, and a method for preparing the same.

The skin is histologically composed of epidermis, dermis, and subcutaneous fat, and its thickness varies depending on the region, age, and sex. Although various skin conditions exist, each of the skins plays a role as a barrier function and other physiological functions from the outside. In the stratum corneum, keratinized dead cells, in which keratin, a relatively highly hydrophobic, insoluble protein, is concentrated at a high density, are stacked between the intercellular lipid bilayer, a thin layer of lipids. There is a structure. Chemical factors derived from the external environment are not permeable by the unique hierarchical structure of the matrix rich in lipids and insoluble proteins. In particular, it is very difficult to permeate the hydrophilic physiologically active substance due to the hydrophobic multi-structure of the stratum corneum.

Therefore, in general, transport of substances through keratin in healthy skin, in particular, skin penetration of hydrophilic physiologically active substances is not easily achieved due to various protective actions of the skin, and even if it is permeated, only a very low concentration is permeated.

In the case of cosmetics, in order for the physiologically active substances contained in the cosmetics to show their efficacy, they must pass through the stratum corneum, the outermost layer of the skin, and in the case of hydrophilic physiologically active substances, due to the hydrophobic multi-structure of the stratum corneum and the resulting barrier function, cosmetics There is a problem in that the physiologically active substance contained in does not sufficiently exhibit its function.

Until now, through various studies, skin penetration promoters that promote skin penetration of active substances have been reported. Their permeation promotion can be largely divided into mechanisms that act on the intercellular lipid bilayer, act on desmosomes and related proteins involved in intercellular binding, and directly act on the internal structure of keratinocytes. The action of the delivery enhancer on the intercellular lipid bilayer is a mechanism that facilitates the delivery of active substances by mainly loosening the structure of the lipid bilayer, and a large number of skin penetration promoters promote delivery through these functions. It is known. In addition, some are known to act on desmosomes and related proteins involved in the intercellular binding of keratinocytes, thereby promoting delivery through a mechanism that increases the intercellular space by separating or loosening the keratinocytes. In addition, some others are known to promote delivery through mechanisms that infiltrate the inside of keratinocytes to denature keratin or affect the internal structure to facilitate delivery through a transcellular route.

The skin penetration promoter inevitably changes the structure of the stratum corneum, the outermost layer of the skin, and promotes skin penetration of physiologically active substances. Such skin penetration promoters have a high cytotoxicity to skin cells and a very high possibility of inducing skin irritation, such as causing skin burning and erythema when applied.

In addition to the problem of skin penetration, the stability of skin active substances is one problem to be solved for substance delivery. Various pharmacologically active substances or physiologically active substances for skin cosmetic use have excellent efficacy, but there are many substances that are limited in formulation use due to poor solubility of the substance itself. Retinol, vitamins, polyphenols, etc. are representative examples. In order to deliver them to target organs and overcome the stability of the substance itself, structures made of single or multilayer lipid bilayers such as micelles and liposomes having a size of several tens of nanometers have been used. However, due to its physicochemical instability, low emulsification stability, drug collection efficiency, and drug stability maintenance efficiency, the efficiency is low not only in blood but also in skin delivery, resulting in very limited efficacy.

Therefore, a carrier that supports a physiologically active material including liposomes and is intended to improve skin penetration must be able to maintain its own stabilization and stabilization of the supported material as much as possible, and the composition, particle size, surface charge of the particle, and zeta potential size , it is necessary to optimize the characteristics of the carrier such as pH, and ultimately, safety should be ensured when applied to target organs and skin, and efficacy improvement by physiologically active molecules should be guaranteed.

In the case of bioactive substances, methods of reducing the particle size of the drug to the nano level to increase the solubility of the substance, increasing the usable surface area, or maximizing the wettability of the drug surface have been studied. It is possible through

Based on metals such as CdS (catmium sulfide) and CdSe (catmium selenide), it has the advantages of chemical stability, biological safety, optical stability and cost reduction than luminescent quantum dots (QDs). Is losing.

Korean Patent No. 1,944,972 Korean Patent Publication No. 2017-0082949 Korean Patent No. 1,862,229 Korean Patent Publication No. 2016-0121693

Accordingly, the present invention has been devised to solve the above problems, and the problem to be solved of the present invention is that the antioxidant carbon particles for cosmetics can be continuously and stably absorbed by vitamin C antioxidant (anti-aging) components into skin cells. Is to provide.

In addition, an object to be solved of the present invention is to provide an antioxidant carbon particle for cosmetics capable of absorbing blue light in a wavelength range that is widely emitted in daily life.

In addition, the problem to be solved by the present invention is to provide an antioxidant carbon particle for cosmetics having excellent biological safety and stability.

However, the technical problems to be achieved in the present invention are not limited to the technical problems mentioned above, and other technical problems that are not mentioned are clearly to those of ordinary skill in the technical field to which the present invention belongs from the following description. It will be understandable.

In order to achieve the above technical problem, the present invention provides antioxidant carbon particles for cosmetics, characterized in that the carbon particles of vitamin C and water-soluble amine compounds are carbonized.

In one embodiment, the antioxidant carbon particles have a function of absorbing 90% or more of light in a wavelength range of 380 nm or less, and absorbing 50% or more of light in a wavelength range of more than 380 nm to 700 nm, and the antioxidant carbon particles are Under the conditions, the antioxidant activity can be maintained over 90% for a long period of 2 years or longer, and the antioxidant activity can be maintained over 50% even after 30 days at moisture and 60℃ temperature. At the same time, the antioxidant substances immobilized on the antioxidant carbon particles from the skin surface It may be continuously permeable to a skin depth of 20 μm or more.

In one embodiment, the antioxidant carbon particles may be colloidal.

In one embodiment, vitamin C may be pure vitamin C or a water-soluble vitamin C derivative.

In one embodiment, the water-soluble amine compound may be at least one selected from the group consisting of alkanol amines, polyalkylene polyamines, aliphatic amines, aromatic amines, cyclic amines, aminoclays, and chitosan.

In addition, the present invention comprises the steps of preparing a mixture by mixing vitamin C and a water-soluble amine compound; And it provides a method for producing antioxidant carbon particles for cosmetics comprising the step of producing a colloidal antioxidant carbon particles by carbonizing the mixture.

In one embodiment, it may further include drying the colloidal antioxidant carbon particles.

In addition, the present invention provides a cosmetic composition containing antioxidant carbon particles.

The antioxidant carbon particles for cosmetics according to the present invention efficiently absorb light in a wide wavelength range of 700 nm or less, and are particularly widely emitted in daily life such as smart device displays and LED lighting devices of TVs, computers, and mobile phones. There is an advantage in that it is easy to absorb blue light in a wavelength range of 400 nm to 700 nm.

In addition, since the antioxidant carbon particles for cosmetics according to the present invention can be continuously and stably absorbed by the skin cells of vitamin C antioxidant (anti-aging), there is an advantage of expecting a skin improvement effect within a short time.

In addition, the antioxidant carbon particles for cosmetics according to the present invention have the advantage of increasing effective activity such as antioxidant activity.

In addition, since the antioxidant carbon particles for cosmetics according to the present invention are obtained from vitamin C, which is a natural product, they are suitable for living organisms compared to conventional metal-based light emitting quantum dots, and can maintain biological safety in terms of intracellular toxicity, and without skin irritation. It has the advantage of delivering antioxidants into the skin.

However, the effects obtainable in the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those of ordinary skill in the art from the following description. I will be able to.

The following drawings appended in the present specification illustrate preferred embodiments of the present invention, and serve to further understand the technical idea of the present invention together with the detailed description of the present invention to be described later, so the present invention is described in such drawings. It is limited to only and should not be interpreted.
1 shows the absorption intensity and wavelength range of antioxidant carbon particles according to an embodiment of the present invention.
FIG. 2 shows a reduction in cytotoxicity (improvement of safety) of antioxidant carbon particles of a vitamin C-soluble amine compound according to an embodiment of the present invention.
FIG. 3 is a graph showing comparable antioxidant activity of pure vitamin C and vitamin C-water-soluble amine compounds (chitosan) antioxidant carbon particles according to an embodiment of the present invention.
4 is a graph showing long-term antioxidant stability improvement of antioxidant carbon particles of a vitamin C-soluble amine compound (chitosan) according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those of ordinary skill in the art may easily implement the present invention. However, since the description of the present invention is merely an embodiment for structural or functional description, the scope of the present invention should not be construed as being limited by the embodiments described in the text. That is, since the embodiments can be variously changed and have various forms, the scope of the present invention should be understood to include equivalents capable of realizing the technical idea. In addition, since the object or effect presented in the present invention does not mean that a specific embodiment should include all of them or only those effects, the scope of the present invention should not be understood as being limited thereto.

The meaning of the terms described in the present invention should be understood as follows.

Terms such as "first" and "second" are used to distinguish one component from other components, and the scope of rights is not limited by these terms. For example, a first component may be referred to as a second component, and similarly, a second component may be referred to as a first component. When a component is referred to as being "connected" to another component, it should be understood that although it may be directly connected to the other component, another component may exist in the middle. On the other hand, when it is mentioned that a component is "directly connected" to another component, it should be understood that there is no other component in the middle. On the other hand, other expressions describing the relationship between the constituent elements, that is, "between" and "just between" or "neighboring to" and "directly neighboring to" should be interpreted as well.

Singular expressions are to be understood as including plural expressions unless the context clearly indicates otherwise, and terms such as "comprises" or "have" refer to specified features, numbers, steps, actions, components, parts, or It is to be understood that it is intended to designate that a combination exists and does not preclude the presence or addition of one or more other features or numbers, steps, actions, components, parts, or combinations thereof.

All terms used herein have the same meaning as commonly understood by one of ordinary skill in the field to which the present invention belongs, unless otherwise defined. Terms defined in a commonly used dictionary should be interpreted as having the meaning of the related technology in context, and cannot be interpreted as having an ideal or excessively formal meaning unless explicitly defined in the present invention.

The present invention relates to antioxidant carbon particles for cosmetics prepared by carbonizing vitamin C and a water-soluble amine compound. The method for producing antioxidant carbon particles for cosmetics according to the present invention comprises the steps of preparing a mixture by mixing vitamin C and a water-soluble amine compound; And carbonizing the mixture to prepare colloidal antioxidant carbon particles.

A detailed look at each step of the method for producing the antioxidant carbon particles for cosmetics according to the present invention is as follows.

First, a mixture is prepared by mixing vitamin C and a water-soluble amine compound.

Vitamin C enhances the body's immune function, and when applied to the skin, it promotes the production of collagen, which is a component of cartilage, capillaries, and muscles, and damages the skin by destroying chemicals generated by UV rays penetrating the skin. It plays a role to prevent In addition, antioxidants inhibit the action of free radicals to prevent wrinkles, keep the skin healthy, help heal damaged skin tissue, prevent the formation of histamine, which is known to cause allergic reactions, and prevent the formation of histamine during the aging process. It is known to have excellent anti-aging effect and whitening effect that prevents the formation of melamine that fades.

However, vitamin C has a structure similar to γ-lactone and is unstable, so it reacts sensitively to external environments such as air, especially oxygen, heat, and light, and is easily decomposed by oxidation. The oxidation reaction of vitamin C is usually two consecutive electron transfer processes, and the dissociation of hydrogen ions produces dihydroascorbate radicals, an oxidizing intermediate of vitamin C, which is highly reactive. It is known to react itself with two molecules to produce one molecule of vitamin C and dihydroascorbic acid. While a very small amount of this vitamin C is dissolved in a non-aqueous solution, a large amount is dissolved in an aqueous solution, but a sufficient amount of vitamin C cannot be stabilized due to the rapid oxidation action.Therefore, active substances ( It is reported that only a small amount of vitamin C can be used as an active ingredient).

The present invention can effectively prevent the deterioration of vitamin C activity by blocking contact with external air, moisture, heat, light, and particularly oxygen, by preparing vitamin C-based antioxidant carbon particles (black vitamin).

Vitamin C according to the present invention may contain pure vitamin C or water-soluble vitamin C derivatives. The vitamin C derivatives include sodium ascorbylphosphate (SAP), magnesium ascorbylphosphate (MAP), calcium ascorbylphosphate, ascorbic acid polypeptide, and ethyl ascorbylphosphate. Ethyl ascorbyl ether, Ascorbyl dipalmitate, Ascorbyl palmitate, Ascorbyl stearate, Ascorbyl glucoside and Ascorbyl glucoside It is preferably selected from the group consisting of corbyl ethylsilanol pectinate.

Water-soluble amine compounds are generally used in the art and are not particularly limited, but specifically, 1 selected from the group consisting of alkanol amines, polyalkylene polyamines, aliphatic amines, aromatic amines, cyclic amines, aminoclays, and chitosan. More than one species can be used, for example, hydroxylamine, monoethanolamine, diethanolamine, triethanolamine, 2-(2-aminoethoxy)ethanol, N,N-dimethylethylamine, N,N-diethyl Alkanol amines such as ethanolamine, N,N-dibutylethanolamine, N-methylethanolamine, N-ethylethanolamine, N-butylethanolamine, N-methyldiethanolamine, monoisopropanolamine, and triisopropanolamine; Diethylenetriamine, triethylenetetraamine, propylenediamine, N,N-diethylethylenediamine, N,N'-diethylethylenediamine, 1,4-butanediamine, N-ethyl-ethylenediamine, 1,2- Polyalkylene polyamines such as propanediamine, 1,3-propanediamine, and 1,6-hexanediamide; Aliphatic amines such as hydrazine, 2-ethyl-hexylamine, dioctylamine, tributylamine, tripropylamine, heptylamine, and cyclohexylamine; Aromatic amines such as morpholine, triazine, triazole, porphyrin, benzylamine, and diphenylamine; Cyclic amines such as piperidine, N-methyl-piperadine, methyl-piperadine, and hydroxylethylpiperidine; Aminoclays; Chitosan, etc. are mentioned.

At this time, the mixing ratio of the vitamin C and the water-soluble amine-based compound may be appropriately adjusted according to the target physical properties, specifically the antioxidant (anti-aging) degree, the absorption wavelength range, and the like.

Next, the mixture is carbonized to prepare colloidal antioxidant carbon particles.

The carbonization is generally used in the art and is preferably heated to a temperature at which carbon particles are produced. At this time, the heating may use microwave or sonication, for example.

In addition, the present invention can be prepared by drying the colloidal antioxidant carbon particles powdery antioxidant carbon particles.

In the case of the colloidal form, it can be used directly in the cosmetic composition, and the powdery form can be dissolved and used.

The antioxidant carbon particles prepared as described above absorb more than 90% of light in the wavelength range of 380 nm or less, and absorb more than 50% of light in the wavelength range of more than 380 nm to 700 nm. It is easy to absorb blue light in the wavelength range of 400 nm to 700 nm that is emitted.

In addition, the antioxidant carbon particles, the carbon particles are capable of maintaining an antioxidant activity of 90% or more for a long time of 2 years or more in atmospheric conditions, and an antioxidant activity of 50% or more even after 30 days at moisture and 60 ℃ temperature, At the same time, the antioxidant substances immobilized on the antioxidant carbon particles can continuously penetrate from the skin surface to the skin depth of 20 μm or more.

In addition, the antioxidant carbon particles may reduce or eliminate the generation of reactive oxygen species (ROS) by the vitamin C antioxidant (anti-aging) component.

In addition, the antioxidant carbon particles were confirmed to be pure substances through TEM, XRD, and XPS analysis, and their structures were confirmed through various analysis equipment.

1 shows the absorption intensity and wavelength range of antioxidant carbon particles according to an embodiment of the present invention. 1 shows antioxidant carbon particles prepared by mixing vitamin C and a water-soluble amine-based compound (chitosan), and it can be confirmed that it has excellent functions as natural UV protection and blue light protection.

FIG. 2 shows a reduction in cytotoxicity (improvement of safety) of the vitamin C-water-soluble amine compound antioxidant carbon particles according to an embodiment of the present invention. In the case of black vitamin, it can be seen that cytotoxicity decreases compared to pure vitamin C. have.

3 is a graph showing a comparison graph of comparable antioxidant capacity between pure vitamin C and vitamin C-water-soluble amine compound antioxidant carbon particles according to an embodiment of the present invention. In this case, it can be seen that in the case of the antioxidant carbon particles, the antioxidant activity hardly decreases.

4 is a graph showing long-term antioxidant stability improvement of vitamin C-water-soluble amine compounds (chitosan) antioxidant carbon particles according to an embodiment of the present invention. In the case of the antioxidant carbon particles (black vitamin), it can be seen that long-term antioxidant activity is improved, and it can be seen that it is easy to further stabilize through additional modification.

In addition, the present invention includes a cosmetic composition containing the antioxidant carbon particles.

The composition may include an antioxidant, an anti-wrinkle agent, a whitening agent, a moisturizer, a sunscreen agent, or a hair loss prevention agent.

The wrinkle improving agent may be selected from the group consisting of skin cell growth factor, protein or peptide group, retinol, retinyl palmitate, adenosine, and polyethoxylated retinamide.

The whitening agent may be selected from the group consisting of arbutin, ascorbic acid, ethyl ascorbyl ether, ascorbyl glucoside, niacinamide, ascorbyl phosphate, bisabolol, and whitening peptide.

The composition is not particularly limited in its formulation, but consists of a softening lotion, a nutritional lotion, a massage cream, a nutritional cream, a pack, a gel, an essence, a lipstick, a makeup base, a foundation, a lotion, an ointment, a gel, a cream, a patch, and a spray. It can be selected from the group.

Claims (8)

Preparing a mixture by mixing vitamin C and a water-soluble amine compound; And In the cosmetic composition comprising a colloidal vitamin C and a water-soluble amine compound prepared by the step of carbonizing the mixture,
In the step of carbonizing the mixture, in order to prevent the vitamin C and the water-soluble amine compound from being easily decomposed by oxidation by reacting sensitively to the external environment such as oxygen, heat, and light , microwave or sonication is used. It is characterized in that it is heated and carbonized,
The vitamin C contains pure vitamin C or a water-soluble vitamin C derivative,
The vitamin C derivatives include sodium ascorbylphosphate (SAP), magnesium ascorbylphosphate (MAP), calcium ascorbylphosphate, ascorbic acid polypeptide, and ethyl ascorbylphosphate. Ethyl ascorbyl ether, Ascorbyl dipalmitate, Ascorbyl palmitate, Ascorbyl stearate, Ascorbyl glucoside and Ascorbyl glucoside Corbyl ethylsilanol pectinate (Ascorbyl ethylsilanol pectinate) is any one selected from the group consisting of,
The water-soluble amine-based compound is hydroxylamine, monoethanolamine, diethanolamine, triethanolamine, 2-(2-aminoethoxy)ethanol, N,N-dimethylethylamine, N,N-diethylethanolamine, N Alkanol amines such as ,N-dibutylethanolamine, N-methylethanolamine, N-ethylethanolamine, N-butylethanolamine, N-methyldiethanolamine, monoisopropanolamine, and triisopropanolamine; Diethylenetriamine, triethylenetetraamine, propylenediamine, N,N-diethylethylenediamine, N,N'-diethylethylenediamine, 1,4-butanediamine, N-ethyl-ethylenediamine, 1,2- Polyalkylene polyamines such as propanediamine, 1,3-propanediamine, and 1,6-hexanediamide; Aliphatic amines such as hydrazine, 2-ethyl-hexylamine, dioctylamine, tributylamine, tripropylamine, heptylamine, and cyclohexylamine; Aromatic amines such as morpholine, triazine, triazole, porphyrin, benzylamine, and diphenylamine; Cyclic amines such as piperidine, N-methyl-piperadine, methyl-piperadine, and hydroxylethylpiperidine; Aminoclays; It is any one selected from the group consisting of chitosan,
The cosmetic composition containing vitamin C and a water-soluble amine compound absorbs 90% or more of light in a wavelength range of 380 nm or less, and absorbs 50% or more of light in a wavelength range of more than 380 nm to 700 nm. Including vitamin C and water-soluble amine compounds, characterized in that it easily absorbs blue light in a wavelength range of 400 nm to 700 nm, which is widely emitted in the interior , and blocks natural ultraviolet rays and protects users from blue light. A cosmetic composition for protecting blue light.
The method of claim 1,
The cosmetic composition containing vitamin C and a water-soluble amine compound can maintain an antioxidant activity of 90% or more for 2 years or more, and an antioxidant activity of 50% or more after 30 days at moisture and 60°C temperature. A cosmetic composition for protecting blue light comprising vitamin C and a water-soluble amine-based compound, characterized in that antioxidants contained in the cosmetic composition containing C and a water-soluble amine-based compound can penetrate from the skin surface to a skin depth of 20 μm or more.
delete delete delete delete The method of claim 1,
A cosmetic composition for blue light protection comprising vitamin C and a water-soluble amine-based compound, characterized in that it further comprises the step of drying the colloidal vitamin C and water-soluble amine-based compound prepared by carbonizing the mixture.

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