KR102204067B1 - Dry tooth patch having water channels - Google Patents

Abstract

The present invention relates to a dry patch attached to a tooth, wherein the patch according to the present invention includes a first layer attached to the tooth and a second layer attached thereto, and moisture flows into the first layer in the second layer. It is characterized by having a hole that can be made. The dry patch for attaching teeth according to the present invention has excellent tooth adhesion, very fast tooth adhesion, and excellent tooth transfer effect of an active ingredient.

Description

Dry tooth patch having water channels}

The present invention relates to a dry patch attached to a tooth. More specifically, it relates to a dry patch for attaching teeth having excellent tooth adhesion and excellent tooth transfer effect of an active ingredient.

Recently, as interest in beauty has increased, interest in teeth whitening is also increasing, and for this reason, whitening agents containing whitening ingredients are being developed. A typical formulation of these whitening agents is a whitening patch that can be attached to the teeth.

In the case of such a whitening patch, it can be divided into a wet type, a semi-wet type, and a dry type according to the degree of wetness of the layer attached to the teeth.

In the case of Proctor & Gamble's Crest Whitestrip, the first product sold in the form of a whitening patch, it is a wet type and is convenient to remove because the adhesive layer, which is the tooth adhesion layer, is low, but when wearing it, it comes off the teeth when coughing or laughing out loud There was. In addition, this wet type is usually a gel type that is uniformly applied to a thin strip, and when it is removed from the release liner and attached to the teeth by hand, the adhesive layer touches the hand and a large amount of the adhesive gel remains on the hand. As a result, the high concentration of peroxide used as a tooth whitening agent acts on unwanted areas, thus reducing safety. In addition to these problems, when carrying around in pouch packaging, the adhesive layer is pushed from the release liner in the pouch and the adhesive layer is lost, or when removing the strip from the release liner, there are problems such as leaving a considerable amount on the release liner. There were many.

Therefore, in general, a dry type whitening patch is more convenient in use than a wet type. In particular, a hydrophilic glassy polymer is selected as the main adhesive polymer of the adhesive layer, and there is little or very low adhesion before being hydrated, and then the polymer is hydrated by moisture and the phase changes, resulting in adhesion, resulting in adhesion than a dry state. An elevated dry type tooth attachment patch is useful.

However, in the case of this dry type tooth attachment patch, there is a disadvantage in that it may take some time until it becomes hydrated, that is, until adhesiveness occurs, and in particular, a strip attached to the outside of the tooth attachment adhesive layer is an adhesive layer. There are disadvantages such as limiting the effect of active ingredients such as whitening by interfering with the inflow of moisture into the water.

Therefore, the problem to be solved by the present invention is a dry (dry) patch for attaching teeth that has better tooth adhesion, that is, it can be attached to the teeth more easily and faster, and has a better effect of the active ingredients included in the patch, such as whitening. Preferably, a whitening patch) is provided.

In order to solve the above problems, the present invention provides a dry patch for attaching teeth including a first layer attached to a tooth and a second layer attached thereto, so that moisture can flow into the first layer in the second layer. It provides a dry patch for tooth attachment, characterized in that it has a hole.

The present invention is based on the following technical idea. Normally, a dry type tooth whitening patch has no adhesiveness immediately before use, and a small amount of moisture flows in or the layer attached to the tooth is hydrated by the saliva remaining on the tooth, resulting in adhesiveness (rubbery). state), and when more water is added to it, it changes into a flowable gel. In other words, in order for the tooth whitening patch to have good adhesion, moisture is transferred to the layer attached to the teeth, and a rapid phase change is required. Or it can be achieved by forming a hole or a water channel through which saliva can pass.

In the present invention, the term'hole' is used with substantially the same meaning as the term'water channel'.

In the dry patch for attaching teeth according to the present invention, the first layer is a layer attached to the teeth and may be referred to as a drug layer or an active ingredient layer including an active ingredient for delivery to the tooth. As such an active ingredient, a tooth whitening agent may be used, and a peroxide may be used as a tooth whitening agent. For example, the first layer may include a peroxide, an adhesive polymer in a dried state, and the like, and may additionally include a surfactant, a stabilizer, a flavoring agent, a colorant, a pH adjuster, and the like.

In particular, the effect of the present invention is more effective when the first layer contains polyvinylpyrrolidone (PVP) in a dried state (ie, in a glassy state). In order to release the peroxide contained in the dried PVP, it is necessary to change the phase of the PVP by water, and the hole according to the present invention is very effective in changing the dried PVP.

Peroxides that can be used in the dry patch for attaching teeth of the present invention include hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, and sodium perborate. , Sodium pyrophosphate peroxidate or mixtures thereof may be used.

In addition, the present invention is based on the surprising discovery that when a peroxide is used as an active ingredient in a dry patch for attaching teeth having such holes or channels, the whitening effect of the teeth is greatly increased. It is assumed that moisture or saliva supplied through holes or waterways in the patch can maximize the activity of peroxide, but the present invention is not limited to these theoretical assumptions.

In the dry patch for attaching teeth according to the present invention, the second layer serves to support the first layer, which is a drug layer, and may be referred to as a support layer. In addition to the role of supporting the first layer, the drug layer is used for oral cavity other than teeth. It can also serve to prevent contact with my other skin. For the purpose of the supporting layer, such a supporting layer may be mainly composed of a non-soluble material such as polyethylene and ethyl cellulose, and may further include components such as plasticizers and oils.

In the dry patch for attaching teeth according to the present invention, a'dry' patch is a concept that is in contrast to a patch on a gel (a patch that can be directly attached without supply of moisture), and is attached to the tooth before moisture or saliva is supplied. It refers to a patch that has no degree of adhesion, or refers to a patch manufactured by a process including a step of removing a solvent such as water during the manufacturing process of the patch. More specifically, the dry patch for attaching teeth of the present invention refers to a patch in which the moisture content is 30% by weight or less based on the total weight of the patch when the moisture contained under the condition of 105°C is measured.

In one aspect of the dry patch according to the present invention, the holes present in the dry patch for attaching teeth of the present invention may exist not only in the first layer, which is the drug layer, but also may exist in the second layer, and the waterway ( The water channel (hole) may be drilled up to the end surface of the drug layer attached to the tooth (see FIG. 2), and although not shown in FIG. 2, it may exist only up to the middle of the drug layer.

In one aspect of the dry patch according to the present invention, the patch may further include another layer present between the first layer (drug layer) attached to the tooth and the second layer (support layer) attached thereto, such a different The layer may contain the same active ingredient as the active ingredient contained in the first layer, or may contain an active ingredient different from the active ingredient contained in the first layer.

In the dry patch according to the present invention, consisting of these three layers, the waterway may exist only in the second layer, or coexist in the second layer and other layers (existing between the first and second layers). Can be, or can exist in all three layers connected to the water channel.

In the dry patch for attaching teeth according to the present invention, the size of the hole present in the patch is preferably 0.01 to 2 mm in diameter, and more preferably 0.05 to 1 mm for the purposes of the present invention.

In the tooth attachment dried patch according to the present invention, the patch is preferred to have a unit area of hole area per cm ² 0.001 ~ 0.3cm ^2, it is more desirable to have a hole area of 0.1 ~ 0.2 cm ^2. If the hole area per unit area is too large, the inflow of moisture increases, and as a result, excessive dilution of the adhesive in the patch results in poor adhesion, which may be a problem.

The dry patch for attaching teeth according to the present invention may further include a release liner attached to the first layer to be removed before use, and further increase the tooth adhesion of the patch between the release layer and the first layer. It may further include an adhesive layer for making. The dry patch for attaching teeth of the present invention may further include a layer other than the release layer and the adhesive layer within a range that does not impair the basic object of the present invention.

Holes included in the dry patch for attaching teeth according to the present invention, for example, make microholes in the entire sheet by passing a cylindrical roller attached with a needle of a certain diameter through the final drying step, or a support layer of a polymer sheet such as polyethylene In the case of making microholes only, it can be formed by using a method such as bonding a drug layer with micropores previously drilled in the polyethylene sheet by the above method, but the present invention provides such a hole forming apparatus, tool, method, etc. It is not limited.

The patch for tooth attachment according to the present invention may be manufactured by a method disclosed in, for example, U.S. Patent Nos. 6,682,721, 6,689,344, 6,780,401, 6,946,142, etc. It is not limited to.

The present invention is a dry (dry) patch (preferably a whitening patch) for tooth attachment that has better tooth adhesion, that is, it can be attached to the tooth more easily and faster, while having a better effect of the active ingredient contained in the patch such as whitening. Provides.

The following drawings attached to the present specification illustrate preferred embodiments of the present invention, and serve to further understand the technical idea of the present invention together with the content of the above-described invention, so the present invention is limited to the matters described in such drawings. It is limited and should not be interpreted.
FIG. 1 schematically shows a dry patch for attaching teeth including a first layer (drug layer) attached to the teeth and a second layer (support layer) attached thereto. A hole for transferring saliva or moisture to the drug layer is formed in the support layer, and moisture flows through the hole, so that the drug layer can be quickly hydrated.
FIG. 2 schematically shows a dry patch for tooth attachment including a first layer (drug layer) attached to the tooth and a second layer (support layer) attached thereto, as shown in FIG. 1, and saliva as a drug layer Or, it shows that holes for supplying moisture are formed in the drug layer as well as the support layer. The water channel (hole) existing in the drug layer may be drilled to the end surface of the drug layer attached to the tooth, as shown in FIG. 2, and may exist only to the middle of the drug layer, although not shown in FIG. 2 .
Figure 3 is a schematic diagram of a dry patch for tooth attachment including a first layer (drug layer) attached to a tooth, another layer attached to the first layer, and a second layer (support layer) attached to another layer Show. In Fig. 3, holes are present in both the support layer (second layer), another layer, and the drug layer (first layer). In the dry tooth whitening patch shown in FIG. 3, a water channel (hole) may exist only in the support layer, or may exist only in the support layer and another layer. In addition, the water channel may exist only between the support layer and another layer and the first layer.

Hereinafter, examples, etc. will be described in detail to aid understanding of the present invention. However, the embodiments according to the present invention may be modified in various other forms, and the scope of the present invention should not be construed as being limited to the following examples. The embodiments of the present invention are provided to more completely explain the present invention to those of ordinary skill in the art.

<Evaluation of whitening effect according to the presence or absence of holes>

The whitening agent composition used in Examples and Comparative Examples was prepared as follows. After making a viscous solution using hydrogen peroxide solution (35%) and polyvinyl virolidon 90, ethanol, glycerin, phosphoric acid, and purified water, make a thin sheet through a roller and pass through a drying chamber at about 60~80℃. It was prepared in a sheet shape so that the moisture content of the obtained product was an average of 20% by weight. The same prescription as for the dry tooth whitening patch (Example), which was made by loading 3% by weight of hydrogen peroxide based on the total weight of the drug layer (first layer) and making holes with a diameter of 0.5 mm in the support layer (second layer) at 50 pieces/cm ² per unit area. To prepare a dry tooth whitening patch (comparative example) without holes.

First, as a result of evaluating the adhesion of the examples and the comparative examples, the adhesion of the examples according to the present invention was remarkably excellent, and the following evaluation was performed to more objectively evaluate the whitening effect of these patches.

1) Laboratory evaluation

An artificial stain was formed on a hydroxyapatite (HAP) specimen, which is the same as a tooth component, and the initial whiteness was measured. The patch of Example or Comparative Example was attached to an artificial stain specimen, and artificial saliva was applied to the support layer (second layer) of the patch. After 1 hour, the whiteness (brightness) of the specimen was measured. The increase in whiteness before and after using the patch was compared. Whiteness (brightness) was measured by Minolta CR-321 (Minolta Camera Co., Japan). The results are shown in Table 1 below.

2) Simple clinical evaluation

Example or Comparative Example A total of 30 subjects were evaluated for 15 subjects per group. For the 4 teeth of the maxillary anterior part, the color was monitored using a standard shade guide, and then a whitening patch was used once a day for a week. On the 7th day, the tooth color was measured again, and the chromaticity level that became bright after use was counted. The results are shown in Table 1 below.

Example Comparative example Whitening effect (evaluation of laboratory performance) Brightened change value (L)
20-25 Brightened change value (L)
10-15 Whitening effect (simple clinical evaluation) Brightness color change stage
2.5 steps on average Brightness color change stage
1.7 steps on average

As shown in Table 1, in the case of the tooth whitening patch having a hole according to the present invention, not only the adhesion was significantly improved, but also the whitening effect was significantly increased compared to the comparative example.

Claims (10)

In the dry patch (patch) for tooth attachment comprising a first layer that is a drug layer attached to the teeth and a second layer that is a support layer attached thereto,
The support layer is a dry patch for attaching teeth, characterized in that it has a hole through which moisture can flow into the drug layer. The dry patch for attaching teeth according to claim 1, wherein the first layer is a drug layer containing a tooth whitening agent. The dry patch for attaching teeth according to claim 2, wherein the tooth whitening agent is peroxide. delete The dry patch for attaching teeth according to claim 1, wherein the hole is present in both the drug layer and the support layer. The dry patch for attaching teeth according to claim 1, wherein the patch further comprises another layer present between the drug layer attached to the tooth and the support layer attached thereto. The dry patch for attaching teeth according to claim 6, wherein in another layer existing between the drug layer attached to the tooth and the support layer attached thereto, there is a hole through which moisture can pass through the drug layer attached to the tooth. delete Claim 1 to claim 3 and to claim 5 to claim 7 according to any one of claims, wherein said patch has a hole diameter of 0.01 ~ 2mm or having a hole area of the unit area cm ² 0.001 ~ 0.3cm ² per Dry patch for tooth attachment characterized by. The tooth according to any one of claims 1 to 3 and 5 to 7, wherein the patch further comprises a release liner attached to the drug layer, wherein the release layer is removed before use. Dry patch for attachment.

Images