KR102164536B1 - 터트-부틸 n-[2-｛4-[6-아미노-5-(2,4-디플루오로벤조일)-2-옥소피리딘-1(2h)-일]-3,5-디플루오로페닐｝에틸)-l-알라니네이트 또는 이의 염, 수화물 또는 용매화물 - Google Patents

터트-부틸 n-[2-｛4-[6-아미노-5-(2,4-디플루오로벤조일)-2-옥소피리딘-1(2h)-일]-3,5-디플루오로페닐｝에틸)-l-알라니네이트 또는 이의 염, 수화물 또는 용매화물 Download PDF

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Publication number
KR102164536B1
KR102164536B1 KR1020157012809A KR20157012809A KR102164536B1 KR 102164536 B1 KR102164536 B1 KR 102164536B1 KR 1020157012809 A KR1020157012809 A KR 1020157012809A KR 20157012809 A KR20157012809 A KR 20157012809A KR 102164536 B1 KR102164536 B1 KR 102164536B1
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South Korea
Prior art keywords
compound
amino
delete delete
difluorobenzoyl
oxopyridin
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Expired - Fee Related
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KR1020157012809A
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English (en)
Korean (ko)
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KR20150067376A (ko
Inventor
스테판 핀탓
스테판 존 다비에스
데이비드 페스터스 찰스 모팻
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매크로파지 파마 리미티드
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Priority claimed from GBGB1218640.9A external-priority patent/GB201218640D0/en
Priority claimed from GB201306881A external-priority patent/GB201306881D0/en
Application filed by 매크로파지 파마 리미티드 filed Critical 매크로파지 파마 리미티드
Publication of KR20150067376A publication Critical patent/KR20150067376A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
KR1020157012809A 2012-10-17 2013-10-15 터트-부틸 n-[2-｛4-[6-아미노-5-(2,4-디플루오로벤조일)-2-옥소피리딘-1(2h)-일]-3,5-디플루오로페닐｝에틸)-l-알라니네이트 또는 이의 염, 수화물 또는 용매화물 Expired - Fee Related KR102164536B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1218640.9A GB201218640D0 (en) 2012-10-17 2012-10-17 Chemical compounds
GB1218640.9 2012-10-17
GB201306881A GB201306881D0 (en) 2013-04-16 2013-04-16 Chemical compounds
GB1306881.2 2013-04-16
PCT/GB2013/052689 WO2014060742A1 (en) 2012-10-17 2013-10-15 Tert-butyl n-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2h)-yl]-3,5- difluorophenyl}ethyl]-l-alaninate or a salt, hydrate or solvate thereof

Publications (2)

Publication Number Publication Date
KR20150067376A KR20150067376A (ko) 2015-06-17
KR102164536B1 true KR102164536B1 (ko) 2020-10-12

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KR1020157012809A Expired - Fee Related KR102164536B1 (ko) 2012-10-17 2013-10-15 터트-부틸 n-[2-｛4-[6-아미노-5-(2,4-디플루오로벤조일)-2-옥소피리딘-1(2h)-일]-3,5-디플루오로페닐｝에틸)-l-알라니네이트 또는 이의 염, 수화물 또는 용매화물

Country Status (27)

Country Link
US (3) US9388136B2 (https=)
EP (2) EP3222616B1 (https=)
JP (2) JP6260975B2 (https=)
KR (1) KR102164536B1 (https=)
CN (2) CN106496106B (https=)
AU (1) AU2013333636B2 (https=)
BR (1) BR112015008167B1 (https=)
CA (1) CA2888928C (https=)
CY (2) CY1119080T1 (https=)
DK (2) DK3222616T3 (https=)
ES (2) ES2743768T3 (https=)
HR (2) HRP20171320T1 (https=)
HU (2) HUE046132T2 (https=)
IL (2) IL237863B (https=)
IN (1) IN2015DN02721A (https=)
LT (1) LT3222616T (https=)
MX (1) MX364782B (https=)
NZ (1) NZ706717A (https=)
PL (2) PL3222616T3 (https=)
PT (2) PT3222616T (https=)
RS (2) RS59458B1 (https=)
RU (1) RU2676329C2 (https=)
SG (2) SG10201708166SA (https=)
SI (2) SI3222616T1 (https=)
SM (2) SMT201900524T1 (https=)
WO (1) WO2014060742A1 (https=)
ZA (1) ZA201501958B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE046132T2 (hu) * 2012-10-17 2020-02-28 Macrophage Pharma Ltd N-[2-{4-[6-amino-5-(2,4-difluor-benzoil)-2-oxopiridin-1(2H)-il]-3,5-difluor-fenil}etil]-l-alanin és annak tercbutil-észtere
GB201713975D0 (en) 2017-08-31 2017-10-18 Macrophage Pharma Ltd Medical use

Citations (1)

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WO2009060160A1 (en) 2007-11-07 2009-05-14 Chroma Therapeutics Ltd. P38 map kinase inhibitors

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GB0509227D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Intracellular enzyme inhibitors
BRPI0610368A8 (pt) 2005-05-05 2015-09-08 Glaxosmithkline Ip Dev Ltd Modulação de enzima e de receptor
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Also Published As

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ES2743768T3 (es) 2020-02-20
JP2015534974A (ja) 2015-12-07
US10370332B2 (en) 2019-08-06
US20160297760A1 (en) 2016-10-13
JP2018048160A (ja) 2018-03-29
PL2909175T3 (pl) 2017-10-31
HRP20171320T1 (hr) 2017-10-20
SMT201700399T1 (it) 2017-09-07
US20150246883A1 (en) 2015-09-03
CY1119080T1 (el) 2018-01-10
IL256560A (en) 2018-02-28
IL237863B (en) 2018-06-28
CN104781235B (zh) 2016-12-21
HUE035525T2 (en) 2018-05-28
NZ706717A (en) 2018-02-23
RS56184B1 (sr) 2017-11-30
HRP20191874T1 (hr) 2020-01-10
EP2909175B1 (en) 2017-06-07
CN106496106A (zh) 2017-03-15
DK2909175T3 (en) 2017-08-14
CA2888928C (en) 2020-05-26
BR112015008167A2 (pt) 2017-07-04
CN104781235A (zh) 2015-07-15
RU2676329C2 (ru) 2018-12-28
EP3222616B1 (en) 2019-07-17
BR112015008167B1 (pt) 2020-11-17
MX2015004368A (es) 2015-06-10
US9388136B2 (en) 2016-07-12
IN2015DN02721A (https=) 2015-09-04
ZA201501958B (en) 2016-01-27
PL3222616T3 (pl) 2019-12-31
RU2015115213A (ru) 2016-12-10
SI2909175T1 (sl) 2017-08-31
RS59458B1 (sr) 2019-11-29
CN106496106B (zh) 2019-05-10
SI3222616T1 (sl) 2019-10-30
CA2888928A1 (en) 2014-04-24
PT2909175T (pt) 2017-09-13
MX364782B (es) 2019-05-07
HUE046132T2 (hu) 2020-02-28
CY1122194T1 (el) 2020-11-25
LT3222616T (lt) 2019-09-10
ES2635240T3 (es) 2017-10-03
AU2013333636B2 (en) 2017-11-23
WO2014060742A1 (en) 2014-04-24
US20180127371A1 (en) 2018-05-10
EP2909175A1 (en) 2015-08-26
SG10201708166SA (en) 2017-11-29
EP3222616A1 (en) 2017-09-27
PT3222616T (pt) 2019-09-26
DK3222616T3 (da) 2019-08-19
KR20150067376A (ko) 2015-06-17
HK1211028A1 (en) 2016-05-13
US9896417B2 (en) 2018-02-20
SMT201900524T1 (it) 2019-11-13
IL256560B (en) 2019-07-31
AU2013333636A1 (en) 2015-04-09
JP6464244B2 (ja) 2019-02-06
SG11201502515VA (en) 2015-05-28
JP6260975B2 (ja) 2018-01-17

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