KR102150481B1 - 시알화 당단백질 조성물 및 이의 용도 - Google Patents

시알화 당단백질 조성물 및 이의 용도 Download PDF

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KR102150481B1
KR102150481B1 KR1020167026994A KR20167026994A KR102150481B1 KR 102150481 B1 KR102150481 B1 KR 102150481B1 KR 1020167026994 A KR1020167026994 A KR 1020167026994A KR 20167026994 A KR20167026994 A KR 20167026994A KR 102150481 B1 KR102150481 B1 KR 102150481B1
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mol
rhgus
glucuronidase
recombinant
composition
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KR20160127124A (ko
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스티븐 정글스
가브리엘 모리스
제프 그럽
마이클 벨라드
에밀 디. 카키스
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울트라제닉스 파마수티컬 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01031—Beta-glucuronidase (3.2.1.31)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
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  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020167026994A 2014-03-05 2015-03-05 시알화 당단백질 조성물 및 이의 용도 Active KR102150481B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461948421P 2014-03-05 2014-03-05
US61/948,421 2014-03-05
US201562114313P 2015-02-10 2015-02-10
US62/114,313 2015-02-10
PCT/US2015/018859 WO2015134696A1 (en) 2014-03-05 2015-03-05 Sialylated glycoprotein compositions and uses thereof

Publications (2)

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KR20160127124A KR20160127124A (ko) 2016-11-02
KR102150481B1 true KR102150481B1 (ko) 2020-09-02

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US (8) US9457067B2 (enExample)
EP (1) EP3113781B1 (enExample)
JP (1) JP6581590B2 (enExample)
KR (1) KR102150481B1 (enExample)
CN (1) CN106102749B (enExample)
AU (1) AU2015227137B2 (enExample)
BR (1) BR112016019893B1 (enExample)
CA (1) CA2940318C (enExample)
ES (1) ES2704923T3 (enExample)
IL (1) IL247550B (enExample)
MX (1) MX368972B (enExample)
MY (1) MY188028A (enExample)
PE (1) PE20161417A1 (enExample)
PH (1) PH12016501658A1 (enExample)
RU (1) RU2689119C2 (enExample)
TW (1) TWI702049B (enExample)
WO (1) WO2015134696A1 (enExample)

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JP6581590B2 (ja) 2014-03-05 2019-09-25 ウルトラジェニクス ファーマシューティカル インク．Ｕｌｔｒａｇｅｎｙｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｃ． シアル化糖タンパク質組成物及びその使用
EP3724314A1 (en) 2017-12-13 2020-10-21 3M Innovative Properties Company Water-reconstitutable culture medium resistant to liquefaction by microorganisms
TWI667252B (zh) * 2018-07-13 2019-08-01 中原大學 阿伐-選擇性唾液酸供體及其於製備唾液酸苷的用途

Citations (1)

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Publication number Priority date Publication date Assignee Title
KR101179029B1 (ko) 2005-02-23 2012-09-07 할로자임, 아이엔씨 가용성 글리코사미노글리카나제와 가용성글리코사미노글리카나제의 제조 및 사용 방법

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US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
SI1543106T1 (sl) * 2002-07-15 2007-08-31 Immunex Corp Postopki in mediji za nadziranje sialilacije proteinov, ki jih proizvajajo sesalske celice
JP2008504008A (ja) * 2003-12-31 2008-02-14 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 改良された薬物動態を有するＦｃ−エリスロポエチン融合タンパク質
EP1818395A1 (en) * 2006-02-08 2007-08-15 Diatos Compositions and methods for treating lysosomal storage diseases
KR20150126730A (ko) * 2006-09-10 2015-11-12 글리코토페 게엠베하 항체 발현을 위한 골수성 백혈병 기원의 인간 세포의 용도
US20090041741A1 (en) * 2007-03-06 2009-02-12 Saint Louis University Modified enzyme and treatment method
US8940876B2 (en) * 2010-02-08 2015-01-27 Korea Advanced Institute Of Science And Technology Method for preparing recombinant glycoproteins with high sialic acid content
WO2012101671A1 (en) * 2011-01-25 2012-08-02 Jcr Pharmaceuticals Co., Ltd. Method for production of human recombinant iduronate 2-sulfatase
KR101457514B1 (ko) * 2011-11-21 2014-11-03 한국생명공학연구원 우렁쉥이(멍게) 유래의 시알산 전이효소 및 이를 이용한 시알화 복합당질 합성 방법
US10138474B2 (en) * 2012-08-17 2018-11-27 Research Foundation Of The City University Of New York Scavenger receptor uptake for fabry disease enzyme replacement therapy
JP6581590B2 (ja) 2014-03-05 2019-09-25 ウルトラジェニクス ファーマシューティカル インク．Ｕｌｔｒａｇｅｎｙｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｃ． シアル化糖タンパク質組成物及びその使用

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
KR101179029B1 (ko) 2005-02-23 2012-09-07 할로자임, 아이엔씨 가용성 글리코사미노글리카나제와 가용성글리코사미노글리카나제의 제조 및 사용 방법

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RU2689119C2 (ru) 2019-05-24
US9937243B2 (en) 2018-04-10
AU2015227137A1 (en) 2016-09-15
US20150366951A1 (en) 2015-12-24
US20240245759A1 (en) 2024-07-25
WO2015134696A1 (en) 2015-09-11
TWI702049B (zh) 2020-08-21
MX368972B (es) 2019-10-23
US20220202915A1 (en) 2022-06-30
US9457068B2 (en) 2016-10-04
EP3113781A4 (en) 2017-08-09
EP3113781B1 (en) 2018-11-21
PH12016501658A1 (en) 2016-10-03
AU2015227137B2 (en) 2019-06-06
TW201615210A (zh) 2016-05-01
CA2940318C (en) 2020-09-22
RU2016138790A (ru) 2018-04-09
US20200282028A1 (en) 2020-09-10
PE20161417A1 (es) 2017-01-22
US20150250860A1 (en) 2015-09-10
US20170326210A1 (en) 2017-11-16
KR20160127124A (ko) 2016-11-02
US20190054153A1 (en) 2019-02-21
BR112016019893B1 (pt) 2023-02-14
IL247550B (en) 2020-10-29
JP6581590B2 (ja) 2019-09-25
US9457067B2 (en) 2016-10-04
US9687532B2 (en) 2017-06-27
CN106102749B (zh) 2019-07-12
MX2016011416A (es) 2016-12-02
BR112016019893A2 (pt) 2017-10-24
US20160367646A1 (en) 2016-12-22
IL247550A0 (en) 2016-11-30
CN106102749A (zh) 2016-11-09
RU2016138790A3 (enExample) 2018-08-23
JP2017508455A (ja) 2017-03-30
ES2704923T3 (es) 2019-03-20
EP3113781A1 (en) 2017-01-11
MY188028A (en) 2021-11-10
CA2940318A1 (en) 2015-09-11

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