KR102093498B1 - 저선량 방사선을 이용한 초파리의 퇴행성 질환 치료를 확인하는 바이오마커 - Google Patents

저선량 방사선을 이용한 초파리의 퇴행성 질환 치료를 확인하는 바이오마커 Download PDF

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KR102093498B1
KR102093498B1 KR1020180056068A KR20180056068A KR102093498B1 KR 102093498 B1 KR102093498 B1 KR 102093498B1 KR 1020180056068 A KR1020180056068 A KR 1020180056068A KR 20180056068 A KR20180056068 A KR 20180056068A KR 102093498 B1 KR102093498 B1 KR 102093498B1
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남선영
황수진
정해민
홍은희
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한국수력원자력 주식회사
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Abstract

본 발명은 저선량 방사선에 감응성 있는 면역 활성 유전자, 신경세포 재생에 관여하는 유전자 및 운동성 기능에 관여하는 유전자를 포함하는 초파리 퇴행성 질환 치료확인 바이오마커에 관한 것으로서, 더욱 상세하게는 초파리의 퇴행성 질환을 저선량 방사선으로 치료할 때 반응하는 유전자를 분류하여 선정한 것에 관한 것이다.
상기와 같은 본 발명에 따르면 저선량 방사선에 의해 발현 변화를 나타낸 유전자들을 기능별 분류하고, 저선량 방사선에 의한 반응 지표 유전자를 제시함으로써, 퇴행성 질환에 저선량 방사선 조사 시 치료 마커 개발에 대한 기초자료로 활용할 수 있는 효과가 있다.

Description

저선량 방사선을 이용한 초파리의 퇴행성 질환 치료를 확인하는 바이오마커 {BIOMARKERS TO CONFIRM TREATMENT OF DEGENERATIVE DISEASES OF FRUIT FLIES USING LOW-DOSE RADIATION}
본 발명은 저선량 방사선을 이용한 알츠하이머 질환 치료의 유효성 및 안전성 검증을 위한 in vivo 모델과 지표를 제시하고, 퇴행성 질환에 저선량 방사선 조사 시 치료 마커 개발에 대한 기초자료로 활용 가능하게 하는 기술에 관한 것이다.
최근 저선량 방사선은 퇴행성 질환의 치료 수단으로 대두되고 있으며, 초파리에는 다양한 연구에서 유용하게 사용되고 있는 퇴행성 질환의 일종으로서 알츠하이머 모델 초파리(elav>Aβ42)가 존재하여, 알츠하이머의 발병과 치료 기작 연구 및 치료제 테스트에 활용되고 있다.
현재, 임상 전 저선량 방사선의 치료 효과 테스트가 가능한 in vivo 모델로서 초파리 퇴행성질환 모델이 구축되었으나, 퇴행성 질환 증상을 개선시키는 과정에 관여하는 저선량 방사선 특이적 반응유전자 지표들에 대한 연구는 전무한 실정이다.
따라서 알츠하이머 모델 초파리로부터 저선량 방사선에 대한 반응 지표 유전자를 발굴하여, 추후 방사선 치료의 임상 테스트 등을 위한 in vivo 모델에서의 관련 기초 자료에 대한 구축이 요구되고 있다.
한국공개특허 제10-2017-0083704호
본 발명의 목적은, 누적 선량률을 서로 다르게 조사해 부화한 초파리 성체의 머리 조직을 분리하여 RNA sequencing method을 통해 전체 유전자의 발현 변화 패턴을 분석함으로써, 저선량 방사선을 이용한 알츠하이머 질환 치료의 유효성 및 안전성 검증을 위한 in vivo 모델과 지표개발 방법으로 활용이 가능하게 하는데 있다.
또한 저선량 방사선에 의해 발현 변화를 나타낸 유전자들을 기능별 분류하고, 저선량 방사선에 의한 반응 지표 유전자를 제시함으로써, 퇴행성 질환에 저선량 방사선 조사 시 치료 마커 개발에 대한 기초자료로 활용이 가능하게 하는데 있다.
상기 목적을 달성하기 위하여 본 발명은 저선량 방사선을 이용한 초파리의 퇴행성 질환 치료에 반응하는 바이오마커를 제공한다.
상기 저선량 방사선은 누적선량이고, 바람직하게는 0.01 내지 0.2 Gy 를 조사할 수 있다.
상기 초파리는 알츠하이머 질환 모델 초파리인 것을 특징으로 한다. 또한, 상기 알츠하이머 질환 모델 초파리는 GMR>Aβ42 또는 elav>Aβ42인 것을 특징으로 한다.
상기 퇴행성 질환은 알츠하이머병(Alzheimer's disease)인 것을 특징으로 한다.
상기 바이오마커는 면역 활성 반응에 관여하는 유전자, 신경세포 재생에 관여하는 유전자, 운동성 기능에 관여하는 유전자 등이 포함될 수 있으며, 상기 면역 활성에 반응하는 대표 유전자는 PGRP-SC1a, PGRP-SC1b이고, 신경세포 재생에 관여하는 대표 유전자는 en, Oseg4, PCNA, scra이며, 운동성 기능에 관여하는 대표 유전자는 Gas8, TrpA1이다. 그 외에 CG9272, ECSIT 등도 바이오 마커에 포함할 수 있다.
상기와 같은 본 발명에 따르면, 선량률을 서로 다르게 조사해 부화한 초파리 성체의 머리 조직을 분리하여 RNA sequencing method을 통해 전체 유전자의 발현 변화 패턴을 분석함으로써, 저선량 방사선 이용한 알츠하이머 질환 치료의 유효성 및 안전성 검증을 위한 in vivo 모델과 지표개발 방법으로 활용이 가능하게 하는 효과가 있다.
또한 저선량 방사선에 의해 발현 변화를 나타낸 유전자들을 기능별 분류하고, 저선량 방사선에 의한 반응 지표 유전자를 제시함으로써, 퇴행성 질환에 저선량 방사선 조사 시 치료 마커 개발에 대한 기초자료로 활용이 가능하게 하는 효과가 있다.
도 1는 초파리 알츠하이머 모델에서 저선량 방사선의 선량 및 선량률에 따른 개선효과를 비교하여 도시하였다.
도 2은 알츠하이머 모델 초파리에서 저선량 방사선 특이적으로 반응하는 기능별 유전자군을 도시하였다.
도 3는 알츠하이머 완화 방향의 발현 변화를 나타낸 저선량 방사선 특이적 반응 유전자 목록을 도시하였다.
도 4은 도3에 제시된 유전자들에 대하여 Real-time PCR을 통한 발현 변화를 도시하였다.
이하, 본 발명을 상세히 설명한다.
본 발명의 일 형태에 따른 저선량 방사선에 감응성 있는 면역 활성 유전자, 신경제포 재생에 관여하는 유전자 및 운동성 기능에 관여하는 유전자를 포함하는 초파리 퇴행성 질환 치료확인 바이오마커를 제공한다.
상기 저선량 방사선은 누적선량 0.01 내지 0.2 Gy가 되도록 조사하는 것이 바람직하며, 각각 선량률을 다르게하여(137Cs, 15.936 mGy/s, 3.147mGy/s, 5mGy/h), 누적선량이 0.01 내지 0.2 Gy가 되도록 조사하는 것이 바람직하고, 더욱 바람직하게는 누적선량이 0.05 Gy가 되도록 조사하는 것이 더욱 바람직하다. UN산하기구 UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation)에 따르면, 누적선량 100 mGy이하를 저선량으로 규정하고 있다. 따라서 본 발명의 저선량의 기준도 상기 UNSCEAR의 기준을 따랐다.
상기 초파리는 알츠하이머 질환 모델 초파리인 것을 특징으로 한다. 상기 알츠하이머 질환 모델 초파리는 GMR>Aβ42 또는 elav>Aβ42인 것을 특징으로 한다. 상기 GMR>Aβ42와 elav>Aβ42는 알츠하이머 질환 모델 초파리이며, UAS/GAL4 시스템을 이용하여 초파리 신경 (neuron; elav-GAL4 이용) 특이적으로 알츠하이머 원인 유전자 Aβ42 (UAS- Aβ42 이용)를 과발현 시켜 알츠하이머 모델 초파리를 제작하여 실험에 사용하였다. 또한, RNA sequencing에 사용 될 선량을 결정하기 위해, 초파리 눈 (GMR-GAL4 이용) 특이적으로 Aβ42 (UAS- Aβ42 이용)를 과발현 시켜 알츠하이머 모델 초파리를 제작하였으며, 초파리 눈에 Aβ42를 과발현 시키면 눈의 크기가 작아지는 표현형이 관찰되는 특징이 있다.
상기 퇴행성 질환은 알츠하이머병(Alzheimer's disease)인 것을 특징으로 한다. 알츠하이머병은 노인에게 주로 나타나는 치매의 주요 원인 가운데 하나이다. 알츠하이머병의 원인으로는 베타-아밀로이드(beta-amyloid) 단백질과 관련성이 높은 것으로 밝혀졌다. 베타 아밀로이드가 체내에서 과도하게 만들어져 뇌세포에 축적되면, 뇌 신경세포의 기능이 떨어져서 알츠하이머병이 발생한다. 베타 아밀로이드는 신경세포 내 미토콘드리아의 기능을 마비시키거나 왜곡시켜 미토콘드리아에서 배출되는 활성산소를 증가시키게 된다. 이렇게 증가된 활성산소는 세포 내 단백질이나 DNA에 치명적인 상처를 입히게 되고 결국 뇌세포의 손상 또는 세포사멸(apoptosis)을 초래한다.
상기 퇴행성 질환에 반응하는 유전자 분석은 방사선의 선량 및 선량률에 따른 개선효과가 다르게 나타남을 확인하기 위해, 저선량 방사선을 조사한 0-6시간 사이의 초파리 알(embryo)을 부화시켜 초파리 성체의 머리 조직을 분리하여 RNA sequencing method을 통해 전체 유전자의 발현 변화 패턴을 조사하여 저선량 방사선에 의해 발현 변화를 나타낸 유전자들을 분석하였다.
상기 바이오마커는 면역 활성 반응에 관여하는 유전자, 신경세포 재생에 관여하는 유전자, 운동성 기능에 관여하는 유전자 등이 포함하며, 상기 면역 활성에 반응하는 대표 유전자는 PGRP-SC1a, PGRP-SC1b이고, 신경세포 재생에 관여하는 대표 유전자는 en, Oseg4, PCNA, scra이며, 운동성 기능에 관여하는 대표 유전자는 Gas8, TrpA1이다. 그 외에 CG9272, ECSIT 등도 바이오 마커에 포함할 수 있다.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로서, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지는 않는 것은 당업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.
실시예 1. 초파리 알츠하이머 모델에서 저선량 방사선의 선량 및 선량률에 따른 개선효과
초파리 눈에 Aβ42를 과발현 시키면 눈의 크기가 작아지는 표현형이 관찰되었다. 이를 이용하여 GMR-GAL4를 통해 초파리 눈 특이적으로 Aβ42를 과발현시킨 0-6시간 사이의 초파리 알(embryo)에 선량률을 서로 다르게하여(137Cs, 각각 15.936 mGy/s, 3.147 mGy/s, 5 mGy/s) 총 0.01~0.2 Gy의 저선량방사선을 조사한 후 25℃ 인큐베이터에서 성체가 될 때까지 배양하여 초파리 눈의 알츠하이머 표현형이 어떻게 달라지는지 비교하였다. 방사선의 선량 및 선량률에 따라 개선효과는 도 1에 도시하였다.
도 1A를 참조하면, 정상 초파리 (GMR-GAL4)에 비해 감소하였던 알츠하이머 모델 초파리 (GMR>Aβ42)의 눈 크기가 저선량방사선 조사에 의해 변화하는 것을 확인 할 수 있었다. 15.936 mGy/s의 선량률로 0.05 Gy를 조사한 경우 눈의 크기가 가장 많이 증가하였다. 특히, 최종 선량 0.05 Gy를 조사한 경우 세가지 선량률 (a-c) 모두에서 유의미하게 눈의 크기가 증가한 것을 학인 할 수 있다. 이 외에 15.936 mGy/s로 0.1 Gy를 조사한 경우에도 눈의 크기가 증가하였다. 그러나 0.2 Gy를 조사한 경우에는 선량률에 따라 눈의 크기가 감소하거나 비슷하였다. 이 결과를 바탕으로, 0.05 Gy (15.936 mGy/s)의 저선량 방사선이 알츠하이머 질환 개선효과가 가장 크다는 것을 확인할 수 있었다.
실시예 2. 알츠하이머 모델 초파리에서 저선량 방사선 특이적으로 반응하는 기능별 유전자군
상기 실시예 1에서 조사한 결과 중에서 가장 좋게 개선효과가 나타난 0.05 Gy (15.936 mGy/s)를 조사한 알츠하이머 모델 (elav>Aβ42) 초파리 알을 25℃ 인큐베이터에서 성체가 될 때까지 배양하여 부화시키고, 부화된 초파리 성체의 머리 조직을 분리하여 RNA sequencing method를 통해 전체 유전자의 발현 변화 패턴을 조사하였다. 좀더 자세하게는 알츠하이머 모델 초파리에 0.05 Gy의 방사선을 15.936 mGy/s의 선량률로 조사하였을 때, 발현이 2배 이상 변화하는 유전자(발현 증가, 82개; 발현 감소, 345개 - 총 427개)를 선정하였다. 이렇게 얻어진 427개의 유전자를 대상으로 gene ontology 분석과 KEGG pathway 분석을 진행하여, 유전자를 각 기능에 따라 분류하였다.
도 2를 참조하면, 알츠하이머 모델 초파리에서 저선량 방사선에 의해 변화되는 유전자들 기능적 분류 중 알츠하이머 질환과 관련 있을 것으로 생각되는 기능적 분류를 선별하고 그에 속하는 유전자들을 나타내었다. 0.05 Gy 방사선 조사에 따라 발현이 대표적으로 증가 (Up-regulated)하는 유전자와 발현이 감소 (Down-regulated)하는 유전자를 나타내었다. 이러한 저선량 방사선에 의해 발현 변화를 나타낸 유전자들을 기능별로 분류하여 도 2에 도시하였다.
실시예 3. 알츠하이머 완화 방향의 발현 변화를 나타낸 저선량 방사선 특이적 반응 유전자
상기 실시예 2에서 분류하여 제시된 유전자들 중 정상 초파리와 비교하였을 때, 저선량방사선 0.05 Gy에 의해 알츠하이머 증상을 완화시키는 방향으로 발현 변화가 일어난 유전자들을 선별하였다. 선별된 유전자들은 면역 활성 (PGRP-SC1a, PGRP-SC1b), 신경세포 재생 (en, Oseg4, PCNA, scra), 운동 기능 (Gas8, TrpA1)에 관여 한다고 이미 보고된 바 있었다. 그러나 본 연구에서는 저선량 방사선에 의해 특이적으로 변화되어 알츠하이머 질환을 개선하는 효과와 관련 있을 것이라는 것을 처음 제시하였다. 선별 결과는 도 3에 도시하였다.
실시예 4. 저선량방사선에 의해 알츠하이머 완화 방향으로 발현 변화가 나타난 대표적인 유전자들에 대한 Real-time PCR을 통한 발현 변화
상기 실시예 3에서 제시된 저선량 방사선에 의해 알츠하이머 증상을 완화시키는 유전자들의 발현을 real-time RT-PCR을 통해 mRNA 수준에서의 변화를 다시 한번 확인함으로써 저선량 방사선에 의한 유전자의 발현 변화를 검증하였다. 그 결과는 도 4에 도시하였다.
이상, 본 발명내용의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서, 이러한 구체적인 기술은 단지 바람직한 실시양태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의해 정의된다고 할 것이다.
<110> Korea Hydro & Nuclear Power Co.,Ltd. <120> Korea Hydro & Nuclear Power Co.,Ltd. <130> P18-E155 <160> 30 <170> KoPatentIn 3.0 <210> 1 <211> 588 <212> DNA <213> Drosophila melanogaster <400> 1 agcgatcgtc aactattaca gctggtaatc atggtttcca aagtggctct cctcctcgcc 60 gtcctggtct gcagccagta catggcccag ggcgtctatg tcgtctccaa ggcggagtgg 120 ggtggtcgcg gcgccaaatg gaccgtaggc ctgggcaact acctcagcta cgccatcatc 180 caccacaccg ccggctccta ctgcgagacc cgtgcccagt gcaacgccgt gctgcagagc 240 gtccagaact accacatgga ctccctgggc tggcccgaca tcggctacaa cttcctgatc 300 ggcggagacg gcaacgtgta cgaggggcgt ggctggaaca acatgggcgc ccacgccgcc 360 gagtggaacc cctacagcat cggcatcagc ttcctgggca actacaactg ggacaccctg 420 gagccgaaca tgatctccgc cgcccagcag ctgctcaacg acgccgtcaa ccgtggccag 480 ctcagctccg gctacatcct gtacggtcat cgccaggtca gcgccaccga atgccccggc 540 acccacatct ggaacgagat ccgcggctgg tcccactggt ctggctag 588 <210> 2 <211> 558 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(555) <400> 2 atg gtt tcc aaa gtg gct ctc ctc ctc gcc gtc ctg gtc tgc agc cag 48 Met Val Ser Lys Val Ala Leu Leu Leu Ala Val Leu Val Cys Ser Gln 1 5 10 15 tac atg gcc cag ggc gtc tat gtc gtc tcc aag gcg gag tgg ggt ggt 96 Tyr Met Ala Gln Gly Val Tyr Val Val Ser Lys Ala Glu Trp Gly Gly 20 25 30 cgc ggc gcc aaa tgg acc gta ggc ctg ggc aac tac ctc agc tac gcc 144 Arg Gly Ala Lys Trp Thr Val Gly Leu Gly Asn Tyr Leu Ser Tyr Ala 35 40 45 atc atc cac cac acc gcc ggc tcc tac tgc gag acc cgt gcc cag tgc 192 Ile Ile His His Thr Ala Gly Ser Tyr Cys Glu Thr Arg Ala Gln Cys 50 55 60 aac gcc gtg ctg cag agc gtc cag aac tac cac atg gac tcc ctg ggc 240 Asn Ala Val Leu Gln Ser Val Gln Asn Tyr His Met Asp Ser Leu Gly 65 70 75 80 tgg ccc gac atc ggc tac aac ttc ctg atc ggc gga gac ggc aac gtg 288 Trp Pro Asp Ile Gly Tyr Asn Phe Leu Ile Gly Gly Asp Gly Asn Val 85 90 95 tac gag ggg cgt ggc tgg aac aac atg ggc gcc cac gcc gcc gag tgg 336 Tyr Glu Gly Arg Gly Trp Asn Asn Met Gly Ala His Ala Ala Glu Trp 100 105 110 aac ccc tac agc atc ggc atc agc ttc ctg ggc aac tac aac tgg gac 384 Asn Pro Tyr Ser Ile Gly Ile Ser Phe Leu Gly Asn Tyr Asn Trp Asp 115 120 125 acc ctg gag ccg aac atg atc tcc gcc gcc cag cag ctg ctc aac gac 432 Thr Leu Glu Pro Asn Met Ile Ser Ala Ala Gln Gln Leu Leu Asn Asp 130 135 140 gcc gtc aac cgt ggc cag ctc agc tcc ggc tac atc ctg tac ggt cat 480 Ala Val Asn Arg Gly Gln Leu Ser Ser Gly Tyr Ile Leu Tyr Gly His 145 150 155 160 cgc cag gtc agc gcc acc gaa tgc ccc ggc acc cac atc tgg aac gag 528 Arg Gln Val Ser Ala Thr Glu Cys Pro Gly Thr His Ile Trp Asn Glu 165 170 175 atc cgc ggc tgg tcc cac tgg tct ggc tag 558 Ile Arg Gly Trp Ser His Trp Ser Gly 180 185 <210> 4 <211> 1649 <212> DNA <213> Drosophila melanogaster <400> 4 agcgatcgtc aactattaca gctggtaatc atggtttcca aagtggctct cctcctcgcc 60 gtcctggtct gcagccagta tatggcccag ggcgtctatg tcgtctccaa ggcggagtgg 120 ggtggtcgcg gcgccaaatg gaccgtaggc ctgggcaact acctcagcta cgccatcatc 180 caccacaccg ccggctccta ctgcgagacc cgtgcccagt gcaacgccgt gctgcagagc 240 gtccagaact accacatgga ctccctgggc tggcccgaca tcggctacaa cttcctgatc 300 ggcggagacg gcaacgtgta cgaggggcgt ggctggaaca acatgggcgc ccacgccgcc 360 gagtggaacc cctacagcat cggcatcagc ttcctgggca actacaactg ggacaccctg 420 gagccgaaca tgatctccgc cgcccagcag ctgctcaacg acgccgtcaa ccgtggccag 480 ctcagctccg gctacatcct gtacggtcat cgccaggtca gcgccaccga atgccccggc 540 actcacatct ggaacgagat ccgcggctgg tcccactggt ctggttagag tggttcctga 600 aaaggttata aaatagtttg aatgatataa tagcgaattc tatattttcg gggattcggg 660 tattgatttg aatgcagtcg tttaaagggc aaagaagggg acatccaatt gcaaagtcct 720 gctcctatta tccatctttg ttttgcaact gaacgctcac gttcaactgt ccaagtattc 780 attccctccc ttttactgaa acttttcaaa tttataaaat catgaggatg tgtgcctgct 840 cagaaagtta cagaacatcg tccgaactct ttttttggaa gtattttagt tatttctttc 900 atggaaagcc aaagcgggta atacaaaaat gtaaaattaa ctttcaaaac cggactggga 960 tattaaatac cgccaaaacc agcggtcaac ttcacaatcg gtagcagacc agagccaact 1020 atttgccact tgaaccgcag tctcattaac gacatcctcg ttaacaaagt tgctctgaat 1080 gggtttcagt tgtttttgtg cttaataact tgcttaagct ttcagttttt aagttcaact 1140 ccgtcctgcc ataaggaaag cacttggtgg cactcggttg gttggacaaa gtggattgac 1200 aaagtggtta cagcccaacg cactcacctt gctgtccctc tgcaggtctt tcgagctgca 1260 cttctacttc cgtgattacc tgttacttat caagatttac gcgctatgtc tggtcattgg 1320 aaagcgaaat ttctgcaagt cagctacctt aacttgtggc tgataagatg aactatagtt 1380 ctgtaatgcc cccttttaat cagttgttta ataatttttg ttataactaa atacgttata 1440 gtacccagct cagcaagcac aaaccatttt aaataaataa tttaacatat tcatatacgg 1500 tgggaaacat ttcatacgga cagccggatg gatatacgga cgggttgaca gagggacgaa 1560 aatatggtcg gaaacgctac cttctaccta ttaacatacc tatcgataaa tctattctac 1620 cccttttaca taacctaaac ttatattgt 1649 <210> 5 <211> 558 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(555) <400> 5 atg gtt tcc aaa gtg gct ctc ctc ctc gcc gtc ctg gtc tgc agc cag 48 Met Val Ser Lys Val Ala Leu Leu Leu Ala Val Leu Val Cys Ser Gln 1 5 10 15 tat atg gcc cag ggc gtc tat gtc gtc tcc aag gcg gag tgg ggt ggt 96 Tyr Met Ala Gln Gly Val Tyr Val Val Ser Lys Ala Glu Trp Gly Gly 20 25 30 cgc ggc gcc aaa tgg acc gta ggc ctg ggc aac tac ctc agc tac gcc 144 Arg Gly Ala Lys Trp Thr Val Gly Leu Gly Asn Tyr Leu Ser Tyr Ala 35 40 45 atc atc cac cac acc gcc ggc tcc tac tgc gag acc cgt gcc cag tgc 192 Ile Ile His His Thr Ala Gly Ser Tyr Cys Glu Thr Arg Ala Gln Cys 50 55 60 aac gcc gtg ctg cag agc gtc cag aac tac cac atg gac tcc ctg ggc 240 Asn Ala Val Leu Gln Ser Val Gln Asn Tyr His Met Asp Ser Leu Gly 65 70 75 80 tgg ccc gac atc ggc tac aac ttc ctg atc ggc gga gac ggc aac gtg 288 Trp Pro Asp Ile Gly Tyr Asn Phe Leu Ile Gly Gly Asp Gly Asn Val 85 90 95 tac gag ggg cgt ggc tgg aac aac atg ggc gcc cac gcc gcc gag tgg 336 Tyr Glu Gly Arg Gly Trp Asn Asn Met Gly Ala His Ala Ala Glu Trp 100 105 110 aac ccc tac agc atc ggc atc agc ttc ctg ggc aac tac aac tgg gac 384 Asn Pro Tyr Ser Ile Gly Ile Ser Phe Leu Gly Asn Tyr Asn Trp Asp 115 120 125 acc ctg gag ccg aac atg atc tcc gcc gcc cag cag ctg ctc aac gac 432 Thr Leu Glu Pro Asn Met Ile Ser Ala Ala Gln Gln Leu Leu Asn Asp 130 135 140 gcc gtc aac cgt ggc cag ctc agc tcc ggc tac atc ctg tac ggt cat 480 Ala Val Asn Arg Gly Gln Leu Ser Ser Gly Tyr Ile Leu Tyr Gly His 145 150 155 160 cgc cag gtc agc gcc acc gaa tgc ccc ggc act cac atc tgg aac gag 528 Arg Gln Val Ser Ala Thr Glu Cys Pro Gly Thr His Ile Trp Asn Glu 165 170 175 atc cgc ggc tgg tcc cac tgg tct ggt tag 558 Ile Arg Gly Trp Ser His Trp Ser Gly 180 185 <210> 7 <211> 4205 <212> DNA <213> Drosophila melanogaster <400> 7 gagggagcga gcgagagagc gctctggcca gctaatagga gtgagtgagc cggcgaaacc 60 ggttcgcatg gggcaggtga caaggctaag agagagcgaa aatcgatcag tgtaaggccg 120 aaaagacaca tcttctactc tcatctcttc atgtcactgt caccaactgc tgtcactcac 180 tcactcgctc gctcgcacac acttcgccag ctacttgtgg gatctcgccc tctcgctccc 240 gcactcggac ctctctttcc accgtgacag ttcaatcggc tctcgcgtta actctccccg 300 acgtcggcgc tgcgattccg aagtagtcaa ctaattcagt cgttgcgctc gatgtgaaca 360 gacgtgcgtg tcggaacaac agttgcaaat caaacacgaa agcataagcc aaacaaaaaa 420 caccaaacag agaagagaat cagaagattc tgagcaatca gaagaatcag tggctcagtg 480 tcaagtgacc cagtgacaag tgtcttaagc gagttgcgat ttagcaccaa gtcgaaacca 540 atggccctgg aggatcgctg cagtccacag tcagcgccca gccccattac cctacaaatg 600 cagcatcttc accaccagca acagcagcag cagcaacagc agcagcaaat gcagcacctc 660 caccagctgc agcaactgca gcagttgcac caacagcaac tggccgccgg tgtcttccac 720 catccggcaa tggccttcga tgccgctgca gccgccgctg ctgcagctgc tgctgcggcc 780 gcccacgctc atgctgctgc actgcagcag cgcctcagtg gcagtggatc gcccgcatcc 840 tgctccacgc ccgcctcgtc cacgccgctg accatcaagg aggaggaaag cgactccgtg 900 atcggtgaca tgagtttcca caatcagacg cacaccacca acgaggagga ggaggcggag 960 gaggatgacg acattgatgt ggatgtggat gatacgtcgg cgggcggacg cctgccacca 1020 cccgcccacc agcagcagtc gacggccaag ccctcgctgg ccttttccat ctccaacatc 1080 ctgagcgatc gtttcggaga tgtccagaag ccgggcaagt cgatggagaa ccaggccagc 1140 atattccgcc ccttcgaggc gagtcgttcc cagactgcca cgccctccgc ctttacaaga 1200 gtggatctgc tggagtttag ccggcaacag caggctgccg ccgcagccgc tactgcggcc 1260 atgatgctgg aacgggccaa cttccttaac tgcttcaatc cggctgccta tcccaggata 1320 cacgaggaaa tcgtgcagag tcggctgcgc aggagtgcag ccaatgccgt catcccgccg 1380 cccatgagct ccaagatgag cgatgccaat ccagagaaat ctgctctggg atccctgtgc 1440 aaggcggtct cgcagatcgg acaacctgct gcccctacga tgacccaacc tccgctgagt 1500 agcagtgcca gcagcttggc cagtccgcca cccgcctcca atgcctcgac cattagcagc 1560 acctcttccg tggccaccag ctcgagctcc tcctcgtcgg gttgctcctc ggcggccagt 1620 tccttgaact cctcgcccag tagccgactg ggagccagtg gatccggagt caatgccagc 1680 agtccccagc cgcagccaat cccgccgcca tccgccgtta gccgagattc cggaatggag 1740 tcctcggatg acacgcgttc cgagacggga tccaccacca cagagggcgg caagaacgag 1800 atgtggcccg cctgggtgta ctgcacccgc tacagcgatc gtcccagctc aggttagtat 1860 ctatgcgatt acctagcgtt taagtgggtc agaaagaggg ttcgtcgggc accatcttca 1920 gtgttgtcaa aacaaggaag tcccaaaggt tcgttaaaaa aaaaaagatg tgaaaatggt 1980 aaatggtata tggttacatg gggaccaccc ttggggagcg ttatgttggc ggcagccttt 2040 caagcagctc tgttttgtgt cataaatccg aaggacactg ccacaattag gcgacacgcg 2100 gacaatggca atgagcccga atctgactcc catttctata accatgccca ttcccattcc 2160 catttcgtat ccgaatccga atccgatttt gggcctcacg cagtgctgcg ctgcttttga 2220 agagcgacac tttatgtgac aacatgtagc gcagagccag cgcttgtcta tcggaactgt 2280 tagatcctca ggtcgaaggt caccgctcac gcacacacgc cacgcagaag ccgagaccct 2340 aaaacgcgct gacgattgac aggggaaaag taggtgcggg ggagatatga tggcggggga 2400 agccccttcg aaaggagaag agttttccat tgacaagcgg agattttcct tgcagctctt 2460 cttagatcgt gtgttaattg acgagttaag tgctttttta tggtcggcaa tggtttttta 2520 atttggtgtc gatgcaatcg atggcagccc ataagcgagg cgttgatggc cccactccgc 2580 ggctaggaat taatcaaacg atctccactt actggcggtc aattaaatta taatttacaa 2640 tgtgtggaaa tctaataagc actacggatt gctgcggtgc cgcgttgcca attagccggt 2700 gacttggact tagtcgctaa ttagagagtt ggctagctgg caaatcattt gcctaaaata 2760 tgccgtagac ctttgggttc gttaactcgc cggagttcta ctcttctctt gcgctgacag 2820 ctgacaaatt gaacacttcc ccgccagcac gcgaaaggga gctccagctc cggccgagga 2880 attccgccca gacatatgct aattgaatca ttaatattat taatagtatg tggcgcattt 2940 atgcaaatag aactaacgta tttctcgtgt ttttgtttat tccaggaccc cgctaccgcc 3000 gccccaaaca gccaaaggac aagaccaacg acgagaagcg tccacgcacc gcgttctcca 3060 gcgagcagtt ggcccgcctt aaggtgagat tcagttcttt tttccatata tggttatatg 3120 gttataccaa tatccatcca tatccatatc caattgccct acgcttgttg tgtcatattt 3180 gcaccaaaat attgacaccg cccgctgcta atgcatcctg gcaatgtggt gtcccgtccg 3240 tacttaacca atcagccacg ctcggccgaa accgcaaata attgattttc cctacctgac 3300 tatacaacat ggatatcctt gccatccgaa actcatccag cattccattt cttccactta 3360 cagcgggagt tcaacgagaa tcgctatctg accgagcgga gacgccagca gctgagcagc 3420 gagttgggcc tgaacgaggc gcagatcaag atctggttcc agaacaagcg ggccaagatc 3480 aagaagtcga cgggctccaa aaatccgctg gcactgcagc tgatggccca gggattgtac 3540 aaccacacca ccgtgccgct gaccaaggag gaggaggagc tcgagatgcg catgaacggg 3600 cagatcccct aagcgctgac caatggttac ccataagggg ttactccttc tgacgggggc 3660 gtgcaatatt cgagggcgta caaatggttt tcatgtgata taattgtagc gtacatatgt 3720 ttttgtatat atctctaaaa atatatatat atatacgtat aatcctaacc tagagtaaga 3780 cccatccgta gcgaattcga gctgtaagtt gttggcgtat ttatttaacc acccctggat 3840 agccgaaagt attatcgtaa tcacccgaca caaagcctat cgctatcgcc gcacttcaaa 3900 agcttcgacc ttcagacgtt tattcctaca caaaacacta tctatagtta ttactcccta 3960 taaattacgc gcttgcaacc gctctgtaaa ttaagtaact taacagttcc ctagcttaat 4020 tcctagttta cacacttaag gattgctatg aaagagtatt ttagtttcta agcgaaatgt 4080 taacgagcaa ctaatagctg gcaaatgcac ctaagaaaat aacaacgaaa tgtttgtgct 4140 aaagcaagtt catgaaaaga aaattaaaaa caaaataaaa gaattatgga aaaaaattaa 4200 aatgc 4205 <210> 8 <211> 1659 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(1656) <400> 8 atg gcc ctg gag gat cgc tgc agt cca cag tca gcg ccc agc ccc att 48 Met Ala Leu Glu Asp Arg Cys Ser Pro Gln Ser Ala Pro Ser Pro Ile 1 5 10 15 acc cta caa atg cag cat ctt cac cac cag caa cag cag cag cag caa 96 Thr Leu Gln Met Gln His Leu His His Gln Gln Gln Gln Gln Gln Gln 20 25 30 cag cag cag caa atg cag cac ctc cac cag ctg cag caa ctg cag cag 144 Gln Gln Gln Gln Met Gln His Leu His Gln Leu Gln Gln Leu Gln Gln 35 40 45 ttg cac caa cag caa ctg gcc gcc ggt gtc ttc cac cat ccg gca atg 192 Leu His Gln Gln Gln Leu Ala Ala Gly Val Phe His His Pro Ala Met 50 55 60 gcc ttc gat gcc gct gca gcc gcc gct gct gca gct gct gct gcg gcc 240 Ala Phe Asp Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 65 70 75 80 gcc cac gct cat gct gct gca ctg cag cag cgc ctc agt ggc agt gga 288 Ala His Ala His Ala Ala Ala Leu Gln Gln Arg Leu Ser Gly Ser Gly 85 90 95 tcg ccc gca tcc tgc tcc acg ccc gcc tcg tcc acg ccg ctg acc atc 336 Ser Pro Ala Ser Cys Ser Thr Pro Ala Ser Ser Thr Pro Leu Thr Ile 100 105 110 aag gag gag gaa agc gac tcc gtg atc ggt gac atg agt ttc cac aat 384 Lys Glu Glu Glu Ser Asp Ser Val Ile Gly Asp Met Ser Phe His Asn 115 120 125 cag acg cac acc acc aac gag gag gag gag gcg gag gag gat gac gac 432 Gln Thr His Thr Thr Asn Glu Glu Glu Glu Ala Glu Glu Asp Asp Asp 130 135 140 att gat gtg gat gtg gat gat acg tcg gcg ggc gga cgc ctg cca cca 480 Ile Asp Val Asp Val Asp Asp Thr Ser Ala Gly Gly Arg Leu Pro Pro 145 150 155 160 ccc gcc cac cag cag cag tcg acg gcc aag ccc tcg ctg gcc ttt tcc 528 Pro Ala His Gln Gln Gln Ser Thr Ala Lys Pro Ser Leu Ala Phe Ser 165 170 175 atc tcc aac atc ctg agc gat cgt ttc gga gat gtc cag aag ccg ggc 576 Ile Ser Asn Ile Leu Ser Asp Arg Phe Gly Asp Val Gln Lys Pro Gly 180 185 190 aag tcg atg gag aac cag gcc agc ata ttc cgc ccc ttc gag gcg agt 624 Lys Ser Met Glu Asn Gln Ala Ser Ile Phe Arg Pro Phe Glu Ala Ser 195 200 205 cgt tcc cag act gcc acg ccc tcc gcc ttt aca aga gtg gat ctg ctg 672 Arg Ser Gln Thr Ala Thr Pro Ser Ala Phe Thr Arg Val Asp Leu Leu 210 215 220 gag ttt agc cgg caa cag cag gct gcc gcc gca gcc gct act gcg gcc 720 Glu Phe Ser Arg Gln Gln Gln Ala Ala Ala Ala Ala Ala Thr Ala Ala 225 230 235 240 atg atg ctg gaa cgg gcc aac ttc ctt aac tgc ttc aat ccg gct gcc 768 Met Met Leu Glu Arg Ala Asn Phe Leu Asn Cys Phe Asn Pro Ala Ala 245 250 255 tat ccc agg ata cac gag gaa atc gtg cag agt cgg ctg cgc agg agt 816 Tyr Pro Arg Ile His Glu Glu Ile Val Gln Ser Arg Leu Arg Arg Ser 260 265 270 gca gcc aat gcc gtc atc ccg ccg ccc atg agc tcc aag atg agc gat 864 Ala Ala Asn Ala Val Ile Pro Pro Pro Met Ser Ser Lys Met Ser Asp 275 280 285 gcc aat cca gag aaa tct gct ctg gga tcc ctg tgc aag gcg gtc tcg 912 Ala Asn Pro Glu Lys Ser Ala Leu Gly Ser Leu Cys Lys Ala Val Ser 290 295 300 cag atc gga caa cct gct gcc cct acg atg acc caa cct ccg ctg agt 960 Gln Ile Gly Gln Pro Ala Ala Pro Thr Met Thr Gln Pro Pro Leu Ser 305 310 315 320 agc agt gcc agc agc ttg gcc agt ccg cca ccc gcc tcc aat gcc tcg 1008 Ser Ser Ala Ser Ser Leu Ala Ser Pro Pro Pro Ala Ser Asn Ala Ser 325 330 335 acc att agc agc acc tct tcc gtg gcc acc agc tcg agc tcc tcc tcg 1056 Thr Ile Ser Ser Thr Ser Ser Val Ala Thr Ser Ser Ser Ser Ser Ser 340 345 350 tcg ggt tgc tcc tcg gcg gcc agt tcc ttg aac tcc tcg ccc agt agc 1104 Ser Gly Cys Ser Ser Ala Ala Ser Ser Leu Asn Ser Ser Pro Ser Ser 355 360 365 cga ctg gga gcc agt gga tcc gga gtc aat gcc agc agt ccc cag ccg 1152 Arg Leu Gly Ala Ser Gly Ser Gly Val Asn Ala Ser Ser Pro Gln Pro 370 375 380 cag cca atc ccg ccg cca tcc gcc gtt agc cga gat tcc gga atg gag 1200 Gln Pro Ile Pro Pro Pro Ser Ala Val Ser Arg Asp Ser Gly Met Glu 385 390 395 400 tcc tcg gat gac acg cgt tcc gag acg gga tcc acc acc aca gag ggc 1248 Ser Ser Asp Asp Thr Arg Ser Glu Thr Gly Ser Thr Thr Thr Glu Gly 405 410 415 ggc aag aac gag atg tgg ccc gcc tgg gtg tac tgc acc cgc tac agc 1296 Gly Lys Asn Glu Met Trp Pro Ala Trp Val Tyr Cys Thr Arg Tyr Ser 420 425 430 gat cgt ccc agc tca gga ccc cgc tac cgc cgc ccc aaa cag cca aag 1344 Asp Arg Pro Ser Ser Gly Pro Arg Tyr Arg Arg Pro Lys Gln Pro Lys 435 440 445 gac aag acc aac gac gag aag cgt cca cgc acc gcg ttc tcc agc gag 1392 Asp Lys Thr Asn Asp Glu Lys Arg Pro Arg Thr Ala Phe Ser Ser Glu 450 455 460 cag ttg gcc cgc ctt aag cgg gag ttc aac gag aat cgc tat ctg acc 1440 Gln Leu Ala Arg Leu Lys Arg Glu Phe Asn Glu Asn Arg Tyr Leu Thr 465 470 475 480 gag cgg aga cgc cag cag ctg agc agc gag ttg ggc ctg aac gag gcg 1488 Glu Arg Arg Arg Gln Gln Leu Ser Ser Glu Leu Gly Leu Asn Glu Ala 485 490 495 cag atc aag atc tgg ttc cag aac aag cgg gcc aag atc aag aag tcg 1536 Gln Ile Lys Ile Trp Phe Gln Asn Lys Arg Ala Lys Ile Lys Lys Ser 500 505 510 acg ggc tcc aaa aat ccg ctg gca ctg cag ctg atg gcc cag gga ttg 1584 Thr Gly Ser Lys Asn Pro Leu Ala Leu Gln Leu Met Ala Gln Gly Leu 515 520 525 tac aac cac acc acc gtg ccg ctg acc aag gag gag gag gag ctc gag 1632 Tyr Asn His Thr Thr Val Pro Leu Thr Lys Glu Glu Glu Glu Leu Glu 530 535 540 atg cgc atg aac ggg cag atc ccc taa 1659 Met Arg Met Asn Gly Gln Ile Pro 545 550 <210> 10 <211> 4775 <212> DNA <213> Drosophila melanogaster <400> 10 ccacttgcca ccaataccaa ttgaaccact ttttgggccc aaaacaggct tgggtctttg 60 gccagctgac aaaccgaagt tgggatcacc atggaaacca attagttttg ctgccacagc 120 aaatgcggaa aaacattgaa gagaactgaa agaatccaag tgcacttgca actccaagat 180 gttcgtttac ctcagcaaaa aggtaggctt cacttagggt accaacaaat ggtctacaag 240 gtctctcctc cagattgcca tacccaataa tgtgaagctc aattgcatcg cttggaataa 300 ggaggagggc tacatcgcag tggccggaac ggatggactg cttaaggtcc tgaaactgga 360 ccagggtgag tgccacgatc agggatagga agtaacctgg gtcggacatc taggtacttt 420 ctaatcttcc ttgtgcctaa tcgaacgtgt tgaatctcaa ttgctcaata ctcattaaag 480 cttactgttt ccaataatca agataaagaa agttaactac ttccaagtat caagatatat 540 ctcataacat aacccgtttt taataccata tactgctccg atttgatcat tactttatgc 600 ccatctccag ccactcccaa cggacagagc aagggcgggc tggccgccgt ttccaatttg 660 tcgatgaacc agaccctgga tgggcacaag gagtcggtgc gggtggtcac ctggaacgat 720 gcgcagcaga agctgacctc ctcggacacg gacggtgtga tcatggtgtg gatgctgtac 780 aagggatcct ggtacgagga gatgaccaac gacagaaaga agtccacggt ggccagcatg 840 agctggacgt cggacggatc gcggatctgc atcgtctatg aggatggggc gattatagtg 900 ggctcagtgg atggcaaccg catctttggc aaggagctga agggcaccca tctgactggc 960 gtgcagtgga gtccggacaa tcggctaatc ctctttgcgc tggccaacgg ggagtgtcat 1020 ctgtacgata accaaggcaa ctttgctgta agttagtact tgattatcct tcatacttac 1080 ccactttggt tggttatgta ctccagatga agctgcacat ccagtgcgtg aacataagtg 1140 gcggctcctc ctccagaggt caccgcatag ccagcatctg ctggttcagt ggcagggtcg 1200 tccagagtcg aaagcgtcca gttctggcca tttgctatga gaacggaagg gtgcagatca 1260 tgaggaacga aaatgacgac ggtaggaggt gatgcaagct ctagagtctc ctaactaacc 1320 cacatgactt ttagcacccg caatcttcga cactgggatg cgcaatgtgg acgccaagtg 1380 gaaccatgat ggcactgtgt tggccatttg tggcaccacc ttggacgcgg taagtccgac 1440 ttcgcagcgc gacaccaacc aggtgtgctt ctactcgccg ctgggcaaga tctaccgcac 1500 tctgaaggtg cctggcaccg acatcacctc gcttagctgg gagggcaaat cgctgcgcat 1560 cgccatggcc gtggattcgt tcatctactt cgccaacatc cgaccggact acatctggtg 1620 ttacttcgag aagactgtgg tgttcctgaa cagcggcagt gcaaccaggg agtcgcccat 1680 gagcgtgatc accttctgga acaccgtctc aaatcagagt ttcctcaagg aggtggagcc 1740 caccttgtgc ctggcgtcca gcagcgagca ttgcgtcctg ggcgtcgagt gtgtcagcag 1800 caacatcaag gagattgcgc tgagcaccct ggagaaccga agtaatcctg cggacgatag 1860 ggtctaccag ttgctcctct gcaattcaat tggcaccacc gtggattgtg agtagatcac 1920 cgttgttgat gtttcggact aatcccagtt atttttagcc aagtacacgg atattagacc 1980 ctgctttgtg ggcatcaact cgagctatgt ggccatagcg tcccaggagg agattctaat 2040 ttggcactac cacacaccca aggtgggcac tttcagtcat caacctggtt accaattgac 2100 taacccccat tgatctccct tcagagtgcc tccaccctgc acaatgtgaa ggcgcgcaag 2160 gagaagcggt tccatatcga cgacacgccc acgggagtgg aaatggccaa ggacctgatg 2220 ctgagcagta gcagtggcga tggtcactcc acgcagcggg gaatcagtga tcccatctgt 2280 gcgctggcac tctccgagaa gctgctcctt gtcgccaggg aatccggcgc tatcaacgag 2340 tacagcatag caaacgtggc tctgaggaac cgccacctga tgaacgccaa ggtctacaag 2400 atggctatca actgcaattc cacgtgggta gtccaccaca ctcccttgat actagtaata 2460 tttatactcc ttacttagac gagccgccat tatcgaccat atgggcgtga tgaccctgct 2520 cgacctggac gacaacaggg agacccaact gaacttcagt cgggtggagc gcaaggacgt 2580 ttgggccgtg agctgggcca cggataaccc actgctgctg gctctgatgg agaaaacgcg 2640 catgtatatc ttccggggca atgatcccga ggagcccgtg tcctgctccg gctacatatg 2700 caccttcgag gacttggaga tcaccagtgt cctgctggac gacataatca gcgtgggtga 2760 gctgcagaat ttttcgcata tcattcagct gagggtaaag tccctgcgcg ataccgacga 2820 tctactggag cacgtgggac tggaggatgc caagcagttc attgaggaca acccgcatcc 2880 gaggctctgg cgactgctgg cggagtctgc gttgaagaaa ctggaactgg agacggcgga 2940 gaacgccttt gtccgttgtg cccactaccc gggcattaag ttggtcaaga gactgcgcac 3000 catacactcc aaggagctgc agagggcgga gatatcagcc ttctacggag agttcgagga 3060 ggcggagaag ctctacctgg acgcggatcg tcgcgatctg gccatagagc tgcgcatgac 3120 cctttgcgat tggtttcgcg tggtgcagct gtacagaatg ggaggatcgg gagtgtcgga 3180 ccagcagatg gagatcgctt ggcgggagat tggccaccac ttcgccaacc tgcgctcctg 3240 ggagagtgcc agggaatact acgagaagtc ccactacctg gagggttaca tggaggctct 3300 gtaccacttg gagcagttcg acgacttgga aaagtgcgtg gaacggctac cggagaagag 3360 cccgctgctt ccgaagctgg ccgagatgct ggcctccgtg ggcatgtgct ccgaggctgt 3420 tcaagcccat cttcgattcg gcgaccagaa ggccgccgtc gccacctgcg ttaatctccg 3480 gcagtggggc gaggctgttg agctggccca gaggttccag ctgccccagg tgcaaacgct 3540 catagccaag cacgcggcac agttgctcca ggagggacgc ctcaaggaag ccatcgagat 3600 gcagcggaat gctgggcgtc atctagatgc agctcgcctg ctttctcaaa tggcggaacg 3660 ggagcaagag aagcgtgctc cgctgctgag aatcaagaag ctgtacgtgc tggctgctct 3720 gctggccgag gagcacctca aggctgtggc cacgacggag atcgactacg ccagcggcag 3780 gaacacccta ctggactcca ttgccctgga ggatgcggcc gccatcgaga ggctttggca 3840 ctgcgccgag gcctaccact tcatgctcct agcccagagg cagcttcgct tcgggatcgt 3900 ccacagtgcg gtggtcactg cggtgaggct gcgcgactac gaggacgtcc tgcctccaga 3960 gcacatctac agcctgttgg cactggccag ctgtgcggat cgggccttcg gaacctgctc 4020 caaggctttc atgaagttgg agcaacaggc tcatcttccc gaggctaccc ttcaacggta 4080 cgaggagttg gcggctggga tcttcgccaa gtacgatccg gaggacacca ctggcgatag 4140 ggtggattgc tattcctgcg gagtgcccgt gccagatagg taagtgaagg gtcgacgtca 4200 gaagctggat tataatgatg atactcatgg aatgccgatc ctttcagctc cccctcctgc 4260 cccgagtgca atgctcgctt cccggcgtgc atctcctccg ggaaacccat cacccagccg 4320 acgaacaaca tatggatctg taccacctgc caccactgcg cagctcccac cgagatctcc 4380 aggcaccgaa cttgcccact gtgccacagt ttgatcgtgt ccatgacggt ggagatctga 4440 aatgagcggg gactagtgtt ttaattactc cagctgtttt tcattctgct tatcccaggt 4500 ggtacaggcg tatctactcc gcaaataaac aatgtagttt taagatagaa ttcaaattta 4560 ttttcaagtg aaaagtgtta taagtggaaa gagtgactgt tcacagtgag tatttcctgg 4620 ggagtgcgct agggccacac tactagctca tccaacactc gcaaagcggt cacactggcg 4680 agtgcagcta agtaagtcgg ttgtccgttt cttgctgaat tttaaataag ttaaataaat 4740 ttctgcttcg tgcggtggtg tgcgtacgca aatat 4775 <210> 11 <211> 3618 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(3615) <400> 11 atg ttc gtt tac ctc agc aaa aag att gcc ata ccc aat aat gtg aag 48 Met Phe Val Tyr Leu Ser Lys Lys Ile Ala Ile Pro Asn Asn Val Lys 1 5 10 15 ctc aat tgc atc gct tgg aat aag gag gag ggc tac atc gca gtg gcc 96 Leu Asn Cys Ile Ala Trp Asn Lys Glu Glu Gly Tyr Ile Ala Val Ala 20 25 30 gga acg gat gga ctg ctt aag gtc ctg aaa ctg gac cag gcc act ccc 144 Gly Thr Asp Gly Leu Leu Lys Val Leu Lys Leu Asp Gln Ala Thr Pro 35 40 45 aac gga cag agc aag ggc ggg ctg gcc gcc gtt tcc aat ttg tcg atg 192 Asn Gly Gln Ser Lys Gly Gly Leu Ala Ala Val Ser Asn Leu Ser Met 50 55 60 aac cag acc ctg gat ggg cac aag gag tcg gtg cgg gtg gtc acc tgg 240 Asn Gln Thr Leu Asp Gly His Lys Glu Ser Val Arg Val Val Thr Trp 65 70 75 80 aac gat gcg cag cag aag ctg acc tcc tcg gac acg gac ggt gtg atc 288 Asn Asp Ala Gln Gln Lys Leu Thr Ser Ser Asp Thr Asp Gly Val Ile 85 90 95 atg gtg tgg atg ctg tac aag gga tcc tgg tac gag gag atg acc aac 336 Met Val Trp Met Leu Tyr Lys Gly Ser Trp Tyr Glu Glu Met Thr Asn 100 105 110 gac aga aag aag tcc acg gtg gcc agc atg agc tgg acg tcg gac gga 384 Asp Arg Lys Lys Ser Thr Val Ala Ser Met Ser Trp Thr Ser Asp Gly 115 120 125 tcg cgg atc tgc atc gtc tat gag gat ggg gcg att ata gtg ggc tca 432 Ser Arg Ile Cys Ile Val Tyr Glu Asp Gly Ala Ile Ile Val Gly Ser 130 135 140 gtg gat ggc aac cgc atc ttt ggc aag gag ctg aag ggc acc cat ctg 480 Val Asp Gly Asn Arg Ile Phe Gly Lys Glu Leu Lys Gly Thr His Leu 145 150 155 160 act ggc gtg cag tgg agt ccg gac aat cgg cta atc ctc ttt gcg ctg 528 Thr Gly Val Gln Trp Ser Pro Asp Asn Arg Leu Ile Leu Phe Ala Leu 165 170 175 gcc aac ggg gag tgt cat ctg tac gat aac caa ggc aac ttt gct atg 576 Ala Asn Gly Glu Cys His Leu Tyr Asp Asn Gln Gly Asn Phe Ala Met 180 185 190 aag ctg cac atc cag tgc gtg aac ata agt ggc ggc tcc tcc tcc aga 624 Lys Leu His Ile Gln Cys Val Asn Ile Ser Gly Gly Ser Ser Ser Arg 195 200 205 ggt cac cgc ata gcc agc atc tgc tgg ttc agt ggc agg gtc gtc cag 672 Gly His Arg Ile Ala Ser Ile Cys Trp Phe Ser Gly Arg Val Val Gln 210 215 220 agt cga aag cgt cca gtt ctg gcc att tgc tat gag aac gga agg gtg 720 Ser Arg Lys Arg Pro Val Leu Ala Ile Cys Tyr Glu Asn Gly Arg Val 225 230 235 240 cag atc atg agg aac gaa aat gac gac gca ccc gca atc ttc gac act 768 Gln Ile Met Arg Asn Glu Asn Asp Asp Ala Pro Ala Ile Phe Asp Thr 245 250 255 ggg atg cgc aat gtg gac gcc aag tgg aac cat gat ggc act gtg ttg 816 Gly Met Arg Asn Val Asp Ala Lys Trp Asn His Asp Gly Thr Val Leu 260 265 270 gcc att tgt ggc acc acc ttg gac gcg gta agt ccg act tcg cag cgc 864 Ala Ile Cys Gly Thr Thr Leu Asp Ala Val Ser Pro Thr Ser Gln Arg 275 280 285 gac acc aac cag gtg tgc ttc tac tcg ccg ctg ggc aag atc tac cgc 912 Asp Thr Asn Gln Val Cys Phe Tyr Ser Pro Leu Gly Lys Ile Tyr Arg 290 295 300 act ctg aag gtg cct ggc acc gac atc acc tcg ctt agc tgg gag ggc 960 Thr Leu Lys Val Pro Gly Thr Asp Ile Thr Ser Leu Ser Trp Glu Gly 305 310 315 320 aaa tcg ctg cgc atc gcc atg gcc gtg gat tcg ttc atc tac ttc gcc 1008 Lys Ser Leu Arg Ile Ala Met Ala Val Asp Ser Phe Ile Tyr Phe Ala 325 330 335 aac atc cga ccg gac tac atc tgg tgt tac ttc gag aag act gtg gtg 1056 Asn Ile Arg Pro Asp Tyr Ile Trp Cys Tyr Phe Glu Lys Thr Val Val 340 345 350 ttc ctg aac agc ggc agt gca acc agg gag tcg ccc atg agc gtg atc 1104 Phe Leu Asn Ser Gly Ser Ala Thr Arg Glu Ser Pro Met Ser Val Ile 355 360 365 acc ttc tgg aac acc gtc tca aat cag agt ttc ctc aag gag gtg gag 1152 Thr Phe Trp Asn Thr Val Ser Asn Gln Ser Phe Leu Lys Glu Val Glu 370 375 380 ccc acc ttg tgc ctg gcg tcc agc agc gag cat tgc gtc ctg ggc gtc 1200 Pro Thr Leu Cys Leu Ala Ser Ser Ser Glu His Cys Val Leu Gly Val 385 390 395 400 gag tgt gtc agc agc aac atc aag gag att gcg ctg agc acc ctg gag 1248 Glu Cys Val Ser Ser Asn Ile Lys Glu Ile Ala Leu Ser Thr Leu Glu 405 410 415 aac cga agt aat cct gcg gac gat agg gtc tac cag ttg ctc ctc tgc 1296 Asn Arg Ser Asn Pro Ala Asp Asp Arg Val Tyr Gln Leu Leu Leu Cys 420 425 430 aat tca att ggc acc acc gtg gat tcc aag tac acg gat att aga ccc 1344 Asn Ser Ile Gly Thr Thr Val Asp Ser Lys Tyr Thr Asp Ile Arg Pro 435 440 445 tgc ttt gtg ggc atc aac tcg agc tat gtg gcc ata gcg tcc cag gag 1392 Cys Phe Val Gly Ile Asn Ser Ser Tyr Val Ala Ile Ala Ser Gln Glu 450 455 460 gag att cta att tgg cac tac cac aca ccc aag agt gcc tcc acc ctg 1440 Glu Ile Leu Ile Trp His Tyr His Thr Pro Lys Ser Ala Ser Thr Leu 465 470 475 480 cac aat gtg aag gcg cgc aag gag aag cgg ttc cat atc gac gac acg 1488 His Asn Val Lys Ala Arg Lys Glu Lys Arg Phe His Ile Asp Asp Thr 485 490 495 ccc acg gga gtg gaa atg gcc aag gac ctg atg ctg agc agt agc agt 1536 Pro Thr Gly Val Glu Met Ala Lys Asp Leu Met Leu Ser Ser Ser Ser 500 505 510 ggc gat ggt cac tcc acg cag cgg gga atc agt gat ccc atc tgt gcg 1584 Gly Asp Gly His Ser Thr Gln Arg Gly Ile Ser Asp Pro Ile Cys Ala 515 520 525 ctg gca ctc tcc gag aag ctg ctc ctt gtc gcc agg gaa tcc ggc gct 1632 Leu Ala Leu Ser Glu Lys Leu Leu Leu Val Ala Arg Glu Ser Gly Ala 530 535 540 atc aac gag tac agc ata gca aac gtg gct ctg agg aac cgc cac ctg 1680 Ile Asn Glu Tyr Ser Ile Ala Asn Val Ala Leu Arg Asn Arg His Leu 545 550 555 560 atg aac gcc aag gtc tac aag atg gct atc aac tgc aat tcc aca cga 1728 Met Asn Ala Lys Val Tyr Lys Met Ala Ile Asn Cys Asn Ser Thr Arg 565 570 575 gcc gcc att atc gac cat atg ggc gtg atg acc ctg ctc gac ctg gac 1776 Ala Ala Ile Ile Asp His Met Gly Val Met Thr Leu Leu Asp Leu Asp 580 585 590 gac aac agg gag acc caa ctg aac ttc agt cgg gtg gag cgc aag gac 1824 Asp Asn Arg Glu Thr Gln Leu Asn Phe Ser Arg Val Glu Arg Lys Asp 595 600 605 gtt tgg gcc gtg agc tgg gcc acg gat aac cca ctg ctg ctg gct ctg 1872 Val Trp Ala Val Ser Trp Ala Thr Asp Asn Pro Leu Leu Leu Ala Leu 610 615 620 atg gag aaa acg cgc atg tat atc ttc cgg ggc aat gat ccc gag gag 1920 Met Glu Lys Thr Arg Met Tyr Ile Phe Arg Gly Asn Asp Pro Glu Glu 625 630 635 640 ccc gtg tcc tgc tcc ggc tac ata tgc acc ttc gag gac ttg gag atc 1968 Pro Val Ser Cys Ser Gly Tyr Ile Cys Thr Phe Glu Asp Leu Glu Ile 645 650 655 acc agt gtc ctg ctg gac gac ata atc agc gtg ggt gag ctg cag aat 2016 Thr Ser Val Leu Leu Asp Asp Ile Ile Ser Val Gly Glu Leu Gln Asn 660 665 670 ttt tcg cat atc att cag ctg agg gta aag tcc ctg cgc gat acc gac 2064 Phe Ser His Ile Ile Gln Leu Arg Val Lys Ser Leu Arg Asp Thr Asp 675 680 685 gat cta ctg gag cac gtg gga ctg gag gat gcc aag cag ttc att gag 2112 Asp Leu Leu Glu His Val Gly Leu Glu Asp Ala Lys Gln Phe Ile Glu 690 695 700 gac aac ccg cat ccg agg ctc tgg cga ctg ctg gcg gag tct gcg ttg 2160 Asp Asn Pro His Pro Arg Leu Trp Arg Leu Leu Ala Glu Ser Ala Leu 705 710 715 720 aag aaa ctg gaa ctg gag acg gcg gag aac gcc ttt gtc cgt tgt gcc 2208 Lys Lys Leu Glu Leu Glu Thr Ala Glu Asn Ala Phe Val Arg Cys Ala 725 730 735 cac tac ccg ggc att aag ttg gtc aag aga ctg cgc acc ata cac tcc 2256 His Tyr Pro Gly Ile Lys Leu Val Lys Arg Leu Arg Thr Ile His Ser 740 745 750 aag gag ctg cag agg gcg gag ata tca gcc ttc tac gga gag ttc gag 2304 Lys Glu Leu Gln Arg Ala Glu Ile Ser Ala Phe Tyr Gly Glu Phe Glu 755 760 765 gag gcg gag aag ctc tac ctg gac gcg gat cgt cgc gat ctg gcc ata 2352 Glu Ala Glu Lys Leu Tyr Leu Asp Ala Asp Arg Arg Asp Leu Ala Ile 770 775 780 gag ctg cgc atg acc ctt tgc gat tgg ttt cgc gtg gtg cag ctg tac 2400 Glu Leu Arg Met Thr Leu Cys Asp Trp Phe Arg Val Val Gln Leu Tyr 785 790 795 800 aga atg gga gga tcg gga gtg tcg gac cag cag atg gag atc gct tgg 2448 Arg Met Gly Gly Ser Gly Val Ser Asp Gln Gln Met Glu Ile Ala Trp 805 810 815 cgg gag att ggc cac cac ttc gcc aac ctg cgc tcc tgg gag agt gcc 2496 Arg Glu Ile Gly His His Phe Ala Asn Leu Arg Ser Trp Glu Ser Ala 820 825 830 agg gaa tac tac gag aag tcc cac tac ctg gag ggt tac atg gag gct 2544 Arg Glu Tyr Tyr Glu Lys Ser His Tyr Leu Glu Gly Tyr Met Glu Ala 835 840 845 ctg tac cac ttg gag cag ttc gac gac ttg gaa aag tgc gtg gaa cgg 2592 Leu Tyr His Leu Glu Gln Phe Asp Asp Leu Glu Lys Cys Val Glu Arg 850 855 860 cta ccg gag aag agc ccg ctg ctt ccg aag ctg gcc gag atg ctg gcc 2640 Leu Pro Glu Lys Ser Pro Leu Leu Pro Lys Leu Ala Glu Met Leu Ala 865 870 875 880 tcc gtg ggc atg tgc tcc gag gct gtt caa gcc cat ctt cga ttc ggc 2688 Ser Val Gly Met Cys Ser Glu Ala Val Gln Ala His Leu Arg Phe Gly 885 890 895 gac cag aag gcc gcc gtc gcc acc tgc gtt aat ctc cgg cag tgg ggc 2736 Asp Gln Lys Ala Ala Val Ala Thr Cys Val Asn Leu Arg Gln Trp Gly 900 905 910 gag gct gtt gag ctg gcc cag agg ttc cag ctg ccc cag gtg caa acg 2784 Glu Ala Val Glu Leu Ala Gln Arg Phe Gln Leu Pro Gln Val Gln Thr 915 920 925 ctc ata gcc aag cac gcg gca cag ttg ctc cag gag gga cgc ctc aag 2832 Leu Ile Ala Lys His Ala Ala Gln Leu Leu Gln Glu Gly Arg Leu Lys 930 935 940 gaa gcc atc gag atg cag cgg aat gct ggg cgt cat cta gat gca gct 2880 Glu Ala Ile Glu Met Gln Arg Asn Ala Gly Arg His Leu Asp Ala Ala 945 950 955 960 cgc ctg ctt tct caa atg gcg gaa cgg gag caa gag aag cgt gct ccg 2928 Arg Leu Leu Ser Gln Met Ala Glu Arg Glu Gln Glu Lys Arg Ala Pro 965 970 975 ctg ctg aga atc aag aag ctg tac gtg ctg gct gct ctg ctg gcc gag 2976 Leu Leu Arg Ile Lys Lys Leu Tyr Val Leu Ala Ala Leu Leu Ala Glu 980 985 990 gag cac ctc aag gct gtg gcc acg acg gag atc gac tac gcc agc ggc 3024 Glu His Leu Lys Ala Val Ala Thr Thr Glu Ile Asp Tyr Ala Ser Gly 995 1000 1005 agg aac acc cta ctg gac tcc att gcc ctg gag gat gcg gcc gcc atc 3072 Arg Asn Thr Leu Leu Asp Ser Ile Ala Leu Glu Asp Ala Ala Ala Ile 1010 1015 1020 gag agg ctt tgg cac tgc gcc gag gcc tac cac ttc atg ctc cta gcc 3120 Glu Arg Leu Trp His Cys Ala Glu Ala Tyr His Phe Met Leu Leu Ala 1025 1030 1035 1040 cag agg cag ctt cgc ttc ggg atc gtc cac agt gcg gtg gtc act gcg 3168 Gln Arg Gln Leu Arg Phe Gly Ile Val His Ser Ala Val Val Thr Ala 1045 1050 1055 gtg agg ctg cgc gac tac gag gac gtc ctg cct cca gag cac atc tac 3216 Val Arg Leu Arg Asp Tyr Glu Asp Val Leu Pro Pro Glu His Ile Tyr 1060 1065 1070 agc ctg ttg gca ctg gcc agc tgt gcg gat cgg gcc ttc gga acc tgc 3264 Ser Leu Leu Ala Leu Ala Ser Cys Ala Asp Arg Ala Phe Gly Thr Cys 1075 1080 1085 tcc aag gct ttc atg aag ttg gag caa cag gct cat ctt ccc gag gct 3312 Ser Lys Ala Phe Met Lys Leu Glu Gln Gln Ala His Leu Pro Glu Ala 1090 1095 1100 acc ctt caa cgg tac gag gag ttg gcg gct ggg atc ttc gcc aag tac 3360 Thr Leu Gln Arg Tyr Glu Glu Leu Ala Ala Gly Ile Phe Ala Lys Tyr 1105 1110 1115 1120 gat ccg gag gac acc act ggc gat agg gtg gat tgc tat tcc tgc gga 3408 Asp Pro Glu Asp Thr Thr Gly Asp Arg Val Asp Cys Tyr Ser Cys Gly 1125 1130 1135 gtg ccc gtg cca gat agc tcc ccc tcc tgc ccc gag tgc aat gct cgc 3456 Val Pro Val Pro Asp Ser Ser Pro Ser Cys Pro Glu Cys Asn Ala Arg 1140 1145 1150 ttc ccg gcg tgc atc tcc tcc ggg aaa ccc atc acc cag ccg acg aac 3504 Phe Pro Ala Cys Ile Ser Ser Gly Lys Pro Ile Thr Gln Pro Thr Asn 1155 1160 1165 aac ata tgg atc tgt acc acc tgc cac cac tgc gca gct ccc acc gag 3552 Asn Ile Trp Ile Cys Thr Thr Cys His His Cys Ala Ala Pro Thr Glu 1170 1175 1180 atc tcc agg cac cga act tgc cca ctg tgc cac agt ttg atc gtg tcc 3600 Ile Ser Arg His Arg Thr Cys Pro Leu Cys His Ser Leu Ile Val Ser 1185 1190 1195 1200 atg acg gtg gag atc tga 3618 Met Thr Val Glu Ile 1205 <210> 13 <211> 1130 <212> DNA <213> Drosophila melanogaster <400> 13 gtggcttttc acatccctat cccgctcatt tagcccgcct gaaagtaaaa aaaaaaaaca 60 gcccacgtta atcattcatc ccaaagtcac agccgcggta acattactgc tgttaaattc 120 ttaagcccgt catcagtatt taaataataa aacacattca atatgttcga ggcacgcctg 180 ggtcaagcca ccatcctgaa gaagatcttg gatgccatca aggatctgct caatgaggca 240 accttcgatt gcagcgactc cggcattcag gtaaaaattg cacaaaaaag attttaaatg 300 catatcccta acaccttgtt caacttacag ctacaggcca tggacaactc ccatgtgtcg 360 cttgtctcgc tgaccctgcg ttccgatggc ttcgacaagt ttcgctgcga ccgcaatctc 420 tccatgggca tgaatctggg cagcatggcc aagattctga aatgcgccaa caacgaggac 480 aatgtgacga tgaaggcgca ggataacgcc gacactgtca ccatcatgtt cgaatcggct 540 aaccaggaga aggtatcgga ctacgagatg aaactgatga acctcgacca ggagcacctg 600 ggcataccgg agacagactt ctcgtgcgtg gtccgcatgc cggccatgga gttcgctcgc 660 atctgccgcg atctggcgca gttcagcgaa tccgttgtga tctgctgcac caaggagggc 720 gtcaagttct cggccagcgg cgatgtgggc accgccaaca ttaagctagc ccaaaccggc 780 tctgtcgaca aggaggagga ggcggtgatc atcgagatgc aggagccggt gacgctgaca 840 tttgcctgtc gctacctgaa cgccttcaca aaggcgacgc cattgtccac ccaagtgcag 900 ctgtcgatgt gcgcagatgt tccgctggta gtcgagtatg cgatcaagga tctgggtcac 960 attcgctact acctggcacc caagatcgag gacaacgaga cataagtcag ctgtgttcct 1020 catatttatg tccccgcatc gtcaccactc atcttcccac gttcacttca ttcctaactt 1080 ttaagtaaat ccgcattttt tgatcaataa aagctatact gtgtaatgtt 1130 <210> 14 <211> 783 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(780) <400> 14 atg ttc gag gca cgc ctg ggt caa gcc acc atc ctg aag aag atc ttg 48 Met Phe Glu Ala Arg Leu Gly Gln Ala Thr Ile Leu Lys Lys Ile Leu 1 5 10 15 gat gcc atc aag gat ctg ctc aat gag gca acc ttc gat tgc agc gac 96 Asp Ala Ile Lys Asp Leu Leu Asn Glu Ala Thr Phe Asp Cys Ser Asp 20 25 30 tcc ggc att cag cta cag gcc atg gac aac tcc cat gtg tcg ctt gtc 144 Ser Gly Ile Gln Leu Gln Ala Met Asp Asn Ser His Val Ser Leu Val 35 40 45 tcg ctg acc ctg cgt tcc gat ggc ttc gac aag ttt cgc tgc gac cgc 192 Ser Leu Thr Leu Arg Ser Asp Gly Phe Asp Lys Phe Arg Cys Asp Arg 50 55 60 aat ctc tcc atg ggc atg aat ctg ggc agc atg gcc aag att ctg aaa 240 Asn Leu Ser Met Gly Met Asn Leu Gly Ser Met Ala Lys Ile Leu Lys 65 70 75 80 tgc gcc aac aac gag gac aat gtg acg atg aag gcg cag gat aac gcc 288 Cys Ala Asn Asn Glu Asp Asn Val Thr Met Lys Ala Gln Asp Asn Ala 85 90 95 gac act gtc acc atc atg ttc gaa tcg gct aac cag gag aag gta tcg 336 Asp Thr Val Thr Ile Met Phe Glu Ser Ala Asn Gln Glu Lys Val Ser 100 105 110 gac tac gag atg aaa ctg atg aac ctc gac cag gag cac ctg ggc ata 384 Asp Tyr Glu Met Lys Leu Met Asn Leu Asp Gln Glu His Leu Gly Ile 115 120 125 ccg gag aca gac ttc tcg tgc gtg gtc cgc atg ccg gcc atg gag ttc 432 Pro Glu Thr Asp Phe Ser Cys Val Val Arg Met Pro Ala Met Glu Phe 130 135 140 gct cgc atc tgc cgc gat ctg gcg cag ttc agc gaa tcc gtt gtg atc 480 Ala Arg Ile Cys Arg Asp Leu Ala Gln Phe Ser Glu Ser Val Val Ile 145 150 155 160 tgc tgc acc aag gag ggc gtc aag ttc tcg gcc agc ggc gat gtg ggc 528 Cys Cys Thr Lys Glu Gly Val Lys Phe Ser Ala Ser Gly Asp Val Gly 165 170 175 acc gcc aac att aag cta gcc caa acc ggc tct gtc gac aag gag gag 576 Thr Ala Asn Ile Lys Leu Ala Gln Thr Gly Ser Val Asp Lys Glu Glu 180 185 190 gag gcg gtg atc atc gag atg cag gag ccg gtg acg ctg aca ttt gcc 624 Glu Ala Val Ile Ile Glu Met Gln Glu Pro Val Thr Leu Thr Phe Ala 195 200 205 tgt cgc tac ctg aac gcc ttc aca aag gcg acg cca ttg tcc acc caa 672 Cys Arg Tyr Leu Asn Ala Phe Thr Lys Ala Thr Pro Leu Ser Thr Gln 210 215 220 gtg cag ctg tcg atg tgc gca gat gtt ccg ctg gta gtc gag tat gcg 720 Val Gln Leu Ser Met Cys Ala Asp Val Pro Leu Val Val Glu Tyr Ala 225 230 235 240 atc aag gat ctg ggt cac att cgc tac tac ctg gca ccc aag atc gag 768 Ile Lys Asp Leu Gly His Ile Arg Tyr Tyr Leu Ala Pro Lys Ile Glu 245 250 255 gac aac gag aca taa 783 Asp Asn Glu Thr 260 <210> 16 <211> 5124 <212> DNA <213> Drosophila melanogaster <400> 16 ccaccctgcc aaatacgaca aagtggcagc ccttggcaac tcaccactgg cattttctcc 60 ccaatttcgg tatttcgtcg tggtcagttg agggtcctat ggcatttgcg cgtcgttttg 120 aaattattca acacatctga aaagccaacc gccgaaacga gcagaagcga cgcgcagaat 180 ttcgaatgca aacggacgcg caacccgcca gtgaaaaaca aacatcaaat atcgccaacg 240 tggagtgtcg agcagtacag tgaattcaat agcatagtgc gcgcaatcac aactcgcatt 300 tgcatttgca gctgcagcaa caacaatgga cccgtttact caggtacgag gccaattcgc 360 acacagcaaa gccctttgtc tggtgattgc actggtgtta gtgaaggcac ccgcggattt 420 tcactgctat ttcccatttt cccttgcagc acatgctcga gaaggcggaa cagcgcagtc 480 gcgcccttgg catcagcaat gccagcaaat ttccgctcgt cgagtgcagc gttccaagct 540 cctccgccac ctccgcatcc ggcggggatg ctggggtcct ggcaccgagg agccggtcgc 600 ctggaggcca gagcgcggct agcggcggcg gcaaggtcgt tacgttggga aaggccacgc 660 tggaggcgtc gccggcgaag ccgctgcgtc actatacggc ggtaaacaag gaaaacttgg 720 atatgggcat agagataaac ataaccacgg acaagccaat tggggtaagt tttcccgttc 780 ttttctgggt tcttcccttt tgctcatcct tgctgcacta ccttcaggtg caagttgaga 840 ttcaggagca ggaggtgaca gatgacgaag agcaggcgga aggaggtgcg ctaaatcccc 900 tgctggaggc ggaaccagta aaccagcccc tagccaggct aagggacact tcccgcagcc 960 gactgcaacg catgggtgcc ctgtactcaa acacggacga tctatcctcc ccaatccacc 1020 gaaccgaggg gcagttccat gtgacaacgg gtgaggaaga ggactgcggc aaccgtagca 1080 gcaggcaacc aaaacaacgg ttgggcaaac tggccgcctt ggcggatacc atcaatcagt 1140 gggaggatga cacgtcgcac cacgaagtgc acagactgct cgaagcacct ccaccgaaac 1200 cgcatttgtc cagtcgaagg gccgagaagg gtccagctcc actgccaccc aagaaggatg 1260 aagtcgacga ggcaagcagg accaagcagc tgaagtggga tcccaaggta ttgagctctc 1320 tggaggcaca aggttttcag cgccgcgaat catcgaccat taaacacaca tatgattatg 1380 ccaaacagga agaggcggcc ccagcctcca aagtggaaga tgcggtatta actgccaagc 1440 cgccagtgcc gcagaaatca acgacggtca gccaggtcgc caagaacttt gcatcttccg 1500 ccccagcgcc taagcccgca ccagcgcctg ctgttagtgt gaagtccggc ttggtttccg 1560 gacgggcggc tctctttgaa aacaagggaa ccggaggaca gtcgcaaggc ctacgcaacc 1620 agaaggatcc ttgtgagctg tcgctgaagg agcggatgaa gctgttcgaa acgggcaaca 1680 acaaagcgat gttgccgatg gcgccaatag gatctgctcc cagtattacc caaatccgag 1740 cggaagaggt gaaacgtgag tttggcagcc cttctatatt cataatagct actcatactc 1800 attttttttt tgttaacaga acatttagct gcaatgcatc cggtgactgc tgccgcagct 1860 actaccgtgg ttgcagcaac caagccgaaa caggaaaaca agctgcgtga caaggtggcc 1920 gctttggtgg caaatgcgca atcaagtgca gagacgcgta tcaaggacat tgatcgccaa 1980 aggcaggaag acatgcagat tatttctaat cgctttaaca aacaaaagga gctctttgac 2040 aatcaaccat ccgatagttc tgtggctgct caagctcgac ctcccgcgcc agctcccagc 2100 agagtagtgc ggcccatgcc accgcctcca ccaccgccca tcgctgctct ctcgcccgga 2160 ctggccagca gcaagaggcg atcacgtaag aaatgactaa accctttatc taaggacttg 2220 tccttataca tccgcaattt cagctggtga tgcgcccacc actgacgagg attcgaagcg 2280 agcccgcaaa tcgcattcgg atcgtctgta tcccgccctg tccgacctcg actccagcgg 2340 tgacaactgc tgcgccgccg aaactgcctc cgctacggat gacagccatc aacaggacga 2400 ggaggaaacc gaaaggtgcg ctgaaaaatg ctattcctgc ttgctatttc tgctctgcat 2460 cgagtagcat tccaagactg ataggcctaa gagacatagc tttaaacccc atcccctaga 2520 caagaccaac aataaaatcg ctttcttaac taaccgttta tctttgattc gtgcagttgc 2580 atggatgagt ccgacgacca gtcacagact gaggacagta gcgccggcat gtgcaatggc 2640 agtcttggcc gcgagataat gagcgcagtg cagcgcaacg aagtggagat gcagcagcag 2700 cagacgggca agaaggtaag tgcaggtaaa aactgtcaac acagcgggtg gtcaccatta 2760 acacgatttc acacctttcc agactgtgcg ctatgcggac caggacatgt attacgatga 2820 cagctctctg aactcgtcgc aggtctcagc gggcatcgat gattatctgg atgaagcact 2880 tgtcgaggac tacggcagca ctcaggatga ccagagcgac agcggggacg agcaaaatgc 2940 cagtcggctg tccttgggcg tgagtacttg ctgattaagt ttcctcgtat atcaaaacaa 3000 ttctttaatt acattttcag agcaaaggaa cgacggcctc aaacagcttt tccttccgaa 3060 aaaatcctgc ctctatttgc acgcctatcg aagagcacca tgagatggag atggacctgc 3120 agacgccact gctcagtggt gcccagccgg tcaagtctga attgagtgtc aaccaggaca 3180 acgacaacct ggttaccctg gtgcacacgg tcagcttcta tcgccgccaa cagagcgcta 3240 acgtgagttg attacttata tatcacaact aacaaattct aagtactcgt tgtttataga 3300 gctccaattc cacaccggtt cgcaagatct gtcgagagca gcaggtcatg cgatcagccc 3360 tagcaggcga ttgtcatgcc aagcacagac tggagtacga ctctcctcag cagtctgatt 3420 atgtcgcagc agcaactgac atagctgatc agaccgacga ggacgatgaa gagatgcaga 3480 atgcgcggga agtaaacgat gcatcgcagg cacaagacaa gatcaaaaag ctgttgagcg 3540 aggtgtgcaa gcagcagcag gtgataggac aagccagtca ggccctcaac ctttgtgctg 3600 ccaccgtaga attctccggc tccacagagt ccgtggaggg agagcgatat ctccttcttg 3660 caagtaagtg tgatcttcag tgtattcaag tataaattgc ctgttcgttg aattccaaac 3720 cgaattggca atttgaatgt ccaattaagc tgaacatctc tttaatatcc ttgcagccca 3780 tcgacgccag gcgtgtttgg atgaagtcca gcgtttaaga gttgagaaca gtattcgtcc 3840 ggtgggtgca ccaaaagaaa agggcctact gacggtcaag gacataacca ttccactgcg 3900 acaggagtac gtgcgtaaaa tggcctcgaa caacattaac ggccatcatc ttgtgtgcct 3960 cctgaagtac aatgagcacg tgctggccac caagacagta cccacgatgc cagggctgct 4020 gtctgtcaag tttcccgatg tcctgcaact aaacaatgta tatgctgact tcagggtaaa 4080 tattgctttt tgcttcttta gccaatattc gattttattg cgaaaacttc gtctgcagat 4140 cacgctagaa atctatggca tgttggccca acgcgatcag ctgcctcacg agctgaaata 4200 ccacatcaac ttgaacaaga agggtggcat caagacgcca aagaagaagg gcggcgagaa 4260 tcgactggtg atgccgccag tacaaagtcc ggcgggaccg catgtggtac ggacaccgca 4320 gctggtgcaa tacggctttg ccattttctc gctgcgtgaa attcaacgca ccacatggac 4380 gctgacccag gtgctgggcg tcagtccact ggagggtgtg gttcacatga aagtcaattg 4440 cgaactatcc gtaagcgtgg agtacaaggg attccttacc atgttcgaag acatctccgg 4500 tttcggggca tggcatcgtc gttggtgcta tctgaatggc tccgtgatca actactggaa 4560 gtacccggat gatgagaagc gcaagacgcc aatgggtagt atagatctga attcctgcac 4620 ttcgcagaag gtgaccacgg caccgcgcga catttgcgcc cgtctcaaca ccatgctgct 4680 ggagtgcgaa cggccggcgc tggagacaga ccaagagtcc ttgataatcg tacccaacgg 4740 acgtaccacc acggtgcgcc atctgctctc agccgacaca aaggaggagc gcgaggagtg 4800 gtgcgcctac cttaacaagg cactgacact gctgcgcgcc tggggaacca cccactgacc 4860 cgctgaccca ttgcaatttt gtcagcagca cggacaatga ccacaaacgg gcgggttgtt 4920 aacagttttc tctttttaag ttactcaatt tgctatttta atcgtgttcg cattggtatt 4980 aattttgttt tatgtttcca attcaaattt ttcgtttcca tcttggagtg ggacacgttc 5040 gtgttcgtct atatcgacat aactttttac ttatgtacat ttaatttagg atgactcgct 5100 aaatatatat gtgtaaaccc ccgt 5124 <210> 17 <211> 3639 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(3636) <400> 17 atg gac ccg ttt act cag cac atg ctc gag aag gcg gaa cag cgc agt 48 Met Asp Pro Phe Thr Gln His Met Leu Glu Lys Ala Glu Gln Arg Ser 1 5 10 15 cgc gcc ctt ggc atc agc aat gcc agc aaa ttt ccg ctc gtc gag tgc 96 Arg Ala Leu Gly Ile Ser Asn Ala Ser Lys Phe Pro Leu Val Glu Cys 20 25 30 agc gtt cca agc tcc tcc gcc acc tcc gca tcc ggc ggg gat gct ggg 144 Ser Val Pro Ser Ser Ser Ala Thr Ser Ala Ser Gly Gly Asp Ala Gly 35 40 45 gtc ctg gca ccg agg agc cgg tcg cct gga ggc cag agc gcg gct agc 192 Val Leu Ala Pro Arg Ser Arg Ser Pro Gly Gly Gln Ser Ala Ala Ser 50 55 60 ggc ggc ggc aag gtc gtt acg ttg gga aag gcc acg ctg gag gcg tcg 240 Gly Gly Gly Lys Val Val Thr Leu Gly Lys Ala Thr Leu Glu Ala Ser 65 70 75 80 ccg gcg aag ccg ctg cgt cac tat acg gcg gta aac aag gaa aac ttg 288 Pro Ala Lys Pro Leu Arg His Tyr Thr Ala Val Asn Lys Glu Asn Leu 85 90 95 gat atg ggc ata gag ata aac ata acc acg gac aag cca att ggg gtg 336 Asp Met Gly Ile Glu Ile Asn Ile Thr Thr Asp Lys Pro Ile Gly Val 100 105 110 caa gtt gag att cag gag cag gag gtg aca gat gac gaa gag cag gcg 384 Gln Val Glu Ile Gln Glu Gln Glu Val Thr Asp Asp Glu Glu Gln Ala 115 120 125 gaa gga ggt gcg cta aat ccc ctg ctg gag gcg gaa cca gta aac cag 432 Glu Gly Gly Ala Leu Asn Pro Leu Leu Glu Ala Glu Pro Val Asn Gln 130 135 140 ccc cta gcc agg cta agg gac act tcc cgc agc cga ctg caa cgc atg 480 Pro Leu Ala Arg Leu Arg Asp Thr Ser Arg Ser Arg Leu Gln Arg Met 145 150 155 160 ggt gcc ctg tac tca aac acg gac gat cta tcc tcc cca atc cac cga 528 Gly Ala Leu Tyr Ser Asn Thr Asp Asp Leu Ser Ser Pro Ile His Arg 165 170 175 acc gag ggg cag ttc cat gtg aca acg ggt gag gaa gag gac tgc ggc 576 Thr Glu Gly Gln Phe His Val Thr Thr Gly Glu Glu Glu Asp Cys Gly 180 185 190 aac cgt agc agc agg caa cca aaa caa cgg ttg ggc aaa ctg gcc gcc 624 Asn Arg Ser Ser Arg Gln Pro Lys Gln Arg Leu Gly Lys Leu Ala Ala 195 200 205 ttg gcg gat acc atc aat cag tgg gag gat gac acg tcg cac cac gaa 672 Leu Ala Asp Thr Ile Asn Gln Trp Glu Asp Asp Thr Ser His His Glu 210 215 220 gtg cac aga ctg ctc gaa gca cct cca ccg aaa ccg cat ttg tcc agt 720 Val His Arg Leu Leu Glu Ala Pro Pro Pro Lys Pro His Leu Ser Ser 225 230 235 240 cga agg gcc gag aag ggt cca gct cca ctg cca ccc aag aag gat gaa 768 Arg Arg Ala Glu Lys Gly Pro Ala Pro Leu Pro Pro Lys Lys Asp Glu 245 250 255 gtc gac gag gca agc agg acc aag cag ctg aag tgg gat ccc aag gaa 816 Val Asp Glu Ala Ser Arg Thr Lys Gln Leu Lys Trp Asp Pro Lys Glu 260 265 270 gag gcg gcc cca gcc tcc aaa gtg gaa gat gcg gta tta act gcc aag 864 Glu Ala Ala Pro Ala Ser Lys Val Glu Asp Ala Val Leu Thr Ala Lys 275 280 285 ccg cca gtg ccg cag aaa tca acg acg gtc agc cag gtc gcc aag aac 912 Pro Pro Val Pro Gln Lys Ser Thr Thr Val Ser Gln Val Ala Lys Asn 290 295 300 ttt gca tct tcc gcc cca gcg cct aag ccc gca cca gcg cct gct gtt 960 Phe Ala Ser Ser Ala Pro Ala Pro Lys Pro Ala Pro Ala Pro Ala Val 305 310 315 320 agt gtg aag tcc ggc ttg gtt tcc gga cgg gcg gct ctc ttt gaa aac 1008 Ser Val Lys Ser Gly Leu Val Ser Gly Arg Ala Ala Leu Phe Glu Asn 325 330 335 aag gga acc gga gga cag tcg caa ggc cta cgc aac cag aag gat cct 1056 Lys Gly Thr Gly Gly Gln Ser Gln Gly Leu Arg Asn Gln Lys Asp Pro 340 345 350 tgt gag ctg tcg ctg aag gag cgg atg aag ctg ttc gaa acg ggc aac 1104 Cys Glu Leu Ser Leu Lys Glu Arg Met Lys Leu Phe Glu Thr Gly Asn 355 360 365 aac aaa gcg atg ttg ccg atg gcg cca ata gga tct gct ccc agt att 1152 Asn Lys Ala Met Leu Pro Met Ala Pro Ile Gly Ser Ala Pro Ser Ile 370 375 380 acc caa atc cga gcg gaa gag gtg aaa caa cat tta gct gca atg cat 1200 Thr Gln Ile Arg Ala Glu Glu Val Lys Gln His Leu Ala Ala Met His 385 390 395 400 ccg gtg act gct gcc gca gct act acc gtg gtt gca gca acc aag ccg 1248 Pro Val Thr Ala Ala Ala Ala Thr Thr Val Val Ala Ala Thr Lys Pro 405 410 415 aaa cag gaa aac aag ctg cgt gac aag gtg gcc gct ttg gtg gca aat 1296 Lys Gln Glu Asn Lys Leu Arg Asp Lys Val Ala Ala Leu Val Ala Asn 420 425 430 gcg caa tca agt gca gag acg cgt atc aag gac att gat cgc caa agg 1344 Ala Gln Ser Ser Ala Glu Thr Arg Ile Lys Asp Ile Asp Arg Gln Arg 435 440 445 cag gaa gac atg cag att att tct aat cgc ttt aac aaa caa aag gag 1392 Gln Glu Asp Met Gln Ile Ile Ser Asn Arg Phe Asn Lys Gln Lys Glu 450 455 460 ctc ttt gac aat caa cca tcc gat agt tct gtg gct gct caa gct cga 1440 Leu Phe Asp Asn Gln Pro Ser Asp Ser Ser Val Ala Ala Gln Ala Arg 465 470 475 480 cct ccc gcg cca gct ccc agc aga gta gtg cgg ccc atg cca ccg cct 1488 Pro Pro Ala Pro Ala Pro Ser Arg Val Val Arg Pro Met Pro Pro Pro 485 490 495 cca cca ccg ccc atc gct gct ctc tcg ccc gga ctg gcc agc agc aag 1536 Pro Pro Pro Pro Ile Ala Ala Leu Ser Pro Gly Leu Ala Ser Ser Lys 500 505 510 agg cga tca cct ggt gat gcg ccc acc act gac gag gat tcg aag cga 1584 Arg Arg Ser Pro Gly Asp Ala Pro Thr Thr Asp Glu Asp Ser Lys Arg 515 520 525 gcc cgc aaa tcg cat tcg gat cgt ctg tat ccc gcc ctg tcc gac ctc 1632 Ala Arg Lys Ser His Ser Asp Arg Leu Tyr Pro Ala Leu Ser Asp Leu 530 535 540 gac tcc agc ggt gac aac tgc tgc gcc gcc gaa act gcc tcc gct acg 1680 Asp Ser Ser Gly Asp Asn Cys Cys Ala Ala Glu Thr Ala Ser Ala Thr 545 550 555 560 gat gac agc cat caa cag gac gag gag gaa acc gaa agt tgc atg gat 1728 Asp Asp Ser His Gln Gln Asp Glu Glu Glu Thr Glu Ser Cys Met Asp 565 570 575 gag tcc gac gac cag tca cag act gag gac agt agc gcc ggc atg tgc 1776 Glu Ser Asp Asp Gln Ser Gln Thr Glu Asp Ser Ser Ala Gly Met Cys 580 585 590 aat ggc agt ctt ggc cgc gag ata atg agc gca gtg cag cgc aac gaa 1824 Asn Gly Ser Leu Gly Arg Glu Ile Met Ser Ala Val Gln Arg Asn Glu 595 600 605 gtg gag atg cag cag cag cag acg ggc aag aag act gtg cgc tat gcg 1872 Val Glu Met Gln Gln Gln Gln Thr Gly Lys Lys Thr Val Arg Tyr Ala 610 615 620 gac cag gac atg tat tac gat gac agc tct ctg aac tcg tcg cag gtc 1920 Asp Gln Asp Met Tyr Tyr Asp Asp Ser Ser Leu Asn Ser Ser Gln Val 625 630 635 640 tca gcg ggc atc gat gat tat ctg gat gaa gca ctt gtc gag gac tac 1968 Ser Ala Gly Ile Asp Asp Tyr Leu Asp Glu Ala Leu Val Glu Asp Tyr 645 650 655 ggc agc act cag gat gac cag agc gac agc ggg gac gag caa aat gcc 2016 Gly Ser Thr Gln Asp Asp Gln Ser Asp Ser Gly Asp Glu Gln Asn Ala 660 665 670 agt cgg ctg tcc ttg ggc agc aaa gga acg acg gcc tca aac agc ttt 2064 Ser Arg Leu Ser Leu Gly Ser Lys Gly Thr Thr Ala Ser Asn Ser Phe 675 680 685 tcc ttc cga aaa aat cct gcc tct att tgc acg cct atc gaa gag cac 2112 Ser Phe Arg Lys Asn Pro Ala Ser Ile Cys Thr Pro Ile Glu Glu His 690 695 700 cat gag atg gag atg gac ctg cag acg cca ctg ctc agt ggt gcc cag 2160 His Glu Met Glu Met Asp Leu Gln Thr Pro Leu Leu Ser Gly Ala Gln 705 710 715 720 ccg gtc aag tct gaa ttg agt gtc aac cag gac aac gac aac ctg gtt 2208 Pro Val Lys Ser Glu Leu Ser Val Asn Gln Asp Asn Asp Asn Leu Val 725 730 735 acc ctg gtg cac acg gtc agc ttc tat cgc cgc caa cag agc gct aac 2256 Thr Leu Val His Thr Val Ser Phe Tyr Arg Arg Gln Gln Ser Ala Asn 740 745 750 agc tcc aat tcc aca ccg gtt cgc aag atc tgt cga gag cag cag gtc 2304 Ser Ser Asn Ser Thr Pro Val Arg Lys Ile Cys Arg Glu Gln Gln Val 755 760 765 atg cga tca gcc cta gca ggc gat tgt cat gcc aag cac aga ctg gag 2352 Met Arg Ser Ala Leu Ala Gly Asp Cys His Ala Lys His Arg Leu Glu 770 775 780 tac gac tct cct cag cag tct gat tat gtc gca gca gca act gac ata 2400 Tyr Asp Ser Pro Gln Gln Ser Asp Tyr Val Ala Ala Ala Thr Asp Ile 785 790 795 800 gct gat cag acc gac gag gac gat gaa gag atg cag aat gcg cgg gaa 2448 Ala Asp Gln Thr Asp Glu Asp Asp Glu Glu Met Gln Asn Ala Arg Glu 805 810 815 gta aac gat gca tcg cag gca caa gac aag atc aaa aag ctg ttg agc 2496 Val Asn Asp Ala Ser Gln Ala Gln Asp Lys Ile Lys Lys Leu Leu Ser 820 825 830 gag gtg tgc aag cag cag cag gtg ata gga caa gcc agt cag gcc ctc 2544 Glu Val Cys Lys Gln Gln Gln Val Ile Gly Gln Ala Ser Gln Ala Leu 835 840 845 aac ctt tgt gct gcc acc gta gaa ttc tcc ggc tcc aca gag tcc gtg 2592 Asn Leu Cys Ala Ala Thr Val Glu Phe Ser Gly Ser Thr Glu Ser Val 850 855 860 gag gga gag cga tat ctc ctt ctt gca acc cat cga cgc cag gcg tgt 2640 Glu Gly Glu Arg Tyr Leu Leu Leu Ala Thr His Arg Arg Gln Ala Cys 865 870 875 880 ttg gat gaa gtc cag cgt tta aga gtt gag aac agt att cgt ccg gtg 2688 Leu Asp Glu Val Gln Arg Leu Arg Val Glu Asn Ser Ile Arg Pro Val 885 890 895 ggt gca cca aaa gaa aag ggc cta ctg acg gtc aag gac ata acc att 2736 Gly Ala Pro Lys Glu Lys Gly Leu Leu Thr Val Lys Asp Ile Thr Ile 900 905 910 cca ctg cga cag gag tac gtg cgt aaa atg gcc tcg aac aac att aac 2784 Pro Leu Arg Gln Glu Tyr Val Arg Lys Met Ala Ser Asn Asn Ile Asn 915 920 925 ggc cat cat ctt gtg tgc ctc ctg aag tac aat gag cac gtg ctg gcc 2832 Gly His His Leu Val Cys Leu Leu Lys Tyr Asn Glu His Val Leu Ala 930 935 940 acc aag aca gta ccc acg atg cca ggg ctg ctg tct gtc aag ttt ccc 2880 Thr Lys Thr Val Pro Thr Met Pro Gly Leu Leu Ser Val Lys Phe Pro 945 950 955 960 gat gtc ctg caa cta aac aat gta tat gct gac ttc agg atc acg cta 2928 Asp Val Leu Gln Leu Asn Asn Val Tyr Ala Asp Phe Arg Ile Thr Leu 965 970 975 gaa atc tat ggc atg ttg gcc caa cgc gat cag ctg cct cac gag ctg 2976 Glu Ile Tyr Gly Met Leu Ala Gln Arg Asp Gln Leu Pro His Glu Leu 980 985 990 aaa tac cac atc aac ttg aac aag aag ggt ggc atc aag acg cca aag 3024 Lys Tyr His Ile Asn Leu Asn Lys Lys Gly Gly Ile Lys Thr Pro Lys 995 1000 1005 aag aag ggc ggc gag aat cga ctg gtg atg ccg cca gta caa agt ccg 3072 Lys Lys Gly Gly Glu Asn Arg Leu Val Met Pro Pro Val Gln Ser Pro 1010 1015 1020 gcg gga ccg cat gtg gta cgg aca ccg cag ctg gtg caa tac ggc ttt 3120 Ala Gly Pro His Val Val Arg Thr Pro Gln Leu Val Gln Tyr Gly Phe 1025 1030 1035 1040 gcc att ttc tcg ctg cgt gaa att caa cgc acc aca tgg acg ctg acc 3168 Ala Ile Phe Ser Leu Arg Glu Ile Gln Arg Thr Thr Trp Thr Leu Thr 1045 1050 1055 cag gtg ctg ggc gtc agt cca ctg gag ggt gtg gtt cac atg aaa gtc 3216 Gln Val Leu Gly Val Ser Pro Leu Glu Gly Val Val His Met Lys Val 1060 1065 1070 aat tgc gaa cta tcc gta agc gtg gag tac aag gga ttc ctt acc atg 3264 Asn Cys Glu Leu Ser Val Ser Val Glu Tyr Lys Gly Phe Leu Thr Met 1075 1080 1085 ttc gaa gac atc tcc ggt ttc ggg gca tgg cat cgt cgt tgg tgc tat 3312 Phe Glu Asp Ile Ser Gly Phe Gly Ala Trp His Arg Arg Trp Cys Tyr 1090 1095 1100 ctg aat ggc tcc gtg atc aac tac tgg aag tac ccg gat gat gag aag 3360 Leu Asn Gly Ser Val Ile Asn Tyr Trp Lys Tyr Pro Asp Asp Glu Lys 1105 1110 1115 1120 cgc aag acg cca atg ggt agt ata gat ctg aat tcc tgc act tcg cag 3408 Arg Lys Thr Pro Met Gly Ser Ile Asp Leu Asn Ser Cys Thr Ser Gln 1125 1130 1135 aag gtg acc acg gca ccg cgc gac att tgc gcc cgt ctc aac acc atg 3456 Lys Val Thr Thr Ala Pro Arg Asp Ile Cys Ala Arg Leu Asn Thr Met 1140 1145 1150 ctg ctg gag tgc gaa cgg ccg gcg ctg gag aca gac caa gag tcc ttg 3504 Leu Leu Glu Cys Glu Arg Pro Ala Leu Glu Thr Asp Gln Glu Ser Leu 1155 1160 1165 ata atc gta ccc aac gga cgt acc acc acg gtg cgc cat ctg ctc tca 3552 Ile Ile Val Pro Asn Gly Arg Thr Thr Thr Val Arg His Leu Leu Ser 1170 1175 1180 gcc gac aca aag gag gag cgc gag gag tgg tgc gcc tac ctt aac aag 3600 Ala Asp Thr Lys Glu Glu Arg Glu Glu Trp Cys Ala Tyr Leu Asn Lys 1185 1190 1195 1200 gca ctg aca ctg ctg cgc gcc tgg gga acc acc cac tga 3639 Ala Leu Thr Leu Leu Arg Ala Trp Gly Thr Thr His 1205 1210 <210> 19 <211> 13841 <212> DNA <213> Drosophila melanogaster <400> 19 caaattttga attttgccag ttcaaaacca tttgtccctg ccgtagaaat ataattgaga 60 gaagactgaa ccgaaaaaac aacgcttcaa cctttaacct cttctttcgg ttgcccggag 120 acacacacac acacacacac gaatacacga gacacccaca acacacacat tggcaactgc 180 tttatcgata agtttgtttg gttgttggac cgtagaacgc caatagctca gttggcagga 240 aagaccaagc cgaagtggtt cttattctta gcagaggaat cgaagcagag gaagaagcac 300 cggcagcagt atggtgagca ataagttgtt aaatcacatt aacaaagcag tgcacccatt 360 cggccgcctt atggccgcac tgcttggcca gcagcagttt ccgcctctat ccgatttccg 420 gttccatgcc gctgctcctt ttggtctcag cttttcagat tttttttttc agttgcactg 480 caagcggcgc attcaatttt tcatgccaag ccaggctgtt gctgttgctg catatacaaa 540 ctgcactttg cgagtgggct acagtgaagc ctcggcaagg cgctgtcctg ctactgctag 600 tcaaaatgtc aacgttggta tggcgcattc atttcaaagc aactttagta gtcgttctgt 660 ctatataaga acatatgtag ggagaaccta agttagtata actattccct ttacagtggc 720 tccactgtgt atttatagca gtcaagcagg agtcctcctc tccaactcct gctggttgtc 780 tattttcgat catttgttta tgtatagacc tgcccccaac atatatccgc cttttttcca 840 tcggctacat atatatgttt atatttatat ttatatttat atatatatat atataaatat 900 atacattgcg cctttggaca tgcgaaagcg cggttggcga cgggcgcagg cggcttcgaa 960 aatttttgaa taatttgcag tcataaaata tgcaataagc cagcagccaa cagccaacag 1020 ctgttgcgaa attgttttga aagccgcgcc atcacattat ttaaagcaac gatggcagtt 1080 gcccgctttc tccgcctttc gctgcctttc tcccacgtga agggaatcga attaaacgtt 1140 gttaaaggat ttaaagtgcg aaaaatagtg gcgaactgca gacgacaatt gcacagtcag 1200 taccccattt ccattctcct gcgagtagaa ctctttcaat ttgcatagac aaatgtggaa 1260 attctttgct gcaagttcag ccgagacttc aagttgagtt tcctgctcgg ctcggattct 1320 ttaaatgaat taaataagat tttctcttgt aacgtgcgtt ctcttttgag attaaaacta 1380 aatcaaaata ataatttcat ttgaacttat tttcttacag ccgcctaaag ggaaaaaggg 1440 caaaaaaggc aaaaaattgc caggtaagta aaaagctcga gtaaactgca ctttagcata 1500 gatttatgaa ttcccaaatt taactacttt gaacggtaat tgaagtgaag gatatcagtt 1560 aattgttgca aaattcattt agtgccctct ttaagaacac cggctgttaa agaccctcaa 1620 cgagtagaca aactgaacaa ggacgaggac tgcctggcaa ttcattttcg gaacattaat 1680 ggcagcaggg tgccaccact gggtagttgg gtagttggat atctgggcag ccggaatggc 1740 ggacattggt cattcagggc aatttataaa ggccaagcaa aacaattagt aaataacgat 1800 aatctgcgtg aggagagaag caaaagagaa ggcaggacgc gggcgcaacg atagggacga 1860 taggagcgtt gaggacaaga aattcccgat gcaattgctc tgactgcagc cttgcagtca 1920 gaaaatttaa aggcaaaaaa tggggagggg gggttccaaa ctgaccactt aatttgcacg 1980 agtgagcaca ctgtaggttc cacaaatacc caaccatcct ccgctctctg ggatctctct 2040 aacgcacata attgtttctg tgcgtgcact gaaaaacgct cttactcgtg gaacgcaagg 2100 aaactcctag tgtatcgtat tattatagtt atatcatcga tttgtttatg ccacacactt 2160 atcttaacac atgtctctaa atagtttaca cgcgctcctt cactttgact tcaaattgtc 2220 tttgcaatgc aatgtctttg gtcttttttc caccgtgtgg catctagttc gtctcctggt 2280 agtcctgttg gtcctgttgg tcctagtagc ccttcctagg ccgagtcctg gcaccagccg 2340 gccaacgatg ccaattacag aaaacaatta caacacggtc tgctgttggg tcacatatgc 2400 gggcagcggc taagggaagg gggggggggg gcgtggcagg ggtaaaaatg gacgaaaaag 2460 gggcaaaagg gggggggagg agagggtaac caggcgtgcc gctctcatta aatagccata 2520 aggacgggag cccccaatat gcggactaaa cttttcacgg acccctagcc caatattaga 2580 aaataaccaa gacaaaaaaa ttcctgttca cacatgaaca cgaatatatt taaagactta 2640 caattttggg ctccgttcat atcttatgta aatgaatcga gagcgataaa ttatatttag 2700 gattttgtta tctaaggcga catgggtgca ttgctcaaaa acatgtaatt taagtgcaca 2760 ctacatgagt cagtcacttg agatcgttcc ccgcctccta aaatagtccc ttagtgggag 2820 accacagata aggtcctcgc cgctcaagat aggcagatgt gcccgagcgt gggacctcga 2880 taaggcgggg actatttacg taggcctctg cgtaggccat ttactttaag atgcgattct 2940 catgtcacct atttaaaccg aagatatttc caaataaaat cagtttctta caaaaactca 3000 acgagtaaag tcttcttatt tgggatttta catttggtca atcgagcctt taatcgactc 3060 tgcagtttcc ccctaccaaa ggtaaggaac tcagagaaag gccagctcct ttaagcatct 3120 tacagctaaa ggtagcaaaa ataagtgact cttgtttccc cctaccaaag gtaaggaaca 3180 gagtataaat ataaaaagca aaagatacaa aagaatcttt tatgttttaa aacaagcacc 3240 ttatagtcta tagctaaagg ttgctttgtg taccattata aattgtggta aggcgtgctt 3300 gaggccatac atcagcaatt gtgaaattaa aaagtgcata acaaaagtgc cttataaatg 3360 ctctaatagc attaaatcag ctcataaata gagtgcagtg tatatgccat aagagcataa 3420 attaaataaa aagtgcctga aaacagtgcc ttataaatgc tctaatagca ttaaatcagc 3480 tcataaatag agtgcagtgt atatgccaaa agagcataaa tgccgaaata aatggctaaa 3540 aaacaaaaaa tctgactgga ctacaaaaat aataaaacgt gccaaaaaaa aaaaaaaaaa 3600 aaaaaaaaat catctttaaa catcgacgga gccttaaaga agagaaggaa gtcaaattca 3660 aaggagcctc taccagcagc agaagcagca acaacagcag cagcagaagc agcaacagca 3720 gtagcaacag cagcaacaac agcagcaaca gcagcagcaa caacaacgac atcagctaag 3780 tcaaaacaag aattttctgt ttatccaaac acacatatat atataaatac atataaaata 3840 catatacacg tactatatat attaagaaat tacaaaaaat tttcaaaatg atgtcagaaa 3900 agactattca attccttaag aagcagtccg aaattatttt ggaaattaga aagttggaag 3960 taaaaccaac attaacagat gtagaaattc taaaattaaa tgagcttcaa aaatgtttca 4020 ttgctaatca tagcaatttg ttaaagatcg gcgttgtcga tcatgaatat tttaacgcga 4080 agcagtatga tttaataatg atggtgttag aaaaaattaa aaataaaaat gaaaaaatta 4140 agggcgagtc ggtagaaaac actttcccta aatcaaacac tgtccctaaa tcaaaccctc 4200 cccctacatt aaaccttgaa atgcgtggtc accctgaaaa agagggtata gcacaaaaca 4260 acgctttaaa agtagagcag gcatttcgta ataatgttgg ccaatttcga gtatatctag 4320 aagatacgtc taaactaata gacagtagtc cagatttcct taaaataagg aaaaataaaa 4380 ttgaattttt atggcataaa atagataacc tgattgaaca ggtgaatagt cattttgaga 4440 gttcgctatt cgaagaagaa attagcgaac ttgaatttga caaacaaaat attcttacag 4500 ccattaatag tcgactcagt ggcacaataa ataaagctga aatgtcgacg gttgttaagg 4560 cgaaggagtt accaaccctg cctaaaatac agattcccac cttctttggt gattccaaag 4620 aatgggatct ttttaatgaa ctctttacag agctcataca tgtgagagag gatctcagtc 4680 cttctctcaa atttaattat ctaaagtcag cattaaaagg agaagccaga aatgtggtta 4740 ctcatttact gctcggctct ggagaaaatt atgaagccac ttgggagttt ttgaccaagc 4800 gatatgagaa taaaagaaac atattctcag atcatatgaa taggcttatg gatatgccaa 4860 atttaaattt agaatccaat aagcaaataa agacatttat tgacacgatt aacgagtcaa 4920 tttatattat aaaattaaag gcacaattac cagaagatgt ggatgcaatt ttcgctcaca 4980 taattcttcg gaaattcaat aaagaatcac tcaatttata tgaaagccat gttaaaaaga 5040 caaaagaaat acaggcactt tctgatgtca tggacttttt agagcaaagg ctcaattcta 5100 tatcatcatt ctcacaggaa gtaaaacctg taaagaaaat gattaataat aacaagaata 5160 aaaattatag tgacaattgt gcatattgca aactaccagg gcattattta attcaatgcc 5220 ataaatttaa aataatgaat ccagcagaac ggtctgactg ggtaagaaaa aatgggattt 5280 gcctaagatg tctgaggcat ccgtttggta aaaaatgtat aagcgagcag ctttgttcga 5340 cttgtcgtaa acctcaccac acgttacttc actttgcagg tcataatcca gaaaaagtga 5400 atacgtgtag aacaacaggt caagccttgt tggccacggc cttgattcaa gtaaagtcga 5460 ggtatggagg ctttgaacaa ttaagagcat tgattgatag tggctctcaa agcacaatta 5520 tttcagaaga gtctgcacag attctaaaat tgaaaaaatt tcggtctcat actgaaataa 5580 gtggagtatc ttccacagga acgtgcatct ccaagcacaa agcggttatt tcgataagaa 5640 attctccgaa aaatttagaa attgaagcaa ttattctccc aaaacttatg aaggcacttc 5700 cagtcaacac gattaatgtt gatcagaaaa aatggaagaa ctttaaatta gccgaccccg 5760 attttaataa accgggtcgc attgatttaa tcattggagc agacgtatat actcacattc 5820 tgcaaaatgg agttataaaa atagacggtc tccttgggca aaaaactgat ttcgggtgga 5880 tagtttctgg atgtaaaaaa tccaaaggaa aagaaaccat tgtagccaca acaatagaaa 5940 taaaagagtt agatcgctac tgggaagtgg aagaagaaga aaaagatgat atcgagtctg 6000 aaatctgtga aaataaattt atcaaaacga caaaaaaaga ttcagatggg cgatacattg 6060 tgtcaattcc attcaaggag gatgtcacct taggagattc aaagaaacaa gcgatagctc 6120 gttacatgaa tctggagaaa aaactaaaaa gaaatgaaaa acttaaggtt gactacacta 6180 aattcatgaa tgaatacatg gatttaggac acatgattga agtgagtgat gaaggcaaat 6240 attttttacc gcaccaggca gtgattagag attcaagcct tacgaccaaa ttgagagtag 6300 tttttgatgc ttcagcaaaa actacgaata acaaaagttt gaacgacata atgtgggttg 6360 ggccacgagt tcaaaaagat atttttgaca ttattattaa atggagaaaa tgggaatttg 6420 ttgtttcggc agacattgaa aagatgtacc gacaaattaa aatagataat aatgatcaaa 6480 aatatcaata tattttatgg agaaattctc caaaagaaaa aattaaaaca tataaattaa 6540 ccacagtcac ttacggaact gcatctgcac catatttggc taccagggtt ctggtagata 6600 ttgcagataa atgtaaaaac caagttatta gtgcaataat taggaatgat ttctatatgg 6660 atgacctaat gactggagct gattcggtag aagaagctaa taaattaata acattaattc 6720 cccatgaatt gcagaaagtt ggattcaact taaggaaatg gatttccaac aattccaaaa 6780 tattaaccac tgtggaggac acaggggaca ataaggttct caatattatc gaaaatgaat 6840 gtgttaaaac tttaggacta aaatgggaac ctcaaaagga tttatttaag ttcagcgtaa 6900 attgtaatga tgaatcaaaa aatataaata agcgcgttgt gttatcaacg ctagcaaaaa 6960 tatttgatcc gttaggatgg ttggcaccag tcacggtttc aggaaaactt tttattcaaa 7020 aactttggat aaataaaagt gaatgggatc aggaattatc catagaagat aaaaattatt 7080 gggaaaaata taaagaaaat ttattattgt tagagaatat tcgaatccca aggtggatta 7140 attcaaacag ttcttcagtc attcagattc acggatttgc ggacgcctcc gaaaaagcat 7200 atgctgcagt agtctatgct aaagtaggac ctcatgttaa tataatagct agcaaaagta 7260 gagtcaaccc tataaaaaat aggaagacaa ttcccaaact cgagctgtgt gcagctcacc 7320 tgcttagtga attaatccaa agactaaaag gatcaattga caatataatg gagatctatg 7380 cttggagtga ttccacgatt accttagcat ggattaacag tggtcaaagt aagatcaaat 7440 ttataaaaag aagaacggat gacattcgga aattaaaaaa tactgaatgg aatcatgtta 7500 agtcagagga taatccagca gatttagcat ccaggggagt ggattctaac cagttgatca 7560 actgtgattt ttggtggaaa ggtccgaaat ggctagcaga cccaaaagaa ctttggcctc 7620 ggcagcagtc tgtagaagaa cctgtcttaa taaatacggt attaaatgac aaaatagatg 7680 atcctattta cgaattaata gaaaggtatt ccagtataga aaaacttata cgtataatag 7740 catacataaa tagattcgtg cagatgaaaa caagaaataa agcctattca tcaattattt 7800 cagtaaagga gataagaata gcggaaacag ttgttattaa gaaacaacaa gaataccagt 7860 ttaggcaaga gataaagtgc cttaaaatca aaaaggaaat caagacaaat aataaaatat 7920 tgtcattgaa tccatttttg gacaaggatg gggttctaag agttggagga agattgcaaa 7980 attccaatgc agaatttaat gttaaacatc caatcatttt agaaaaatgc cacctaacaa 8040 gcttattaat aaaaaatgct cataaggaaa cattgcatgg agggataaac ctaatgcgaa 8100 actatatcca aagaaagtat tggattttcg ggttgaaaaa ttcgttgaaa aagtatttaa 8160 gagaatgtgt aacgtgtgca aggtataaac aaaatacagc tcagcaaata atgggtaact 8220 tgccaaaata tagagtgacg atgacattcc cgtttcttaa tactggaata gattacgcag 8280 gtccttatta tgttaaatgt tcaaaaaatc gtggccaaaa aacatttaaa ggatacgttg 8340 ctgtattcgt ttgcatggcc accaaagcca tacacttaga aatggtaagc gatctaactt 8400 cagacgcatt tttagcagca ctcagaagat ttattgctag acggggaaaa tgttccaata 8460 tctattcaga caacggaaca aattttgtag gagctgcaag aaaattagat caagagttat 8520 ttaatgcaat acaagaaaat ataacgattg cagcgcagct tgaaaaggac aggattgatt 8580 ggcattttat tcccccggca ggacctcact tcggaggtat ttgggaagct ggagttaagt 8640 caatgaaata ccatttaaag cgtataatcg gcgacactat tttgacttat gaagaaatgt 8700 caactctttt atgtcaaata gaagcatgct taaattcaag gccattatac actatagtta 8760 gtgagaagga ccaacaagaa gttttaacac caggtcattt tttaattgga agaccacctt 8820 tagaaatagt cgaaccaatg gaagatgaaa aaatcggaaa tttggatagg tggagactta 8880 tccaaaaaat gaagaaagat ttctgggtta agtggaaaag tgaatatttg catacgctcc 8940 agcaaaggaa taaatggaaa aaggaaattc ctaatataga agaagggcaa atagttttat 9000 taaaggatga gaattgtcat cctgcaagat ggcctttagg aaaggtggaa aaggtgcata 9060 aggggaatga tgataaggtc cgagtggcta aagtaaagat gcaggaagga tatatcacta 9120 gacccattac taaaatttgt cccttggaag gaataaagtc tgttgacaaa aatgaggctg 9180 accaagagcc aaaaagacga actagagcga catcgggaat gtccaagatc ggaatcatta 9240 tggcaatgtt gttgtttgtg ttaagttgtc aagtttctag cgcattacct aaagatatag 9300 caccaagata ttctatagac aaaataaata aaacctcagc aatatatcta gacccgctag 9360 gagatgttga gattgtgagt acttcttgga atttggttat ctattataaa atggatccat 9420 attttaaaat gttaacaaag ggtaatgcgc ttatacaaag tatgaggaaa gtttgcgaaa 9480 gacttcatag ctttgaagag caatgtagtc tagtcttaga taatatgcaa agtcagttat 9540 cggaacttga agaaaacaat aaattgttta tgatgcagtc tagatctaga agcaagcgtg 9600 cccctttcga atttatgggt tccttgtatc atattttatt tggtataatg gatgaagatg 9660 atagagagca attagaagaa aatatgaaga atttgttaga taaccagaac aaccttgata 9720 aactaattca aaaacaaaca tctgtggttg attcaacttc taatctatta aagagaacaa 9780 cagaagatgt taactccaat tttagaagta tgcaaataag aattgagaac atgacagaag 9840 ttcttaaaga aaattattat gtttataagg aatcaataaa attctttatg attacgaaac 9900 agctacactc attgattgaa gaaggcgaaa aaattcaagc aggcattata agcctgttga 9960 ttgatattaa tcacggtagg ctaaatacaa atattctcag gccaaatcag cttaaaaaag 10020 aaattgccaa aattcagcag agtctttcag agaacctagt aattccagga aaacggtcag 10080 gtacggaact taaggaggtg tatacactgt taacagccag gggtttattc atcgacgata 10140 aattgatcat tagtgcaaaa gtgcctctgt ttagcaggca tccatccaaa ttgttcaggc 10200 ttattccggt gccaattcga aatgaagatc ggataataat ggtgcataca acgtccgaat 10260 atttaattta taattttgag atagattcct atcacataat gacggaagcc acattaaatc 10320 aatgtcagaa atggcaacta aataagagaa tatgcaaagg aagttggccc tggaattcag 10380 cgaatgataa tgcatgtgag attcagcctc taaagccaga taaagcggcg aactgcatct 10440 ataaaacagt agtcgactct aaaagttact gggtagagtt agaaaagaaa agtagttggt 10500 tgtttaaggt tcctgcgaat tcaaaagtcc gtctgcaatg tactggctct caaattgaat 10560 tgtttgattt gcctcagcaa ggagttttaa gcattgcgcc atattgtacg gcaagaaccg 10620 acgataaaat tctagttgcc caccataaca ttcagtccga aagtgaagaa ttattatcaa 10680 caccttatat aggagaagtt agtggagtgc cgaagattat ttgggatccg ctgaaactat 10740 caatattaaa tcatactgag gaatttgaac gattgaataa tgaaattaaa tttatgaaag 10800 agaaccatca aaaattgaaa gatttacatt tccatcatat ttccggacat gctggattaa 10860 ttattgcttt aatactaatg atagtattaa taatatattt catacggaaa tgtgctgtgc 10920 aacaaagaat gcaagcaata acctttgcag gtccgttgcc agtactataa atatcaatag 10980 taaataaaca ataaaataat ataacaaata aaaatataca gtccactaat agaaaatgta 11040 cttctacata gaaaaagcaa aatgtttaaa ataagttaat tgagtacaaa ttgttgaatt 11100 aaaaataata taaaccataa ttgtaatcca ataaaattaa aagccagaaa aactaggccc 11160 attgaaatct tagttgcaaa ataaatgaac atatatcaaa taaatacagt ccactactgt 11220 tataaatgca actaatatac taatgtacat ctcagctttg ctggcccttt ggcagaatgt 11280 tcacacatga acacgaatat atttaaagac ttacaatttt gggctccgtt catatcttat 11340 gtaaatgaat cgagagcgat aaattatatt taggattttg ttatctaagg cgacatgggt 11400 gcattgctca aaaacatgta atttaagtgc acactacatg agtcagtcac ttgagatcgt 11460 tccccgcctc ctaaaatagt cccttagtgg gagaccacag ataaggtcct cgccgctcaa 11520 gataggcaga tgtgcccgag cgtgggacct cgataaggcg gggactattt acgtaggcct 11580 ctgcgtaggc catttacttt aagatgcgat tctcatgtca cctatttaaa ccgaagatat 11640 ttccaaataa aatcagtttc ttacaaaaac tcaacgagta aagtcttctt atttgggatt 11700 ttacaattcc ctttggtaat tagctttaaa agggctagtc gtatcctttg ttttcatttc 11760 aaatcattta gctaaatttt cgtctgccta tattcctgct tagtgctcat cgatggcgtg 11820 gacacctcgg cgatgactcg cgaccagctg gaggcatttg ctctccggct aaaagcggaa 11880 atggatcgtg agcgggagga gcgtaactac ttccagttgg agcgggacaa gattcgcact 11940 ttctgggaga tcacgcgcca gcagctgggt gagtgaatac caggggattt tgccaccttt 12000 cctccatttt tttttttttt ttgttttgtt tttagatgag acccgctacg agctgcagca 12060 gaaggacaag gagatcgagg ccacgcagga tctggcggat atcgatacca agcatgtgat 12120 gcagcagatg aagcatctgc agtttgagaa ccacaatagg ctcggtgagg ttcgggctga 12180 ggcgatgacc caactaaagc tggcgcagga gcaccatgtt ctgcaggaaa acgagcttca 12240 gcgggacaag cgacagttgc gccgaatgct gcgcgaaaga atggagatga gcgagatgca 12300 gctgcgccaa atggaggctc acttcaatga gaaactgctg taggtattat tatcgcagaa 12360 atatgaatca tattctcacg tttttttttt cccattgttt tcgtgcgctg gcagagagca 12420 gcgcatcacc ttcgaacgcg agcgcaagga caacgagatg ctgcacgagg agaaaatgat 12480 cgagcagaag gccaagctag accttttcta cggcacacaa atgttcgagg tagaggagcg 12540 aaagaaccag cagataaagg acctacagga ccaccatgac ctagccttta acgatatgaa 12600 gaactattac aacgatatca cgcttaacaa cctggcgcta attggcagca tgaaggagca 12660 gctagagcat ctgcgcaagc aggccgagag atccgataga atcgccgcag acacggcagc 12720 tgagaatcgg cgactgaagg agcctttgga gcatgccaat atccagttga acgagtatcg 12780 tcgcaaactg gagttctacg agcgggataa gcagcaattg agtcgcctca agacgcgcaa 12840 cactcggctg gaaaagaagg tgaagggtct cacttgggag gcggaaactc tgatcctgcg 12900 caacgactcg ctggtggcag aacgggaggg cctgaaggag cgtttcaacg acgtgatcgt 12960 cgagctgcag cagaagacag gactaaagaa tgtccttctg gagcgcaaga ttgccgcatt 13020 gatgcgcgag gatgagaagc gcagcattgt cctacacgaa acgattgcca cctgcgctcc 13080 caatttcgcc gaaaagttaa ccagcttgga tgaacgggtg ggcaacatca tcgatgagaa 13140 gaacaagata atccttgacc tgcgctatga ggtaactaag gcgcgaaagg cacacgacga 13200 tctactggaa acctacgagt gcaagctcaa gcaatatggt gtgcccactg acgagttggg 13260 cttcaagccc atcaggaatc gggaccaaca gcagctgtac gtgtgcggtc ctgcgggaat 13320 aatcaccgag aataagtagg acctgctgaa gaaaagtcat attcacaagt cggattaaga 13380 aaatatatcg aggcggggaa ggaattcaaa accagaagaa acaaaactta ctccagaaca 13440 aaaagaagta aaggggatta gctgaaaact ctagaagcaa aaggacaaac aaaaaaacga 13500 tcgaattata tttttatcaa ttagaaaaca gttcatggaa taatgggaaa ggcataatgg 13560 aacgcacttt acttggtgat catataaaaa tatactctac aacgcaaatg gagaatttca 13620 tcaagaagaa aacgaggagg aaaatccaat ggaaaatcaa atgaaaaatc caatggaaaa 13680 tccaatgaaa aatcccacct tggtaggcgc agaaaatgta aattgttagt gctgcttggt 13740 ttctttaaga atttattcat tctgtgccta tctggagtgt attatgtaaa ctcccccgcc 13800 cctcaaaaat aatacggaag caataaaacg tttaccaacg t 13841 <210> 20 <211> 1365 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(1362) <400> 20 atg act cgc gac cag ctg gag gca ttt gct ctc cgg cta aaa gcg gaa 48 Met Thr Arg Asp Gln Leu Glu Ala Phe Ala Leu Arg Leu Lys Ala Glu 1 5 10 15 atg gat cgt gag cgg gag gag cgt aac tac ttc cag ttg gag cgg gac 96 Met Asp Arg Glu Arg Glu Glu Arg Asn Tyr Phe Gln Leu Glu Arg Asp 20 25 30 aag att cgc act ttc tgg gag atc acg cgc cag cag ctg gat gag acc 144 Lys Ile Arg Thr Phe Trp Glu Ile Thr Arg Gln Gln Leu Asp Glu Thr 35 40 45 cgc tac gag ctg cag cag aag gac aag gag atc gag gcc acg cag gat 192 Arg Tyr Glu Leu Gln Gln Lys Asp Lys Glu Ile Glu Ala Thr Gln Asp 50 55 60 ctg gcg gat atc gat acc aag cat gtg atg cag cag atg aag cat ctg 240 Leu Ala Asp Ile Asp Thr Lys His Val Met Gln Gln Met Lys His Leu 65 70 75 80 cag ttt gag aac cac aat agg ctc ggt gag gtt cgg gct gag gcg atg 288 Gln Phe Glu Asn His Asn Arg Leu Gly Glu Val Arg Ala Glu Ala Met 85 90 95 acc caa cta aag ctg gcg cag gag cac cat gtt ctg cag gaa aac gag 336 Thr Gln Leu Lys Leu Ala Gln Glu His His Val Leu Gln Glu Asn Glu 100 105 110 ctt cag cgg gac aag cga cag ttg cgc cga atg ctg cgc gaa aga atg 384 Leu Gln Arg Asp Lys Arg Gln Leu Arg Arg Met Leu Arg Glu Arg Met 115 120 125 gag atg agc gag atg cag ctg cgc caa atg gag gct cac ttc aat gag 432 Glu Met Ser Glu Met Gln Leu Arg Gln Met Glu Ala His Phe Asn Glu 130 135 140 aaa ctg cta gag cag cgc atc acc ttc gaa cgc gag cgc aag gac aac 480 Lys Leu Leu Glu Gln Arg Ile Thr Phe Glu Arg Glu Arg Lys Asp Asn 145 150 155 160 gag atg ctg cac gag gag aaa atg atc gag cag aag gcc aag cta gac 528 Glu Met Leu His Glu Glu Lys Met Ile Glu Gln Lys Ala Lys Leu Asp 165 170 175 ctt ttc tac ggc aca caa atg ttc gag gta gag gag cga aag aac cag 576 Leu Phe Tyr Gly Thr Gln Met Phe Glu Val Glu Glu Arg Lys Asn Gln 180 185 190 cag ata aag gac cta cag gac cac cat gac cta gcc ttt aac gat atg 624 Gln Ile Lys Asp Leu Gln Asp His His Asp Leu Ala Phe Asn Asp Met 195 200 205 aag aac tat tac aac gat atc acg ctt aac aac ctg gcg cta att ggc 672 Lys Asn Tyr Tyr Asn Asp Ile Thr Leu Asn Asn Leu Ala Leu Ile Gly 210 215 220 agc atg aag gag cag cta gag cat ctg cgc aag cag gcc gag aga tcc 720 Ser Met Lys Glu Gln Leu Glu His Leu Arg Lys Gln Ala Glu Arg Ser 225 230 235 240 gat aga atc gcc gca gac acg gca gct gag aat cgg cga ctg aag gag 768 Asp Arg Ile Ala Ala Asp Thr Ala Ala Glu Asn Arg Arg Leu Lys Glu 245 250 255 cct ttg gag cat gcc aat atc cag ttg aac gag tat cgt cgc aaa ctg 816 Pro Leu Glu His Ala Asn Ile Gln Leu Asn Glu Tyr Arg Arg Lys Leu 260 265 270 gag ttc tac gag cgg gat aag cag caa ttg agt cgc ctc aag acg cgc 864 Glu Phe Tyr Glu Arg Asp Lys Gln Gln Leu Ser Arg Leu Lys Thr Arg 275 280 285 aac act cgg ctg gaa aag aag gtg aag ggt ctc act tgg gag gcg gaa 912 Asn Thr Arg Leu Glu Lys Lys Val Lys Gly Leu Thr Trp Glu Ala Glu 290 295 300 act ctg atc ctg cgc aac gac tcg ctg gtg gca gaa cgg gag ggc ctg 960 Thr Leu Ile Leu Arg Asn Asp Ser Leu Val Ala Glu Arg Glu Gly Leu 305 310 315 320 aag gag cgt ttc aac gac gtg atc gtc gag ctg cag cag aag aca gga 1008 Lys Glu Arg Phe Asn Asp Val Ile Val Glu Leu Gln Gln Lys Thr Gly 325 330 335 cta aag aat gtc ctt ctg gag cgc aag att gcc gca ttg atg cgc gag 1056 Leu Lys Asn Val Leu Leu Glu Arg Lys Ile Ala Ala Leu Met Arg Glu 340 345 350 gat gag aag cgc agc att gtc cta cac gaa acg att gcc acc tgc gct 1104 Asp Glu Lys Arg Ser Ile Val Leu His Glu Thr Ile Ala Thr Cys Ala 355 360 365 ccc aat ttc gcc gaa aag tta acc agc ttg gat gaa cgg gtg ggc aac 1152 Pro Asn Phe Ala Glu Lys Leu Thr Ser Leu Asp Glu Arg Val Gly Asn 370 375 380 atc atc gat gag aag aac aag ata atc ctt gac ctg cgc tat gag gta 1200 Ile Ile Asp Glu Lys Asn Lys Ile Ile Leu Asp Leu Arg Tyr Glu Val 385 390 395 400 act aag gcg cga aag gca cac gac gat cta ctg gaa acc tac gag tgc 1248 Thr Lys Ala Arg Lys Ala His Asp Asp Leu Leu Glu Thr Tyr Glu Cys 405 410 415 aag ctc aag caa tat ggt gtg ccc act gac gag ttg ggc ttc aag ccc 1296 Lys Leu Lys Gln Tyr Gly Val Pro Thr Asp Glu Leu Gly Phe Lys Pro 420 425 430 atc agg aat cgg gac caa cag cag ctg tac gtg tgc ggt cct gcg gga 1344 Ile Arg Asn Arg Asp Gln Gln Gln Leu Tyr Val Cys Gly Pro Ala Gly 435 440 445 ata atc acc gag aat aag tag 1365 Ile Ile Thr Glu Asn Lys 450 <210> 22 <211> 10387 <212> DNA <213> Drosophila melanogaster <400> 22 cgattgaaaa tgtaagtgca tcctgtcagc tgctctccaa gaaaatacca aacgcgctga 60 gtggaaaaac gagctagggt ttgaatagtt ggaatatagc aaaggtaagg caataatctg 120 aataatatat ccaccatttt tgcaagacca tgtagatagt gtactcatga cccaaagtaa 180 ccccttaaat ttccctttaa ttaagggatt tatttacccg atggcccgtc aatgtttgct 240 ctgatatttg cccaccatca ccacttagac taatcaaaaa gcctctagtt ttgtcaactc 300 atccaattgg gtgtagaaat aatcagagct ttttttctca cctaaggctt agtacctcta 360 atttcattag acggaaatcg tccaaatcat ctgataagta tctcttcaat gtaattaaat 420 gttcaatacc cgcctagaaa tatctgcgca ctatgagaag ccttgcagtt tgaatccttt 480 gctcgtcgaa agcagttcga aaatggggct ggcggaagtt aagtaagtct ggatttacaa 540 aggcttggca ttatgcaaat ttctccagtc gagtggcgaa aataaacaaa ccattaatta 600 gacagttcca gttaatgggc ccgcgaaagg gagtcccggc ttcgattccc tcgggcggca 660 gtggctataa atgtgtagaa tgacaaatgg ccattgactt gctagccagc tgtactttta 720 tacatacagt atatatatac ggctcagtgc gtgtaaattg gccaagggtt actgctaaat 780 tagccctagt tgcagttacg cttcagttct agtccgacac agttgtatct agtgtgaatc 840 gtcgtatcgc tcgtatctcc tatatctggc gatatcatgt gacacacggt ttatctaaat 900 tgctttgctg tcggtttacg cgtttgcaaa ccgtttaacc caatcaatat ctaattagtc 960 cactgattgc tgcccagccc gatgatgttt gataagttgc aaaatacaaa cgaggcacta 1020 accagcgcgt acagtcgcga ccagcggccc tttatgatta cagctccggc cacggccacg 1080 gaacgcaacc agagttccaa gagcaccagg atgcccaagc tctacaacgg agtctacagc 1140 ggtcagtgcg gcgccctatc gccacctgac ctcatggagg cccagccgaa gctacttccc 1200 aagccaagga gcaacagcag cggcagcacc ggccggaaca gcaaggtatg aaacagcaaa 1260 aaagaaaaat gattcttttt tgtataatag ggatagcttt tatttaaaat ctgtgccaat 1320 tcctcaccta tggtgacgcc aggtagatgt gctcttctca gataaaaaaa cccccgatga 1380 gattcgaact tacgatctcc tgtttactag acaggcgctt tgcccaacta agccacggcg 1440 ccacattttg aaatttatga taatattatt ttattaaaat catgttaata ttggttttaa 1500 agcagtttga acctagaaaa atatattaat tatattctaa attaagaagt gaagtggatt 1560 aaatatacta gacctattcg aatttcagtt cgaactcgtt cgataatatt ccattttata 1620 attagccagc acttataaat aatttatgac ttaacataac ttaaccaatt tgacatcttt 1680 ttgcagtatt ggatattttc aatgataatc gagcgcagtg cgggtcccaa gcggattgaa 1740 atcgatggcg atgatgcgga cacgccgctg gaggccatcc tgccagccga accgccggcg 1800 gaggtctgcc tcttgcgtga cagccccttc aggatattgc gggtgagtag atccagaatg 1860 ggttccatgc aggtgcgggc cggcaattct ccaaagtgaa gacccgaggc aattcccgca 1920 gcgagagcca tgataaatgc ttctcgatgt gcacctagcc tcgtgttttg aatgttcgag 1980 aagcggccaa ggaagcccga tagatattat tcaataaaat gtcaatcgtt ttttttataa 2040 aaaatataaa agaacactta tgaagactta agcaaatata agttatttta atgacttata 2100 ttcaagcagt taacagatcc attgaggata tttttaccta gaagtgattg gagcaacaag 2160 tcctttttcg cattcagcgc cagagaaaga aagattgaaa ttgaaaccaa aattgaccgg 2220 cgagttcaac aaaataacac gaagcgcatc cttctccaaa aggacctgtg ccacacgcac 2280 ccgaagttgc cgccagttgg ctataaaagc aagactgttt ggtccgagat ttcagtcatt 2340 cagcgactct tcccgcgtgg actcaacctt tttttttcct ctggatatat ttactctccg 2400 tcgagcttac caaaaatcaa gttaacttgg cagcaaatca gtggcacagc aatttcattt 2460 attacatttg tggcagttaa ctaactcaat aacgacttgt gctaaagaaa aaaaagttta 2520 tacacaaaac cgtgcaacac caaggatatt ttacacattt aaaattcgta tgacaagtga 2580 acgcgaattt tgaaaaatta actttaatac attccacagt acaaatataa cattaaatat 2640 acaaaatatt gctcaaatag tgataacaac tgaacttgtt ttttttttta taacaataac 2700 aatatataca aaactgcaat ttatgaaacg tacgcatatc aaagctgcaa gtcttctgat 2760 tatcgcaatc taattgagtt tcgatcggaa ttaaaacacc aaacgaactg caaaacagag 2820 ctgaattcat aagatgagct aaaggactca gttcataagt tcgcataacc aaactacaag 2880 ctgtcgtaac gaaacgctat ttctggaatg caaaacgcat tctaattgaa tgtccactgg 2940 cattaaggac ccattgagtc atcacgtaaa ggcagaaaat cagaaactga attcagaagg 3000 cacaaggcga acgcatatgg aaatcatatt ggaaaaaatc cataacaagt caaggctctc 3060 tcgaaacttc gtccgatgtt gccagctgag ctgtaaggac aataagagtt aatccactaa 3120 ctaaacacaa atgtaattaa agtcgacaat gacttcgggc gacaaggaga ctcctaagag 3180 ggaagatttc gccagtgcgc tgcgattctt gatgggcggc tgtgcccgcg aaccggaaat 3240 gactgcaatg gcgccgctta acctgcccaa aaagtgggca cgcatcctgc ggatgtcctc 3300 gactccaaag ataccaatcg tggactatct ggaggtaaaa ctgcagccgg cgaactcatt 3360 aaattagcca cgcgcgaatc acaaaatgac ctctctgggt tggctaaaag tttcatttca 3420 ccccctcctt ttaagtgatt cacagaatta tactcctgga catttccaga aaaacgctgt 3480 tcaatacagt gttttcaaat tctttttttt tttttttttg aagaaaacag gaaaggcaat 3540 aagacaatca aattactcag tcgccggaag gcgttaatgt cctaaaatct attgacattt 3600 tgctgtagga caatgttttg cactttcttt gctttgcact acgaaaggca aacagaaagt 3660 tcttagagaa agtaaatgaa actaaaagaa cttcgccttg aactagcaaa gcacctttat 3720 aacacaaaaa ttaaaagaaa aaataaattg catgcaaaag aattttgtat tgttatgaca 3780 ttttaattta ttaacccgaa ggaagttaaa gactcggaat actaggaatg ttcctcacct 3840 ccgaacaaga gttcaaaatc agttttataa attaaaattt ttcttaatta agtatttttc 3900 ccagtgctgg caaaccaaac atagcttaat gttttaattg atgttgctgc aaagtgaaag 3960 acacctgttt ttcctgtttc aggcggctga gtccggaaac cttgacgact tcaagcgact 4020 cttcatggcg gacaactcgc gcattgcttt aaaggatgcg aaaggacgaa cggctgccca 4080 tcaggcggcg gcccgtaata gggttaacat tttgcggtac attcgcgacc agaatggcgg 4140 taagtgaacg gataaagcca ttaacccgga ctccttatca agcgtgattt acagacttta 4200 atgcgaagga taatgccggc aataccccgc tccacatcgc cgtggagagc gatgcctacg 4260 acgctctgga ctatctattg tccatgtaag tggctcaagc catggttgat ttagcccgat 4320 tgaacttcaa aatatatctt gccgacaatc cttacagccc agtggatacg ggagtgctga 4380 acgagaagaa gcaggcacca gtgcacttgg ccaccgagct gaacaaagtg aagtcccttc 4440 gggtgatggg tcagtaccgc aatgtcatcg atattcagca gggcggcgaa catggacgta 4500 ccgctctgca cttggccgcc atctatgatc acgaggagtg cgctcgcatc ctggtaagtg 4560 gtgtgagttt tggccaatca tttcatttga ttatttttta tgttcggcct tgcttttgta 4620 tttactcatg cattttattt gcattggttt gatttatatt aagccattaa tcaacttgat 4680 tcacccacca tcgtcctttc gaaaaacaca ctcatccgta caaaagttta atttatcata 4740 gagaacatga aaaataaagg ttggtatatg cagtagaaga aaattgaaat tgttttgcct 4800 gcttttatac tagacccaaa tattaaagag tgtgtctgtg tgcgtgtgtg tatgttccta 4860 gtgctagcat attatattag acgcatttat atttgtttac aataactcat cgtatcttcc 4920 agataactga gttcgatgca tgcccacgta agccctgtaa caatggttat tatcccatac 4980 acgaagcggc caagaatgcc agctccaaga caatggaggt cttcttccag gcaagttatc 5040 ctttccattt cccgattcgc acttgtccca gctgcatgct acaactacga gtatgtcatc 5100 tcatccagct ttgatcctat tgtggaagct atccccattg gacactgacc cgatttgctt 5160 gattcctaca actcctaccc ctcttactta ctttcttact tacatcccat ccagaccttt 5220 cgtgcactct cttcggtttt gggtttattt ttatttggtt tttgattttg ctttgctcct 5280 tgattgaagt tgcgtatacg ccgcgttgtc agcgacctct ttaaaaagta tcaaatttgt 5340 tatgggtcac actgtcgctg tcgagagttg aaaggcatgg agaataacat gttttccaca 5400 aaattttaag ctgcagaaaa atatcagatg ttggataact caggcggggt cggtcattca 5460 ctttggacaa cagtttactg gtcgccttaa gacacttcta ggatgcccaa aagttaaagc 5520 gttgcaaaaa aaaagaaaaa aaaaacagag tgatgtgtta ttttgattgc ttttcttgac 5580 ttggtttact taaatgtgta atcaattata gaaggaatgt tcttagatat aagtatgagc 5640 ttagactgca ctgccgcttc atagaattac ttgttcaagt tttttaatag taatttaatc 5700 ttttgtgtag ctattgttat taatatattg acacctgctt ttaaaagctg tcttaagacc 5760 attgaggata aatacgagaa cggtgacgca aacaagtctg ttaatttctt tttttcacaa 5820 ttaaatctct gcaggaatga gctcatctaa tgtttttatt cattttccag tggggcgagc 5880 agcgcggctg cacccgcgag gagatgatat ccttctacga ctcggagggc aatgtgccgc 5940 tccattcggc tgtccatggt ggcgacatca aggctgtgga gctgtgcctc aagtccgggg 6000 ccaagatatc tacgcagcaa cacgatctct cgacgccagt gcacctggct tgtgcccagg 6060 tgagtgtatg ctttggatgc acaggtgtgc tgatgactgg gaaatccttc agcggcgacc 6120 aactgacagt ctgccaagca attgaaaact ctcatatttc cacgtggagt tgagcaaaca 6180 aagcgttctt ggccagtaag cgaaaggaaa acagcattaa agcatatcca atgggcggtg 6240 aaaagtggct gtggtggttt cctttcggtc tccttcggat tgcctcgtgt cttggtgtcc 6300 ttagttgact ttaatttgac aaattcttat gcaaattcac taagaagaac gtgactttgc 6360 cgttaacaaa acaaagcact tttcatgttg gggaaataca tactacggat gaatgattcc 6420 gacatggttt tccatttcca tttccgcttc ttgttctttt tgtttttttt tttgtctagg 6480 gagccataga cattgtaaag ctcatgttcg agatgcagcc aatggagaag cgactatgtc 6540 tgagttgcac ggatgtgcag aagatgacgc cgctgcactg cgcctccatg ttcgatcatc 6600 cggacattgt gtcctatctg gtggccgagg gagcggacat caatgccctg gacaaggagc 6660 atcgctctcc gttactgctg gcggcatctc gtagcggttg gaaaacaggt gaccttagtt 6720 aaccctttta tatatctatt gtgtaaactt ggctttccat ttttccagtc cacctcctga 6780 ttcgcctggg ggcgtgcatt agtgtcaagg acgccgccgc ccgcaatgtg ctgcacttcg 6840 tcatcatgaa cggcggccgg ctgacggact tcgcggagca ggtggccaat tgccagacgc 6900 aggcgcagct gaagctgctg ctcaacgaga aggacagcat gggctgctcg ccgctgcact 6960 acgccagtcg ggatggacac atccgttcgt tggagaacct cattcgactg ggagcctgca 7020 tcaacctgaa gaacaacaac aacgagagtc cgctgcactt tgccgcacgc tacggaagat 7080 acaatacggt gcggcagctc ttggattccg agaagggatc cttcatcatc aacgaaagtg 7140 acggtgcagg gatgacacca ctgcacatat cctcgcagca aggacacacg cgagtggtgc 7200 agctgctact caatcgagga gccctgctcc atcgggacca caccggacgc aatcctctcc 7260 agctagcggc catgtccgga tacaccgaga ccatcgagct gctgcactcg gtgcactcgc 7320 atctgctcga tcaggtggac aaggatgggg tgagtgataa tacttggcaa cttggttaat 7380 caaggtaacc attaaacatg gctaatcccc attagaacac cgctcttcac ctggccacca 7440 tggagaataa gccccatgcg atctccgtgc tgatgtctat gggctgtaag ctggtctata 7500 acgttctgga catgagtgcc attgactatg ccatctacta caaatatccg gaggctgccc 7560 tggccatggt cacccacgag gagcgggcca acgaggtgat ggctctgcgt tccgacaagc 7620 atccgtgcgt gaccctcgcc ttaattgcct ccatgcccaa ggtattcgag gcggtgcagg 7680 acaagtgcat taccaaggcc aattgcaaga aggactcgaa gagtttctac gtaagtttgt 7740 cgttttccca gggtgaagcc caatcatcat ctcattccat cgaagctaat tgatttctat 7800 tcgcccccat tgacatcgcc gtgaccagat caaatactct ttcgcattct tgcaatgccc 7860 ctttatgttt gccaagattg atgagaaaac cggagagtcg attacgaccg ccagtcccat 7920 tccgttgccg gctttgaatg taagcggaaa ctggaatcct tcccagatct gttgcatgcg 7980 tgttttttta atgttgctcc tccttcctgg ccttgatacg tgatcttggg gttattgtgg 8040 gctgggatgt agcccacaat cgagtataga atgaggttta gcgggcacat catgatccat 8100 aattcatatt aatggctaag ttccatacat cgatactcat tacttggtta ccatccagat 8160 aaaatattcg ttttggccct accaaaagac acccgaacag attgaggcca agcgcaaaga 8220 gttcaatgac cccaagtggc gacccgcgcc tttggccgtg gtgaacgtga gtgtccccga 8280 actctcttaa aggtcccaga gctctgcaat tgtgaaccgt cccccaaact aacccactaa 8340 ccgactcact ttccggcttt tgtatcttgt atgttgtgtg cgtgtttatt agactttatg 8400 ctacccattt ctgatatatg tttccctata atccctcgat cagaccatgg taacacatgg 8460 cagggtggag ctgctggccc atccgctcag tcagaagtat ctgcagatga agtggaactc 8520 ctacggcaag tactttcacc tggccaacct gctaatctac tcgatattcc tggtctttgt 8580 aaccatctac tcttcgctga tgatgaacaa catcgaactg aaggctgggg acaacaagac 8640 gatgagtcaa tactgcaata tggggtgagt tgagatcata gttacccgaa aacatatagc 8700 aacacctcca tttttcagat gggagcagct gaccatgaat ctctcgcaga acccgtcggt 8760 ggcatcacag attcgtttgg attcctgcga ggagcgtata aatagaacca ctgcaatact 8820 tttctgtgcg gtggtcatcg tggtctatat actgctcaac tcgatgcggg aactaataca 8880 gatataccag cagaaattgc actatatcct ggagacagtt aatttgatat cctgggtgct 8940 gtacatctcg gctttggtga tggtaacacc ggcatttcag ccggatggag gaatcaatac 9000 cattcattac tcggccgctt caatagcagt ctttctgtcg tggttccgat tgctactgtt 9060 cctgcaaaga ttcgaccagg tcggcatcta tgtggtcatg ttcttggaga ttctgcagac 9120 gctcattaaa gtgctgatgg tattctccat acttataatc gcctttggtc tggctttcta 9180 tatactactt tcaaaggtag gtgcttttat ttggattttt cgagtgagat atttcctact 9240 tatcccttag attattgacc cccaaccgaa ccacttgtcc ttctccaaca tacccatgtc 9300 cttgctgcga actttctcaa tgatgctggg cgagctggac tttgtgggta cctatgtgaa 9360 cacctactat cgggatcagt tgaaagtgcc catgacatcc tttttgattt tgagtaagta 9420 ttgtttacac cattacattt ccttcaattg atattaaatt tattatgtca ggtgtcttta 9480 tgatccttat gcccattctt ctgatgaact tgctcatcgg tttggccgtc ggcgatattg 9540 agtcagtgcg tcgcaatgcc cagctcaaga gactggccat gcaggtggtg ctccacacgg 9600 agctggagag gaagttgccc catgtctggc tgcagcgagt tgacaagatg gagctgattg 9660 agtatcccaa tgaaaccaag tgcaagctgg gcttctgcga tttcatcctg cgcaagtggt 9720 tctcgaatcc attcaccgag gattgtaagt tgtctgggaa aagatctggt actaggtcca 9780 tccaatacac tttcaacttc tatgcagcct ccatggacgt catctccttc gacaacaatg 9840 atgactacat caacgcagaa ttggaacggc agaggcgaaa gttgcgcgac ataagtcgca 9900 tgctggagca acagcaccat ctggttcggc tcattgtcca aaagatggag atcaagacgg 9960 aggcggatga cgtggacgag ggtatatccc caaacgagtt gcgatccgtc gtcggtttga 10020 gatcggcagg cggaaatcga tggaactcgc cgcgagtccg gaataaactc cgagccgccc 10080 tgagcttcaa taagagcatg tagatccctt cgttcgaagg aacttggctt tataacaaaa 10140 tctgtgtatc gtccttagta gaaaaattgc accattttta atatatctct atgtgtgtgt 10200 aaatcgttgt cccacagtga cgtggatcgt gtgtgtatgt gacgatcgta ttgtgtgagg 10260 tcctgaaagg aataatacat cgaatttata ggcaaggatc atgggctgtt ctcgtaactt 10320 gattaagctg tggaattcaa cagatctatt gtagttttaa atgcaatttg caaaagtgtg 10380 tattgtt 10387 <210> 23 <211> 3588 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(3585) <400> 23 atg ccc aag ctc tac aac gga gtc tac agc ggt cag tgc ggc gcc cta 48 Met Pro Lys Leu Tyr Asn Gly Val Tyr Ser Gly Gln Cys Gly Ala Leu 1 5 10 15 tcg cca cct gac ctc atg gag gcc cag ccg aag cta ctt ccc aag cca 96 Ser Pro Pro Asp Leu Met Glu Ala Gln Pro Lys Leu Leu Pro Lys Pro 20 25 30 agg agc aac agc agc ggc agc acc ggc cgg aac agc aag tat tgg ata 144 Arg Ser Asn Ser Ser Gly Ser Thr Gly Arg Asn Ser Lys Tyr Trp Ile 35 40 45 ttt tca atg ata atc gag cgc agt gcg ggt ccc aag cgg att gaa atc 192 Phe Ser Met Ile Ile Glu Arg Ser Ala Gly Pro Lys Arg Ile Glu Ile 50 55 60 gat ggc gat gat gcg gac acg ccg ctg gag gcc atc ctg cca gcc gaa 240 Asp Gly Asp Asp Ala Asp Thr Pro Leu Glu Ala Ile Leu Pro Ala Glu 65 70 75 80 ccg ccg gcg gag gtc tgc ctc ttg cgt gac agc ccc ttc agg ata ttg 288 Pro Pro Ala Glu Val Cys Leu Leu Arg Asp Ser Pro Phe Arg Ile Leu 85 90 95 cgg gcg gct gag tcc gga aac ctt gac gac ttc aag cga ctc ttc atg 336 Arg Ala Ala Glu Ser Gly Asn Leu Asp Asp Phe Lys Arg Leu Phe Met 100 105 110 gcg gac aac tcg cgc att gct tta aag gat gcg aaa gga cga acg gct 384 Ala Asp Asn Ser Arg Ile Ala Leu Lys Asp Ala Lys Gly Arg Thr Ala 115 120 125 gcc cat cag gcg gcg gcc cgt aat agg gtt aac att ttg cgg tac att 432 Ala His Gln Ala Ala Ala Arg Asn Arg Val Asn Ile Leu Arg Tyr Ile 130 135 140 cgc gac cag aat ggc gac ttt aat gcg aag gat aat gcc ggc aat acc 480 Arg Asp Gln Asn Gly Asp Phe Asn Ala Lys Asp Asn Ala Gly Asn Thr 145 150 155 160 ccg ctc cac atc gcc gtg gag agc gat gcc tac gac gct ctg gac tat 528 Pro Leu His Ile Ala Val Glu Ser Asp Ala Tyr Asp Ala Leu Asp Tyr 165 170 175 cta ttg tcc atc cca gtg gat acg gga gtg ctg aac gag aag aag cag 576 Leu Leu Ser Ile Pro Val Asp Thr Gly Val Leu Asn Glu Lys Lys Gln 180 185 190 gca cca gtg cac ttg gcc acc gag ctg aac aaa gtg aag tcc ctt cgg 624 Ala Pro Val His Leu Ala Thr Glu Leu Asn Lys Val Lys Ser Leu Arg 195 200 205 gtg atg ggt cag tac cgc aat gtc atc gat att cag cag ggc ggc gaa 672 Val Met Gly Gln Tyr Arg Asn Val Ile Asp Ile Gln Gln Gly Gly Glu 210 215 220 cat gga cgt acc gct ctg cac ttg gcc gcc atc tat gat cac gag gag 720 His Gly Arg Thr Ala Leu His Leu Ala Ala Ile Tyr Asp His Glu Glu 225 230 235 240 tgc gct cgc atc ctg ata act gag ttc gat gca tgc cca cgt aag ccc 768 Cys Ala Arg Ile Leu Ile Thr Glu Phe Asp Ala Cys Pro Arg Lys Pro 245 250 255 tgt aac aat ggt tat tat ccc ata cac gaa gcg gcc aag aat gcc agc 816 Cys Asn Asn Gly Tyr Tyr Pro Ile His Glu Ala Ala Lys Asn Ala Ser 260 265 270 tcc aag aca atg gag gtc ttc ttc cag tgg ggc gag cag cgc ggc tgc 864 Ser Lys Thr Met Glu Val Phe Phe Gln Trp Gly Glu Gln Arg Gly Cys 275 280 285 acc cgc gag gag atg ata tcc ttc tac gac tcg gag ggc aat gtg ccg 912 Thr Arg Glu Glu Met Ile Ser Phe Tyr Asp Ser Glu Gly Asn Val Pro 290 295 300 ctc cat tcg gct gtc cat ggt ggc gac atc aag gct gtg gag ctg tgc 960 Leu His Ser Ala Val His Gly Gly Asp Ile Lys Ala Val Glu Leu Cys 305 310 315 320 ctc aag tcc ggg gcc aag ata tct acg cag caa cac gat ctc tcg acg 1008 Leu Lys Ser Gly Ala Lys Ile Ser Thr Gln Gln His Asp Leu Ser Thr 325 330 335 cca gtg cac ctg gct tgt gcc cag gga gcc ata gac att gta aag ctc 1056 Pro Val His Leu Ala Cys Ala Gln Gly Ala Ile Asp Ile Val Lys Leu 340 345 350 atg ttc gag atg cag cca atg gag aag cga cta tgt ctg agt tgc acg 1104 Met Phe Glu Met Gln Pro Met Glu Lys Arg Leu Cys Leu Ser Cys Thr 355 360 365 gat gtg cag aag atg acg ccg ctg cac tgc gcc tcc atg ttc gat cat 1152 Asp Val Gln Lys Met Thr Pro Leu His Cys Ala Ser Met Phe Asp His 370 375 380 ccg gac att gtg tcc tat ctg gtg gcc gag gga gcg gac atc aat gcc 1200 Pro Asp Ile Val Ser Tyr Leu Val Ala Glu Gly Ala Asp Ile Asn Ala 385 390 395 400 ctg gac aag gag cat cgc tct ccg tta ctg ctg gcg gca tct cgt agc 1248 Leu Asp Lys Glu His Arg Ser Pro Leu Leu Leu Ala Ala Ser Arg Ser 405 410 415 ggt tgg aaa aca gtc cac ctc ctg att cgc ctg ggg gcg tgc att agt 1296 Gly Trp Lys Thr Val His Leu Leu Ile Arg Leu Gly Ala Cys Ile Ser 420 425 430 gtc aag gac gcc gcc gcc cgc aat gtg ctg cac ttc gtc atc atg aac 1344 Val Lys Asp Ala Ala Ala Arg Asn Val Leu His Phe Val Ile Met Asn 435 440 445 ggc ggc cgg ctg acg gac ttc gcg gag cag gtg gcc aat tgc cag acg 1392 Gly Gly Arg Leu Thr Asp Phe Ala Glu Gln Val Ala Asn Cys Gln Thr 450 455 460 cag gcg cag ctg aag ctg ctg ctc aac gag aag gac agc atg ggc tgc 1440 Gln Ala Gln Leu Lys Leu Leu Leu Asn Glu Lys Asp Ser Met Gly Cys 465 470 475 480 tcg ccg ctg cac tac gcc agt cgg gat gga cac atc cgt tcg ttg gag 1488 Ser Pro Leu His Tyr Ala Ser Arg Asp Gly His Ile Arg Ser Leu Glu 485 490 495 aac ctc att cga ctg gga gcc tgc atc aac ctg aag aac aac aac aac 1536 Asn Leu Ile Arg Leu Gly Ala Cys Ile Asn Leu Lys Asn Asn Asn Asn 500 505 510 gag agt ccg ctg cac ttt gcc gca cgc tac gga aga tac aat acg gtg 1584 Glu Ser Pro Leu His Phe Ala Ala Arg Tyr Gly Arg Tyr Asn Thr Val 515 520 525 cgg cag ctc ttg gat tcc gag aag gga tcc ttc atc atc aac gaa agt 1632 Arg Gln Leu Leu Asp Ser Glu Lys Gly Ser Phe Ile Ile Asn Glu Ser 530 535 540 gac ggt gca ggg atg aca cca ctg cac ata tcc tcg cag caa gga cac 1680 Asp Gly Ala Gly Met Thr Pro Leu His Ile Ser Ser Gln Gln Gly His 545 550 555 560 acg cga gtg gtg cag ctg cta ctc aat cga gga gcc ctg ctc cat cgg 1728 Thr Arg Val Val Gln Leu Leu Leu Asn Arg Gly Ala Leu Leu His Arg 565 570 575 gac cac acc gga cgc aat cct ctc cag cta gcg gcc atg tcc gga tac 1776 Asp His Thr Gly Arg Asn Pro Leu Gln Leu Ala Ala Met Ser Gly Tyr 580 585 590 acc gag acc atc gag ctg ctg cac tcg gtg cac tcg cat ctg ctc gat 1824 Thr Glu Thr Ile Glu Leu Leu His Ser Val His Ser His Leu Leu Asp 595 600 605 cag gtg gac aag gat ggg aac acc gct ctt cac ctg gcc acc atg gag 1872 Gln Val Asp Lys Asp Gly Asn Thr Ala Leu His Leu Ala Thr Met Glu 610 615 620 aat aag ccc cat gcg atc tcc gtg ctg atg tct atg ggc tgt aag ctg 1920 Asn Lys Pro His Ala Ile Ser Val Leu Met Ser Met Gly Cys Lys Leu 625 630 635 640 gtc tat aac gtt ctg gac atg agt gcc att gac tat gcc atc tac tac 1968 Val Tyr Asn Val Leu Asp Met Ser Ala Ile Asp Tyr Ala Ile Tyr Tyr 645 650 655 aaa tat ccg gag gct gcc ctg gcc atg gtc acc cac gag gag cgg gcc 2016 Lys Tyr Pro Glu Ala Ala Leu Ala Met Val Thr His Glu Glu Arg Ala 660 665 670 aac gag gtg atg gct ctg cgt tcc gac aag cat ccg tgc gtg acc ctc 2064 Asn Glu Val Met Ala Leu Arg Ser Asp Lys His Pro Cys Val Thr Leu 675 680 685 gcc tta att gcc tcc atg ccc aag gta ttc gag gcg gtg cag gac aag 2112 Ala Leu Ile Ala Ser Met Pro Lys Val Phe Glu Ala Val Gln Asp Lys 690 695 700 tgc att acc aag gcc aat tgc aag aag gac tcg aag agt ttc tac acc 2160 Cys Ile Thr Lys Ala Asn Cys Lys Lys Asp Ser Lys Ser Phe Tyr Thr 705 710 715 720 atg gta aca cat ggc agg gtg gag ctg ctg gcc cat ccg ctc agt cag 2208 Met Val Thr His Gly Arg Val Glu Leu Leu Ala His Pro Leu Ser Gln 725 730 735 aag tat ctg cag atg aag tgg aac tcc tac ggc aag tac ttt cac ctg 2256 Lys Tyr Leu Gln Met Lys Trp Asn Ser Tyr Gly Lys Tyr Phe His Leu 740 745 750 gcc aac ctg cta atc tac tcg ata ttc ctg gtc ttt gta acc atc tac 2304 Ala Asn Leu Leu Ile Tyr Ser Ile Phe Leu Val Phe Val Thr Ile Tyr 755 760 765 tct tcg ctg atg atg aac aac atc gaa ctg aag gct ggg gac aac aag 2352 Ser Ser Leu Met Met Asn Asn Ile Glu Leu Lys Ala Gly Asp Asn Lys 770 775 780 acg atg agt caa tac tgc aat atg gga tgg gag cag ctg acc atg aat 2400 Thr Met Ser Gln Tyr Cys Asn Met Gly Trp Glu Gln Leu Thr Met Asn 785 790 795 800 ctc tcg cag aac ccg tcg gtg gca tca cag att cgt ttg gat tcc tgc 2448 Leu Ser Gln Asn Pro Ser Val Ala Ser Gln Ile Arg Leu Asp Ser Cys 805 810 815 gag gag cgt ata aat aga acc act gca ata ctt ttc tgt gcg gtg gtc 2496 Glu Glu Arg Ile Asn Arg Thr Thr Ala Ile Leu Phe Cys Ala Val Val 820 825 830 atc gtg gtc tat ata ctg ctc aac tcg atg cgg gaa cta ata cag ata 2544 Ile Val Val Tyr Ile Leu Leu Asn Ser Met Arg Glu Leu Ile Gln Ile 835 840 845 tac cag cag aaa ttg cac tat atc ctg gag aca gtt aat ttg ata tcc 2592 Tyr Gln Gln Lys Leu His Tyr Ile Leu Glu Thr Val Asn Leu Ile Ser 850 855 860 tgg gtg ctg tac atc tcg gct ttg gtg atg gta aca ccg gca ttt cag 2640 Trp Val Leu Tyr Ile Ser Ala Leu Val Met Val Thr Pro Ala Phe Gln 865 870 875 880 ccg gat gga gga atc aat acc att cat tac tcg gcc gct tca ata gca 2688 Pro Asp Gly Gly Ile Asn Thr Ile His Tyr Ser Ala Ala Ser Ile Ala 885 890 895 gtc ttt ctg tcg tgg ttc cga ttg cta ctg ttc ctg caa aga ttc gac 2736 Val Phe Leu Ser Trp Phe Arg Leu Leu Leu Phe Leu Gln Arg Phe Asp 900 905 910 cag gtc ggc atc tat gtg gtc atg ttc ttg gag att ctg cag acg ctc 2784 Gln Val Gly Ile Tyr Val Val Met Phe Leu Glu Ile Leu Gln Thr Leu 915 920 925 att aaa gtg ctg atg gta ttc tcc ata ctt ata atc gcc ttt ggt ctg 2832 Ile Lys Val Leu Met Val Phe Ser Ile Leu Ile Ile Ala Phe Gly Leu 930 935 940 gct ttc tat ata cta ctt tca aag att att gac ccc caa ccg aac cac 2880 Ala Phe Tyr Ile Leu Leu Ser Lys Ile Ile Asp Pro Gln Pro Asn His 945 950 955 960 ttg tcc ttc tcc aac ata ccc atg tcc ttg ctg cga act ttc tca atg 2928 Leu Ser Phe Ser Asn Ile Pro Met Ser Leu Leu Arg Thr Phe Ser Met 965 970 975 atg ctg ggc gag ctg gac ttt gtg ggt acc tat gtg aac acc tac tat 2976 Met Leu Gly Glu Leu Asp Phe Val Gly Thr Tyr Val Asn Thr Tyr Tyr 980 985 990 cgg gat cag ttg aaa gtg ccc atg aca tcc ttt ttg att ttg agt gtc 3024 Arg Asp Gln Leu Lys Val Pro Met Thr Ser Phe Leu Ile Leu Ser Val 995 1000 1005 ttt atg atc ctt atg ccc att ctt ctg atg aac ttg ctc atc ggt ttg 3072 Phe Met Ile Leu Met Pro Ile Leu Leu Met Asn Leu Leu Ile Gly Leu 1010 1015 1020 gcc gtc ggc gat att gag tca gtg cgt cgc aat gcc cag ctc aag aga 3120 Ala Val Gly Asp Ile Glu Ser Val Arg Arg Asn Ala Gln Leu Lys Arg 1025 1030 1035 1040 ctg gcc atg cag gtg gtg ctc cac acg gag ctg gag agg aag ttg ccc 3168 Leu Ala Met Gln Val Val Leu His Thr Glu Leu Glu Arg Lys Leu Pro 1045 1050 1055 cat gtc tgg ctg cag cga gtt gac aag atg gag ctg att gag tat ccc 3216 His Val Trp Leu Gln Arg Val Asp Lys Met Glu Leu Ile Glu Tyr Pro 1060 1065 1070 aat gaa acc aag tgc aag ctg ggc ttc tgc gat ttc atc ctg cgc aag 3264 Asn Glu Thr Lys Cys Lys Leu Gly Phe Cys Asp Phe Ile Leu Arg Lys 1075 1080 1085 tgg ttc tcg aat cca ttc acc gag gat tcc tcc atg gac gtc atc tcc 3312 Trp Phe Ser Asn Pro Phe Thr Glu Asp Ser Ser Met Asp Val Ile Ser 1090 1095 1100 ttc gac aac aat gat gac tac atc aac gca gaa ttg gaa cgg cag agg 3360 Phe Asp Asn Asn Asp Asp Tyr Ile Asn Ala Glu Leu Glu Arg Gln Arg 1105 1110 1115 1120 cga aag ttg cgc gac ata agt cgc atg ctg gag caa cag cac cat ctg 3408 Arg Lys Leu Arg Asp Ile Ser Arg Met Leu Glu Gln Gln His His Leu 1125 1130 1135 gtt cgg ctc att gtc caa aag atg gag atc aag acg gag gcg gat gac 3456 Val Arg Leu Ile Val Gln Lys Met Glu Ile Lys Thr Glu Ala Asp Asp 1140 1145 1150 gtg gac gag ggt ata tcc cca aac gag ttg cga tcc gtc gtc ggt ttg 3504 Val Asp Glu Gly Ile Ser Pro Asn Glu Leu Arg Ser Val Val Gly Leu 1155 1160 1165 aga tcg gca ggc gga aat cga tgg aac tcg ccg cga gtc cgg aat aaa 3552 Arg Ser Ala Gly Gly Asn Arg Trp Asn Ser Pro Arg Val Arg Asn Lys 1170 1175 1180 ctc cga gcc gcc ctg agc ttc aat aag agc atg tag 3588 Leu Arg Ala Ala Leu Ser Phe Asn Lys Ser Met 1185 1190 1195 <210> 25 <211> 1542 <212> DNA <213> Drosophila melanogaster <400> 25 ataggttcga aatgtaaaca aacatggaaa ctgaaactga agcgcagaaa ttgtattagc 60 tatggccaaa aatgtaaaga aattaacgtt ggccaacaag ttggcaaaac gcggagatct 120 tataaaaccc acggaaataa aaagtcgtcc aaatagggcg gataacgtga gggtaggcgg 180 aaatgcatga taaacaatga aattgatact caagacgcag tttctaaatc ttccaggata 240 tagaggatct ggttggtgta tctgctggcg cagcaggatc gagtagctca gtgttcttct 300 cccccgtgca aacccgcaag cagcgtctct taaatgggga agccgtgaag aaaactaaca 360 ttaaaatgga gcccttgtct ccagctcgag tggcacccaa aaagtttaga aaggatgatc 420 gcatggtaac cagagttcaa atgggttcgg ctactgtggt catatgcaag gtggtccctg 480 atgctgtgga ctccccagtg agagtggata agataagaga ggaggtggaa ccccaaataa 540 aacaggaagc tccggaggat tccccttctt tttctgaggt gcaagcacca catcctttgt 600 ggtttaacca cctagaaaac attcgcatta tgagaaactc cagaactgcg ccagtggaca 660 ccatgggatg ccaccgatgc gccgatttaa aagcagactc gaaggtattt ccaataagtg 720 gaattaagta catagaagaa tatgttacaa gcaaacaact tccttgcaga cccagcgctt 780 ccaaaactta gtggcattga tgctgtccag tcaaaccaaa gaccaaacta cttatgaagc 840 catgaatcgc cttaaagacc gaggtctaac tccactgaaa gtaaaggaaa tgccagtgac 900 tgaactcgag aatttactgc atcccgtatc cttctacaag gtttggtgga attaataata 960 aataaatata tcgcacttac tctcgatctc ttccagaaca aagctaaata cctcaagcaa 1020 accgtggaga tactgacgga caagtatggt tcggacattc cagataatgt caaggacctt 1080 gtagctcttc caggagttgg ccccaagatg gcccatatat gcatggcagt ggcctggaac 1140 aagataaccg gaatcggagt ggacgtccac gtccaccgcc tttctaacag gctgggctgg 1200 gtgccgaagc ccaccaagga gcccgagcaa acccgtgtgg cgttggagaa gtggctgcca 1260 ttcagcctct ggtcagaggt caatcatttg ttcgtgggat tcggacaaac catttgcacc 1320 ccagtgaagc caaattgtgg ggagtgcctg aacaaggaca tttgtccttc agcccatgct 1380 gaaactaaag aaaaaaggaa gaaagaccga taggaaagag gttcagcgaa cgctgaaaaa 1440 ggttttaggt ttctaagtgt ttctgaaatt attagtgcta agaaaaatat tgtgttaccc 1500 ataagaaaat aaatgaatta ttaagggggc tgtaagtcct gt 1542 <210> 26 <211> 1167 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(1164) <400> 26 atg gcc aaa aat gta aag aaa tta acg ttg gcc aac aag ttg gca aaa 48 Met Ala Lys Asn Val Lys Lys Leu Thr Leu Ala Asn Lys Leu Ala Lys 1 5 10 15 cgc gga gat ctt ata aaa ccc acg gaa ata aaa agt cgt cca aat agg 96 Arg Gly Asp Leu Ile Lys Pro Thr Glu Ile Lys Ser Arg Pro Asn Arg 20 25 30 gcg gat aac gtg agg gat ata gag gat ctg gtt ggt gta tct gct ggc 144 Ala Asp Asn Val Arg Asp Ile Glu Asp Leu Val Gly Val Ser Ala Gly 35 40 45 gca gca gga tcg agt agc tca gtg ttc ttc tcc ccc gtg caa acc cgc 192 Ala Ala Gly Ser Ser Ser Ser Val Phe Phe Ser Pro Val Gln Thr Arg 50 55 60 aag cag cgt ctc tta aat ggg gaa gcc gtg aag aaa act aac att aaa 240 Lys Gln Arg Leu Leu Asn Gly Glu Ala Val Lys Lys Thr Asn Ile Lys 65 70 75 80 atg gag ccc ttg tct cca gct cga gtg gca ccc aaa aag ttt aga aag 288 Met Glu Pro Leu Ser Pro Ala Arg Val Ala Pro Lys Lys Phe Arg Lys 85 90 95 gat gat cgc atg gta acc aga gtt caa atg ggt tcg gct act gtg gtc 336 Asp Asp Arg Met Val Thr Arg Val Gln Met Gly Ser Ala Thr Val Val 100 105 110 ata tgc aag gtg gtc cct gat gct gtg gac tcc cca gtg aga gtg gat 384 Ile Cys Lys Val Val Pro Asp Ala Val Asp Ser Pro Val Arg Val Asp 115 120 125 aag ata aga gag gag gtg gaa ccc caa ata aaa cag gaa gct ccg gag 432 Lys Ile Arg Glu Glu Val Glu Pro Gln Ile Lys Gln Glu Ala Pro Glu 130 135 140 gat tcc cct tct ttt tct gag gtg caa gca cca cat cct ttg tgg ttt 480 Asp Ser Pro Ser Phe Ser Glu Val Gln Ala Pro His Pro Leu Trp Phe 145 150 155 160 aac cac cta gaa aac att cgc att atg aga aac tcc aga act gcg cca 528 Asn His Leu Glu Asn Ile Arg Ile Met Arg Asn Ser Arg Thr Ala Pro 165 170 175 gtg gac acc atg gga tgc cac cga tgc gcc gat tta aaa gca gac tcg 576 Val Asp Thr Met Gly Cys His Arg Cys Ala Asp Leu Lys Ala Asp Ser 180 185 190 aag acc cag cgc ttc caa aac tta gtg gca ttg atg ctg tcc agt caa 624 Lys Thr Gln Arg Phe Gln Asn Leu Val Ala Leu Met Leu Ser Ser Gln 195 200 205 acc aaa gac caa act act tat gaa gcc atg aat cgc ctt aaa gac cga 672 Thr Lys Asp Gln Thr Thr Tyr Glu Ala Met Asn Arg Leu Lys Asp Arg 210 215 220 ggt cta act cca ctg aaa gta aag gaa atg cca gtg act gaa ctc gag 720 Gly Leu Thr Pro Leu Lys Val Lys Glu Met Pro Val Thr Glu Leu Glu 225 230 235 240 aat tta ctg cat ccc gta tcc ttc tac aag aac aaa gct aaa tac ctc 768 Asn Leu Leu His Pro Val Ser Phe Tyr Lys Asn Lys Ala Lys Tyr Leu 245 250 255 aag caa acc gtg gag ata ctg acg gac aag tat ggt tcg gac att cca 816 Lys Gln Thr Val Glu Ile Leu Thr Asp Lys Tyr Gly Ser Asp Ile Pro 260 265 270 gat aat gtc aag gac ctt gta gct ctt cca gga gtt ggc ccc aag atg 864 Asp Asn Val Lys Asp Leu Val Ala Leu Pro Gly Val Gly Pro Lys Met 275 280 285 gcc cat ata tgc atg gca gtg gcc tgg aac aag ata acc gga atc gga 912 Ala His Ile Cys Met Ala Val Ala Trp Asn Lys Ile Thr Gly Ile Gly 290 295 300 gtg gac gtc cac gtc cac cgc ctt tct aac agg ctg ggc tgg gtg ccg 960 Val Asp Val His Val His Arg Leu Ser Asn Arg Leu Gly Trp Val Pro 305 310 315 320 aag ccc acc aag gag ccc gag caa acc cgt gtg gcg ttg gag aag tgg 1008 Lys Pro Thr Lys Glu Pro Glu Gln Thr Arg Val Ala Leu Glu Lys Trp 325 330 335 ctg cca ttc agc ctc tgg tca gag gtc aat cat ttg ttc gtg gga ttc 1056 Leu Pro Phe Ser Leu Trp Ser Glu Val Asn His Leu Phe Val Gly Phe 340 345 350 gga caa acc att tgc acc cca gtg aag cca aat tgt ggg gag tgc ctg 1104 Gly Gln Thr Ile Cys Thr Pro Val Lys Pro Asn Cys Gly Glu Cys Leu 355 360 365 aac aag gac att tgt cct tca gcc cat gct gaa act aaa gaa aaa agg 1152 Asn Lys Asp Ile Cys Pro Ser Ala His Ala Glu Thr Lys Glu Lys Arg 370 375 380 aag aaa gac cga tag 1167 Lys Lys Asp Arg 385 <210> 28 <211> 1330 <212> DNA <213> Drosophila melanogaster <400> 28 gcaaaacgcg aactagttcc gcagcttgtg caatgttttg taatcgtatt tgcaaattta 60 ttcaattaat taattataaa taaaaaatgc tgcgccgcgc acaatgcctg ctccggctgc 120 acggcaatgg aggccattcg ctggtcagcc gctttcgaaa ctacgctacg gacgagggaa 180 atccgaaaca gaacccgaat ccaaatccca gggcacaaaa acccggcacc aaaaacctgc 240 cggctttaag gaaccccttt gccgccgccc aggacaggac gaaaaacagc tacctgacca 300 tggtggagat attccaggag cgcgacgtcc accgtcggaa ccatgtggag ttcatctacg 360 cggcactcaa gaatatggcg gatttcgggg tggaaagaga cttggaggtc tacaaggccc 420 tgatcaacgt gatgcccaag ggcaagttca tacccaccaa catgttccag gcagagttca 480 tgcactaccc caaacagcag cagtgtatca ttgatctgct tgagcagatg gaagattgcg 540 gggtgatgcc cgatcacgag atggaggcga tgctgcttaa tgtgtttggc aggcagggac 600 atccactgcg caagtattgg cgcatgatgt actggatgcc aaagtttaag aacctatcac 660 cgtggccact gcccgatcct gttccggatg atacattgga aatggccaag ctggcgctag 720 agcggatgtg cacggtcgac ctgcggtcca aaatcacggt tttcgagacc agcgagctga 780 aggatgccat tgacgatacg tggatcgtga gcggaatgag tcccgagcag gagaaactgc 840 tgcgggagca ctctcgccag aaagctctgt acatcgaggg accctttcac atatggctta 900 ggaatcgccg gatcaactac tttaccctgc gcgctgatgc agattctgag ttcctgtctg 960 aattagatga gcggcagctg gacgaggacg atgtctccca catcgaagta cccttctttg 1020 gtcgtgctcc accaaggcga cacaaccagc tgggaaagct gcgctctgtc caccaacagg 1080 acgacggaac cattatggcc atctgtgcca caggcacctc cacaaaggac tcattgctct 1140 cgtggattcg cctgttggaa gcgaacggaa atccctccat aggagaggtg cccgtcctct 1200 tccggttcac atccgaagtg ccagccaagg cggaggaaat tgaaggtggc gccagtgtcc 1260 cggcaacaag tgataacagt agtcaagatg agcacattag cagtagacag aaataaacaa 1320 attgttgagc 1330 <210> 29 <211> 1230 <212> DNA <213> Drosophila melanogaster <220> <221> CDS <222> (1)..(1227) <400> 29 atg ctg cgc cgc gca caa tgc ctg ctc cgg ctg cac ggc aat gga ggc 48 Met Leu Arg Arg Ala Gln Cys Leu Leu Arg Leu His Gly Asn Gly Gly 1 5 10 15 cat tcg ctg gtc agc cgc ttt cga aac tac gct acg gac gag gga aat 96 His Ser Leu Val Ser Arg Phe Arg Asn Tyr Ala Thr Asp Glu Gly Asn 20 25 30 ccg aaa cag aac ccg aat cca aat ccc agg gca caa aaa ccc ggc acc 144 Pro Lys Gln Asn Pro Asn Pro Asn Pro Arg Ala Gln Lys Pro Gly Thr 35 40 45 aaa aac ctg ccg gct tta agg aac ccc ttt gcc gcc gcc cag gac agg 192 Lys Asn Leu Pro Ala Leu Arg Asn Pro Phe Ala Ala Ala Gln Asp Arg 50 55 60 acg aaa aac agc tac ctg acc atg gtg gag ata ttc cag gag cgc gac 240 Thr Lys Asn Ser Tyr Leu Thr Met Val Glu Ile Phe Gln Glu Arg Asp 65 70 75 80 gtc cac cgt cgg aac cat gtg gag ttc atc tac gcg gca ctc aag aat 288 Val His Arg Arg Asn His Val Glu Phe Ile Tyr Ala Ala Leu Lys Asn 85 90 95 atg gcg gat ttc ggg gtg gaa aga gac ttg gag gtc tac aag gcc ctg 336 Met Ala Asp Phe Gly Val Glu Arg Asp Leu Glu Val Tyr Lys Ala Leu 100 105 110 atc aac gtg atg ccc aag ggc aag ttc ata ccc acc aac atg ttc cag 384 Ile Asn Val Met Pro Lys Gly Lys Phe Ile Pro Thr Asn Met Phe Gln 115 120 125 gca gag ttc atg cac tac ccc aaa cag cag cag tgt atc att gat ctg 432 Ala Glu Phe Met His Tyr Pro Lys Gln Gln Gln Cys Ile Ile Asp Leu 130 135 140 ctt gag cag atg gaa gat tgc ggg gtg atg ccc gat cac gag atg gag 480 Leu Glu Gln Met Glu Asp Cys Gly Val Met Pro Asp His Glu Met Glu 145 150 155 160 gcg atg ctg ctt aat gtg ttt ggc agg cag gga cat cca ctg cgc aag 528 Ala Met Leu Leu Asn Val Phe Gly Arg Gln Gly His Pro Leu Arg Lys 165 170 175 tat tgg cgc atg atg tac tgg atg cca aag ttt aag aac cta tca ccg 576 Tyr Trp Arg Met Met Tyr Trp Met Pro Lys Phe Lys Asn Leu Ser Pro 180 185 190 tgg cca ctg ccc gat cct gtt ccg gat gat aca ttg gaa atg gcc aag 624 Trp Pro Leu Pro Asp Pro Val Pro Asp Asp Thr Leu Glu Met Ala Lys 195 200 205 ctg gcg cta gag cgg atg tgc acg gtc gac ctg cgg tcc aaa atc acg 672 Leu Ala Leu Glu Arg Met Cys Thr Val Asp Leu Arg Ser Lys Ile Thr 210 215 220 gtt ttc gag acc agc gag ctg aag gat gcc att gac gat acg tgg atc 720 Val Phe Glu Thr Ser Glu Leu Lys Asp Ala Ile Asp Asp Thr Trp Ile 225 230 235 240 gtg agc gga atg agt ccc gag cag gag aaa ctg ctg cgg gag cac tct 768 Val Ser Gly Met Ser Pro Glu Gln Glu Lys Leu Leu Arg Glu His Ser 245 250 255 cgc cag aaa gct ctg tac atc gag gga ccc ttt cac ata tgg ctt agg 816 Arg Gln Lys Ala Leu Tyr Ile Glu Gly Pro Phe His Ile Trp Leu Arg 260 265 270 aat cgc cgg atc aac tac ttt acc ctg cgc gct gat gca gat tct gag 864 Asn Arg Arg Ile Asn Tyr Phe Thr Leu Arg Ala Asp Ala Asp Ser Glu 275 280 285 ttc ctg tct gaa tta gat gag cgg cag ctg gac gag gac gat gtc tcc 912 Phe Leu Ser Glu Leu Asp Glu Arg Gln Leu Asp Glu Asp Asp Val Ser 290 295 300 cac atc gaa gta ccc ttc ttt ggt cgt gct cca cca agg cga cac aac 960 His Ile Glu Val Pro Phe Phe Gly Arg Ala Pro Pro Arg Arg His Asn 305 310 315 320 cag ctg gga aag ctg cgc tct gtc cac caa cag gac gac gga acc att 1008 Gln Leu Gly Lys Leu Arg Ser Val His Gln Gln Asp Asp Gly Thr Ile 325 330 335 atg gcc atc tgt gcc aca ggc acc tcc aca aag gac tca ttg ctc tcg 1056 Met Ala Ile Cys Ala Thr Gly Thr Ser Thr Lys Asp Ser Leu Leu Ser 340 345 350 tgg att cgc ctg ttg gaa gcg aac gga aat ccc tcc ata gga gag gtg 1104 Trp Ile Arg Leu Leu Glu Ala Asn Gly Asn Pro Ser Ile Gly Glu Val 355 360 365 ccc gtc ctc ttc cgg ttc aca tcc gaa gtg cca gcc aag gcg gag gaa 1152 Pro Val Leu Phe Arg Phe Thr Ser Glu Val Pro Ala Lys Ala Glu Glu 370 375 380 att gaa ggt ggc gcc agt gtc ccg gca aca agt gat aac agt agt caa 1200 Ile Glu Gly Gly Ala Ser Val Pro Ala Thr Ser Asp Asn Ser Ser Gln 385 390 395 400 gat gag cac att agc agt aga cag aaa taa 1230 Asp Glu His Ile Ser Ser Arg Gln Lys 405

Claims (9)

  1. 저선량 방사선에 감응성 면역 활성 유전자, 신경세포 재생에 관여하는 유전자 및 운동성 기능에 관여하는 유전자를 검출할 수 있는 제제를 포함하고,
    상기 감응성 면역 활성 유전자는 PGRP-SC1a, PGRP-SC1b 으로 이루어진 군에서 1 이상이고,
    상기 신경세포 재생에 관여하는 유전자는 en, Oseg4, PCNA, scra 으로 이루어진 군에서 1 이상이며,
    상기 운동성 기능에 관여하는 유전자는 Gas8, TrpA1 으로 이루어진 군에서 1 이상인 것을 특징으로 하는 초파리 알츠하이머 질환 치료 확인용 조성물.
  2. 제 1항에 있어서,
    상기 저선량 방사선은 누적선량 0.01 내지 0.2 Gy가 되도록 조사하는 것을 특징으로 하는 초파리 알츠하이머 질환 치료 확인용 조성물.
  3. 삭제
  4. 삭제
  5. 삭제
  6. 삭제
  7. 삭제
  8. 삭제
  9. 제1항에 있어서,
    상기 조성물은 유전자 CG9272, ECSIT 로 이루어진 군에서 1 이상의 유전자를 더 검출할 수 있는 것을 특징으로 하는 초파리 알츠하이머 질환 치료 확인용 조성물.
KR1020180056068A 2018-05-16 2018-05-16 저선량 방사선을 이용한 초파리의 퇴행성 질환 치료를 확인하는 바이오마커 KR102093498B1 (ko)

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PCT/KR2019/005816 WO2019221502A1 (ko) 2018-05-16 2019-05-15 저선량 방사선을 이용한 초파리의 퇴행성 질환 치료를 확인하는 바이오마커
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