KR102090971B1 - Cosmetic composition - Google Patents

Abstract

The present invention relates to a cosmetic composition, more specifically Dracosephalum Moldavica extract; And at least one selected from the group consisting of aloe vera extract and phytantriol.

Description

Cosmetic composition {COSMETIC COMPOSITION}

The present invention relates to a cosmetic composition.

Human skin undergoes changes by various internal and external factors as it ages. In other words, the secretion of various hormones that regulate metabolism decreases internally, and the function of immune cells and the activity of cells decreases, thereby reducing the biosynthesis of immune proteins and bio-constitutive proteins necessary for living organisms, and externally by the destruction of the ozone layer. Due to the increase in the amount of ultraviolet rays reaching the surface of the sun's rays and the environmental pollution becomes more severe, free radicals and free radicals, etc. increase, thereby reducing the thickness of the skin, increasing wrinkles, and reducing elasticity. Not only that, skin troubles often occur, and spots, freckles, and blotch also increase, causing various changes.

As aging progresses, symptoms of changes or decreases in the content and arrangement of collagen, elastin, hyaluronic acid, and glycoproteins that constitute the skin appear, and are subject to oxidative stress caused by free radicals and free radicals. Cyclooxygenase-2, an enzyme that produces proinflammatory cytokines, which are known to cause inflammation in most cells that make up the skin, as aging progresses or by UV light Increases the biosynthesis, increases the biosynthesis of matrix metalloproteinase (MMP), an enzyme that breaks down skin tissue by these inflammatory factors, and produces NO (nitric oxide) by iNOS (inducible nitric oxide synthase) It is known to increase. That is, due to the progression of endogenous aging that progresses naturally, the biosynthesis of the matrix material is reduced by micro-inflammation, and external factors such as increased stress by various harmful environments and increased free radical species by sunlight. The decomposition and denaturation are accelerated, and the skin matrix is destroyed and thinned, and various symptoms of skin aging appear. Therefore, it is a reality that many studies have been conducted on active ingredients capable of preventing and improving such aging phenomena.

Korean Patent Registration No. 10-1599907 discloses an antioxidant containing natural raw material extract and its use.

Korean Registered Patent No. 10-1599907

One object of the present invention is to provide a cosmetic composition excellent in suppressing aging of skin, improving wrinkles, whitening and moisturizing effects.

1. Dracocephalum Dracocephalum moldavica ) extract; And at least one selected from the group consisting of aloe vera extract and phytantriol.

2. In the above 1, 0.1 to 2 parts by weight of the Dracosephalum Moldavica extract with respect to 100 parts by weight of the composition; And at least one 0.1 to 4 parts by weight selected from the group consisting of the aloe vera extract and phytantriol.

3. In the above 1, the aloe vera extract and the phytantriol is contained in a weight ratio of 1: 0.5 to 1.5, cosmetic composition.

4. In the above 1, further comprising adenosine, cosmetic composition.

5. In the above 1, oil and fat ingredients, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, pH adjusters, alcohols, pigments, flavorings, purified water, thickening A cosmetic composition further comprising at least one selected from the group consisting of agents, emulsifiers, viscosity modifiers, skin softeners, and skin conditioning agents.

6. The cosmetic composition according to the above 1, which is a formulation selected from the group consisting of skin, lotion, essence, lotion, nourishing cream, massage cream, moisture cream, hand cream, foundation, body lotion, body oil and body essence.

The cosmetic composition according to the embodiments of the present invention exhibits an excellent antioxidant effect, and thus has excellent effects of preventing skin aging, improving wrinkles, and whitening.

In addition, the cosmetic composition according to embodiments of the present invention is excellent in skin moisturizing effect.

The present invention relates to a cosmetic composition, more specifically, Dracosephalum moldavica ( Dracocephalum moldavica ) extract; And at least one selected from the group consisting of aloe vera extract and phytantriol.

Hereinafter, embodiments of the present invention will be described in detail.

The cosmetic composition according to the embodiments includes a Dracocephalum moldavica extract.

Dracosephalum Moldavica is an herb belonging to the family Lamiaceae Dracocephalum and is known to be native or distributed in China, Russia, and the United States, and has been used as a traditional medicine for treatment and sterilization for centuries.

The Dracosephalum Moldavica extract may be an extract of Dracosephalum Moldavika, preferably an essential oil component of Dracosephalum Moldavika.

The cosmetic composition according to the embodiments may include the Dracosephalum Moldavica extract, and thus, when applied to the skin, may exhibit skin aging suppression, wrinkle improvement and whitening effects according to excellent antioxidant effects, and improve water storage capacity in the skin It can show excellent skin moisturizing effect.

In addition, the Dracosephalum Moldavica extract contains phospholipids and the like, and thus, an active ingredient contained in a cosmetic composition, for example, an aloe vera extract, pittantriol, or an active ingredient thereof will be described in a deep layer of the skin. Can effectively absorb and deliver. Thus, the Dracosephalum moldavica extract according to the embodiments can help the various active ingredients contained in the cosmetic composition together with its active ingredients to be easily penetrated and absorbed into the skin.

In addition, the Dracosephalum Moldavica extract is a natural substance that has less skin irritation and is safe for the human body than other substances known to have wrinkle-improving effects, resulting in the use of skin redness, dry skin, or chemical preservatives, antibiotics, etc. Side effects can be prevented.

The method for producing the Dracosephalum Moldavica extract is not particularly limited, and for example, Dracosephalum Moldavica is extracted by hot water extraction method, ultrasonic extraction method, filtration method, reflux extraction method, cold compression method, etc. known in the art. Can be manufactured. These methods may be performed alone or in combination of two or more methods, and may be filtered, concentrated and dried after extraction.

Further, the cosmetic composition according to the embodiments may include aloe vera extract and / or phytantriol. The aloe vera extract and / or phytantriol is a component that, when applied to the skin, provides moisture and moisturizing effects with the Dracosephalum Moldavica extract.

Aloe Vera (Aloe vera, Aloe barbadensis miller) is a perennial plant belonging to the genus of succulent Liliaceae aloe, has been used for wound of the skin, burns, and inflammation therapy.

The cosmetic composition according to the examples includes aloe vera extract extracted from aloe vera, and when applied to the skin, has a very excellent hydration effect, moisturizing effect on skin, and has excellent effects on wound healing, skin soothing, and cell regeneration. .

The method for preparing the aloe vera extract is not particularly limited, and a method known in the art may be used, and as the extraction solvent, ethyl acetate, ether, chloroform, butanol, propanol diacid, or a combination of two or more thereof may be used without limitation.

The phytantriol is easily soluble in oil or alcohol, is a viscous yellow liquid, and is a common name of the aliphatic alcohol 3,7,11,15-tetramethylhexadecane-1,2,3-triol. to be. The chemical formula of phytantriol is C ₂₀ H ₄₂ O ₃ , and the molecular weight is 330.55.

Since the cosmetic composition according to the examples contains phytantriol, it is very excellent in moisturizing effect and skin moisturizing effect when applied to the skin.

In some embodiments, the aloe vera and the phytantriol may be included in a weight ratio of 1: 0.5 to 1.5, and the skin moisture retention and moisturizing effect may be further improved when the weight ratio.

The cosmetic composition according to the embodiments, by using the Dracosephalum Moldavica extract, and the aloe vera extract and / or the phytantriol together, improves wrinkles according to antioxidant effects, prevents skin aging, and whitening effects and skin Moisture retention and moisturizing effects can be better exhibited. In particular, the Dracosephalum Moldavica extract has excellent compatibility with the aloe vera extract and / or phytantriol, and functions to effectively deliver their active ingredients to the deep layers of the skin, providing excellent moisturizing, soothing, and moisture It can exhibit a maintenance effect and the like.

In some embodiments, the cosmetic composition is 0.1 to 2 parts by weight of the Dracosephalum Moldavica extract, and the aloe vera extract and / or the phytantriol extract 0.1 to 4 parts by weight based on 100 parts by weight of the cosmetic composition It may include, preferably, the Dracosephalum Moldavica extract 0.6 to 1.5 parts by weight, and may include the aloe vera extract and the phytantriol 0.6 to 3 parts by weight, antioxidant by synergy in the content range , Anti-aging, wrinkle improvement, moisturizing effect can be further maximized.

In some embodiments, the cosmetic composition may further include adenosine. The adenosine may be included in a cosmetic composition to further improve wrinkle improvement and anti-aging effects. In one embodiment, the adenosine, while further improving the antioxidant activity and wrinkle improvement effect, in terms of not inhibiting the effect of improving the skin penetration rate of the active ingredient of the Dracosephalum Moldavica extract 0.01 parts by weight based on 100 parts by weight of the cosmetic composition It may be included as 0.1 parts by weight.

In some embodiments, the cosmetic composition may further include other additional ingredients that can be formulated into cosmetic products.

Additional ingredients that can be blended include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, UV absorbers, preservatives, fungicides, antioxidants, pH adjusters, alcohols, pigments, flavorings, purified water, thickeners , Emulsifiers, viscosity modifiers, skin softeners, skin conditioning agents, and the like. These may be used alone or in combination of two or more.

As the fat or oil component, ester-based fats and oils, hydrocarbon-based fats and oils, fluorine-based fats, animal fats, vegetable fats and oils known in the art can be used without limitation.

Ester oils include tri2-ethylhexanoate glyceryl, 2-ethylhexanoate cetyl, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, and stearic acid. Butyl acid, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, diadi Diisopropyl finate, isoalkyl neopentanoate, tri (capryl, capric acid) glyceryl, trimethylethylpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, pentaelisley tritetraethylethylhexanoate Tol, cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinooleate, Isostearyl laurate, isotridecyl myristate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl oleate, isopropyl isoleate, 2- Cetostearyl ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprate, propylene glycol di (capryl, capric acid), dicapryl Propylene glycol acid, neopentyl glycol dicapric acid, neopentyl glycol dioctanoate, glyceryl tricaprylic acid, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, octyl dodecyl neopentane, Isostearyl octanoate, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, Octyldecyl stearate, polyglycerin oleic acid ester, polyglycerin isostearic acid ester, triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate , Acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearic acid, di2-ethylhexyl succinate, diisobutyl succinate, diisopropyl sebacic acid, seba Dioctyl citrate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytsteryl isostearate, phthalate oleate, 12 -Isocetyl stearoylhydroxystearate, stearyl 12-stealoylhydroxystearate, 12-stealoyl And ester systems such as isostearyl hydroxystearate.

Examples of hydrocarbon-based oils and fats include hydrocarbon-based oils such as squalene, liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, and waselin.

Silicone-based fats and oils include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane ㆍ methylcetyloxysiloxane copolymer, dimethylsiloxane ㆍ methylsteaoxysiloxane copolymer, And alkyl-modified silicone oils, amino-modified silicone oils, and the like.

Perfluoropolyether etc. are mentioned as a fluorine-type oil and fat.

Animal or plant oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, new flower oil, soybean oil, corn oil, rapeseed oil, almond oil, palm kernel oil, palm oil, castor oil, sunflower oil, grapes Seed Oil, Cottonseed Oil, Palm Oil, Cucumin Nut Oil, Wheat Germ Oil, Rice Germ Oil, Shea Butter, Moon Seed Colostrum, Marker Demi Nut Oil, Meadow Home Oil, Egg Yolk Oil, Uji, Horse Oil, Mink Oil, Orange Rape Oil, Jojoba And animal or vegetable oils such as milk, candelary wax, carnauba wax, liquid lanolin, and hardened castor oil.

Examples of the moisturizing agent include water-soluble low molecular moisturizing agents, oil-soluble molecular moisturizing agents, water-soluble polymers, and fat-soluble polymers.

Water-soluble low molecular moisturizers include serine, glutamine, sorbitol, mannitol, sodium pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or higher), poly And propylene glycol (polymerization degree n = 2 or more), polyglycerin B (polymerization degree n = 2 or more), lactic acid, lactic acid salt, and the like.

Examples of fat-soluble low-molecular moisturizers include cholesterol and cholesterol esters.

Water-soluble polymers include carboxyvinyl polymer, polyasparaginate, tragacanth, xanthan gum, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, water-soluble chitin, chitosan, dextrin, etc. Can be lifted.

Examples of the fat-soluble polymer include polyvinylpyrrolidone-eicosen copolymer, polyvinylpyrrolidone-hexadecene copolymer, nitrocellulose, dextrin fatty acid ester, and polymer silicone.

As an emollient agent, long-chain acyl glutamate cholesteryl ester, hydroxystearate cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl ester, cyclopentasiloxane, sorbitan sesquioli Eight, Cetyl PEG / PPG-10 / 1 Dimethicone, and the like.

Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants.

Nonionic surfactants include self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbit fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hardened castor oil, POE castor oil, POE ㆍ POP (polyoxyethylene ㆍ polyoxypropylene) copolymer, POE ㆍ POP alkyl ether, polyether modified silicone, laurine And acid alkanolamides, alkylamine oxides, and hydrogenated soybean phospholipids.

Examples of the anionic surfactant include fatty acid soap, alpha-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate, alkylamide sulfate, alkyl phosphate, POE alkyl phosphate, alkyl Amide phosphate, alkyloyl alkyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, sodium alkyl sulfoacetate, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate ester, etc. You can.

Cationic surfactants include alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, And benzalkonium chloride, diethylaminoethyl stearate, dimethylaminopropylamide stearate, and quaternary ammonium salts of lanolin derivatives.

The amphoteric surfactants include carboxybetaine type, amidebetaine type, sulfobetaine type, hydroxysulfobetaine type, amidesulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amideamine type, etc. And amphoteric surfactants.

Organic and inorganic pigments include silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium film mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, and oxidation. Inorganic pigments such as aluminum, calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine, chromium oxide, chromium hydroxide, calamine and complexes thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene ㆍ styrene copolymer, And organic pigments such as silk powder, cellulose, CI pigment yellow, and CI pigment orange, and composite pigments of these inorganic pigments and organic pigments.

Examples of the organic powder include metal soaps such as calcium stearate; Alkyl phosphate metal salts such as sodium cetyl acid zinc, lauryl acid zinc, and calcium lauryl acid; Acylamino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroylglycine calcium; Amide sulfonic acid polyvalent metal salts such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N such as N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoylazine, N-alpha-paritoylolnitine, N-alpha-lauroylarginine, N-alpha-cured Uji fatty acid acyl arginine -Acyl basic amino acids; N-acylpolypeptides, such as N-lauroylglycylglycine; Alpha-amino fatty acids such as alpha-amino caprylic acid and alpha-amino lauric acid; And polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene-styrene copolymer, and ethylene tetrafluoride.

UV absorbers include paraaminobenzoic acid, ethyl paraaminobenzoate, amyl paraaminobenzoate, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomentyl salicylate, cinnamic acid Benzyl, paramethoxy cinnamic acid-2-ethoxyethyl, paramethoxy cinnamic acid octyl, paramethoxy cinnamic acid ethylhexyl, diparamethoxy cinnamic acid mono-2-ethylhexaneglyceryl, paramethoxy cinnamic acid isopropyl, diisopropyl ㆍ Diisopropyl cinnamic acid ester mixture, urocanoic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and salts thereof, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenonedi Sodium sulfonate, dihydroxybenzophenone, tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino-p- (carbo-2'-ethylhexyl -1'-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole, titanium oxide, and the like.

Disinfectants include hinokitiol, triclosan, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zincfilionone, benzalkonium chloride, Photoresist 301, mononitrowire sodium, undeciric acid, and the like.

Antioxidants include butyl hydroxyanisole, propyl gallic acid, and elisoric acid.

Examples of the pH adjusting agent include citric acid, sodium citrate, malic acid, sodium malate, fmalic acid, sodium malate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogen phosphate, and the like.

Examples of the alcohol include higher alcohols such as cetyl alcohol and stearyl alcohol.

Emulsifiers include stearic acid, sorbitan monolaurate, sorbitan monoisostearate, sorbitan tristearate, sorbitan sesquioleate, glycerol monostearate, glycerol monooleate, dimethicone copolyol, cetyldimethicone Copolyol, polyethylene glycol-9 polydimethylsiloxyethyl dimethicone, polyethylene glycol-7 dimethicone, cyclopentasiloxane, cetyl page / fiji-10 / 1 dimethicone, etc. Can be mentioned.

Examples of the thickener include cellulose gum, xanthan gum, genran gum, agar, tamarind gum, guar gum, gum arabic, cetyl alcohol, stearyl alcohol, cetearyl alcohol, sodium chloride, polyquaternium-7, and the like.

Dimethicone, cetearyl alcohol, etc. are mentioned as a viscosity modifier.

Skin emollients include cyclopentasiloxane, isohexadecane, cyclohexasiloxane, octyldodecanol, caprylic / capric triglyceride, dimethicone, sweet almond oil, grapeseed oil, macadamia seed oil, and the like.

Examples of the skin conditioning agent include polyquaternium-7, niacinamide, sodium hyaluronate, and tocopheryl acetate.

In addition, the compounding components that may be added in addition are not limited thereto, and any of the above components can be blended within a range not impairing the objects and effects of the present invention, but is preferably from 0.01 to 5% by weight with respect to 100 parts by weight of the cosmetic composition. Part, more preferably it can be blended to 0.01 to 3 parts by weight.

The cosmetic composition of the present invention according to some embodiments may take the form of solutions, emulsions, viscous mixtures, and the like.

Ingredients included in the cosmetic composition of the present invention according to some embodiments may include ingredients commonly used in cosmetic compositions in addition to the extract as an active ingredient, for example, preservatives, stabilizers, solubilizers, vitamins, pigments And conventional adjuvants and carriers such as fragrances.

The cosmetic composition prepared by the method of the present invention may have a conventional formulation, for example, skin, lotion, essence, lotion, nourishing cream, massage cream, moisture cream, hand cream, sunscreen cream, foundation, body lotion , Body oil, body essence, etc. The composition of each of these formulations may contain various bases and additives necessary and appropriate for the formulation of the formulation, and the types and amounts of these components can be easily selected by those skilled in the art.

Hereinafter, examples will be described in detail to specifically describe the present invention.

Examples and comparative examples

A cosmetic composition was prepared with the ingredients and contents (parts by weight) shown in Table 1 below, and mixed with the ingredients shown in Table 2 to prepare a moisture cream.

Category (parts by weight) Example Comparative example One 2 3 4 5 6 7 8 9 One 2 3 4 5 Dracosephalum Moldavica Extract 1.0 1.0 0.1 0.5 2.5 1.0 1.0 1.0 1.0 - - - - 1.0 Aloe vera extract 1.0 1.0 1.0 1.0 1.0 0.2 2.0 2.0 - 1.0 - 1.0 1.0 - Phytantriol 1.0 1.0 1.0 1.0 1.0 0.2 2.0 - 2.0 1.0 - 1.0 1.0 - Adenosine 0.05 - - - - - - - - - - 1.0 - - Retinol - - - - - - - - - - - - 1.0 - Serine - - - - - - - - - - - - - 2.0

division Parts by weight Skin softener Cyclopentasiloxane 12.0 Octyldodecanol 1.5 Skin conditioning agent Polyquaternium-7 10.0 Niacinamide 2.2 Sodium hyaluronate 2.0 Tocopheryl Acetate 0.01 Moisturizer 1,3-butylene glycol 5.0 glycerin 2.0 Dimethicone 4.0 Thickener Cetearyl alcohol 4.0 Sodium chloride 1.5 Emulsifier Cetyl Fiji / Piji-10 / 1 Dimethicone 2.2 Stearic acid 1.0 Sorbitan sesquioleate 0.4 UV absorber Titanium oxide 1.5 Ethyl hexyl paramethoxy citrate 1.0 Purified water Remaining amount in 100 parts by weight of the composition

Experimental example

1. Evaluation of antioxidant activity

Antioxidant activity was evaluated by confirming free radical scavenging activity by 1,1-diphenyl-2-picryl-hydrazyl (1,1-diphenyl-2-picryl-hydrazyl, DPPH) method.

A 0.1 mM DPPH solution diluted in 4 ml of ethanol and 100 mg / ml of the cosmetic compositions of Examples and Comparative Examples were mixed and left at room temperature for 30 minutes. Thereafter, absorbance (%) was measured at 517 nm, and the results are shown in Table 4.

2. Skin moisturizing evaluation

Moisturizing creams of Examples and Comparative Examples were applied to 18 experimenters (women aged 20 to 35 years) to the faces of each Example and Comparative Example for 2 weeks each for 4 weeks consecutively.

After completion of the experiment, facial skin moisture (%) was measured with corneometer CM820 (Courage & Khazaka, Cologne, Germany) and tewameter TM210 (Courage & Khazaka, Cologne, Germany), and the results are shown in Table 4.

3. Evaluation of whitening effect

After attaching an opaque tape with a square hole of 1.5cm in width and length to the upper part of the experimenter in 18 subjects (women aged 20-35 years), the minimum erythema amount of each subject (Minimal Erythema Dose) The skin was darkened by irradiation with ultraviolet rays (UV B) of 1.5 to 2 times.

After the investigation, the moisture creams of Examples and Comparative Examples were applied as a test substance, and a control site to which nothing was applied was prepared to observe the state change after 6 weeks. The color of the skin was measured with a colorimeter CR2002 (Minolta, Japan). Differences in skin color (L *) at the start and finish times of application were calculated. Then, the difference in L * between the sample application site and the control site for the whitening effect was calculated and shown in Table 4.

4. Skin irritation evaluation

The skin irritation properties of the cosmetic compositions of Examples and Comparative Examples were confirmed in 18 subjects (women aged 20-35).

20 µm of the cosmetic composition of Examples and Comparative Examples was dropped into the IQ chamber for patching test, and after being applied to the back area for 48 hours, the chamber was removed. Then, changes in skin condition were visually read at the time point of 30 minutes and 24 hours. The evaluation criteria and corresponding scores of the skin reaction are shown in Table 3 below. The first determination was made 30 minutes after the removal of the patch, and the second determination was made after 24 hours had elapsed, and the average reaction rate (%) was calculated according to Equation 1 below. The degree of irritation to human skin was expressed as the average response rate (%) of the 1st and 2nd judgments, and it is shown in Table 5 below.

score Evaluation standard 0 No response One Weak erythema 2 Moderate uniform erythema 3 Pronounced erythema, accompanied by edema 4 Clear erythema, edema and minor vesicles

[Equation 1]

Average response rate (%) = {Σ (number of experimenters with reaction after 24 hours × score) + Σ (number of experimenters with reaction after 48 hours × score)} × 100 / (total number of tests × maximum score × total number of experimenters)

division Example Comparative example One 2 3 4 5 6 7 8 9 One 2 3 4 5 Antioxidant activity evaluation (%) 93 90 82 83 81 85 85 80 80 62 63 75 77 78 Skin moisturizing evaluation (%) 80 80 75 75 71 70 70 72 73 67 58 65 65 70 Whitening effect evaluation (L *) 1.8 1.6 1.0 1.1 1.2 1.2 1.2 1.0 1.1 0.6 0.6 0.7 0.7 0.7

Test substance Number of subjects with reaction after 24 hours (persons) Number of experimenters who responded after 48 hours (persons) Average response rate (%) 0 points 1 point 2 points 3 points 4 points 0 points 1 point 2 points 3 points 4 points Example 1 18 0 0 0 0 18 0 0 0 0 0 Example 2 18 0 0 0 0 18 0 0 0 0 0 Example 3 18 0 0 0 0 18 0 0 0 0 0 Example 4 18 0 0 0 0 18 0 0 0 0 0 Example 5 18 0 0 0 0 18 0 0 0 0 0 Example 6 18 0 0 0 0 18 0 0 0 0 0 Example 7 18 0 0 0 0 18 0 0 0 0 0 Example 8 18 0 0 0 0 18 0 0 0 0 0 Example 9 18 0 0 0 0 18 0 0 0 0 0 Comparative Example 1 18 0 0 0 0 18 0 0 0 0 0 Comparative Example 2 18 0 0 0 0 18 0 0 0 0 0 Comparative Example 3 18 0 0 0 0 18 0 0 0 0 0 Comparative Example 4 16 2 0 0 0 15 3 0 0 0 3.5 Comparative Example 5 18 0 0 0 0 18 0 0 0 0 0

Referring to Table 4 and Table 5, it can be seen that the cosmetic composition according to the Examples shows excellent effects in antioxidant activity, skin moisturizing, whitening and skin irritation reduction, but the comparative example was not.

Particularly, in the case of Comparative Examples 3 and 4, adenosine or retinol, which is known to have a wrinkle improvement effect, was added, but in Comparative Examples 3 and 4, the point of having some performance in antioxidant activity is that the skin penetration rate of the active ingredient is low, so in the moisturizing evaluation. It was confirmed that it was not good, and particularly, Comparative Example 4 had poor results in skin irritation evaluation.

In addition, it can be seen that in the case of Comparative Example 5 in which serine was used instead of the aloe vera extract and / or phytantriol, the skin moisturizing effect was lowered compared to the examples.

Claims (6)

Dracocephalum moldavica extract 0.6 to 1.5 parts by weight; And
Aloe vera extract and phytantriol total 0.6 to 3 parts by weight; containing,
The aloe vera extract and the phytantriol are contained in a weight ratio of 1: 0.5 to 1.5, cosmetic composition for skin whitening.
delete delete The cosmetic composition according to claim 1, further comprising adenosine.
The method according to claim 1, fats and oils, moisturizing agents, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, pH adjusters, alcohols, pigments, fragrances, purified water, thickeners, A cosmetic composition further comprising at least one selected from the group consisting of emulsifiers, viscosity modifiers, skin softeners, and skin conditioning agents.
The method according to claim 1, Skin, lotion, essence, lotion, nourishing cream, massage cream, moisture cream, hand cream, foundation, body lotion, body oils and body essence is a formulation selected from the group consisting of, cosmetic composition.