KR102083658B1 - Microneedle system having flow passage inside - Google Patents

Abstract

The present invention provides a microneedle system or kit for skin administration with reduced pain, ease of use, and improved absorption of useful ingredients.

Description

Microneedle system having flow passage inside

The present invention relates to a microneedle system having a plurality of microprojections (microneedles), which can promote skin absorption of a medically, pharmaceutical or cosmetically useful active ingredient.

In general, microneedle (microneedle) is used for the delivery of active substances such as drugs, vaccines, in vivo, detection of the analytes in the body and biopsy (biopsy). In particular, microneedles are mainly used for the purpose of improving the absorption of useful ingredients through the skin because they can make a fine hole in the skin to avoid the stratum corneum, which is an absorption barrier of external components.

Among the various types of microneedle systems, the stamp microneedle system, which is a type that can be used in reality, temporarily makes pores in the skin using microprotrusions, and then reapplies a formulation containing useful ingredients (for example, , Step 2), and the pain caused by the needle when puncturing the skin of the microneedle was delivered to the skin as it is.

Microneedles can cause significant pain because they puncture the skin with physical force, and contact with the perforated skin is advantageous as short as possible or shorter to reduce pain as much as possible.

Therefore, the problem to be solved by the present invention is to reduce the steps for use as possible to achieve the reduction of pain, ease of use, ease of manufacture, etc., and at the same time reduce the pain caused by skin puncture using the microneedle It is to provide a microneedle system.

Other objects and advantages of the present invention can be understood by the following description, and will be more clearly understood by the embodiments of the present invention. It will also be readily apparent that the objects and advantages of the present invention can be realized by the means and combinations thereof indicated in the claims.

In order to solve the above problems, the present invention is a plurality of fine projections; A layer capable of absorbing the liquid substance to which the microprojections are connected; And a layer in which a flow passage through which the liquid substance moves is formed, which is in contact with the layer capable of absorbing the liquid substance on the opposite side where the microprojections are located.

Preferably, the present invention provides a microneedle system, characterized in that the microneedle system according to the present invention is formed with a plurality of holes through which the liquid material can move to a layer capable of absorbing the liquid material. do. More preferably, the plurality of holes provides a microneedle system, characterized in that connected to the flow path. More preferably, the hole provides a microneedle system, characterized in that the diameter is 10 to 2,000 μm in size.

Preferably, the present invention provides a microneedle system, characterized in that in the microneedle system according to the present invention, the flow path formed layer has an inlet through which liquid material can be introduced.

Preferably, the present invention provides a microneedle system, characterized in that in the microneedle system according to the present invention, the channeled layer has a handle.

Preferably, the present invention provides a microneedle system according to the present invention, wherein the layer capable of absorbing the liquid substance is in the form of a sponge or a cosmetic puff.

Preferably, in the microneedle system according to the present invention, the microneedle system provides a microneedle system, characterized in that the size of 10-2,000 ㎛ based on the triangular cross-section of the center.

The present invention provides a microneedle system according to one aspect of the present invention, wherein a film exists between a layer capable of absorbing liquid material and a layer in which a flow path is formed in the microneedle system according to the present invention.

The present invention, in one aspect, provides a microneedle system in which the flow path is directly connected to a layer capable of absorbing liquid material in the microneedle system according to the present invention.

The present invention provides a microneedle system according to one aspect of the present invention, wherein in the microneedle system according to the present invention, the microprojections are attached to a surface of a layer capable of absorbing a liquid material.

The present invention is an aspect of the present invention, in the microneedle system according to the present invention, the microprojections are buried inside the layer capable of absorbing the liquid material, and the surface of the layer where the tip of the microprojections can absorb the liquid material. A microneedle system is provided that is protruding out.

Preferably, the present invention provides a microneedle system, characterized in that, in the microneedle system according to the present invention, the channeled layer has a space for accommodating the liquid material.

The present invention also provides a flow path through which (a) a member of a sponge type capable of absorbing a liquid material connected to a plurality of fine protrusions and (b) the member of the sponge type, and in which a liquid material can move ( Provided is a kit for skin administration of a useful ingredient comprising a member having a flow passage).

Preferably, the kit may further comprise a container containing a useful liquid component.

The microneedle system according to the present invention can realize the skin puncture effect of the microneedle and the application of useful ingredients in one use.

In addition, the microneedle system according to the present invention can reduce the pain, in particular, the microneedle (micro projections) is attached to the puff or sponge can reduce the pain while maintaining the effect of the microneedle.

The following drawings, which are attached to this specification, illustrate exemplary embodiments of the present invention, and together with the contents of the present invention serve to further understand the technical spirit of the present invention, the present invention is limited to the matters described in the drawings. It should not be construed as limited.
1 is a schematic plan view from above of one aspect of a microneedle system according to the present invention;
2 is a schematic cross-sectional view of one aspect of a microneedle system according to the present invention.
3 is a schematic bottom view of a layer in which a layer capable of absorbing liquid material is removed, that is, a channel is formed in the microneedle system according to the present invention.
4 is a schematic bottom view of one aspect of a microneedle system according to the present invention.
5-9 are schematic side cross-sectional views of one aspects of a microneedle system in accordance with the present invention.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. Prior to this, terms or words used in the present specification and claims should not be construed as having a conventional or dictionary meaning, and the inventors should properly explain the concept of terms in order to best explain their own invention. It should be interpreted as meaning and concept corresponding to the technical idea of the present invention based on the principle that it can be defined.

Therefore, the embodiments described in the specification and the drawings shown in the drawings are only the most preferred embodiment of the present invention and do not represent all of the technical spirit of the present invention, various modifications that can be replaced at the time of the present application It should be understood that there may be equivalents and variations.

1 is a plan view from above of a preferred aspect 100 of a microneedle system according to the present invention. Microneedle system according to the invention a plurality of fine projections; A layer (absorption layer) capable of absorbing the liquid substance to which the fine protrusions are connected; And a layer (flow layer) formed therein with a flow passage through which liquid material can move, which is in contact with the layer capable of absorbing the liquid material on the opposite side where the microprojections are located, the plan view of FIG. The layer in which the flow path is formed is shown schematically.

Preferably, the flow path formed layer has an inlet 112 through which the useful component in a liquid state can be introduced, and when the useful component of the container 200 containing the useful component is introduced through the inlet, the absorbent layer passes through the internal flow path. And useful components are absorbed through the pores of the skin formed through the microprojections attached to the absorbent layer. Thus, if the size of the inlet 112 and the lid size of the vessel 200 containing the liquid component match, it is easy to transfer the useful liquid component from the vessel 200 into the system 100.

Preferably, the microneedle system according to the present invention is provided with a handle 111, and has a space for putting 3 to 4 fingers into the handle portion. The finger is placed in the handle and the system of the present invention is used. That is, the system according to the present invention can be used by inserting a finger and tapping the skin like a general foundation puff, and when using, micropores are formed in the skin by the microprojections, and useful components such as drugs are provided through the puff. Delivered to the skin.

Figure 2 is a side cross-sectional view of one aspect of a microneedle system according to the present invention, a plurality of fine protrusions 130; A layer (absorption layer) 120 capable of absorbing the liquid material to which the microprojections are connected; And a layer (euro layer) 110 in which a flow passage 113 through which liquid material can move is formed, which is in contact with the layer capable of absorbing the liquid material on the opposite side where the microprojections are located. Giving.

The flow path may be formed at an edge of the flow path layer 110 and may also be formed at the center thereof. The flow path layer 110 is not particularly limited in shape, and for example, a cross section may include a polygon such as a circle, a triangle, a rectangle, a pentagon, a hexagon, and an octagon. In addition, the material for forming the flow path layer may be polyethylene, polycarbonate, polyvinyl chloride, polypropylene, polyetherimide, and the like, but the present invention is not limited to the material of the flow path layer case.

In FIG. 2, the fine protrusions 130 are attached to the bottom of the absorbing layer 120.

Preferably, the absorber layer 120 serves to reduce pain when puncturing the skin in the form of puff or sponge. The puff or sponge is preferably in the form that can be inserted into the flow path layer 110, it may be made of a material used in general color cosmetics. For example, the material of the puff or sponge according to the present invention may be polyurethane, rubber, silicone, plastic injection molding, foam material or mixtures thereof, but the present invention is not limited thereto.

The fine protrusions 130 may be made of silicon, glass, metal (including SUS), polymers, and the like, which are commonly used in the manufacture of microneedles. For example, stainless steel or a mixture thereof may be used as the metal, but the present invention is not limited thereto. In addition, the polymers used in the production of microprotrusions include poly (lactide), poly (glycolide), poly (lactide-co-glycolide), polyanhydride, polyorthoester, Polyetherester, polycaprolactone, polyesteramide, poly (butyric acid), poly (balic acid), polyurethane, acrylic, polyacrylate, polycarbonate, epoxy, poly Biodegradable polymers including esters, polyetherether ketones, polyvinyl chloride, polyolefins, liquid crystalline polyesters or copolymers thereof; Polyacrylates, ethylene-vinylacetate polymers, acrylic substituted cellulose acetates, non-degradable polyurethanes, polystyrenes, polyvinyl chlorides, polyvinyl fluorides, poly (vinyl imidazoles), chlorosulphonate polyolefins, polyethylene Non-biodegradable polymers including oxides or copolymers thereof; Celluloses including polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), polymethacrylate, hydroxypropylmethylcellulose (HPMC), ethylcellulose (EC), hydroxypropylcellulose (HPC) or carboxymethylcellulose It may be any one or more selected from the group consisting of a water-soluble polymer including a starch-based polymer containing a cyclopolymer or a cyclodextrin, but the present invention is not limited to such a micro-projection forming material.

The microprojections may include components (including polymers) that melt or dissolve to promote absorption into the skin, and may include useful components of the present invention described below.

The fine protrusions 130 of the microneedle system 100 of the present invention preferably have a height of 10 to 2,000 μm, more preferably 20 to 1,000 μm, and more preferably 50 to 500, based on a central triangular cross section. It is most preferable that it is micrometer. However, the shape of the micro-projections is not particularly limited as long as it can penetrate the skin, and a cone, a polygonal pyramid, or the like, which is formed in an 'spit' shape toward the upper layer, is preferable.

1 to 1,000 of these microprojections may be used per microneedle system according to the present invention.

As shown in Figure 2, preferably, the flow path layer 110 of the microneedle system according to the present invention is formed with a plurality of holes 114 through which the liquid material can move to the absorbing layer 120, the holes are formed in the system 1-200 may be present, preferably 10-100, and more preferably 20-80. It is preferable that such a hole is 10-2,000 micrometers in diameter, It is more preferable that it is 50-1,000 micrometers, It is most preferable that it is 100-500 micrometers.

3 is a bottom view schematically illustrating the plurality of holes 114 of the flow path layer 110. The liquid substance flowing out through these holes 114 is absorbed into the absorbent layer and consequently absorbed into the skin.

4 is a bottom view schematically illustrating a plurality of fine protrusions 130 connected to the absorbing layer 120. There may be 1-200 such microprojections per system, preferably 10-100, and more preferably 20-80.

In the microneedle system of the present invention, a useful component that is a liquid itself or a liquefied useful component dissolved or suspended in a suitable solvent (water, ethanol, ethanol aqueous solution, etc.) is introduced into the inlet 112, and then the flow passage 113 and the hole. It is absorbed into the absorbing layer via 114. Such useful components may be any substance that is allowed to be used pharmaceutically, medically or cosmetically, such as small molecular weight chemical compounds, proteins, antibodies, such as pharmaceuticals, vaccines, cosmetic ingredients, and the like.

For example, interferon, erythropoietin (EPO), follicle stimulating hormone (FSH), parathyroid hormone (PTH), granulocyte macrophage colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-) CSF), human chorionic gonadotropin, progesterone, calcitonin, glucagon, GNRH antagonist, insulin, human growth hormone (GHD), testosterone, lidocaine, diclofenac, oxybutynin, ketoprofen, alendronate, enna Prill maleate, phenylpropanolamine, chromoline, isotretinoin, oxytocin, paroxetine, flurbiprofen, certalin, venlafaxine, leuprolide, risperidone, galantamine, ethanoxaprine, an anticoagulant, etanercept, pain Drugs such as fentanyl, filgrastin, anticoagulant heparin, parathyroid hormone (PTH), somatropin, growth hormone sumatriptan, etc. It can be administered using a different system, and also A-type, B-type and C-type hepatitis; HIV vaccine; influenza; diphtheria; tetanus; whooping cough; Lyme disease; hydrophobia; Pneumococcal; yellow fever; cholera; Vaccinia; Tuberculosis; German measles; Measles; things to see; Rotavirus; Botulism; Vaccines such as herpes virus can be inoculated using the system according to the invention. In addition, botox toxin, disodium phenyldibenzimadazole tetrasulfonate, diosmethine, magnesium ascorbyl phosphate, mayesignan, white oil, butylmethoxydibenzoylmethane, bis-ethylhexyloxyphenol mexoxyphenyl triazine, acetylpy Tosphingosine, ascorbyl glucoside, asiaticoside, arbutin, ethyl ascorbyl ether, ethylhexyl methoxycinnamate, ethylhexyl trizone, ethylhexyl salicylate, octocrylene, ginsenosides, zinc oxide, Titanium Oxide, Polydatin, Polyethoxylatedretinamide, Frangenidine, Hydroxyproline, Homosalate, Human Oligopeptide-1, Retinol Cosmetic ingredients such as can be administered using the system of the present invention.

Preferably, the flow path layer 110 according to the present invention may have a space for accommodating the liquid material.

5 schematically shows the basic configuration of a microneedle system according to the present invention. The microneedle system of the present invention comprises a main body (euro layer) 110 that occupies a major volume of the system and serves as a support when used; A layer (absorption layer) 120 which serves to absorb and release the useful components and serves to relieve pain when perforating the skin; And a plurality of fine protrusions 130 for forming holes in the skin in micro or nano units to promote absorption of useful components.

FIG. 6 schematically shows a plurality of holes 114 through which a liquid material passes, which is formed of an inner flow path (fluid movement passage) 113 and an absorbing layer 120 formed in the flow path layer 110. The plurality of holes 114 are connected to the flow passage 113, and may also be the flow passage 113 itself. 6 also shows a container 200 containing a useful component that is liquid or a liquid composition comprising the useful component, wherein the inlet of the container 200 preferably matches the inlet size of the flow path 113. The invention also provides a kit comprising a microneedle system 100 and a container 200 containing useful components according to the invention.

FIG. 7 is a view illustrating a microneedle system according to the present invention, in which the flow path layer 110 and the absorber layer 120 are separated into a membrane 140 which is a liquid material impermeable. This aspect has the advantage of allowing the liquid material to stay in the flow path without being absorbed by the absorbent layer until just before use. The film 140 is, for example, vinyl, epoxy, synthetic resin Or it may be made using a mixture thereof as a material, but the present invention is not limited to these materials.

8 is a schematic view of a microneedle system according to an embodiment of the present invention in which a flow path 113 is in direct contact with an absorbent layer 120 in a large area.

In the system according to the present invention, the fine protrusions 130 may be attached to the surface of the absorbing layer 120, as shown in FIG. 8, or alternatively, may be present inside the absorbing layer 120 as shown in FIG. 9. have. When the fine protrusions 130 are present in the absorbent layer 120, the fine protrusions 130 may be attached to the middle of the absorbent layer 120, or may be attached to the flow path layer 110 as shown in FIG. 9. .

The present invention also provides a flow path through which (a) a member of a sponge type capable of absorbing a liquid material connected to a plurality of fine protrusions and (b) the member of the sponge type, and in which a liquid material can move ( Provided is a kit for skin administration of a useful ingredient comprising a member having a flow passage). Preferably, the kit may further comprise a container containing a useful liquid component.

Consumers can directly use the (a) and (b) members directly before use, and in this case, the (b) member can be recycled, which is not in contact with the skin.

As described above, although the present invention has been described by way of limited embodiments and drawings, the present invention is not limited thereto and is intended by those skilled in the art to which the present invention pertains. Of course, various modifications and variations are possible within the scope of equivalents of the claims to be described.

In addition, terms used to indicate directions such as distal, proximal, up, down, left, and right are used in the present specification, but these terms merely indicate relative positions for convenience of description, and the observer's observation position or arrangement of objects. It is apparent to those skilled in the art that the present invention may be replaced with other terms according to the present invention.

100: microneedle system according to the present invention
110: the main body formed with an internal flow path
111: handle
112: hole for fluid
113: internal euro
114: hole connected to the drug absorber
120: drug absorber
130: fine protrusion
140: membrane blocking the body and the drug absorber
200: container containing fluid

Claims (15)

A plurality of fine protrusions;
A sponge-like layer capable of absorbing a liquid substance to which the microprojections are connected; And
A layer having a flow passage through which the liquid material moves, which is in contact with the layer capable of absorbing the liquid material on the opposite side of the microprojection,
Microprojections are attached to the surface of the sponge-like layer, or buried in the sponge-like layer so that the sponge-like layer is a microneedle system, characterized in that serves to relieve pain when puncture the skin. The microneedle system of claim 1, wherein the flow path formed layer is a layer capable of absorbing the liquid material and has a plurality of holes through which the liquid material can move. 3. The microneedle system of claim 2, wherein the plurality of holes are connected to a flow path. 3. The microneedle system of claim 2, wherein said aperture is 10 to 2,000 microns in diameter. 2. The microneedle system of claim 1, wherein said flow path formed layer has an inlet through which liquid material can be introduced. 2. The microneedle system of claim 1, wherein said flow path formed layer has a handle. delete The microneedle system according to claim 1, wherein the microprojections have a height of 10 to 2,000 μm, the size of which is based on a triangular cross section of the center. 2. The microneedle system of claim 1, wherein the system comprises a membrane between the layer capable of absorbing liquid material and the layer in which the flow path is formed. 2. The microneedle system of claim 1, wherein said flow path is directly connected with a layer capable of absorbing liquid material. delete delete 2. The microneedle system of claim 1, wherein said flow path formed layer has a space for accommodating liquid material. It includes a member of the sponge type that can absorb the liquid material and a plurality of fine projections connected, and a member that can be attached to the sponge type member, a flow passage through which the liquid material can move, The micro-projection is attached to the surface of the sponge-type member layer, or buried in the sponge-type member is a kit for skin administration of the useful ingredient, characterized in that it serves to relieve pain when puncturing the skin. 15. The kit for skin administration of a useful ingredient according to claim 14, wherein the kit further comprises a container containing a liquid useful ingredient.

Images