KR20150010443A - Microneedle system having flow passage inside - Google Patents

Abstract

Provided in the present invention is a microneedle system or kit for application to the skin which reduces pain, enables a user to easily use, and has the improved absorption rate of an effective component. Provided in the present invention is a microneedle system which is characterized by comprising multiple fine protrusions; a layer connected to the fine protrusions and available of absorbing a liquid material; and a layer contacting with the layer available of absorbing a liquid material, and including a flow passage where the liquid material can flow inside.

Description

[0001] The present invention relates to a microneedle system having an internal flow path,

The present invention relates to a microneedle system with a plurality of microprojections (microneedles) capable of promoting skin absorption of a medical, pharmaceutical or cosmetically useful active ingredient.

In general, microneedle (microneedle) is used for delivery of active substances such as drugs and vaccines in vivo, detection of biological analyte, and biopsy. In particular, the micro needle is used mainly for the purpose of enhancing absorption of a useful ingredient through the skin because it can avoid the stratum corneum which is an absorption barrier of an external ingredient by making a minute hole in the skin.

Of the various microneedle systems, in the case of stamped microneedle systems, which are realistically available types, microprojections are used to temporarily make holes in the skin and then reapply the formulation containing the useful ingredient (for example, , And a second step, and the pain caused by the needles of the needles of the microneedle was passed through the skin.

Micro-needles can cause considerable pain because they are punctured by physical force, and contact with perforated skin is as good or as short as possible to reduce pain as much as possible.

Therefore, the problem to be solved by the present invention is to reduce the steps for use as much as possible, thereby achieving reduction of pain, ease of use, easiness of manufacturing, etc., and at the same time, To provide a micro needle system.

Other objects and advantages of the present invention will become apparent from the following description, and it will be understood by those skilled in the art that the present invention is not limited thereto. It will also be readily apparent that the objects and advantages of the invention may be realized and attained by means of the instrumentalities and combinations particularly pointed out in the appended claims.

According to an aspect of the present invention, there is provided a semiconductor device comprising: a plurality of micro-projections; A layer capable of absorbing a liquid material to which the microprojections are connected; And a layer formed on the opposite side of the microprojection, which is in contact with the layer capable of absorbing the liquid material, and in which a flow passage through which the liquid material can move is formed.

Preferably, in the microneedle system according to the present invention, the layer in which the flow path is formed is a layer capable of absorbing the liquid material, and a plurality of holes through which the liquid material can move are formed in the microneedle system do. More preferably, the plurality of holes are connected to the flow path. More preferably, the hole has a diameter of 10 to 2,000 [mu] m in size.

Preferably, in the microneedle system according to the present invention, the layer in which the flow path is formed has an inlet through which liquid material can be injected.

Preferably, in the microneedle system according to the present invention, the flow path formed layer has a handle.

Preferably, the microneedle system according to the present invention is characterized in that the layer capable of absorbing the liquid material is in the form of a sponge or a cosmetic puff.

Preferably, in the microneedle system according to the present invention, the microneedle system is characterized in that the fine protrusions are 10-2,000 μm in size based on a triangular cross section at the center.

According to an aspect of the present invention, there is provided a microneedle system in which a membrane is present between a layer capable of absorbing a liquid material and a layer formed with a channel in the microneedle system according to the present invention.

The present invention provides, in one aspect of the present invention, a microneedle system in which the channel is directly connected to a layer capable of absorbing a liquid substance in the microneedle system according to the present invention.

According to one aspect of the present invention, there is provided a microneedle system, wherein the microneedle is attached to a surface of a layer capable of absorbing a liquid material in the microneedle system according to the present invention.

According to one aspect of the present invention, in the microneedle system according to the present invention, the microprojections are buried in a layer capable of absorbing a liquid material, and the tips of the microprojections are embedded in a layer surface And protruding outwardly of the micro needle system.

Preferably, in the microneedle system according to the present invention, the present invention provides a microneedle system in which a layer in which a flow path is formed has a space capable of accommodating a liquid material.

The present invention also relates to a sponge-type member capable of absorbing a liquid substance, to which a plurality of fine projections are connected, and (b) a spout-type member which can be attached to the sponge-type member, a flow passage for the skin of the user.

Preferably, the kit may further comprise a container containing a liquid useful ingredient.

The microneedle system according to the present invention can realize the skin puncturing effect of the micro needle and the application of the useful component at one time by one use.

In addition, the micro needle system according to the present invention can reduce the pain, and in particular, since the micro needle is attached to the puff or the sponge, the pain can be reduced while maintaining the effect of the micro needle.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate exemplary embodiments of the invention and, together with the description of the invention, It should not be construed as limited.
1 is a schematic top plan view of an embodiment of a microneedle system according to the present invention, viewed from above.
2 is a schematic cross-sectional view of one embodiment of a micro needle system according to the present invention.
3 is a schematic bottom view of a layer in which a layer capable of absorbing a liquid material is removed, that is, a layer in which a flow path is formed in the microneedle system according to the present invention.
4 is a schematic bottom view of one embodiment of a microneedle system in accordance with the present invention.
Figures 5 to 9 are schematic side cross-sectional views of one embodiment of a microneedle system in accordance with the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. Prior to this, terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary terms, and the inventor should appropriately interpret the concepts of the terms appropriately It should be interpreted in accordance with the meaning and concept consistent with the technical idea of the present invention based on the principle that it can be defined.

Therefore, the embodiments described in the present specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention and do not represent all the technical ideas of the present invention. Therefore, It is to be understood that equivalents and modifications are possible.

1 is a top view of a preferred embodiment 100 of a microneedle system according to the present invention, viewed from above. A microneedle system according to the present invention includes: a plurality of micro-projections; A layer (absorbent layer) capable of absorbing the liquid material to which the microprojections are connected; And a layer (flow path layer) formed on the opposite side of the fine protrusions and in contact with the layer capable of absorbing the liquid material, wherein a flow passage through which the liquid material can move is formed. And schematically shows a layer in which a flow path is formed.

Preferably, the layer in which the flow path is formed has an inlet 112 through which a useful component in a liquid state can be injected. When the useful component of the container 200 containing the useful component is introduced through the inlet, And the useful component is absorbed through the holes of the skin formed through the microprojections attached to the absorbent layer. Thus, it is possible to transfer useful components in the liquid form from the container 200 into the system 100 easily if the size of the inlet 112 and the size of the lid of the container 200 containing the liquid component coincide.

Preferably, the microneedle system according to the present invention includes a handle 111, and the handle has a space for accommodating three to four fingers. The system of the present invention is used by putting a finger on the handle. That is, it is possible to use the system according to the present invention by using the system according to the present invention in such a manner that a finger is inserted into a foundation puff and then the skin is knocked. In use, fine pores are formed in the skin, It is delivered to the skin.

2 is a side cross-sectional view of one aspect of a microneedle system according to the present invention, which includes a plurality of fine protrusions 130; A layer (absorbent layer) 120 capable of absorbing the liquid material to which the microprojections are connected; And a layer (flow path layer) 110 in which a flow passage 113 through which a liquid material can move is formed, which is in contact with a layer capable of absorbing the liquid material on the opposite side of the fine protrusions, is formed Giving.

The flow path may be formed at the edge of the flow path layer 110 or may be formed at the center. The shape of the channel layer 110 is not particularly limited. For example, the channel layer 110 may include polygons such as circular, triangular, square, pentagonal, hexagonal, and octagonal. The material of the case forming the channel layer may be polyethylene, polycarbonate, polyvinyl chloride, polypropylene, polyetherimide or the like, but the present invention is not limited to the material of the channel layer case.

In FIG. 2, the fine protrusions 130 are attached to the bottom of the absorbent layer 120.

Preferably, the absorbent layer 120 serves to reduce pain when perforating the skin in the form of puffs or sponges. The puff or sponge is preferably in a form that can be fitted to the flow path layer 110, and may be made of a material used in general color cosmetics. For example, the material of the puff or sponge according to the present invention may be polyurethane, rubber, silicone, synthetic resin injection, foaming agent or a mixture thereof, but the present invention is not limited thereto.

The fine protrusions 130 may be made of silicon, glass, metal (including SUS), polymers, etc., which are conventionally used in the manufacture of microneedles. For example, stainless steel or a mixture thereof may be used as the metal, but the present invention is not limited thereto. The polymer used in the production of the microprojections may include poly (lactide), poly (glycolide), poly (lactide-co-glycolide), polyanhydride, polyorthoester, Polyesters, polycaprolactones, polyesteramides, poly (butyric acid), poly (valeric acid), polyurethanes, acrylics, polyacrylates, polycarbonates, epoxies, poly Ester, polyether ether ketone, polyvinyl chloride, polyolefin, liquid crystal polyester, or copolymers thereof; Polyvinyl chloride, polyvinyl fluoride, poly (vinyl imidazole), chlorosulphonate polyolefins, polyethylene (polyvinyl chloride), polyvinyl chloride, polyvinyl pyrrolidone, polyvinyl pyrrolidone, Non-biodegradable polymers comprising oxides or copolymers thereof; Cellulose including hydroxypropylcellulose (HPC) or carboxymethylcellulose, polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), polymethacrylate, hydroxypropylmethylcellulose (HPMC), ethylcellulose Based polymer or a water-soluble polymer containing a starch-based polymer including cyclodextrin. However, the present invention is not limited to such a material for forming microprojections.

The microprojections may include components (including polymers) that are melted or dissolved to promote absorption into the skin, and may include useful components of the present invention described below.

The fine protrusion 130 in the microneedle system 100 of the present invention preferably has a size of 10 to 2,000 mu m, more preferably 20 to 1,000 mu m, more preferably 50 to 500 mu m, Is most preferable. However, the shape of the microprojections is not particularly limited as long as the microprojections can penetrate the skin, and a cone or a polygonal pyramid in the form of a needle is preferable as it goes to the upper layer.

These microprojections can be used in a number of from 1 to 1,000 per micro needle system according to the present invention.

2, preferably, the channel layer 110 of the microneedle system according to the present invention is formed with a plurality of holes 114 through which the liquid material can move into the absorbent layer 120, There can be 1 to 200, preferably 10 to 100, more preferably 20 to 80, groups. Such a hole preferably has a diameter of 10 to 2,000 mu m, more preferably 50 to 1,000 mu m, and most preferably 100 to 500 mu m.

3 is a bottom view schematically showing a plurality of holes 114 of the flow path layer 110. Fig. The liquid material flowing through these holes 114 is absorbed by the absorbent layer and is consequently absorbed into the skin.

4 is a bottom view schematically showing a plurality of fine protrusions 130 connected to the absorbent layer 120. As shown in FIG. There may be 1 to 200 such fine protrusions per system, preferably 10 to 100, more preferably 20 to 80, may be present.

In the microneedle system of the present invention, a liquefied useful ingredient, which is itself liquid or dissolved or suspended in a suitable solvent (water, ethanol, aqueous ethanol solution, etc.) is introduced into the inlet 112, (114). Such useful components may be any substance which is allowed to be used for pharmaceutical, medical or cosmetic purposes, such as a chemical compound of small molecular weight, a drug substance such as a protein, an antibody, a vaccine or a cosmetic ingredient.

For example, interferons, erythropoietin (EPO), follicle stimulating hormone (FSH), parathyroid hormone (PTH), granulocyte macrophage colony stimulating factor (G-CSF), granulocyte- macrophage colony stimulating factor (GM- (GHD), testosterone, lidocaine, diclofenac, oxybutynin, ketoprofen, alendronate, enanthorrhoids, and the like), human chorionic gonadotropin, human chorionic gonadotropin, progesterone, calcitonin, glucagon, GNRH antagonist, insulin, human growth hormone Etanercept, etanercept, which is a therapeutic agent for rheumatoid arthritis, pain, and the like, which is a therapeutic agent for rheumatoid arthritis, which is an anticoagulant, rheumatol, Drugs such as fentanyl, peplastatin, heparin as an anticoagulant, parathyroid hormone (PTH), somatropin, and growth hormone sumatriptan, which are therapeutic agents, It can be administered using a different system, and also A-type, B-type and C-type hepatitis; HIV vaccine; influenza; diphtheria; tetanus; whooping cough; Lyme disease; hydrophobia; Pneumococcus; yellow fever; cholera; Vaccinia; Tuberculosis; German measles; Measles; things to see; Rotavirus; Botulism; A vaccine such as a herpes virus can be inoculated using the system according to the present invention. It is also possible to use a combination of a botox toxin, disodium phenyldibenzimidazole disulfonate, diosmetin, magnesium ascorbyl phosphate, mace lignan, castor oil, butylmethoxydibenzoylmethane, bis-ethylhexyloxyphenolmethoxyphenyltriazine, But are not limited to, Tosiphingosine, Aspolyl Glucoside, Ascorbyl Glucoside, Asian Ticoside, Arbutin, Ethyl Ascorbyl Ether, Ehexylmethoxycinnamate, Ethylhexyltriazone, Ethylhexyl Salicylate, Octocrylene, Ginsenoside Alk, Titanium oxide, polyadin, polyethoxylated retinamide, flangenidine, hydroxyproline, homosalate, human oligopeptide-1, retinol May be administered using the system of the present invention.

Preferably, the channel layer 110 according to the present invention may have a space capable of accommodating the liquid material.

5 schematically shows a basic structure of a microneedle system according to the present invention. The microneedle system of the present invention mainly comprises a main body (flow path layer) 110 which occupies the main volume of the present system and serves as a support in use; A layer (absorbent layer) 120 serving to absorb and release a useful component and mitigate pain upon perforation of the skin; And a plurality of micro-protrusions 130 for forming micro or nano-unit holes in the skin to promote absorption of useful components.

6 schematically shows a plurality of holes 114 through which a liquid material passes, which is formed by an inner flow path (fluid moving path) 113 formed in the flow path layer 110 and an absorbing layer 120. FIG. The plurality of holes 114 are connected to the flow path 113 and may be the flow path 113 itself. FIG. 6 also shows a container 200 containing a liquid composition containing a useful component or useful ingredient in a liquid phase, and it is preferred for the inlet of such a container 200 to coincide with the inlet size of the flow passage 113. The present invention also provides a kit comprising a microneedle system 100 according to the present invention and a container 200 containing a useful component.

FIG. 7 shows an embodiment of the microneedle system according to the present invention in which the channel layer 110 and the absorbent layer 120 are separated into a membrane 140 that is impermeable to liquid matter. One such advantage is that the liquid material can remain in the flow path without being absorbed by the absorbent layer until just prior to use. The membrane 140 may be formed of, for example, vinyl, epoxy, Or a mixture thereof. However, the present invention is not limited to these materials.

8 is a schematic view showing that the channel 113 is in direct contact with the absorbent layer 120 in a wide area as an embodiment of the microneedle system according to the present invention.

In the system according to the present invention, the fine protrusions 130 may be attached to the surface of the absorbent layer 120 as shown in FIG. 8, etc. Alternatively, the fine protrusions 130 may exist inside the absorbent layer 120 have. When the fine protrusions 130 are present inside the absorbing layer 120, the fine protrusions 130 may be attached to the middle of the absorbing layer 120 or may be attached to the flow path layer 110 as shown in FIG. 9 .

The present invention also relates to a sponge-type member capable of absorbing a liquid substance, to which a plurality of fine projections are connected, and (b) a spout-type member which can be attached to the sponge-type member, a flow passage for the skin of the user. Preferably, the kit may further comprise a container containing a liquid useful ingredient.

Consumers can directly use the (a) member and the (b) member directly before use, and in this case, the member (b) which is not in contact with the skin can be recycled.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. It will be understood that various modifications and changes may be made without departing from the scope of the appended claims.

In this specification, terms indicating directions such as a distal, a proximal, an upper, a lower, a left, and a right are used, but these terms are merely relative positions for convenience of explanation, It will be apparent to those skilled in the art that the present invention is susceptible of alternative embodiments.

100: Micro needle system according to the present invention
110: a body
111: Handle
112: hole for holding fluid
113: internal flow path
114: hole connected with drug absorber
120: drug absorber
130: fine protrusion
140: membrane which blocks the body and the drug absorber
200: container containing fluid

Claims (15)

A plurality of micro-projections;
A layer capable of absorbing a liquid material to which the microprojections are connected; And
A layer in which a flow passage through which a liquid material can move is formed, which is in contact with a layer capable of absorbing the liquid material,
The micro needle system comprising: The microneedle system according to claim 1, wherein the layer in which the flow path is formed has a plurality of holes through which the liquid material can move, the layer being capable of absorbing the liquid material. 3. The microneedle system of claim 2, wherein the plurality of holes are connected to a flow path. 3. The microneedle system of claim 2, wherein the orifice has a diameter ranging from 10 to 2,000 microns. The microneedle system according to claim 1, wherein the layer in which the flow path is formed has an inlet through which liquid material can be injected. The microneedle system according to claim 1, wherein the layer in which the flow path is formed has a handle. The microneedle system according to claim 1, wherein the layer capable of absorbing the liquid material is in the form of a sponge. The microneedle system according to claim 1, wherein the fine protrusions have a diameter of 10 - 2,000 탆 based on a center triangular cross section. The microneedle system according to claim 1, wherein the system comprises a membrane between a layer capable of absorbing liquid matter and a layer formed with a flow path. The microneedle system according to claim 1, wherein the flow path is directly connected to a layer capable of absorbing the liquid material. The microneedle system according to claim 1, wherein the microprojections are attached to a surface of a layer capable of absorbing a liquid material. The microneedle system according to claim 1, wherein the fine protrusions are buried in a layer capable of absorbing the liquid material, and the tips of the fine protrusions protrude from the surface of the layer capable of absorbing the liquid material. The microneedle system according to claim 1, wherein the layer in which the flow path is formed has a space capable of accommodating a liquid material. A sponge type member capable of absorbing a liquid material to which a plurality of fine projections are connected and a member capable of attaching to the sponge type member and having a flow passage through which a liquid material can move, Characterized in that it comprises a kit for skin application of a useful ingredient. 15. The kit of claim 14, wherein the kit further comprises a container containing a liquid useful ingredient.

Images