JP2008154849A - Injector - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an injector which secures communication with a medicine solution contained in a container and reduces burden imposed on a person receiving injection when injecting plural kinds of medicine solutions. <P>SOLUTION: The injector comprises the container holding a medicine solution, a multi-needle unit 13 detachable from the container which has a housing 40 having an inner space 44 for receiving the medicine solution, a plurality of first hollow needles 43 projecting outward from the housing 40 and communicating with the inner space 44, and a second hollow needle 41 with a flow passage cross section larger than those of first hollow needles 44 that communicates with the inner space 44 and is capable of connecting the inner space 44 and a space within the container by inserting itself into the container, wherein the injector is provided with an extruding mechanism which pushes out the medicine solution into the inner space 44 via the second hollow needle 43 inserted into the container by pressing the medicine solution. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an injection device, and more particularly to an injection device for injecting a chemical solution or the like.

  Conventionally, various injection devices have been proposed in which a needle is inserted into a human body and a chemical solution is injected into the human body. Further, in recent years, there has been a demand for an injection device that can reduce pain given to a person who receives an injection.

For example, by adopting a microneedle as an injection needle, a syringe has been proposed in which pain given to a person who receives an injection is reduced (Patent Documents 1 to 4 below).
JP 2002-172169 A JP 2005-87521 A JP 2004-503341 A JP 2004-501725 A

  The syringes described in JP-A-2002-172169 and JP-T-2004-501725 use microneedles instead of ordinary needles, and a container containing a drug solution and microneedles are integrated. It has become. In addition, an administration device described in Japanese Patent Application Laid-Open No. 2004-503341 includes a bag containing a medical solution in a housing, and a double-ended needle composed of a cannula that pierces the bag and a plurality of fine needles that puncture the skin. The container in which the chemical | medical solution was accommodated and the injection needle are united. For this reason, when inject | pouring a multiple types of chemical | medical solution, it is necessary to replace | exchange syringe itself, and it will be necessary to pierce a skin many times, and the burden on the person who receives injection will become large.

  On the other hand, FIG. 4 of Japanese Patent Application Laid-Open No. 2005-87521 discloses a chemical injection device in which a housing provided with fine needles and a container containing a chemical are separate. According to this chemical solution injection device, by exchanging the chemical solution container with the fine needle punctured in the patient, it is possible to inject a plurality of chemical solutions at one time for puncturing the skin. However, in such a chemical solution injection device, the proximal end side of the fine needle is directly inserted into the sealing member of the container containing the chemical solution, so that the proximal end portion of the fine needle may be broken or clogged by the sealing member. There is.

  The present invention has been made in view of the problems as described above, and its purpose is to ensure the flowability of the chemical solution contained in the container and to receive injection even when injecting a plurality of types of chemical solutions. It is to propose an injection device with a reduced burden on the person.

  An injection device according to the present invention includes a container in which a chemical solution is stored, a housing having an internal space that can receive the chemical solution, a plurality of first hollow needles that protrude outward from the housing and communicate with the internal space, and an internal space. A second hollow needle having a channel cross-sectional area larger than the channel cross-sectional area of each of the first hollow needles in communication and capable of communicating the internal space and the space in the container by being inserted into the container; And a multi-needle unit that can be attached and detached, and an extrusion mechanism that presses the chemical solution and can extrude the chemical solution from the second hollow needle inserted into the container into the internal space. Preferably, a filter provided in the internal space and capable of filtering a chemical solution is further provided. Preferably, the extrusion mechanism is accommodated in a container. Preferably, the extrusion mechanism is filled in a gas storage portion provided in the container, and can be moved in the container by a gas whose pressure is higher than atmospheric pressure, and the pressure from the gas, and can store a chemical solution in the container And a regulating member that defines the chemical container and the gas container. Preferably, the gas storage unit further includes a supply unit capable of supplying gas. Preferably, a connection pipe for connecting the second hollow needle and the housing is further provided.

  In the injection device according to the present invention, the second hollow needle that pierces the container in which the chemical solution is stored and the first hollow needle that injects the chemical solution are separated from each other, and the second hollow needle is inserted into the chemical solution from the first hollow needle. Since it is larger than the cross-sectional area of the flow path, the second hollow needle can be prevented from being bent or clogged when the container is pierced, and the chemical solution can be distributed well. In addition, since the multi-needle unit is detachable from the container, a plurality of types of drug solutions can be injected by puncturing the skin once by exchanging the container.

  A chemical liquid injector 100 according to the present embodiment will be described with reference to FIGS. In addition, about the structure corresponding to the same or the same, the same code | symbol may be attached | subjected and description may not be repeated.

  FIG. 1 is a side sectional view of a chemical liquid injector 100 according to the present embodiment. As shown in FIG. 1, the chemical solution injector 100 includes a container 10 in which a chemical solution is stored, and a multi-needle unit 13 that is detachably provided on the container 10.

  The container 10 includes a storage case 16 having an opening 16a formed at one end, a closing member 12 that closes the opening 16a of the storage case 16, a fixing member 11 that fixes the closing member 12 to the storage case 16, and a storage And an extruding mechanism that pressurizes the chemical liquid A stored in the case 16 and pushes it out.

  The storage case 16 is provided so as to be movable within the chemical solution storage unit 20 for storing the chemical solution A, the gas storage unit 21 in which the high-pressure gas B is stored, and the storage case 16, and the chemical solution storage unit 20 in the storage case 16. And a defining member 46 that defines the gas accommodating portion 21. Further, the storage case 16 is provided with a switching valve 30 capable of supplying the gas B into the gas storage portion 21. The storage case 16 is made of, for example, PET (polyethylene terephthalate).

  Examples of the drug solution A include high molecular weight drugs such as insulin preparations, growth hormone preparations, and interferon preparations, morphine, epinephrine, and the like. The amount of the medicinal solution A is appropriately changed according to various diseases. As shown in FIG. 1, when the chemical liquid injector 100 is portable, the volume of the chemical liquid storage unit 20 is, for example, about 5 to 50 ml.

  The extrusion mechanism includes a defining member 46 and a gas B filled in the gas storage unit 21. The gas B is set to be higher than the pressure around the container 10 (atmospheric pressure), and presses the chemical solution A through the gasket portion 14. The gas B can be supplied from the outside into the gas storage unit 21 by the switching valve 30.

  The defining member 46 includes a gasket portion 14 made of a resin such as rubber, and a plunger 15 embedded in the gasket portion 14 in order to maintain the shape of the gasket portion 14. The gasket portion 14 is configured so that when the closing member 12 is broken or the like and the inside of the chemical solution storage portion 20 communicates with the outside, the chemical solution A in the chemical solution storage portion 20 is pushed out by the pressure from the gas B. Move in 16.

  The closing member 12 is made of, for example, polyethylene or rubber. The fixing member 11 includes an opening 5 formed in a portion located at the center of the opening 16a, and a part of the closing member 12 is exposed. The fixing member 11 presses and fixes the outer peripheral edge of the closing member 12 that closes the opening 16a of the housing case 16 to the edge of the opening 16a.

  FIG. 2 is a side sectional view showing a detailed configuration of the multi-needle unit 13. In the example shown in FIG. 2, the multi-needle unit 13 includes a housing 40 in which an internal space 44 is defined, a multi-needle structure (first hollow needle) 45 provided in the housing 40, and one of the housings 40. And a perforating needle (second hollow needle) 41 protruding outward from the surface.

  The multi-needle structure 45 is fitted on the surface of the housing 40 located on the opposite side to the piercing needle 41. FIG. 3 is a perspective view showing details of the multi-needle structure 45. In the example shown in FIG. 3, the multi-needle structure 45 includes a substrate 42 formed in a flat plate shape and a plurality of microneedles 43 formed on the main surface of the substrate 42. Each microneedle 43 has a substantially conical shape.

  By making the shape of the microneedle 43 into a sharp conical shape, the microneedle 43 can be smoothly inserted into the skin. The microneedle 43 is composed of a material having relatively high strength and rigidity among degradable polymer materials such as polylactic acid (PLA) and L-type polylactic acid (PLLA). The height of the microneedle 43 is about 250 μm to about 1000 μm. The diameter of the bottom surface of the microneedle 43 is about 200 μm. Since the small diameter and the height are about several hundred μm, the microneedle 43 is less likely to be painful and can be inserted into the skin without pain. The microneedle 43 is formed with a through hole 43a that extends from the upper end of the microneedle 43 to the surface of the substrate 42 that is located on the opposite side of the surface on which the microneedle 43 is located. The through hole 43a communicates with the internal space 44 shown in FIG. The diameter of the through hole 43a is, for example, about 20 μm.

  In FIG. 2, the multi-needle unit 13 includes a piercing needle 41 that projects outward from the upper surface of the housing 40 and communicates with the internal space 44. The piercing needle 41 is made of a metal material such as stainless steel. The bottom surface of the punch needle 41 is, for example, about 5.0 × 5.0 (mm 2), and the height is, for example, about 7.0 mm.

  And the cross-sectional area (flow-path cross-sectional area in which a chemical | medical solution distribute | circulates) S2 of this piercing needle 41 becomes larger than the cross-sectional area (flow-path cross-sectional area) S1 of the through-hole 43a of each microneedle 43 shown in FIG. Yes. Furthermore, the cross-sectional area S2 of the piercing needle 41 shown in FIG. 2 is larger than the sum of the cross-sectional areas S1 of the through holes 43a of the microneedles 43 shown in FIG. Thus, the perforation needle 41 is higher than the microneedle 43, has a larger bottom area, and has high rigidity.

  When injecting a chemical into the human body using the chemical injection device 100 as described above, first, as shown in FIG. 4, the multineedle unit 13 is pressed against the skin 200 and the microneedle 43 is inserted into the skin 200. To do.

  The skin 200 has an epidermis 201, a dermis 202, and a subcutaneous tissue 203 under the dermis 202 from the outer surface side. A muscle layer 204 is located on the lower surface side of the subcutaneous tissue 203. And the thickness of the epidermis 201 of a person's arm is 40 micrometers-130 micrometers, and the thickness of the dermis 202 is about 1 mm-3 mm.

  Since the height of the microneedle 43 is 250 μm to 1000 μm, the tip of the microneedle 43 reaches at least the dermis 202. Further, even when the surface of the skin 200 is dented when the multi-needle unit 13 is pressed against the skin 200, the tip of the microneedle 43 can reach the dermis 202. In addition, you may make it reach the subcutaneous tissue 203 by making the height of the microneedle 43 still higher.

  Since the microneedles 43 are arranged in a plurality of arrays on the substrate 42, even when any of the microneedles 43 is clogged when the microneedles 43 are inserted into the skin 200, other microneedles The chemical solution can be injected by 43.

  Then, with the microneedle 43 reaching the dermis 202, the container 10 shown in FIG. At this time, the piercing needle 41 of the multi-needle unit 13 pierces the closing member 12 shown in FIG. 1, and the chemical solution storage unit 20 in the container 10 and the internal space 44 of the multi-needle unit 13 communicate with each other.

  Here, the perforating needle 41 has higher rigidity than the microneedle 43, is not easily bent, and can reliably penetrate the closing member 12. Furthermore, since the flow path cross-sectional area of the piercing needle 41 is larger than the sum of the flow path cross-sectional areas of all the microneedles 43, clogging of the piercing needle 41 is suppressed when the closing member 12 is pierced. be able to.

  When the closing member 12 is an elastically deformable member such as rubber, when the perforating needle 41 perforates the closing member 12, the closing member 12 tightens around the perforating needle 41 and the chemical liquid A leaks. Can be suppressed. Further, when the perforating needle 41 perforates the closing member 12, the outer surface of the fixing member 11 and the surface of the multi-needle unit 13 come into contact with each other, and the leakage of the chemical solution A is suppressed.

Here, when the microneedle 43 is inserted into the skin 200 and the perforating needle 41 perforates the closing member 12, the gas B presses the drug solution A through the gasket portion 14 shown in FIG. For this reason, the gasket part 14 is displaced so as to narrow the chemical liquid storage part 20, and the chemical liquid A stored in the chemical liquid storage part 20 flows into the internal space 44 shown in FIG. The drug solution A that has flowed into the internal space 44 is injected into the dermis 202 or the subcutaneous tissue 203 through the through holes 43 a of the microneedles 43. And the chemical | medical solution inject | poured in the dermis 202 or the subcutaneous tissue 203 is absorbed into a vein from a peripheral blood vessel.

Here, since the power source for injecting the chemical liquid A uses the pressure of the gas B accommodated in the container 10, it is not necessary to connect to an external power source or the like. Therefore, the chemical injection device 100 is small and lightweight, can be carried, and can continuously perform subcutaneous injection in daily life. Furthermore, the injection speed of the chemical solution A can be adjusted by adjusting the pressure of the gas B, the cross-sectional area S2 of the punch needle 41, and the like.

  Immediately before puncturing the multi-needle unit 13 into the skin 200 or attaching the container 10 to the multi-needle unit 13, the gas A is supplied from the switching valve 30 shown in FIG. Is preferred. Thereby, even if the gas B leaks outside and the pressure of the gas B falls while storing the container 10 before use, a predetermined pressure can be ensured at the time of use.

  When subcutaneously injecting a plurality of types of chemical solutions, the container 10 is removed from the multi-needle unit 13 and another type of chemical solution is reinserted into the multi-needle unit 13 to inject the multiple types of chemical solutions. can do.

  In particular, since the container 10 can be replaced while the multi-needle unit 13 is punctured into the skin 200, it is possible to inject a plurality of types of medicinal liquids with a single puncture, reducing the burden on the person being injected. can do.

  The multi-needle unit 13 may be provided with wings on the outer peripheral surface of the housing 40, and the wings may be taped to fix the multi-needle unit 13 to the skin 200. An adhesive material may be provided to fix the multi-needle unit 13 to the skin 200.

  The internal space 44 of the multi-needle unit 13 is for allowing the drug solution flowing in from the perforation needles 41 to flow out from all the microneedles 43, and the volume is as small as possible due to the problem of dead space as long as the function can be performed. It is preferable. The inner space 44 may be a completely formed space as shown in FIG. 2, but a groove 441 is formed on the inner surface of the housing 40 on the side where the piercing needle 41 is provided as shown in FIG. Alternatively, grooves 442 may be formed on the inner surface of the substrate 42 as shown in FIG. Either one of these grooves 441 and 442 may be formed, or both of them may be formed. However, when the filter 46 described later is disposed, a groove 441 on the housing 40 side is more preferably formed. preferable.

  FIG. 7 is a cross-sectional view showing a first modification of the multi-needle unit 13. In the example shown in FIG. 7, the multi-needle unit 13A further includes a filter 46 that is provided in the internal space 44 and divides the internal space 44 into an upper space and a lower space. The filter 46 removes bacteria, fungi, minute foreign matters, bubbles, etc. mixed in the chemical liquid A flowing into the upper space, and filters minute precipitates generated by changes in the composition and temperature. And the chemical | medical solution A from which the foreign material etc. were removed passes through lower space, and is inject | poured in the skin 200 from the microneedle 43. FIG. Examples of the filter 46 include a foreign matter removal filter having a pore size of about 5 μm for the purpose of removing glass pieces, rubber pieces, fiber pieces, metal pieces, etc., and about 0 for the purpose of removing E. coli and staphylococci. A sterilizing filter having a pore size of 2 μm is employed. The filter 46 is disposed in the internal space 44 of the multi-needle unit 13 </ b> A, but may be disposed in substantially the entire internal space 44 by being sandwiched between the housing 40 and the substrate 42. The injection speed can be adjusted by adjusting the coarseness of the filter 46.

  FIG. 8 is a cross-sectional view showing a second modification of the multi-needle unit 13. In the example shown in FIG. 8, the multi-needle unit 13 </ b> B includes a connection tool 70 provided with a piercing needle 41, and a connection pipe 60 that communicates the piercing needle 41 with the internal space 44 of the housing 40. Since the connecting tool 70 is placed separately from the multi-needle unit 13B, there is a risk that the impact when the piercing needle 41 is pierced into the closing member 12 is directly transmitted to the person who receives the injection when the container containing the chemical solution is replaced. Absent. Such a multi-needle unit 13B inserts a perforated needle 41 into a container 10 containing about 500 ml to about 1000 ml of drug solution A, and provides a liquid replacement by continuous subcutaneous injection for about 24 hours to an elderly person with dehydration. Used for.

  FIG. 9 is a cross-sectional view showing a third modification of the multi-needle unit 13 and the container 10. As shown in FIG. 9, an annular protrusion 51 is formed on the outer peripheral surface of the fixing member 11 of the container 10. The multi-needle unit 13 </ b> C includes an engaging portion 50 that is formed on the surface on which the perforating needle 41 is provided and engages the protruding portion 51.

  FIG. 10 is a cross-sectional view showing a state where the multi-needle unit 13C and the container 10 are engaged. As shown in FIGS. 9 and 10, when the container 10 is pushed toward the multi-needle unit 13C, the engaging portion 50 and the protruding portion 51 are engaged to connect the container 10 and the multi-needle unit 13C. Can be fixed. When the container 10 and the multi-needle unit 13C are connected to each other, the perforation needle 41 is configured so as to penetrate the closing member 12 for the first time, thereby preventing erroneous connection between the multi-needle unit 13C and the container 10 before puncturing the skin. Can be prevented. Further, by providing a plurality of notches in the projecting portion and making the engaging portion a shape corresponding thereto, the engaging portion 50 is passed through the notched portion, and then the container 10 is rotated to engage the engaging portion. 50 and the protruding portion 51 may be engaged with each other. In addition, the connection method of the container 10 and the multi-needle unit 13C may be another method.

  FIG. 11 is a cross-sectional view showing a fourth modification of the multi-needle unit 13. As shown in FIG. 11, the multi-needle unit 13 </ b> D includes a bulging portion 54 formed on the surface of the housing 40 in which the piercing needle 41 is provided. The bulging portion 54 is tapered from the base side of the piercing needle 41 toward the tip side, and the peripheral surface 55 is tapered. The opening 53 of the fixing member 11 is inclined so as to be tapered from the outer surface side of the fixing member 11 toward the inner surface side.

  When the multi-needle unit 13D is mounted on the container 10, the peripheral surface 55 of the bulging portion 54 of the multi-needle unit 13 and the inner surface of the opening 53 of the fixing member 11 come into contact with each other and come into close contact with each other. Thereby, when the piercing needle 41 penetrates the closing member 12, it is possible to suppress the leakage of the chemical liquid to the outside. The multi-needle unit 13D may be further provided with a fixing means in order to ensure the close contact between the bulging portion 54 and the fixing member 11. As such fixing means, known fixing means such as engagement with screws as well as engagement between the engaging portion 50 and the protruding portion 51 as shown in FIGS. 9 and 10 are employed.

  FIG. 12 is a cross-sectional view showing a first modification of chemical liquid injector 100 according to the present embodiment. In this chemical injection device 100A, an elastic member 31 such as a spring is adopted as an extrusion mechanism. The regulating member 46 is pressed by the elastic member 31. The chemical solution storage unit 20 is provided with a chemical solution supply unit 32 that can supply a chemical solution from the outside.

  In this chemical solution injection device 100A, the chemical solution injection time can be adjusted by adjusting the elastic coefficient of the elastic member 31.

  FIG. 13 is a cross-sectional view showing a second modification of chemical liquid injector 100 according to the present embodiment. In this chemical solution injection device 100B, the container case 16 of the container 10 is filled with the chemical solution A and accommodates a balloon 90 that is elastically deformable. The drug solution A accommodated in the balloon 90 is pressurized by the contraction force of the balloon 90 inflated by filling the drug solution A. The balloon 90 is connected to a cylindrical portion 92 and a cylindrical portion 91 formed in the housing case 16. The cylindrical portion 92 is closed by the closing member 12, and the cylindrical portion 91 can be opened and closed by a switching valve (not shown).

  For this reason, when the blocking member 12 is pierced by the piercing needle 41, the drug solution A flows into the multi-needle unit 13 and is injected subcutaneously.

  Here, a method for manufacturing the multi-needle structure 45 will be described. The microneedle 43 is manufactured by X-ray lithography using a PCT (Plane-pattern to Cross-section Transfer) method, and will be described in detail with reference to FIGS.

  FIG. 14 is an explanatory diagram showing a first step in the manufacturing process of the microneedle 43. As shown in FIG. 14, a PMMA (polymethylmethacrylate) layer 151 having a thickness of several hundreds μm is formed on the main surface of a metal substrate 150 disposed on a resist stage. Then, the SR light X-ray is irradiated toward the mask 152, and during the X-ray exposure, the metal substrate 150 and the PMMA layer 151 are reciprocated in one axis direction at a speed of 2 mm / sec, for example, in the chamber. Let

  The mask 152 includes, for example, polyimide having a thickness of 50 μm, an X-ray absorber 153 made of, for example, Au, and a frame made of, for example, Al. The absorber 153 is formed on the surface of the mask 152, and is formed so that a plurality of triangles are arranged in one direction. Note that during X-ray exposure, the triangular absorber 153 is arranged such that the apex portion and the bottom portion are arranged in the moving direction of the PMMA layer 151.

  As an X-ray generator, a superconducting small synchrotron radiation device “AURORA” at the SR Center of Ritsumeikan University is used. The synchrotron radiation wavelength ranges from 0.15 nm to 0.73 nm, and the peak wavelength is 0.4 nm. Has been.

  FIG. 15 is a perspective view of the PMMA layer 151 after the first step. As described above, when the PMMA layer 151 is subjected to the exposure process, the polymer chain in the exposed portion is broken, the molecular weight is reduced, and the portion 151B that can be dissolved in the developer and the unexposed portion 151A are formed.

  As shown in FIG. 15, the unexposed portion 151A has a bottom surface of a square shape and both side surfaces of a triangle shape, and is arranged in one direction.

  FIG. 16 is an explanatory diagram showing a second step of the manufacturing process of the microneedle 43. As shown in FIG. 16, a mask 152 is formed such that the direction from the bottom to the top of the absorber 153 formed in a triangular shape intersects with the direction in which the triangular prism-shaped PMMA layer 151 extends. And the PMMA layer 151 is disposed. Specifically, from the state shown in FIGS. 14 and 15, the PMMA layer 151 is rotated approximately 90 degrees with the position of the mask 152 fixed.

  Then, when performing the exposure process with X-rays, the PMMA layer 151 is reciprocated in the direction from the bottom side of the absorber 153 toward the top. Thereafter, the exposed portion is removed with a developer, and the unexposed portion is left on the metal substrate 150.

  FIG. 17 is a perspective view showing the PMMA layer 151 remaining on the surface of the metal substrate 150 after the second step. As shown in FIG. 17, a plurality of PMMA layers 151 having a quadrangular pyramid shape are formed on the surface of the metal substrate 150.

  FIG. 18 is an explanatory diagram showing a third step of the manufacturing process of the microneedle 43. As shown in FIG. 18, a mask 154 on which an X-ray absorber 155 formed in an annular shape is disposed above the PMMA layer 151. The outer diameter of the absorber 155 is, for example, 100 μm, and the diameter of the hollow portion is, for example, 30 μm. Then, exposure processing is performed, and then development processing is performed.

  FIG. 19 is a perspective view showing the PMMA layer 151 remaining on the surface of the metal substrate 150 by the third step. As shown in FIG. 19, on the main surface of the metal substrate 150, a through hole 151 a reaching from the upper end portion to the surface of the metal substrate 150 is formed, and a PMMA layer 151 having a conical shape is formed. The conical PMMA layer 151 has the same shape as the microneedle 43 shown in FIG.

  FIG. 20 is an explanatory view showing a fourth step in the manufacturing process of the microneedle 43. As shown in FIG. 20, a metal structure 160 is formed by depositing metal on the pattern of the formed PMMA layer 151 by plating with Ni or the like (electroforming process).

  Thereafter, the unreacted PMMA layer 151 is removed, and the metal structure 160 in which the pattern of the microneedles 43 is simulated can be obtained. A multi-needle structure 45 in which a plurality of microneedles 43 shown in FIG. 2 are formed can be manufactured using the metal structure 160 as a mold.

Although the embodiment of the present invention has been described above, it should be considered that the embodiment disclosed this time is illustrative and not restrictive in all respects. The scope of the present invention is defined by the terms of the claims, and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims. Furthermore, the above numerical values are examples, and are not limited to the above numerical values and ranges.

  The present invention is suitable for an injection device for injecting a chemical solution or the like.

It is a sectional side view of the chemical injection device concerning this embodiment. It is a sectional side view which shows the detailed structure of a multi-needle unit. It is a perspective view which shows the detail of a multineedle structure. It is sectional drawing which shows the state which mounted | wore the multineedle unit with skin. It is a perspective view which shows the inner surface to which the piercing needle of the housing was connected. It is the perspective view which looked at the board | substrate from the upper direction. It is sectional drawing which shows the 1st modification of a multineedle unit. It is sectional drawing which shows the 2nd modification of a multineedle unit. It is sectional drawing which shows the 3rd modification of a multineedle unit and a container. It is sectional drawing which shows the state which the multineedle unit and the container engaged. It is sectional drawing which shows the 4th modification of a multineedle unit. It is sectional drawing which shows the 1st modification of the chemical injection device which concerns on this Embodiment. It is sectional drawing which shows the 2nd modification of the chemical injection device which concerns on this Embodiment. It is explanatory drawing which shows the 1st process of the manufacturing process of a microneedle. It is explanatory drawing of the PMMA layer after a 1st process. It is explanatory drawing which shows the 2nd process of the manufacturing process of a microneedle. It is explanatory drawing which shows the PMMA layer which remained on the surface of the metal substrate after the 2nd process. It is explanatory drawing which shows the 3rd process of the manufacturing process of a microneedle. It is explanatory drawing which shows the PMMA layer which remained on the surface of the metal substrate by the 3rd process. It is explanatory drawing which shows the 4th process of the manufacturing process of a microneedle.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 10 Container, 11 Fixing member, 12 Closure member, 13 Multi-needle unit, 14 Gasket part, 15 Plunger, 16 Storage case, 20 Chemical liquid storage part, 21 Gas storage part, 30 Switching valve, 32 Chemical liquid supply part, 40 Housing, 41 Perforated needle, 43 microneedle, 44C filter, 44 internal space, 45 multi-needle structure, 46 regulating member, 100 chemical solution injector.

Claims (6)

A container containing a chemical solution;
A housing having an internal space capable of receiving the chemical solution; a plurality of first hollow needles protruding outward from the housing and communicating with the internal space; and a flow path of each of the first hollow needles communicating with the internal space A second hollow needle having a flow path cross-sectional area larger than the cross-sectional area and capable of communicating with the internal space and the space in the container by being inserted into the container; A needle unit;
An extruding mechanism capable of pushing the medicinal solution and extruding the medicinal solution from the second hollow needle inserted into the container into the internal space;
Infusion device with.   The injection device according to claim 1, further comprising a filter provided in the internal space and capable of filtering the chemical solution.   The injection device according to claim 1, wherein the extrusion mechanism is accommodated in the container. The extrusion mechanism is filled in a gas storage section provided in the container, and a gas whose pressure is higher than atmospheric pressure,
The inside of the said container can be moved by the pressure from the said gas, The regulation member which prescribes | regulates the inside of the said container to the chemical | medical solution storage part which can accommodate the said chemical | medical solution, and the said gas storage part is included. The injection device according to any one of the above.   The injection device according to claim 4, further comprising a supply unit capable of supplying the gas to the gas storage unit.   The injection device according to any one of claims 1 to 5, further comprising a connection pipe that connects between the second hollow needle and the housing.

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