KR102070567B1 - 바이시클릭 피라지논 유도체 - Google Patents

바이시클릭 피라지논 유도체 Download PDF

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Publication number
KR102070567B1
KR102070567B1 KR1020147029895A KR20147029895A KR102070567B1 KR 102070567 B1 KR102070567 B1 KR 102070567B1 KR 1020147029895 A KR1020147029895 A KR 1020147029895A KR 20147029895 A KR20147029895 A KR 20147029895A KR 102070567 B1 KR102070567 B1 KR 102070567B1
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South Korea
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het
phenyl
unsubstituted
formula
mmol
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Expired - Fee Related
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KR1020147029895A
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English (en)
Korean (ko)
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KR20140140099A (ko
Inventor
디에터 도르슈
한스-페터 부흐슈탈러
제라르 무아네
안스가르 베게너
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메르크 파텐트 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020147029895A 2012-03-28 2013-03-19 바이시클릭 피라지논 유도체 Expired - Fee Related KR102070567B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12002215 2012-03-28
EP12002215.7 2012-03-28
PCT/EP2013/000827 WO2013143663A1 (en) 2012-03-28 2013-03-19 Bicyclic pyrazinone derivatives

Publications (2)

Publication Number Publication Date
KR20140140099A KR20140140099A (ko) 2014-12-08
KR102070567B1 true KR102070567B1 (ko) 2020-01-29

Family

ID=48013911

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147029895A Expired - Fee Related KR102070567B1 (ko) 2012-03-28 2013-03-19 바이시클릭 피라지논 유도체

Country Status (31)

Country Link
US (1) US9120805B2 (https=)
EP (1) EP2831077B1 (https=)
JP (1) JP6096879B2 (https=)
KR (1) KR102070567B1 (https=)
CN (1) CN104169284B (https=)
AR (1) AR090496A1 (https=)
AU (1) AU2013242492B2 (https=)
CA (1) CA2868620C (https=)
CL (1) CL2014002557A1 (https=)
CO (1) CO7111292A2 (https=)
DK (1) DK2831077T3 (https=)
EA (1) EA027416B1 (https=)
EC (1) ECSP14024526A (https=)
ES (1) ES2585044T3 (https=)
HR (1) HRP20160908T1 (https=)
HU (1) HUE030067T2 (https=)
IL (1) IL234713A (https=)
MX (1) MX351149B (https=)
MY (1) MY172308A (https=)
NZ (1) NZ630489A (https=)
PE (1) PE20142186A1 (https=)
PH (1) PH12014501829B1 (https=)
PL (1) PL2831077T3 (https=)
PT (1) PT2831077T (https=)
RS (1) RS54997B1 (https=)
SG (1) SG11201405750YA (https=)
SI (1) SI2831077T1 (https=)
TW (1) TWI576346B (https=)
UA (1) UA112795C2 (https=)
WO (1) WO2013143663A1 (https=)
ZA (1) ZA201407828B (https=)

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WO2013132253A1 (en) 2012-03-07 2013-09-12 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
CA2868620C (en) 2012-03-28 2020-02-25 Dieter Dorsch Bicyclic pyrazinone derivatives
EP2864330A1 (en) * 2012-06-20 2015-04-29 F. Hoffmann-La Roche AG Pyrrolopyrazone inhibitors of tankyrase
EP3044221B1 (en) 2013-09-11 2018-02-21 Institute of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
RU2672885C2 (ru) * 2013-12-23 2018-11-20 Мерк Патент Гмбх Производные имидазопиразинона
WO2016006974A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof
KR101739003B1 (ko) 2014-07-11 2017-05-23 에스티팜 주식회사 신규한 트리아졸로피리미디논 또는 트리아졸로피리디논 유도체, 및 이들의 용도
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
CN107278203B (zh) 2014-12-05 2020-05-19 阵列生物制药公司 作为JANUS激酶抑制剂的4,6-取代的吡唑并[1,5-a]吡嗪
CR20180168A (es) 2015-08-17 2018-06-27 Lupin Ltd Derivados de heteroarilo como inhibidores de parp
CN109071546B (zh) 2016-02-24 2021-03-02 辉瑞大药厂 作为jak抑制剂的吡唑并[1,5-a]吡嗪-4-基衍生物
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
EP3793559A1 (en) 2018-05-17 2021-03-24 Bayer Aktiengesellschaft Substituted dihydropyrazolo pyrazine carboxamide derivatives
GB2632307A (en) * 2023-08-02 2025-02-05 Duke Street Bio Ltd PARP1 inhibitor compounds
GB2632441A (en) * 2023-08-08 2025-02-12 Duke Street Bio Ltd Deuterated PARP1 inhibitor compounds
WO2025084446A1 (ko) * 2023-10-16 2025-04-24 에스티팜 주식회사 트리아졸로피리미디논 유도체의 결정형

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20090209523A1 (en) 2006-05-31 2009-08-20 Philip Jones Pyrrolo[1,2-A] Pyrazin-1(2H)-One and Pyrrolo[1,2-D][1,2,4]Triazin-1(2H)-One Derivatives as Inhibitors of Poly(Adp-Ribose)Polymerase (Parp)
US20110053929A1 (en) 2007-07-11 2011-03-03 Bayer Schering Pharma Aktiengesellschaft Imidazo-, pyrazolopyrazines and imidazotriazines and their use

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GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
DE69720965T2 (de) 1996-02-13 2004-02-05 Astrazeneca Ab Chinazolinderivate und deren verwendung als vegf hemmer
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
SE9702706D0 (sv) 1997-07-11 1997-07-11 Pharmacia & Upjohn Ab Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
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MXPA02012905A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como agentes de dano vascular..
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CA2672860C (en) * 2006-12-28 2013-01-29 Abbott Laboratories Inhibitors of poly(adp-ribose)polymerase
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
WO2009130231A1 (en) 2008-04-24 2009-10-29 Glaxo Group Limited Pyrrolo [1, 2-a] pyrazine derivatives as vasopressin vib receptor antagonists
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JP5579724B2 (ja) 2008-10-17 2014-08-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ホスファチジルイノシトール−３−キナーゼ（ｐｉ−３キナーゼ）阻害剤としてのテトラ−アザ−複素環
US9073927B2 (en) 2010-01-22 2015-07-07 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Inhibitors of PI3 kinase
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CA2868620C (en) 2012-03-28 2020-02-25 Dieter Dorsch Bicyclic pyrazinone derivatives
EP2864330A1 (en) * 2012-06-20 2015-04-29 F. Hoffmann-La Roche AG Pyrrolopyrazone inhibitors of tankyrase

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US20090209523A1 (en) 2006-05-31 2009-08-20 Philip Jones Pyrrolo[1,2-A] Pyrazin-1(2H)-One and Pyrrolo[1,2-D][1,2,4]Triazin-1(2H)-One Derivatives as Inhibitors of Poly(Adp-Ribose)Polymerase (Parp)
US20110053929A1 (en) 2007-07-11 2011-03-03 Bayer Schering Pharma Aktiengesellschaft Imidazo-, pyrazolopyrazines and imidazotriazines and their use

Also Published As

Publication number Publication date
PE20142186A1 (es) 2014-12-29
EA201401062A1 (ru) 2015-04-30
MX351149B (es) 2017-10-04
CA2868620C (en) 2020-02-25
CN104169284A (zh) 2014-11-26
MX2014011420A (es) 2014-11-25
ZA201407828B (en) 2015-12-23
WO2013143663A1 (en) 2013-10-03
PH12014501829A1 (en) 2014-11-10
TWI576346B (zh) 2017-04-01
AU2013242492B2 (en) 2016-12-15
DK2831077T3 (en) 2016-08-15
CO7111292A2 (es) 2014-11-10
KR20140140099A (ko) 2014-12-08
CN104169284B (zh) 2017-03-29
IL234713A (en) 2016-09-29
MY172308A (en) 2019-11-21
CL2014002557A1 (es) 2014-12-19
ECSP14024526A (es) 2015-09-30
PH12014501829B1 (en) 2014-11-10
CA2868620A1 (en) 2013-10-03
NZ630489A (en) 2016-04-29
HRP20160908T1 (hr) 2016-09-23
HUE030067T2 (en) 2017-04-28
EP2831077A1 (en) 2015-02-04
HK1203961A1 (en) 2015-11-06
JP6096879B2 (ja) 2017-03-15
US9120805B2 (en) 2015-09-01
TW201343650A (zh) 2013-11-01
SG11201405750YA (en) 2014-10-30
EA027416B1 (ru) 2017-07-31
AR090496A1 (es) 2014-11-19
SI2831077T1 (sl) 2016-09-30
EP2831077B1 (en) 2016-04-27
ES2585044T3 (es) 2016-10-03
AU2013242492A1 (en) 2014-11-13
PT2831077T (pt) 2016-08-12
PL2831077T3 (pl) 2016-10-31
RS54997B1 (sr) 2016-11-30
US20150057264A1 (en) 2015-02-26
UA112795C2 (uk) 2016-10-25
JP2015511609A (ja) 2015-04-20

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