KR102050070B1 - Oil based composition having oxidation stability and soft capsules comprising the same - Google Patents

Abstract

The present invention relates to a fat and oil composition. More specifically, the present invention relates to: a fat and oil composition having excellent oxidative stability, in which original nutrition, physical properties, and palatability are maintained for a long time by preventing or minimizing oxidation occurring in fats and oils; and a soft capsule formulation comprising the same.

Description

Oil based composition having oxidation stability and soft capsules comprising the same

The present invention relates to a fat and oil composition, and more particularly, a fat and oil composition having excellent oxidative stability, which is maintained for a long time by preventing or minimizing oxidation occurring in fats and oils, and maintaining the original nutrition, physical properties, and palatability. It is about.

Recently, the physiological action of fats and oils containing unsaturated fatty acids such as omega-3 has become widely known, and as the interest and demand for health have increased, such fats and oils have been widely used as medicines and food materials. .

However, oils and fats are not completely sealed, and during storage at room temperature, they constantly react with oxygen to cause oxidation, or hydrolysis occurs due to acid, alkali, enzymes, etc. Inherent.

The rancidity is particularly rapid in the heating and processing process to reduce nutrients, physical properties, palatability, etc., as well as to produce odors, destruction of essential fatty acids, color change and toxicity. Efforts are needed to prevent rancidity in the process. In addition, rancidity can be accelerated by external factors such as light rays during storage, fatty acid unsaturation in fats and oils, temperature, pigments, oxygen, metal ions, etc., and efforts to prevent rancidity are also required during storage to store manufactured products.

On the other hand, recently, due to the rise in temperature caused by global warming, the temperature of the room often exceeds 30 ℃ in summer, the storage of foods and medicines containing fats and oils is more problematic, the oxidation prevention to prevent the rancidity of fats known in the art Zero has a problem that it is difficult to prevent rancidity caused by relatively high storage conditions exceeding 30 ° C, or rancidity caused by light rays.

Therefore, it is urgent to study the maintenance composition stabilized against long-term rancidity by effectively preventing rancidity due to relatively high storage temperature conditions or rays that may be applied during storage.

Patent Application Publication No. 10-0058297

The present invention has been made in view of the above-mentioned point, and it is very excellent in oxidation stability in which oxidation occurring in fats and oils, in particular, oxidation by heat or light is prevented or minimized, and thus the fats, nutrition, physical properties and palatability of the fats are maintained for a long time. It is an object of the present invention to provide an oil-fat composition and a soft capsule formulation containing the same.

In addition, the present invention provides an oil-resistant composition having an oxidative stability that can greatly reduce the restriction on the storage conditions, the color selection limitation of the film when encapsulation as it is excellent in the oxidation prevention by heat or light, etc. and a soft capsule formulation comprising the same For other purposes.

In order to solve the above problems, the present invention provides a fat-and-oil-containing oil composition comprising an antioxidant comprising at least one plant extract of oil and citrus extract, grapefruit seed extract, berry fruit extract and rosemary extract. .

According to an embodiment of the present invention, the oil or fat may include at least one fatty acid selected from the group consisting of EPA, DHA and lirolic acid.

In addition, the antioxidant may be included in 0.3 to 0.8 parts by weight based on 100 parts by weight of fat and oil.

In addition, the antioxidant may further comprise one or more of citric acid, ascorbic acid, tocopherol and ascorbyl palmitate.

In addition, the antioxidant includes a rosemary extract as a plant extract, and may further include one or more of α-tocopherol and ascorbyl palmitate.

In addition, the antioxidant includes a rosemary extract as a plant extract, and further comprises ascorbyl palmitate, the rosemary extract and ascorbyl palmitate may be included in a weight ratio of 1: 1.4 to 4.0, more preferably 1: may be included in a weight ratio of 1.8 to 3.0.

In addition, the antioxidant further comprises lecithin, the rosemary extract and the lecithin may be included in a weight ratio of 1: 15 to 25.

In addition, the present invention provides a cap? Formulation comprising a holding composition according to the present invention and a film encapsulating the holding composition.

The present invention also provides an antioxidant composition for oil and fat containing at least one plant extract of citrus extract, grapefruit seed extract, berry fruit extract and rosemary extract.

According to an embodiment of the present invention, the fat or oil may include one or more fatty acids selected from the group consisting of EPA, DHA and linolenic acid.

In addition, it may further include one or more of citric acid, ascorbic acid, tocopherol and ascorbyl palmitate.

In addition, the antioxidant composition includes a rosemary extract as a plant extract, and may further include one or more of α-tocopherol and ascorbyl palmitate.

In addition, the antioxidant composition includes a rosemary extract as a plant extract, and further comprises ascorbyl palmitate, the rosemary extract and ascorbyl palmitate may be included in a weight ratio of 1: 1.4 to 4.0, more preferably 1: may be included in a weight ratio of 1.8 to 3.0.

In addition, the antioxidant composition further comprises lecithin, the rosemary extract and the lecithin may be included in a weight ratio of 1: 15 to 25.

The oil or fat composition according to the present invention is prevented or minimized by oxidation caused by oils and fats, especially by heat or light, and thus the food or medicine itself is very excellent in oxidative stability that maintains the original nutrition, physical properties, palatability, etc. for a long time. As well as excellent quality maintenance, it is possible to realize a transparent capsule formulation by reducing the limitations on storage temperature, color selection of the film for light transmission, storage conditions, and packaging conditions during storage, and a significant reduction in packaging and storage costs. You can expect.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily practice. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention.

The oil-fat composition according to the present invention comprises an oil-fat and an antioxidant comprising at least one plant extract of citrus extract, grapefruit seed extract, berry fruit extract and rosemary extract.

The fat or oil is a main ingredient of the fat or oil composition, and the fat or oil may be derived from a vegetable fat or an animal fat. Specific types of fats and oils may include fish oils such as bonito, sardine oil, tuna oil, oils extracted from microalgae, linseed oil, perilla oil, soybean oil, rapeseed oil, and the like. Moreover, what fractionated and mixed these fats and oils, and also adjusted the fatty acid composition by hydrogenation, a transesterification reaction, etc. can be used. In addition, the fat or oil may be one containing at least one fatty acid preferably selected from the group consisting of EPA, DHA and linolenic acid.

The antioxidant is a component that is responsible for preventing or delaying rancidity of the emulsion. Preferably the antioxidant may be provided in 0.3 to 0.8 parts by weight based on 100 parts by weight of fat and oil. If the antioxidant is provided in less than 0.3 parts by weight it may be difficult to achieve the sufficient maintenance of the antioxidant effect at the desired level. In addition, if the content exceeds 0.8 parts by weight, the content of the relatively main oil or fat decreases, so that the desired effect may not be sufficiently achieved through the maintenance, or there is a concern that the dosage is increased to consume the desired level.

The present invention includes at least one plant extract of citrus extract, grapefruit seed extract, berry fruit extract and rosemary extract as an antioxidant. When plant extracts are used as antioxidants, natural antioxidants derived from plants have the advantage of reducing the side effects of chemical components due to synthetic antioxidants.

The plant extract may be extracted through water or an organic solvent, the organic solvent may be a lower alcohol having 1 to 4 carbon atoms, a known extraction solvent such as ether, ethyl ether, hexane or a solvent for fractionation. In addition, the extraction conditions can be adopted by appropriately changing known extraction conditions, the present invention is not particularly limited thereto.

As the antioxidant of the present invention, the plant extract includes at least one of citrus extract, grapefruit seed extract, berry fruit extract and rosemary extract. These plant extracts may be advantageous to suppress the rancidity of fats and oils by heat or light, among other factors.

Preferably, the plant extract may essentially include rosemary extract as a plant extract in order to significantly suppress the rancidity of fats and oils by heat or light.

On the other hand, the plant extract may further include plant extracts other than the listed types, for example may further include a green tea extract. In this case, when the rosemary extract and green tea extract are included and include ascorbyl palmitate and lecithin, which will be described later, an increased anti-corruption effect by light rays may be achieved. At this time, the green tea extract may be included in 30 to 50 parts by weight based on 100 parts by weight of rosemary extract. If the green tea extract is out of the preferred range, the anti- rancidity effect is rather insignificant or heat rancidation effect may not be expressed.

According to an embodiment of the present invention, the antioxidant may further include one or more of citric acid, ascorbic acid, tocopherol and ascorbyl palmitate in addition to the aforementioned plant extracts. These components, together with the plant extracts described above, can express an elevated effect on rancidity of oils and fats. In this case, the tocopherol may be α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol or a mixture of two or more thereof.

For example, when the plant extract essentially contains a rosemary extract, the antioxidant further includes at least one of α-tocopherol and ascorbyl palmitate to express a more synergistic effect on the rancidity of fat or oil by heat or light. And more preferably ascorbyl palmitate.

According to an embodiment of the present invention, when the antioxidant includes a rosemary extract as a plant extract, and further includes ascorbyl palmitate, the rosemary extract is used to prevent the rancidity of fats and oils due to light or heat. And ascorbyl palmitate may be included in a weight ratio of 1: 1.4 to 4.0, and more preferably 1: 1.8 to 3.0. If ascorbyl palmitate is present in an amount of less than 1.4 times the weight of rosemary extract, synergistic effects due to the suppression or prevention of rancidity of fats and oils by heat or light may be minimal. In addition, if ascorbyl palmitate is more than 4.0 times the weight of rosemary extract, the effect of preventing the rancidity of fat and oil is suppressed by heat or light, especially high temperature and light, and the problem of homogeneity in oil formulations. However, in the suspending agent, the proportion of the base may increase, making it difficult to mix homogeneously.

In addition, more preferably the antioxidant further comprises lecithin, the rosemary extract and the lecithin may be included in a weight ratio of 1: 15 to 25. If the lecithin is less than 15 times the weight of the rosemary extract, the synergistic effect of inhibiting or preventing rancidity of fats and oils according to the combination of the lecithins may be insignificant. In addition, if the lecithin is provided in an amount of more than 25 times the weight of the rosemary extract, the viscosity of the composition may be increased, so that the process of encapsulation may be difficult, and other antioxidant content such as limited antioxidant dose plant extract may be reduced, rather Anti- rancidity effects can be significantly reduced.

Oil composition according to an embodiment of the present invention may further include one or more components selected from the group consisting of lead, rice bran wax as a suspending agent to ensure the homogeneity of the contents in addition to the fat and oil and antioxidants described above.

The above-mentioned oil-and-oil composition implements a capsule formulation with the film which encloses it.

In the case of the film used as the soft capsule for oral use, the film can be used without limitation, so the present invention is not particularly limited thereto. For example, as the coating of the soft capsule, gelatin containing a highly reactive functional group (-COOH, -NH ₂ , -SH, -OH) in the polypeptide chain may be used as a main component, but is not limited thereto. In addition, the functional group may be introduced into the raw material by an acid or alkali treatment, or a method of treating the functional group with succinic acid.

On the other hand, the method for preparing the capsule formulation using the oil-fat composition may adopt or change the method commonly used in the art for the preparation of the capsule formulation, so the present invention will not be described in detail.

The preferred dosage of the capsule formulation may be determined in consideration of the age, weight, degree of disease, etc. of the subject to be administered, and may be administered 0.5 to 2 g / day per day for a typical adult, for example, 2 per day Can be divided into three times, but is not limited thereto.

Although the present invention will be described in more detail with reference to the following examples, the following examples are not intended to limit the scope of the present invention, which will be construed as to aid the understanding of the present invention.

Example 1

5 parts by weight of an antioxidant having a rosemary ethanol extract as a plant extract alone with respect to 100 parts by weight of purified fish oil was prepared to prepare a fat or oil composition as shown in Table 1 below.

<Examples 2 to 12>

Preparation was carried out in the same manner as in Example 1, but by changing the composition of the antioxidant as shown in Table 1 and Table 2 to prepare a maintenance composition as shown in Table 1 and Table 2.

At this time, both berry fruit extract and grapefruit seed extract used ethanol extract.

<Comparative Examples 1 to 3>

Prepared in the same manner as in Example 1, but changed to the composition of the antioxidant as shown in Table 2 to prepare a maintenance composition as shown in Table 2.

Experimental Example 1

The oil and fat composition according to Examples 1 to 12 and Comparative Examples 1 to 3, respectively, was implemented as a soft capsule formulation in the following manner, and then left at 40 ° C. and 75 RH% for 1 day, 3 days and 9 days, respectively, and then the peroxide value was measured. The results are shown in Tables 1 and 2 below.

Specifically, the soft capsule formulation is a thin and wide ribbon of a soft capsule film formed by mixing 10 to 45% by weight of animal and vegetable gelatin, 10 to 30% by weight of plasticizer glycerin and sorbitol, 15 to 35% by weight of modified starch, and remaining water. After forming in the form, the ribbon-shaped film was added to each of the molds so as to seal the holding composition, and then the edges of the film were bonded to realize a soft capsule formulation having a capsule size of 24.3 mm long and 9.2 mm short.

* Peroxide value measurement method

Peroxide value was measured for the soft capsule formulation through the following method. Specifically, in the test method, the soft capsule was incised to recover the contents composition, and then 1 g was added to 25 mL of acetic acid: chloroform (3: 2) mixed solution, and the film was dissolved. After leaving for 10 minutes, 30 mL of water was added thereto, and the mixture was shaken vigorously, followed by titration with 0.01 N sodium thiosulfate solution using 1 mL of starch reagent as an indicator.

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Antioxidant A Rosemary Citrus Bodhi tree Grapefruit seeds Rosemary Rosemary Rosemary Rosemary Rosemary B - - - Citrus green tea Citric acid Ascorville Palmitate α-tocopherol Mixed weight ratio (A: B) - - - 1: 1.5 1: 1.5 1: 1.5 1: 1.5 1: 1.5 Peroxide value (meq / kg) Day 1 17.15 19.22 17.92 15.35 9.70 7.43 8.08 1.68 3.07 Day 3 23.10 31.28 32.64 24.54 13.15 2.47 6.02 1.13 2.66 Day 9 39.03 36.12 46.02 31.76 26.42 21.37 32.56 6.94 12.47

Example 10 Example 11 Example 12 Comparative Example 1 Comparative Example 2 Comparative Example 3 Antioxidant A Rosemary Citrus Citrus Ascorville Palmitate α-tocopherol green tea B lecithin Ascorville Palmitate lecithin lecithin Ascorville Palmitate Ascorville Palmitate Mixed weight ratio (A: B) 1: 1.5 1: 1.5 1: 1.5 1: 1.5 1: 1.5 1: 1.5 Peroxide value (meq / kg) Day 1 2.97 5.69 12.02 3.56 2.57 6.65 Day 3 18.90 24.65 34.18 21.87 22.44 32.57 Day 9 28.86 32.79 34.30 25.81 24.92 41.79

As Table 1 and Table 2 show,

Embodiments using the plant extract as an antioxidant included in the present invention can confirm that there is an antioxidant effect on the oil even when the plant extract alone. In addition, some embodiments may confirm that there is a synergy in the antioxidant effect by combining two or more antioxidants.

<Examples 13 to 20>

Preparation was carried out in the same manner as in Example 8, to prepare a maintenance composition as shown in Table 3 by changing the mixing ratio or adding the composition as shown in Table 3.

Experimental Example 2

Examples 8 and 13 to 20 for the maintenance composition according to the rancidation prevention evaluation by heat is shown in Table 3 below. Specifically, the peroxide value was measured in the same manner as in Experimental Example 1 after the soft capsule formulation was prepared in the method according to Experimental Example 1, but the peroxide value was measured at 40 ° C. and 75 RH% for 120 days. Based on the peroxide value of 100, the peroxide value for the remaining examples is expressed as a relative percentage.

Example 8 Example 13 Example
14 Example
15 Example
16 Example
17 Example
18 Example
19 Example
20 Antioxidant A Rosemary Rosemary Rosemary Rosemary Rosemary Rosemary Rosemary Rosemary Rosemary B Ascorville Palmitate Ascorville Palmitate Ascorville Palmitate Ascorville Palmitate Ascorville Palmitate Ascorville Palmitate Ascorville Palmitate Ascorville Palmitate Ascorville Palmitate C - - - - - - - - lecithin Mixed weight ratio (A: B) 1: 1.5 1: 1.1 1: 1.8 1: 2.5 1: 3.0 1: 3.2 1: 3.9 1: 4.3 1: 2.5: 20 Peroxide value (%) 100 290.2 42.2 12.7 28.7 117.5 124.6 187.6 4.3

As can be seen from Table 3, even when rosemary and ascorbyl palmitate are mixed, it can be seen that excellent stability against heat for a long time is a preferable range of the present invention.

Although one embodiment of the present invention has been described above, the spirit of the present invention is not limited to the embodiments set forth herein, and those skilled in the art who understand the spirit of the present invention, within the scope of the same idea, the addition of components Other embodiments may be easily proposed by changing, deleting, adding, and the like, but this will also fall within the spirit of the present invention.

Claims (11)

maintain; And
An antioxidant comprising a plant extract comprising rosemary extract and ascorbyl palmitate; wherein the rosemary extract and ascorbyl palmitate are oxidatively stable oil and fat composition comprising 1: 1.8 to 3.0 weight ratio. The method of claim 1,
The fats and oils are oxidative stability oil-fat composition, characterized in that it comprises one or more fatty acids selected from the group consisting of EPA, DHA, DPA and lirolenic acid. The method of claim 1,
The antioxidant is an oil-soluble stability composition, characterized in that contained in 0.3 to 0.8 parts by weight based on 100 parts by weight of oil and fat. The method of claim 1,
The antioxidant is an oil-stable oil or fat composition, characterized in that it further comprises at least one of citric acid, ascorbic acid and tocopherol. The method of claim 1,
The antioxidant is an oil-stable oil and fat composition, characterized in that it further comprises α-tocopherol. delete The method of claim 1,
The antioxidant further comprises lecithin, wherein the rosemary extract and the lecithin is an oxidative stability fat and oil composition, characterized in that it is included in a weight ratio of 1: 15 to 25. delete A fat or oil composition according to any one of claims 1 to 5 and 7; And
Soft capsule formulation comprising a; a film for encapsulating the holding composition. Plant extract comprising rosemary extract and ascorbyl palmitate, wherein the rosemary extract and ascorbyl palmitate 1: 1.8 to 3.0 antioxidant composition for maintenance. The method of claim 10,
Antioxidant composition for fats and oils, characterized in that it further comprises at least one of citric acid, ascorbic acid and tocopherol.