KR102027827B1 - Composition comprising lemon balm extract for lipolysis - Google Patents

Abstract

According to an embodiment of the present invention, provided is a composition for lipolysis, comprising: purified water, sodium chloride, a lemon balm leaf extract, an Aesculus hippocastanum seed extract, a Juglans regia extract, tyrosine, a Fucus vesiculosus extract, adenosine phosphate, disodium adenosine triphosphate, methylpropanediol, and methylsilanol mannuronate.

Description

Cosmetic composition for lipolysis comprising lemon balm extract as an active ingredient {Composition comprising lemon balm extract for lipolysis}

The present invention relates to a cosmetic composition for lipolysis comprising lemon balm extract as an active ingredient.

Cosmeceutical is a compound word of cosmetics and pharmaceuticals and means medicinal cosmetics. The product combines proven ingredients with cosmetics. Cosmetics in which medical experts such as doctors and pharmacists participated in research and development belong to cosmeceuticals. If existing cosmetics are for skin care, cosmeceutical products are focused on skin treatment.

On the other hand, with the increase of various diseases due to obesity, the interest in personal beauty is greatly increased, various ways to remove the subcutaneous fat as one of the diet.

 The demand for slimming and anti-cellulite cosmetics that is effective in removing excess subcutaneous fat and promoting skin elasticity is steadily increasing.

In order to improve obesity from a health and aesthetic point of view, various attempts have been made. The conventional methods of resolving obesity are known as diet and exercise therapy for the purpose of inhibiting energy intake or increasing energy consumption. Various methods such as surgery, surgery, and drug therapy are currently used for the treatment of obesity. However, not only do these methods completely solve obesity, but yo-yo or serious side effects have been reported, so there is no clear guarantee on safety. In addition, since obesity from the aesthetic point of view requires an additional effect on the skin in addition to lipolysis, it can be said that the application of these therapies is still inadequate to meet all necessary conditions. Therefore, there is a need to develop a new material that is equivalent to or higher than the conventional material but more safe for the human body.

Republic of Korea Patent No. 10-1545706 Republic of Korea Patent No. 10-1909869 Republic of Korea Patent No. 10-1865914 Republic of Korea Patent No. 10-0998990

The present invention is to solve the above-mentioned problems of the prior art, it is an object to provide a cosmetic composition for lipolysis that can be applied to the skin to directly decompose fat in fat cells and exhibit cellulite removal effect.

An object of the present invention is to provide a cosmetic composition that decomposes fat in a region to be applied by using lemon balm leaf extract as an active ingredient.

According to an embodiment of the present invention, it provides a cosmetic composition for lipolysis using lemon balm leaf extract as an active ingredient.

According to another embodiment of the present invention, purified water, sodium chloride, lemon chestnut leaf extract, spinach seed extract, walnut (Juglans Regia) extract, tyrosine (Tyrosine), bladder rack extract (FUFUUS VESICULOSUS EXTRACT), adenosine phosphate (Adenosine Phosphate) ), Disodium adenosine triphosphate (DISODIUM ADENOSINE TRIPHOSPHATE), methyl propanediol (METHYLPROPANEDIOL), methyl silanol mannuronate (METHYLSILANOL MANNURONATE) provides a cosmetic composition for fat decomposition.

According to another embodiment of the present invention, 0.898% by weight of sodium chloride, 0.01875% by weight of lemon balm leaf extract, 0.00800% by weight of tyrosine, 0.00560% by weight of horse chestnut extract, 0.00560% by weight of walnut extract, 0.00240% by weight of bladder extract, adenosine phosphate Provided is a cosmetic composition for decomposing fat comprising 0.00024% by weight, disodium adenosine triphosphate, 0.00024% by weight, methylpropanediol 0.04000% by weight, methylsilanol mannuronate 0.00180% by weight and the residual amount of purified water.

According to the present invention, it is possible to provide a cosmetic composition for decomposing fat and removing cellulite by applying lemon balm leaf extract as an active ingredient.

1 and 2 are tables showing the clinical results.
Figure 2 is an enlarged photograph showing a tissue in which fat cells are distributed before the lipolysis composition is added according to an embodiment of the present invention.
3 is an enlarged photograph showing a tissue in which fat cells are reduced by 80% after incorporation of a lipolytic composition according to an embodiment of the present invention.
4 and 5 show photographs before and after performing a procedure using a lipolysis composition according to an embodiment of the present invention for four weeks.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

The lipolytic cosmetic composition comprising the lemon balm extract according to the embodiment of the present invention as an active ingredient may be applied as a cosmetic composition for lipolysis, lymph circulation, V-line face, elastic face.

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Lipolytic composition according to an embodiment of the present invention is lemon balm leaf extract, horse chestnut (Aesculus Hippocastanum) extract, Fucus Veciculus (FucusVesiculosus) extract, walnut (JuglansRegia) extract, ADP (Disodium Adenosine Phosphate), Adenosine Triphosphate, Tyrosine It is preferable to include.

Fatty cosmetic composition according to an embodiment of the present invention is preferably composed of the following components.

INGREDIENT (ICID) weight% AQUA Purified water 99.01937 SODIUM CHLORIDE Sodium chloride 0.898 MELISSA OFFICINALIS LEAF EXTRACT Lemon Chestnut Leaf Extract 0.01875 AESCULUS HIPPOCASTANUM (HORSECHESTNUT) SEED EXTRACT Spiny Maple Seed Extract 0.0056 JUGLANS REGIA (WALNUT) SEED EXTRACT Walnut Extract 0.0056 TYROSINE Tyrosine 0.008 FUCUS VESICULOSUS EXTRACT Bladder Rack Extract 0.0024 ADENOSINE PHOSPHATE Adenosine Phosphate 0.00024 DISODIUM ADENOSINE TRIPHOSPHATE Disodium adenosine triphosphate 0.00024 METHYLPROPANEDIOL Methylpropanediol 0.04 METHYLSILANOL MANNURONATE Methyl silanol mannuronate 0.0018

Table 1 is a table showing the components and the blending ratio of the cosmetic composition for fat decomposition according to an embodiment of the present invention. The numbers represent weight percent.

Lemon balm (Melissa officinalis) is a plant belonging to the labiatae, a variety of active flavonoids (cynaroside, cosmosin, rhamnocitrin, isoquercitrin, terpene and It is known to contain triterpene acids (ursolic acid and oleanolic acid) (Herodez SS, Hadolin M, Skerget M, Knez Z Solvent extraction study of antioxidants from balm (Melissa officinalis L ) Leaves Food Chemistry 200; 80: 275-82), essential oils, caffeic and rosemary acids, monoterpenes and sesquiterpenes, phenolic substances and tannins were also extracted from lemon balm. Antiseptic of lemon balm extract to date (Ulbricht C, Brendler T, Gruenwald J, Kligler B, Keifer D, Abrams TR, Woods J, Boon H, Kirkwood CD, Hackman DA, Basch E, Lafferty HJ; Natural Standard Research Collaboration Lemon balm (Melissa officinalis L): an evidence-based systematic review by the Natural Standard Research Collaboration J Herb Pharmacother 2005; 5: 71-114), antiviral), and antimicrobial and antioxidant activities have been reported (Bolkent S, Yanardag R, Karabulut-Bulan O, Yesilyaprak B Protective role of Melissa officinalis L extract on liver of hyperlipidemic rats: a morphological and biochemical study J Ethnopharmacol 2005; 99: 391-8, Ali Zarei1, Saeed Changizi Ashtiyani, Soheila Taheri, Fateme Rasekh Comparison between effects of different doses ofofficinalisatorvastatin on the activity of liver enzymes in hypercholesterolemia rats AJP 2014; 4 (1) 15-23). The lemon balm leaf extract is a medicinal herb of Melissa officinalis leaf extract, which grows in the Mediterranean and central regions, and is also called "Melissa". It has a lemon-like scent and contains abundant rosemary acid. Rosemary acid helps with diet, antioxidants and anti-inflammatory effects. Lemon balm leaf extract is excellent in protecting skin with polyphenol and tannin. Lemon balm extract is powdered by extracting and spray drying the leaves of lemon balm starch, preferably lemon balm with a polar solvent selected from the group consisting of water, methanol, ethanol and a mixture of two or more thereof. . In this embodiment, the lemon balm extract was used to reduce fat and cellulite when applied to the skin.

AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) SEED EXTRAC is an anti-edema, anti-inflammatory, edema formation on the walls of vascular tissues, decreases sharpness, protects the skin from UV rays, prevents blemishes, It is effective to prevent.

 Walnut Extract (JUGLANS REGIA (WALNUT) SEED EXTRACT) promotes the differentiation of the stratum corneum by keratinocytes in the cell, restores the barrier function of damaged skin, and has an excellent effect on increasing and maintaining moisturizing power. Degranulation inhibitory and immune cell proliferation effect of the excellent anti-inflammatory, irritant effect.

FRACUS VESICULOSUS EXTRACT is an ingredient extracted from large brown seaweed and contains a large amount of minerals, vitamins and amino acids, which protects and hydrates the skin and moisturizes rough and dry skin. It absorbs fats and helps with waste products.

Sodium chloride (SODIUM CHLORIDE) is an inorganic salt that is a compound of sodium (sodium) and chloride (chloride). It is used as an acidity regulator, antiseptic, flavoring agent and viscosity enhancer in cosmetics and beauty products.

Methylpropanediol (METHYLPROPANEDIOL) is a type of glycol used as a solvent. Helps ingredients penetrate the skin. Hydrating properties help to soften and moisturize the skin.

TYROSINE is a skin amino acid that initiates the production of melanin. Catecholamine in the body, a precursor of thyroid hormone thyroxine, promotes fat metabolism.

METHYLSILANOL MANNURONATE is a combination of organic silicon organic silicon (SI), silanol, and mannuronic acid derived from alginic acid of brown algae. Preventive effect, antioxidant, lipolysis, moisturizing effect.

Adenosine phosphate (ADENOSINE PHOSPHATE) is a complex, anti-wrinkle, anti-inflammatory, sedative, and cell-communicating agent that delivers skin cell activated oxygen in the dermal layer and promotes collagen synthesis by enhancing the size and proliferation of fibroblasts.

DISODIUM ADENOSINE TRIPHOSPHATE is a disodium salt component of adenosine triphosphate. Used to impart conditioning to the skin.

Figure 5 shows an electron micrograph showing the result of the action on the adipocytes composition according to an embodiment of the present invention comprising a lemon balm extract. (a) is a photograph before adding the composition, (b) is a photograph after adding the composition. You can see that the red circle shows fat cells and about 80% of fat cells are reduced.

Clinical trials were performed on 100 subjects from January to March 2019 using the composition.

The subjects were classified into cellulite types of the subjects as shown in Table 2 below.

Soft cellulite 49% Hard cellulite 19% Edematous cellulite 32%

 The age of the subject was as follows. 70% of the subjects were 15 to 35 years old.

 Although circulatory disease is particularly important, the symptoms associated with cellulite varied widely as shown in Table 4 below.

Deficient venous return 65% Flaccidity 65% Intestinal constipation 51% Smoking 44% Varicose vein abnormalities in family history
(family history of varicose veins) 44% Regular alcohol consumption 32% Copy edema (malleolar edema) 31% Abdominal distension (meteorism) 25% Use of oral contraceptive 21% Menopause 12% Antidepressant 10% Arterial hypertension 4% Hypercholesterolemia 2% Non-insulin dependent diabetes 2%

As shown in Table 4, 65% of the subjects had a deficient venous return, 44% had a family history of varicose veins, and 31% had at least two days prior to menstrual edema (malleolar edema). ) All these symptoms are statistically proven to be related to vascular manifestations and thus to poor circulatory function and esthetic cellulite problems.

Electroporation was applied to the entire area, including the peritrochanteric and the inside of the knee. The results were as follows. Electroporation, which means electroporation, is more effective for absorbing a formula such as a composition according to an embodiment of the present invention because electroporation temporarily opens skin lipids by applying an electric pulse to skin lipids.

Clinical trials were conducted once a week for 4 to 10 weeks, depending on the condition of the subject. After that, a biweekly session was held, and a total of two sessions were conducted. After two sessions, the program was held only once a month for "maintenance purposes." The time per run ranged from a minimum of 30 minutes to a maximum of 40 minutes with a power level of 75 to 90%. Note that you massage the area gently with a circle. 71% of the total patients received 5 ~ 10 procedures except for “maintain” procedure, 25% of those who received 11 ~ 20 times including “maintain” procedure and 25% who received more than 21 times 4%.

Changes in weight loss are shown in Table 5 below.

1 is a table showing a diameter reduction range of the peritrochanteric (eric 字 部 周圍). 21% had 2cm, 46% had 3cm, and 21% had 4cm reduction.

2 is a table showing the comprehensive evaluation of the subjects. Subjective evaluations were performed by the subjects. The criteria included not only changes in body weight, but also the degree of syndrome (side effects) that may occur during the procedure and a rapid return to daily life.

In 3% of subjects, general vasodilation in both thighs was observed. It was transient and painless, and was not symptomatic of the vagal nerves. The lower thigh is reddish and then faded out, which makes sense as a response to homeopathic products.

Notably, none of the participants in the clinic did not develop resistance and there was no rejection of homeopathy. The acceptance of the product by the subjects was very good and there was no itching, swelling, allergy, pain or severe erythema.

Figure 3 is a photograph of the 29-year-old woman before the procedure (a) after (b), the results of the procedure six times a week.

4 is a photograph of a 43-year-old woman before (a) and after (b), the results of the procedure 10 times once a week.

As shown, the breakdown of fat and cellulite may reveal dramatic changes.

Claims (3)

In the cosmetic composition for lipolysis,
Sodium chloride 0.898%, lemon chestnut leaf extract 0.01875% by weight, tyrosine 0.00800% by weight, spinach chinensis seed extract 0.00560% by weight, walnut extract 0.00560% by weight, bladder rack extract 0.00240%, adenosine phosphate 0.00024% by weight, disodium adenosine triphosphate 0.00024% by weight, methylpropanediol 0.04000% by weight, methylsilanol mannuronate 0.00180% by weight and the balance of purified water,
The composition is a composition for lipolysis, characterized in that applied to the skin with an ultrasonic device, high frequency device, electroporation, or needle-free inject.


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