KR102006599B1 - 방사성 조성물 및 그의 치료적 사용 방법 - Google Patents

방사성 조성물 및 그의 치료적 사용 방법 Download PDF

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KR102006599B1
KR102006599B1 KR1020197011613A KR20197011613A KR102006599B1 KR 102006599 B1 KR102006599 B1 KR 102006599B1 KR 1020197011613 A KR1020197011613 A KR 1020197011613A KR 20197011613 A KR20197011613 A KR 20197011613A KR 102006599 B1 KR102006599 B1 KR 102006599B1
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formula
radioactive
composition
entity
present
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KR20190047101A (ko
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데이빗 에이. 윌슨
알. 키스 프랭크
제임 사이먼
드루스 케이. 크럼프
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아이소테라퓨틱스 그룹 엘엘씨
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Assigned to 아이쥐엘 파마, 인크. reassignment 아이쥐엘 파마, 인크. 권리의 전부이전등록 Assignors: 아이소테라퓨틱스 그룹 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nanotechnology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
KR1020197011613A 2011-12-21 2012-12-21 방사성 조성물 및 그의 치료적 사용 방법 Active KR102006599B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161578630P 2011-12-21 2011-12-21
US61/578,630 2011-12-21
US201261606734P 2012-03-05 2012-03-05
US61/606,734 2012-03-05
PCT/US2012/071256 WO2013096776A2 (en) 2011-12-21 2012-12-21 Radioactive compositions and methods for their therapeutic use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147019820A Division KR101973830B1 (ko) 2011-12-21 2012-12-21 방사성 조성물 및 그의 치료적 사용 방법

Publications (2)

Publication Number Publication Date
KR20190047101A KR20190047101A (ko) 2019-05-07
KR102006599B1 true KR102006599B1 (ko) 2019-08-01

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KR1020197011613A Active KR102006599B1 (ko) 2011-12-21 2012-12-21 방사성 조성물 및 그의 치료적 사용 방법
KR1020147019820A Active KR101973830B1 (ko) 2011-12-21 2012-12-21 방사성 조성물 및 그의 치료적 사용 방법

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Country Status (8)

Country Link
US (3) US9687574B2 (https=)
EP (1) EP2793955B1 (https=)
JP (2) JP6219841B2 (https=)
KR (2) KR102006599B1 (https=)
AU (1) AU2012358364B2 (https=)
CA (1) CA2859971C (https=)
ES (1) ES2671622T3 (https=)
WO (1) WO2013096776A2 (https=)

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KR102006599B1 (ko) * 2011-12-21 2019-08-01 아이소테라퓨틱스 그룹 엘엘씨 방사성 조성물 및 그의 치료적 사용 방법
JP2016520650A (ja) * 2013-06-05 2016-07-14 アール−エヌエーヴィ・エルエルシー スズ−１１７ｍでの免疫性、炎症性及び変形性関節炎の治療
WO2020122729A1 (en) 2018-12-14 2020-06-18 Quirem Medical B.V. Particle comprising lanthanide hydroxide
CA3143686A1 (en) * 2019-06-18 2020-12-24 Serene, Llc A novel tin-117m colloid formulation with the ability to distinguish it from existing tin-117m colloid formulations
JP2023512214A (ja) 2020-01-28 2023-03-24 リフレクション メディカル， インコーポレイテッド 放射性核種および外部ビーム放射線療法の共同最適化

Citations (1)

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WO2009045230A1 (en) 2007-10-05 2009-04-09 Iso Therapeutics Group Llc Compositions for treatment of tumors by direct administration of a radioisotope

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WO1988003910A1 (en) * 1986-11-17 1988-06-02 Clarkson University Process for synthesis of uniform colloidal particles of rare earth oxides
US4906450A (en) 1987-03-26 1990-03-06 Ephraim Lieberman Treatment of arthritis, including rheumatoid arthritis, with the radionuclide, tin SN-121
US5045289A (en) * 1989-10-04 1991-09-03 Research Corporation Technologies, Inc. Formation of rare earth carbonates using supercritical carbon dioxide
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US5137709A (en) 1991-02-15 1992-08-11 The Dow Chemical Company Layered mixed metal hydroxides for the stabilization of radioactive colloids
JP3122319B2 (ja) 1994-05-02 2001-01-09 アソシエーティド ユニバーシティーズ，インコーポレイティド 錫−１１７ｍ−含有放射性治療剤
EP0797649B1 (en) * 1994-07-01 2000-09-06 Sarnoff Corporation Method of preparing small particle size phosphors
US6132642A (en) 1994-07-01 2000-10-17 Sarnoff Corporation Method of preparing small particle size phosphors
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KR102006599B1 (ko) * 2011-12-21 2019-08-01 아이소테라퓨틱스 그룹 엘엘씨 방사성 조성물 및 그의 치료적 사용 방법
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Also Published As

Publication number Publication date
AU2012358364B2 (en) 2017-08-10
KR20190047101A (ko) 2019-05-07
US20170258949A1 (en) 2017-09-14
WO2013096776A2 (en) 2013-06-27
JP6356854B2 (ja) 2018-07-11
EP2793955A4 (en) 2016-01-06
CA2859971A1 (en) 2013-06-27
US9687574B2 (en) 2017-06-27
US10583211B2 (en) 2020-03-10
US20150023869A1 (en) 2015-01-22
WO2013096776A3 (en) 2015-01-08
EP2793955A2 (en) 2014-10-29
JP2015510496A (ja) 2015-04-09
AU2012358364A1 (en) 2014-08-07
US10918746B2 (en) 2021-02-16
CA2859971C (en) 2020-08-04
KR20140105016A (ko) 2014-08-29
JP6219841B2 (ja) 2017-10-25
EP2793955B1 (en) 2018-04-11
JP2017149722A (ja) 2017-08-31
ES2671622T3 (es) 2018-06-07
US20200155716A1 (en) 2020-05-21
KR101973830B1 (ko) 2019-04-29

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