KR101937260B1 - 당뇨병의 치료 및/또는 진행을 제한하기 위한 후보화합물의 동정 방법 - Google Patents

당뇨병의 치료 및/또는 진행을 제한하기 위한 후보화합물의 동정 방법 Download PDF

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KR101937260B1
KR101937260B1 KR1020147000028A KR20147000028A KR101937260B1 KR 101937260 B1 KR101937260 B1 KR 101937260B1 KR 1020147000028 A KR1020147000028 A KR 1020147000028A KR 20147000028 A KR20147000028 A KR 20147000028A KR 101937260 B1 KR101937260 B1 KR 101937260B1
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cells
apociii
voltage
apolipoprotein
calcium channel
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KR20140051206A (ko
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페르 올라프 베르그렌
샤오-니안 양
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바이오크린 에이비
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
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    • G—PHYSICS
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KR1020147000028A 2011-06-27 2012-06-26 당뇨병의 치료 및/또는 진행을 제한하기 위한 후보화합물의 동정 방법 Expired - Fee Related KR101937260B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161501480P 2011-06-27 2011-06-27
US61/501,480 2011-06-27
PCT/EP2012/062371 WO2013000920A2 (en) 2011-06-27 2012-06-26 Methods for treating and/or limiting development of diabetes

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KR20140051206A KR20140051206A (ko) 2014-04-30
KR101937260B1 true KR101937260B1 (ko) 2019-01-10

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US (6) US8557513B2 (enExample)
EP (1) EP2724155B1 (enExample)
JP (1) JP6242790B2 (enExample)
KR (1) KR101937260B1 (enExample)
CN (1) CN103620404B (enExample)
WO (1) WO2013000920A2 (enExample)

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US8557513B2 (en) * 2011-06-27 2013-10-15 Biocrine Ab Methods for treating and/or limiting development of diabetes
PL2936151T3 (pl) 2012-12-18 2018-11-30 Biocrine Ab Sposoby leczenia i/lub ograniczania rozwoju cukrzycy
JP2014161257A (ja) * 2013-02-22 2014-09-08 Univ Of Tokyo 多能性幹細胞から膵ランゲルハンス島を製造する方法
WO2014131008A1 (en) 2013-02-25 2014-08-28 Intrinsic Metabio Solutions, Llc A polipoprotein c3 (apociii) antagonists and methods of their use to remove apociii inhibition of lipoprotein lipase (lpl)
PL2970463T3 (pl) * 2013-03-13 2018-04-30 Biocrine Ab Sposoby leczenia i/lub ograniczania rozwoju cukrzycy
KR20150046852A (ko) * 2013-10-23 2015-05-04 삼성전자주식회사 전자 장치 및 전자 장치의 암호를 이용한 인증 방법
KR102206054B1 (ko) * 2014-05-09 2021-01-21 삼성전자주식회사 지문 처리 방법 및 그 전자 장치
US9474951B2 (en) * 2015-01-21 2016-10-25 William Chuang Golf tee structures, assemblies, and systems with improved accuracy
US9700617B2 (en) 2015-02-09 2017-07-11 Biocrine Ab Methods for treating and/or limiting development of diabetes in subjects with amyotrophic lateral sclerosis
JP7341916B2 (ja) * 2015-04-01 2023-09-11 ビーエーエスエフ エーエス アポｃ３を低下させるためのチアオキソ化合物の使用
MA45602A (fr) 2016-07-08 2019-05-15 Staten Biotechnology B V Anticorps anti-apoc3 et leurs méthodes d'utilisation
CN110506056A (zh) 2017-04-21 2019-11-26 斯塔滕生物技术有限公司 抗apoc3抗体和其使用方法
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
MX2020004512A (es) 2017-10-31 2020-08-13 Anticuerpos anti apolipoproteina c-iii (anti-apoc3) y metodos de uso de los mismos.
MX2021000621A (es) * 2018-07-19 2021-04-13 Biocrine Ab Metodos y reactivos para tratar la diabetes.
US11310268B2 (en) 2019-05-06 2022-04-19 Secureworks Corp. Systems and methods using computer vision and machine learning for detection of malicious actions
US11381589B2 (en) 2019-10-11 2022-07-05 Secureworks Corp. Systems and methods for distributed extended common vulnerabilities and exposures data management

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JP2002529423A (ja) * 1998-11-06 2002-09-10 バイオジェン インコーポレイテッド 末梢神経障害を治療し又は予防するための方法及び組成物
US20040224304A1 (en) * 2003-04-29 2004-11-11 Biostratum, Inc. ApoCIII and the treatment and diagnosis of diabetes
JP2005512955A (ja) * 2001-07-09 2005-05-12 エラン ファーマシューティカルズ，インコーポレイテッド アミロイド毒性の阻害方法
JP2008518932A (ja) * 2004-10-29 2008-06-05 オデュッセイ セラ インコーポレイテッド 糖尿病及び肥満の治療のためのキナーゼ阻害剤

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US6492325B1 (en) * 1998-05-22 2002-12-10 Boys Town National Research Hospital Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease
DK1905457T3 (da) * 1999-12-22 2012-05-29 Scripps Research Inst Farmaceutiske sammensætninger omfattende Src og/eller Yes samt anvendelse deraf
WO2006110082A1 (en) * 2005-04-11 2006-10-19 Astrazeneca Ab A method and a kit for diagnosing type 2 diabetes, metabolic syndrome, sub clinical atherosclerosis, myocardial infarct, stroke or clinical manifestations of diabetes.
US20090060843A1 (en) 2007-08-31 2009-03-05 Biocrine Ab Non-Invasive In Vivo Imaging and Methods for Treating Type I Diabetes
US20110008901A1 (en) * 2009-07-07 2011-01-13 Kiernan Urban A Apolipoprotein ciii in pre- and type 2 diabetes
US8557513B2 (en) * 2011-06-27 2013-10-15 Biocrine Ab Methods for treating and/or limiting development of diabetes

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
JP2002529423A (ja) * 1998-11-06 2002-09-10 バイオジェン インコーポレイテッド 末梢神経障害を治療し又は予防するための方法及び組成物
JP2005512955A (ja) * 2001-07-09 2005-05-12 エラン ファーマシューティカルズ，インコーポレイテッド アミロイド毒性の阻害方法
US20040224304A1 (en) * 2003-04-29 2004-11-11 Biostratum, Inc. ApoCIII and the treatment and diagnosis of diabetes
JP2008518932A (ja) * 2004-10-29 2008-06-05 オデュッセイ セラ インコーポレイテッド 糖尿病及び肥満の治療のためのキナーゼ阻害剤

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US9353183B2 (en) 2016-05-31
CN103620404B (zh) 2016-03-30
WO2013000920A3 (en) 2013-02-28
US10226530B2 (en) 2019-03-12
EP2724155A2 (en) 2014-04-30
US20150252112A1 (en) 2015-09-10
WO2013000920A2 (en) 2013-01-03
EP2724155B1 (en) 2018-08-15
US20160194634A1 (en) 2016-07-07
JP6242790B2 (ja) 2017-12-06
US9744232B2 (en) 2017-08-29
KR20140051206A (ko) 2014-04-30
US8557513B2 (en) 2013-10-15
US20140004102A1 (en) 2014-01-02
JP2014527400A (ja) 2014-10-16
CN103620404A (zh) 2014-03-05
US20120328630A1 (en) 2012-12-27
US20170333555A1 (en) 2017-11-23
US20160193331A1 (en) 2016-07-07
US9068973B2 (en) 2015-06-30

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