KR101926419B1 - 치료제로서 올리고뉴클레오타이드 유사체의 설계 - Google Patents

치료제로서 올리고뉴클레오타이드 유사체의 설계 Download PDF

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KR101926419B1
KR101926419B1 KR1020137008383A KR20137008383A KR101926419B1 KR 101926419 B1 KR101926419 B1 KR 101926419B1 KR 1020137008383 A KR1020137008383 A KR 1020137008383A KR 20137008383 A KR20137008383 A KR 20137008383A KR 101926419 B1 KR101926419 B1 KR 101926419B1
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compound
compounds
virus
alkyl
antiviral
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KR20140048068A (ko
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라다크리슈난 피. 아이어
존 에드워드 코플린
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스프링 뱅크 파마슈티칼스, 인크.
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
KR1020137008383A 2010-08-30 2011-08-25 치료제로서 올리고뉴클레오타이드 유사체의 설계 Expired - Fee Related KR101926419B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40238010P 2010-08-30 2010-08-30
US61/402,380 2010-08-30
PCT/US2011/049213 WO2012030626A2 (en) 2010-08-30 2011-08-25 Design of oligonucleotide analogs as therapeutic agents

Publications (2)

Publication Number Publication Date
KR20140048068A KR20140048068A (ko) 2014-04-23
KR101926419B1 true KR101926419B1 (ko) 2018-12-10

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KR1020137008383A Expired - Fee Related KR101926419B1 (ko) 2010-08-30 2011-08-25 치료제로서 올리고뉴클레오타이드 유사체의 설계

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US (2) US9040234B2 (https=)
EP (2) EP3524252A1 (https=)
JP (3) JP2014500230A (https=)
KR (1) KR101926419B1 (https=)
CN (2) CN103298475A (https=)
WO (1) WO2012030626A2 (https=)

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Publication number Priority date Publication date Assignee Title
KR101926419B1 (ko) * 2010-08-30 2018-12-10 스프링 뱅크 파마슈티칼스, 인크. 치료제로서 올리고뉴클레오타이드 유사체의 설계
US9012427B2 (en) * 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
EP2956145A4 (en) * 2013-02-18 2016-08-17 Spring Bank Pharmaceuticals Inc DESIGN OF SHORT OLIGONUCLEOTIDES AS VACCINATE ADJUVANTIES AND THERAPEUTICS
ES2891903T3 (es) * 2015-02-17 2022-01-31 Cipherome Inc Método para seleccionar agente antineoplásico basado en información de daño proteínico de individuos para evitar los efectos secundarios del agente antineoplásico
KR20170132327A (ko) * 2015-04-07 2017-12-01 스프링 뱅크 파마슈티칼스, 인크. Hbv 감염의 치료를 위한 조성물 및 방법
EP3317290A4 (en) * 2015-07-02 2019-04-10 Spring Bank Pharmaceuticals, Inc. COMPOSITIONS AND METHOD FOR TREATING VIRUS INFECTION
TW201717968A (zh) * 2015-07-14 2017-06-01 春季銀行製藥公司 誘導ｒｉｇ－ｉ和其他模式辨識受體之化合物及組成物
WO2018009466A1 (en) * 2016-07-05 2018-01-11 Aduro Biotech, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
MX2019000660A (es) * 2016-07-15 2019-10-02 Sperovie Biosciences Inc Compuestos, composiciones y métodos para el tratamiento de enfermedades.
WO2018013887A1 (en) * 2016-07-15 2018-01-18 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease
JP2019532027A (ja) 2016-08-17 2019-11-07 ソルスティス バイオロジクス，リミティッド ポリヌクレオチド構築物
WO2019006455A1 (en) 2017-06-30 2019-01-03 Solstice Biologics, Ltd. AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF
CN111484541B (zh) * 2019-01-25 2023-06-02 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物及其制备方法
WO2021237067A1 (en) * 2020-05-22 2021-11-25 President And Fellows Of Harvard College Interferon- inducing oligonucleotide duplexes and methods of use

Citations (1)

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WO2007070598A2 (en) * 2005-12-13 2007-06-21 Spring Bank Nucleotide and oligonucleotide prodrugs

Family Cites Families (9)

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CN101113160A (zh) 2001-05-16 2008-01-30 米珍尼克斯公司 基于核酸的化合物及其使用方法
CN101094594B (zh) * 2003-12-08 2012-08-15 海布里顿公司 通过基于小寡核苷酸的化合物调节免疫刺激性质
WO2005097993A2 (en) * 2004-02-19 2005-10-20 Coley Pharmaceutical Group, Inc. Immunostimulatory viral rna oligonucleotides
JP2008523785A (ja) 2004-10-12 2008-07-10 カーランテック，インコーポレーテッド 神経変性、自己免疫脱髄、および糖尿病のウイルス病原に対する動物モデル系
EP3342415B1 (en) * 2006-08-08 2022-01-26 Rheinische Friedrich-Wilhelms-Universität Bonn Structure and use of 5' phosphate oligonucleotides
US20100040576A1 (en) 2007-12-18 2010-02-18 The Texas A&M University System Modified Oligonucleotides For The Treatment Of Hepatitis C Infection
GB2471806B (en) * 2008-04-03 2012-12-19 Spring Bank Pharmaceuticals Inc Compositions and methods for treating viral infections
EP2297323A1 (en) * 2008-05-21 2011-03-23 Hartmann, Gunther 5' triphosphate oligonucleotide with blunt end and uses thereof
KR101926419B1 (ko) * 2010-08-30 2018-12-10 스프링 뱅크 파마슈티칼스, 인크. 치료제로서 올리고뉴클레오타이드 유사체의 설계

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2007070598A2 (en) * 2005-12-13 2007-06-21 Spring Bank Nucleotide and oligonucleotide prodrugs

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JP6210392B2 (ja) 2017-10-11
US20120053226A1 (en) 2012-03-01
EP2611451A2 (en) 2013-07-10
CN103298475A (zh) 2013-09-11
WO2012030626A2 (en) 2012-03-08
CN107973833A (zh) 2018-05-01
JP2014500230A (ja) 2014-01-09
EP3524252A1 (en) 2019-08-14
US9040234B2 (en) 2015-05-26
US20150329864A1 (en) 2015-11-19
WO2012030626A3 (en) 2012-05-31
JP2018010001A (ja) 2018-01-18
JP2016164148A (ja) 2016-09-08
EP2611451A4 (en) 2014-01-15
KR20140048068A (ko) 2014-04-23

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