KR101926419B1 - 치료제로서 올리고뉴클레오타이드 유사체의 설계 - Google Patents

치료제로서 올리고뉴클레오타이드 유사체의 설계 Download PDF

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KR101926419B1
KR101926419B1 KR1020137008383A KR20137008383A KR101926419B1 KR 101926419 B1 KR101926419 B1 KR 101926419B1 KR 1020137008383 A KR1020137008383 A KR 1020137008383A KR 20137008383 A KR20137008383 A KR 20137008383A KR 101926419 B1 KR101926419 B1 KR 101926419B1
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compound
compounds
virus
alkyl
antiviral
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KR20140048068A (ko
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라다크리슈난 피. 아이어
존 에드워드 코플린
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스프링 뱅크 파마슈티칼스, 인크.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020137008383A 2010-08-30 2011-08-25 치료제로서 올리고뉴클레오타이드 유사체의 설계 Expired - Fee Related KR101926419B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40238010P 2010-08-30 2010-08-30
US61/402,380 2010-08-30
PCT/US2011/049213 WO2012030626A2 (en) 2010-08-30 2011-08-25 Design of oligonucleotide analogs as therapeutic agents

Publications (2)

Publication Number Publication Date
KR20140048068A KR20140048068A (ko) 2014-04-23
KR101926419B1 true KR101926419B1 (ko) 2018-12-10

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KR1020137008383A Expired - Fee Related KR101926419B1 (ko) 2010-08-30 2011-08-25 치료제로서 올리고뉴클레오타이드 유사체의 설계

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US (2) US9040234B2 (https=)
EP (2) EP3524252A1 (https=)
JP (3) JP2014500230A (https=)
KR (1) KR101926419B1 (https=)
CN (2) CN107973833A (https=)
WO (1) WO2012030626A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040234B2 (en) * 2010-08-30 2015-05-26 Spring Bank Pharmaceuticals, Inc. Oligonucleotide analogs as therapeutic agents
WO2013142157A1 (en) * 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
JP6502267B2 (ja) * 2013-02-18 2019-04-17 スプリング バンク ファーマシューティカルズ，インコーポレイテッド ワクチンアジュバントおよび治療剤としての短鎖オリゴヌクレオチドの設計
ES2891903T3 (es) * 2015-02-17 2022-01-31 Cipherome Inc Método para seleccionar agente antineoplásico basado en información de daño proteínico de individuos para evitar los efectos secundarios del agente antineoplásico
WO2016164619A2 (en) * 2015-04-07 2016-10-13 Spring Bank Pharmaceuticals, Inc. Compositions and methods for the treatment of hbv infection
EP3317290A4 (en) * 2015-07-02 2019-04-10 Spring Bank Pharmaceuticals, Inc. COMPOSITIONS AND METHOD FOR TREATING VIRUS INFECTION
TW201717968A (zh) * 2015-07-14 2017-06-01 春季銀行製藥公司 誘導ｒｉｇ－ｉ和其他模式辨識受體之化合物及組成物
EP3507367A4 (en) * 2016-07-05 2020-03-25 Aduro BioTech, Inc. CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
WO2018013887A1 (en) * 2016-07-15 2018-01-18 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease
CN109715202A (zh) * 2016-07-15 2019-05-03 斯必乐维生物科学公司 用于治疗疾病的化合物、组合物和方法
CA3033867A1 (en) 2016-08-17 2018-02-22 Solstice Biologics, Ltd. Polynucleotide constructs
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
CN111484541B (zh) * 2019-01-25 2023-06-02 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物及其制备方法
US20230242918A1 (en) * 2020-05-22 2023-08-03 President And Fellows Of Harvard College Interferon- inducing oligonucleotide duplexes and methods of use

Citations (1)

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WO2007070598A2 (en) * 2005-12-13 2007-06-21 Spring Bank Nucleotide and oligonucleotide prodrugs

Family Cites Families (9)

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WO2002092006A2 (en) * 2001-05-16 2002-11-21 Micrologix Biotech, Inc. Nucleic acid-based compounds and methods of use thereof
CA2549173A1 (en) 2003-12-08 2005-07-07 Hybridon, Inc. Modulation of immunostimulatory properties by small oligonucleotide-based compounds
JP2007526253A (ja) 2004-02-19 2007-09-13 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫刺激性ウイルスｒｎａオリゴヌクレオチド
JP2008523785A (ja) 2004-10-12 2008-07-10 カーランテック，インコーポレーテッド 神経変性、自己免疫脱髄、および糖尿病のウイルス病原に対する動物モデル系
ES2911034T3 (es) * 2006-08-08 2022-05-17 Univ Bonn Rheinische Friedrich Wilhelms Estructura y uso de oligonucleótidos 5' fosfato
US20100040576A1 (en) * 2007-12-18 2010-02-18 The Texas A&M University System Modified Oligonucleotides For The Treatment Of Hepatitis C Infection
GB2471806B (en) * 2008-04-03 2012-12-19 Spring Bank Pharmaceuticals Inc Compositions and methods for treating viral infections
WO2009141146A1 (en) * 2008-05-21 2009-11-26 Gunther Hartmann 5' triphosphate oligonucleotide with blunt end and uses thereof
US9040234B2 (en) * 2010-08-30 2015-05-26 Spring Bank Pharmaceuticals, Inc. Oligonucleotide analogs as therapeutic agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007070598A2 (en) * 2005-12-13 2007-06-21 Spring Bank Nucleotide and oligonucleotide prodrugs

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Publication number Publication date
US20150329864A1 (en) 2015-11-19
EP3524252A1 (en) 2019-08-14
WO2012030626A3 (en) 2012-05-31
JP2016164148A (ja) 2016-09-08
CN107973833A (zh) 2018-05-01
JP2018010001A (ja) 2018-01-18
US9040234B2 (en) 2015-05-26
WO2012030626A2 (en) 2012-03-08
JP2014500230A (ja) 2014-01-09
EP2611451A2 (en) 2013-07-10
EP2611451A4 (en) 2014-01-15
US20120053226A1 (en) 2012-03-01
CN103298475A (zh) 2013-09-11
JP6210392B2 (ja) 2017-10-11
KR20140048068A (ko) 2014-04-23

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