KR101925546B1 - Coated organic acid for feed additive composition, coating method of the organic acid and feed containing thereof - Google Patents

Abstract

The present invention relates to a coated organic acid for a feed additive, a method for producing the same, and a livestock feed containing the same, and more particularly, to a method for preparing a coated organic acid for a feed additive, which comprises dissolving a vegetable fatty acid, mixing the organic acid with the dissolved vegetable fatty acid, And spraying the mixed suspension into a cooling chamber to solidify the coated organic acid particles, wherein the coated organic acid particles comprise a matrix comprising a vegetable fatty acid and an organic acid dispersed in the matrix, The organic acid is characterized by being citric acid, malic acid and fumaric acid.
According to the present invention, it is possible to produce a coated organic acid having a matrix structure of an organic acid-vegetable fatty acid, thereby improving productivity of livestock, shortening the number of days of shipment, controlling intestinal microflora and improving feed efficiency, There is an advantage to increase income.

Description

TECHNICAL FIELD The present invention relates to a coated organic acid for use as a feed additive, a method for producing the same, and a livestock feed containing the same. BACKGROUND ART < RTI ID = 0.0 >

The present invention relates to a coated organic acid for a feed additive, a method for producing the same, and a livestock feed containing the same.

Feeds are used to maintain the life of livestock and produce the livestock products (egg, milk, meat, hair, etc.) and the organic, inorganic nutrients necessary for growth, reproduction, And the like.

Organic acids are acidic substances including carbon. Organic acids commonly used in animal husbandry include formic acid, acetic acid, propionic acid, butyric acid, lactic acid, citric acid, malic acid, and fumaric acid. Among them, formic acid, acetic acid, and propionic acid are highly volatile and highly corrosive, and have a disagreeable flavor and flavor. They are used as an antifungal agent in livestock feed. However, there is an adverse effect of reducing feed intake by decreasing palatability when used in large amounts. Butyric acid is also a volatile organic acid, and its peculiar odor causes complaints to the people around the factory.

Organic acid uses several organic acids at the same time, rather than using a single organic acid, in order to increase antimicrobial and antifungal properties in the feed. Specifically, volatile strong acids such as formic acid, acetic acid, propionic acid, and butyric acid are added.

These organic acids give antimicrobial properties when applied to livestock feeds, and are used in the form of organic acids or salts of organic acids adsorbed on porous materials.

First, the organic acid adsorbed on the porous material easily dissolves and plays a role in the mouths and stomachs of feed and livestock, and its role in the small intestine and large intestine is inevitable.

The salt-type organic acid has low antimicrobial activity in the feed and has antimicrobial activity in digestive organs. However, in the case of salt-type organic acids, organic acids are eluted from the digestive organs due to the elimination of salts. In this case, the organic acids in the form of dissociated organic acids, which have lost their acidity, are hardly antimicrobial. The dissociated organic acid means a state in which the hydrogen ion of the organic acid is separated. In other words, the separated hydrogen ion lowers pH and acidity, so that the dissociated organic acid of hydrogen ion has lost its original antimicrobial property. The difference in antimicrobial activity between the organic acid and the dissociative acid is shown in Table 1 below.

Difference in Antimicrobial Activity of Organic Acid compared to Harry Organic Acid division Mountain form MIC concentration of organic acids MIC concentration of dissociated organic acids
E. coli K88
Malic acid 0.9 250 Fumaric acid 2 600 Citric acid 0.02 430 S. Typimurium
KCCM 40253 Malic acid 0.01 480 Fumaric acid 10 750 Citric acid 3.62 500

The mechanism by which the organic acid kills the bacteria can be described as in Fig. Usually, harmful bacteria are sensitive to pH change. Organic acid releases pH of organic acid in the intestinal environment, which is difficult to survive these harmful bacteria. It lowers pH in the intestines. And it is known that the dissociated organic acid, in which the hydrogen ion is eliminated, accumulates in the cell and causes the osmotic pressure difference to cause the water in the bacteria to be infiltrated into the cell.

Therefore, in order to regulate pH in the intestines and induce the death of bacteria susceptible to pH, a coating organic acid that can reach safely in the small intestine and large intestine in which most bacteria are present is required.

KR 10-1676356 B1 KR 10-2015-0098081 A

Accordingly, an object of the present invention is to solve the problems of conventional organic acids for feed addition, and it is an object of the present invention to provide a method of coating organic acids containing citric acid, malic acid, and fumaric acid, It is intended to provide a coated organic acid for feed addition which is capable of safely reaching the small intestine and large intestine in which bacteria are most abundant, while having excellent antimicrobial activity, by coating such that the organic acid is dispersed in a matrix of a fatty acid.

Further, it is intended to provide a coated organic acid and a compounded feed for feed addition which have a more excellent antibacterial and antifungal action by further containing a heavy chain fatty acid and a herbal extract.

To achieve the above object, the present invention provides a coated organic acid for a feed additive comprising a matrix containing a vegetable fatty acid and an organic acid dispersed in the matrix, wherein the organic acid is citric acid, malic acid, and fumaric acid.

Wherein the vegetable fatty acid is stearic acid, palmitic acid or a mixture thereof, and the matrix further comprises an emulsifier and a herbal extract.

The mixture of vegetable fatty acids, emulsifiers, herbal extracts, organic acids and heavy chain fatty acids may be used in an amount of 3 to 20 parts by weight of an emulsifier, 0.1 to 1 part by weight of an herbal extract, 80 to 120 parts by weight of an organic acid, To 10 parts by weight, and the organic acid comprises 30 to 40% by weight of citric acid, 20 to 30% by weight of malic acid, and 30 to 50% by weight of fumaric acid.

The method for preparing a coated organic acid for feed additive according to the present invention comprises the steps of: dissolving vegetable fatty acid; preparing a suspension by mixing the organic acid with the dissolved vegetable fatty acid; spraying the mixed suspension into a cooling chamber Wherein the coated organic acid particles are composed of a matrix comprising a vegetable fatty acid and an organic acid dispersed in the matrix, wherein the organic acid is citric acid, malic acid, and fumaric acid .

The livestock feed according to the present invention is characterized by 0.05 to 0.4% by weight of the coated organic acid for the feed additive based on 100% by weight of the feed.

According to the present invention, it is possible to produce a coated organic acid having a matrix structure of an organic acid-vegetable fatty acid, thereby improving productivity of livestock, shortening the number of days of shipment, controlling intestinal microflora and improving feed efficiency, There is an advantage to increase income.

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 shows the mechanism by which organic acids kill bacteria.
2 shows a schematic structure of a coated organic acid particle according to the present invention.
3 is a view showing a procedure for producing a coating organic acid according to the present invention.
4 is a graph showing the results of Test Example 2 according to the present invention.
5 is a graph showing the results of Test Example 4 according to the present invention.
6 and 7 are graphs showing the results of Test Example 5 according to the present invention.

Hereinafter, the present invention will be described in detail.

First, the conventional organic acid for feed additive was added in a state of being adsorbed to a salt or a porous substance in the feed without any coating, but this form can not sufficiently exhibit the antibacterial property of the organic acid and can not reach the small intestine and the large intestine safely There were disadvantages. In addition, these disadvantages necessitated the use of excess organic acids.

Accordingly, it is an object of the present invention to provide a coated organic acid by coating an organic acid with a vegetable fatty acid, thereby having sufficient antibacterial and antifungal activity even with a small amount of organic acid. Furthermore, as shown in FIG. 2, the coated organic acid particles of the present invention can be used as a coating material for preventing the internal effective ingredient from being exposed to the outside and stably protected by the coating agent even if deformation or cleavage of particles due to heat and physical friction occurs. (2) containing an organic acid (1) dispersed in the matrix, and an organic acid (1) dispersed in the matrix. That is, it is a matrix structure of an organic acid-vegetable fatty acid in which the organic acid is dispersed in the vegetable fatty acid.

Therefore, the organic acid (1), which is an active ingredient, is dispersed and distributed in the matrix (2) of vegetable fatty acids, so that even if deformation and cleavage of the particles occur, the organic acid (1) dispersed in the matrix (2) is stably protected, And the vegetable fatty acid constituting the matrix 2 is decomposed by the lipase secreted into the duodenum so that the organic acid 1 can reach the small intestine and the large intestine safely.

Therefore, the coated organic acids having the above structure actively react in the small intestine and the large intestine to exhibit antibacterial and antifungal activity even if only a relatively small amount is added to the compound feed, thereby promoting the growth of the livestock.

At this time, as the organic acid, at least one of citric acid, malic acid, and fumaric acid, which have a large amount of hydrogen ions, and most preferably all three species are used. The blending ratio thereof is preferably 30 to 40% by weight of citric acid, 20 to 30% by weight of malic acid, and 30 to 50% by weight of fumaric acid, and exhibits excellent antibacterial and antifungal activity within such blending ratios.

In addition, the coated organic acid further includes an emulsifier, a herbal extract, and a medium chain fatty acid. The emulsifier is intended to allow the vegetable fatty acid to stably form a matrix structure.

The herb extract is also used for its excellent antimicrobial activity, and its kind is not limited, but most preferably, both the peppermint extract and the eucalyptus extract are used together. The use amount of peppermint extract and eucalyptus extract is about 1: 1, but it is not limited thereto. Here, the peppermint extract and the eucalyptus extract can be used by purchasing commercial products.

The emulsifier and the herbal extract together with the vegetable fatty acid constitute the matrix (2).

The above-mentioned medium-chain fatty acids are medium chain triglycerides obtained from coconut fruit, and have excellent antibacterial and antifungal activity. At this time, since the heavy chain fatty acid is also dispersed in the matrix, that is, in a scattered form, the small intestine and the large intestine can be safely protected.

The coated organic acid of the present invention is preferably composed of 3 to 20 parts by weight of an emulsifier, 0.1 to 1 part by weight of an herbal extract, 80 to 120 parts by weight of an organic acid, and 1 to 10 parts by weight of a heavy chain fatty acid based on 100 parts by weight of the vegetable fatty acid, But is not necessarily limited. However, since they exhibit excellent antibacterial and antifungal activity within such blending ratios, it is preferable to configure them at such a blending ratio.

In addition, the above-mentioned vegetable fatty acids are not limited, but preferable forms are stearic acid, palmitic acid, or a mixture thereof.

The emulsifier may be at least one selected from the group consisting of propylene glycol fatty acid esters, lecithin, glycerin fatty acid esters, sucrose fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters and polyoxyethylene glycerol fatty acid esters. The present invention is not limited to the use of various known emulsifiers.

The organic acid for feed additive of the present invention having the above-described structure has an advantage that the organic acid is stably protected by the vegetable fatty acid and the small intestine and the large intestine can be safely reached.

Hereinafter, a method for producing a coating organic acid according to the present invention will be described in detail with reference to FIG. In the description of the production method of the present invention, the description of the structure sufficiently described in the coating organic acid is omitted.

A method for producing a coated organic acid according to the present invention comprises the steps of dissolving a vegetable fatty acid, mixing the dissolved vegetable fatty acid with an organic acid containing citric acid, malic acid, and fumaric acid to prepare a suspension, Spraying into a cooling chamber to solidify the coated organic acid particles.

First, the vegetable fatty acid is dissolved and put into a mixing tank. At this time, the dissolving method of the fatty acid is of course not limited, and it is of course possible to dissolve in the mixing tank.

And organic acids, emulsifiers, heavy chain fatty acids and herbal extracts are put into the mixing tank and mixed with the dissolved vegetable fatty acids. Here, since the organic acid is not dissolved, it becomes a suspension state.

Next, the suspension is sprayed with a nozzle in a cooling chamber to solidify the organic acid particles. At this time, the size of the nozzle, the injection pressure, the temperature in the cooling chamber and the like are not limited. For example, the inlet diameter of the nozzle may be 0.1 to 3 mm, the injection pressure may be 10 to 200 kg / cm 2, and the temperature in the cooling chamber may be -50 to 0 ° C.

The coated organic acid thus prepared is fed to livestock in the form of a compounded feed mixed with other feeds. It is preferable that 0.05 to 0.4% by weight of the coated organic acid for the feed additive is blended based on 100% by weight of the feed. This takes into account productivity improvements and feed efficiency.

In addition, the livestock feed of the present invention can be fed to various kinds of livestock for which the supply of organic acid is required, but is most preferably fed to the pig or poultry. In the pig, sows, wean pads, growers, .

Hereinafter, the present invention will be described in detail with reference to examples.

(Example 1)

Preparation of coated organic acids.

500 g of a mixture of stearic acid and palmitic acid (1: 1 weight ratio) was dissolved. 30 g of an emulsifier having an HLB value of 4.3 of sorbitan fatty acid ester, 40 g of a heavy chain fatty acid and 4 g of a herbal extract (mixture of peppermint extract and eucalyptus extract in a weight ratio of 1: , And 400 g of organic acid were mixed to prepare a suspension. Then, the suspension was sprayed into a cooling chamber of -20 ° C at a pressure of 30 kg / cm 2 with a nozzle having a diameter of 2 mm to prepare coated organic acid particles. The prepared organic acid particles showed organic acid and medium chain fatty acid dispersed in a matrix of vegetable fatty acid.

As the organic acid, citric acid 32.5 wt.%, Malic acid 25 wt.% And fumaric acid 42.5 wt.% Were used. Herbal extracts and medium chain fatty acids were purchased from commercial companies.

(Test Example 1)

Animal specimens were tested to improve the productivity of the sows and the piglets of Example 1.

The samples were prepared in the same manner as in Example 1 except that 500 g (0.05%, T1), 1 kg (0.1%, T2) and 2 kg (0.2% , T3) and 4 kg (0.4%, T4) were mixed to prepare a sample. Only the basic diet was used as control (CON).

15 sows (3 pcs per treatment) were prepared and fed for 24 days from the time of delivery until the time of weaning. Feeding and specimen management were performed by dividing the samples prepared in the above into two groups, morning and evening, twice a day, feeding no feed on the day of delivery, and 2.5-3.0 kg per sow per day after sowing And gradually fed 0.5 ~ 0.7 ㎏ / day of feed to increase the amount of unlimited feed. Water was allowed to be free in the automatic water dispenser.

The average daily gain (ADG: kg / d) was calculated by the following equation (1).

(1) Average daily gain (ADG, kg / d) = (final weight (kg) - initial weight (kg)) / two

The results are shown in Table 2 below.

Test Example 1 Results. division CON T1
T2 T3 T4 SE P-value
(Linear) P-value
(Quadratic) Bady
Weight
(kg) Birth 1.32 1.42 1.30 1.34 1.36 0.13 0.991 0.954 week 1 2.73 2.91 2.80 2.82 2.80 0.16 0.982 0.731 week 2 4.30 4.57 4.41 4.42 4.36 0.17 0.952 0.476 week 3 6.09 6.30 6.23 6.27 6.26 0.17 0.580 0.608 day 24 6.80 7.11 7.06 7.08 7.15 0.17 0.269 0.581 ADG
(g)



week 1 206 213 214 212 205 11 0.947 0.500 week 2 220 237 230 228 224 8 0.910 0.257 week 3 254 248 260 264 271 11 0.208 0.656 day 24 244 ^b 267 ^ab 277 ^ab 270 ^ab 297 ^a 11 0.017 0.850 Total Average
daily gain 229 237 240 239 241 6 0.185 0.511

 SE: Standard error of means.

^{a, b} Means in the same row with different superscripts differ (P <0.05).

As shown in the above Table 2, the body weight of the piglets after 24 days was further increased to 23 g, 33 g, 26 g, and 53 g, respectively, in the T1 to T4 treatments, which was 9.4%, 13.5%, 10.7%, 21.7 % More productivity than the other groups.

(Test Example 2)

Animal Species Tests were conducted to test the productivity improvement of the coated organic acids according to Example 1 on the weaned piglets.

As a sample, a commercially available standard feed for piglets was prepared, and 1 kg (0.1%, MC1) and 2 kg (0.2%, MC2) of the coated organic acid of the above Example 1 were prepared to the prepared basic diet. As the control (CON), only the basic diet was used. Uncoated organic acids (32.5 wt% citric acid, 25 wt% malic acid, 42.5 wt% fumaric acid) were mixed as a positive control (UPO).

120 specimens (30 specimens per treatment) were subjected to a 6 - week specification test. Feeding and specimen management were carried out at each bank in the treatment room, and then every morning at 8:00 am Each of the samples prepared above was subjected to unrestricted free feeding according to the treatments.

The average daily gain per day during the test period was measured and the results are shown in FIG. As can be seen from FIG. 4, it was confirmed that the average daily weight gain of the MC2 treatment group, which is the same as that of the UPO treatment group, increased by 9 g.

(Test Example 3)

Animal specimens were tested for productivity improvement, intestinal microflora control and improvement of the fecal indices of the pigments of coated organic acids according to Example 1.

As a sample, a commercially available standard feed for piglets was prepared, and 2 kg (0.2%, MC1) and 4 kg (0.4%, MC2) of the coated organic acid of the above Example 1 were prepared to the prepared basic diet. Only the basic diet was used as control (CON).

30 specimens (10 specimens per treatment) were tested for 3 weeks. Feeding and specimen management were carried out at each bank in the treatment room, and then at 8 o'clock every morning, each of the samples prepared above was subjected to unrestricted free feeding according to the treatments. The average daily feed intake was determined at 8 o'clock the next day. For each treatment, diarrhea was induced by direct oral administration of E. coli to the weaning pig on the morning of the 8th. The challenge was E. coli K88.

The average daily gain was measured, and the results are shown in Table 3. The fecal indices were measured, and the microbial changes were measured in Table 4 and shown in Table 5.

Here, the average daily gain was calculated in the same manner as in Test Example 1, and the average daily feed intake (ADFI: kg / day / day) was calculated by subtracting the remaining feed from the fed feed as shown in Equation (2) Respectively. Daily average feed intake per individual was calculated. The feed efficiency (G / F) means the amount of feed (kg) required for 1 kg of body weight, and is calculated by dividing the daily average weight gain by the daily average feed intake as shown in the following equation (3).

(2) Daily average feed intake (ADFI, kg / d) = ((Fed fed (kg) - Left feed (kg)) /

(3) Feed efficiency (G / F,%) = (Average daily gain (kg / d) / Daily average feed intake (kg / d))

The fecundity index was determined by counting the number of E. coli per 1 g of feces after 21 days of rearing.

The results of Test Example 3 (productivity) division CON MC1 MC2 SE Body weight (kg) Initial 6.24 6.24 6.24 0.02 week 1 8.11 ^c 8.40 ^b 8.44 ^ab 0.03 week 2 9.16 ^c 9.91 ^b 10.03ab 0.04 week 2 11.45 ^c 12.84 ^b 13.20 ^a 0.07 phase 1
(d-7 to d 0, week 1) ADG (g) 267 ^c 309 ^b 314 ^ab 6 ADFI (g) 321 ^c 351 ^b 252 ^b 4 G / F 0.832 ^b 0.878 ^a 0.891 ^a 0.12 phase 2
(d 0 to d 7, week 2) ADG (g) 150 ^b 216 ^a 227 ^a 4 ADFI (g) 213 ^b 286 ^a 310 ^a 16 G / F 0.711 0.754 0.734 0.031 phase 3
(d 7 to d 14, week 3) ADG (g) 318 ^b 418 ^a 454 ^a 14 ADFI (g) 403 ^b 515 ^a 549 ^a 24 G / F 0.791 ^b 0.812 ^a 0.827 ^a 0.009 Overall

ADG (g) 248 ^c 314 ^b 332 ^a 3 ADFI (g) 312 ^b 384 ^a 403 ^a 7 G / F 0.795 ^b 0.818 ^a 0.822 ^a 0.009

SE: Standard error of means.

^{a, b, c} Means in the same row with different superscripts differ (P <0.05).

As shown in Table 3, it was confirmed that the average daily gain per day of MC1 treatment was further increased by 66 g and that of MC2 treatment was increased by 84 g as compared with the control where productivity was drastically lowered due to inoculation of E. coli.

The results of Test Example 3 (fecal index) Fecal score CON MC1 MC2 SE Week 1 3.50 ^a 3.25 ^b 3.25 ^b 0.04 Week 2 4.29 ^a 3.61 ^b 3.68 ^b 0.07 Week 3 3.21 3.07 3.07 0.06 Fecal score: 1 = hard, dry pellets in a small, hard mass;
2 = hard, formed stool that remains firm and soft;
3 = soft, formed, and moist stool that retains its shape;
4 = soft, unformed stool that assumes the shape of the container;
5 = watery, liquid stool that can be poured

SE: Standard error of means.

^{a, b} Means in the same row with different superscripts differ (P <0.05).

As can be seen from the above Table 4, the fecal incontinence index was also 3.96 in the MC1 treatment group and 3.68 in the MC2 treatment group, .

The results of Test Example 3 (microbial change, logarithm of colonization) division CON MC1 MC2 SE Lactobacillus 7.33 ^b 7.43 ^ab 7.47 ^ab 0.05 E. coli 7.42 ^a 7.25 ^b 7.27 ^b 0.04

SE: Standard error of means.

^{a, b} Means in the same row with different superscripts differ (P <0.05).

The microbial changes were also confirmed, and it was confirmed that the number of lactic acid bacteria, which are useful bacteria in MC1 and MC2 treatment, increased and the number of coliform bacteria decreased.

(Test Example 4)

Through the animal test, the productivity improvement effect of the growth seed of Example 1 was tested.

(0.1%, MC1), 2 kg (0.2%, MC2) and 4 kg (0.4%) of the coated organic acid of the above Example 1 were added to the prepared basic feed, , MC3). Only the basic diet was used as control (CON).

A total of 100 pigs (25 pigs per treatment) were fed a 6 - week feeding test. Feeding and specimen management were carried out in each bank of the treatment area, and each of the samples prepared above was divided into morning and evening treatments and fed unlimited twice a day. Water was allowed to be free in the automatic water dispenser.

The daily average weight gain was obtained in the same manner as in Test Example 1 and is shown in Fig.

As can be seen from FIG. 5, it was confirmed that the average daily gain of 11 g, 23 g (3.2%) and 32 g (4.5%) was increased in the MC1, MC2 and MC3 treatment groups, respectively.

(Test Example 5)

Through the animal test, the productivity improvement of the finishing pigeon of Example 1 was tested.

As a sample, commercially available pig basic feeds were prepared, and 1 kg (0.1%, MA1) and 2 kg (0.2%, MA2) of the coated organic acids of the above Example 1 were prepared to the prepared basic feeds. Only the basic diet was used as control (CON).

120 weekly (40 pigs per treatment) were fed a 12 - week feeding test. Feeding and specimen management were carried out in each bank of the treatment area, and each of the samples prepared above was divided into morning and evening treatments and fed unlimited twice a day. Water was allowed to be free in the automatic water dispenser.

The average daily gain was calculated in the same manner as in Test Example 1 and is shown in FIG.

As can be seen from FIG. 6, in the MA1 treatment, the daily average weight gain of the entire test period was further increased by 26 g in the 6th week and 34 g in the 12th week, And the average daily weight gain was increased by 47g.

In addition, the ammonia gas emission was measured and the results are shown in FIG. 7. As shown in FIG. 7, it was confirmed that the ammonia gas emission of 15% on average was reduced in the MA1 treatment at 6 hours.

(Test Example 6)

Through the animal test, the productivity improvement of the broiler line of Example 1 was tested.

As a sample, a commercially available basic nutrient for poultry was prepared and 500 g (0.05%, MC1), 1 kg (0.1%, MC2), 2 kg (0.2 %, MA3). Only the basic diet was used as control (CON). The positive control group was a mixture of 0.02% of avilamycin antibiotics.

A total of 510 broilers (102 broilers per treatment) were prepared and a 33 day feeding test was conducted. For feeding and specification control, samples were fed unlimited twice a day. Water was allowed to be free in the automatic water dispenser.

Daily average weight gain (BWG), daily average feed intake (FI) and feed efficiency (FCR) were calculated in the same manner as in Test Example 3, and the results are shown in Table 6 below.

Test Example 6 Results. division CON AV MC1 MC2 MC3 SEM 5-19 day

BWG (g) 596.5 ^b 625.2 ^a 621.0 ^a 624.3 ^a 626.0 ^a 9.28 FI (g) 736.8 ^a 744.8 ^ab 742.3 ^ab 734.5 ^b 755.5 ^ab 8.51 FCR 1.25 1.19 1.2 1.18 1.21 0.02 19-33 day

BWG (g) 774.8 ^b 781.3 ^ab 778.7 ^ab 790.5 ^a 785.8 ^ab 33.42 FI (g) 1284.7 1274.2 1279.2 1284.0 1278.8 17.37 FCR 1.66 1.65 1.65 1.63 1.63 0.08 Overall

BWG (g) 1426.2 ^b 1459.8 ^ab 1452.2 ^ab 1466.2 ^a 1465.7 ^a 28.95 FI (g) 2112.8 2086.5 2088.5 2087.8 2013.8 20.75 FCR 1.48 1.43 1.44 1.42 1.43 0.03

SE: Standard error of means.

^{a, b} Means in the same row with different superscripts differ (P <0.05).

As shown in Table 6, it was confirmed that the daily average weight gain of MC1 treatment was slightly increased compared with that of the control, and the daily average weight gain of MC2 and MC3 treatments was significantly increased compared with the control. This was higher than that of antibiotic treatment.

(Test Example 7)

In addition, tests were conducted to determine if the coating of organic acids affects the activity of other nutrients in the feed. The target nutrient was vitamin C, and the composition was tested so as to contain 10% by weight of Example 1 in the pig feed composition. The results are shown in Table 7.

Test Example 7 Results Vitamin C 0 day (%) 30 day (%) 90 day (%) % of reduction period 0-90 days Control 10.45 11.10 10.17 97.3% Test group 10.09 10.35 10.03 99.4%

As shown in Table 7, it was confirmed that the coating organic acid did not affect the activity of vitamin C.

Therefore, as can be seen from the above test examples, it was found that the coated organic acid of the present invention has an excellent effect in replacing antibiotics to improve productivity by controlling intestinal microflora in swine and poultry.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, It will be understood that the invention may be practiced. It is therefore to be understood that one embodiment described above is illustrative in all aspects and not restrictive.

1: Organic acid
2: Matrix

Claims (7)

A matrix comprising vegetable fatty acids, emulsifiers and herbal extracts,
An organic acid and a medium chain fatty acid dispersed in the matrix,
Wherein the organic acid is citric acid, malic acid, and fumaric acid,
Wherein the vegetable fatty acid is stearic acid, palmitic acid or a mixture thereof,
The blending ratio of the above-mentioned vegetable fatty acids, emulsifiers, herbal extracts, organic acids,
3 to 20 parts by weight of an emulsifier, 0.1 to 1 part by weight of an extract of a herb, 80 to 120 parts by weight of an organic acid and 1 to 10 parts by weight of a heavy chain fatty acid based on 100 parts by weight of the vegetable fatty acid,
Wherein the organic acid comprises 30 to 40% by weight of citric acid, 20 to 30% by weight of malic acid, and 30 to 50% by weight of fumaric acid.
delete delete Dissolving vegetable fatty acids,
Preparing a suspension by mixing the dissolved vegetable fatty acid with an organic acid, an emulsifier, a herbal extract and a heavy chain fatty acid;
Spraying the mixed suspension into a cooling chamber to solidify the coated organic acid particles,
The coated organic acid particles may contain,
A matrix comprising vegetable fatty acids, emulsifiers and herbal extracts,
And an organic acid and a medium-chain fatty acid dispersed in the matrix,
Wherein the organic acid is citric acid, malic acid, and fumaric acid,
Wherein the vegetable fatty acid is stearic acid, palmitic acid or a mixture thereof,
The step of producing the suspension comprises:
3 to 20 parts by weight of an emulsifier, 0.1 to 1 part by weight of an herbal extract, 80 to 120 parts by weight of an organic acid and 1 to 10 parts by weight of a heavy chain fatty acid are mixed with 100 parts by weight of the vegetable fatty acid,
Wherein the organic acid comprises 30 to 40 wt% of citric acid, 20 to 30 wt% of malic acid, and 30 to 50 wt% of fumaric acid.
delete delete A coated organic acid for the feed additive of claim 1,
And 0.05 to 0.4% by weight of a coating organic acid for the feed additive based on 100% by weight of the feed.

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