CN109198187A - A kind of feed addictive and its preparation method and application for preventing and treating pig bloody flux - Google Patents
A kind of feed addictive and its preparation method and application for preventing and treating pig bloody flux Download PDFInfo
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- CN109198187A CN109198187A CN201811397170.2A CN201811397170A CN109198187A CN 109198187 A CN109198187 A CN 109198187A CN 201811397170 A CN201811397170 A CN 201811397170A CN 109198187 A CN109198187 A CN 109198187A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a kind of feed addictives and its preparation method and application for preventing and treating pig bloody flux, additive of the invention includes Thymol, carvacrol, cinnamic acid, eugenol, manna oligosacchride, tributyrin, cosolvent and carrier, Thymol in the present invention, carvacrol, cinnamic acid, eugenol, cosolvent and carrier are mixed with water in blending tank, homogeneous is carried out through high pressure homogenizer again, it is spray-dried intermediate material obtained, the intermediate material again with manna oligosacchride, tributyrin is added to the mixer, the feed addictive of prevention and treatment pig bloody flux is made after mixing.The bloody flux of pig significantly can be prevented and treated and be cured using feed addictive of the invention, and the growth performance of pig, noresidue and withdrawal time can also be improved, it is green safe.
Description
Technical field
The present invention relates to a kind of feed addictives, and in particular to it is a kind of prevent and treat pig bloody flux feed addictive and its preparation
Methods and applications.
Background technique
Pig blood dysentery, also known as swine dysentery are the serious intestines of a kind of harm for causing pig by pathogenic swine dysentery Serpulina
Road illness.Characterized by colorectal mucosa Catarrhal, hemorrhagic and gangrenous inflammation.Main clinical symptom is that serious mucus goes out
Hemorrhagic diarrhea, acute based on hemorrhagic diarrhea, it is subacute and it is chronic with mucous diarrhoea schedule to last based on.
The pig for suffering from bloody flux shows as thin, mucus or hemorrhagic diarrhea；The equal easy infection of the pig of various ages and kind,
7~12 week old pigs occur more.Sick pig and the pig that carries disease germs are major source of infection.
The pig growth and development for suffering from bloody flux is obstructed, and efficiency of feed utilization reduces, and brings huge economic loss to pig breeding industry.
Summary of the invention
It is an object of the invention to: a kind of feed addictive for preventing and treating pig bloody flux (1) is provided；(2) a kind of prevention and treatment is provided
The preparation method of the feed addictive of pig bloody flux；(3) a kind of application of feed addictive for preventing and treating pig bloody flux is provided.It uses
The bloody flux of pig significantly can be prevented and treated and be cured to feed addictive of the invention, and can also improve the growth performance of pig, nothing
Residual and withdrawal time, it is green safe.
To achieve the above object, the invention provides the following technical scheme:
It is a kind of prevent and treat pig bloody flux feed addictive, including Thymol, carvacrol, cinnamic acid, eugenol, manna oligosacchride,
Tributyrin, cosolvent and carrier.
As preferred further scheme, the component of the feed addictive of the prevention and treatment pig bloody flux matches in parts by weight
Are as follows: 12-20 parts of Thymol, 9-18 parts of carvacrol, 16-24 parts of cinnamic acid, 7-14 parts of eugenol, 4-18 parts of manna oligosacchride, three
4-15 parts of glycerol monobutyralte, 4-9 parts of cosolvent and 45-65 parts of carrier.
As preferred further scheme, the cosolvent is lauryl sodium sulfate, in polyethylene glycol, poloxamer
Any one.
As preferred further scheme, the polyethylene glycol is polyethylene glycol-4000.
As preferred further scheme, the carrier is maltodextrin or beta-cyclodextrin.
A kind of preparation method of feed addictive that preventing and treating pig bloody flux, comprising the following steps:
Step (1): Thymol, carvacrol, cinnamic acid, eugenol, cosolvent and carrier are added in blending tank, and water is added
And stir evenly, solid content is 20%~35% in mixed solution in adjustment blending tank, then mixed solution obtained is led
Enter homogenizer and carry out homogeneous, obtains the liquid mixture A of stable uniform；
Step (2): uniformly introducing spray dryer for liquid mixture A obtained in step (1) and be spray-dried, and powder is made
Last mixture B；
Step (3): mixture of powders B obtained in step (2), manna oligosacchride, tributyrin are added to the mixer,
The feed addictive of prevention and treatment pig bloody flux is made after mixing.
As preferred further scheme, in step (2), the machined parameters of the spray drying are that inlet air temperature is
150-160 DEG C, compressed air require 9-10L/min, inlet amount 6-9ml.
The present invention also provides the application of the feed addictive of above-mentioned prevention and treatment pig bloody flux, the feeding of the prevention and treatment pig bloody flux
Adding proportion of the feed additives in pannage is 0.04%~0.2%.
Various components employed in the present invention are unique in that:
Thymol has good aroma and very strong bactericidal effect, to gram-positive bacteria (staphylococcus aureus and production gas
Capsular clostridium) and gramnegative bacterium (Escherichia coli and salmonella) have antibacterial activity.
Carvacrol is a kind of antibacterial agent (including gram-positive bacteria and Gram-negative bacteria) of wide spectrum, and carvacrol is to cholera
Vibrios, campylobacter jejuni, staphylococcus aureus, salmonella, pseudomonas aeruginosa, Listeria etc. have inhibition to make
With.In addition, there are antibacterial synergistic effects to salmonella typhi for intestinal organic acids and carvacrol and Thymol.
Show that addition carvacrol and Thymol can alleviate inflammatory reaction by test, inhibit TNF-α release, prevent it is white
Recruiting cells, to alleviate inflammatory reaction.The anti-inflammatory effect of carvacrol and Thymol has animal productiong extremely important
Meaning, especially avoid the enteron aisle excessive immune of young animal and inflammation damnification, to establish early stage function of intestinal canal and Tiny ecosystem flat
Weighing apparatus.
Plants essential oil in enteron aisle other than antibacterial also to host intestine cells play adjust it is immune, anti-inflammatory, anti-oxidant,
The effects of promoting enteraden secretion, this is not available for other additive products, can be with the simple antibacterial product of organic acid
Complementation on formation mechanism improves intestinal health from antibacterial and adjusting 2 angles of host cell.
Cinnamic acid has the stimulation of mitigation to stomach, can reinforce gastrointestinal movement, can promote saliva and gastric secretion, also
It can increase the secretion of pig bile, the activity of intestinal mucosa and pancreas digestive ferment can be stimulated, enhance digestive function, and then increase dynamic
Object appetite releases gastrointestinal smooth muscle spasmus, alleviates intestinal cramps pain.
On the other hand, naturally distinctive fragrance can improve the feeding urges of pig to cinnamic acid, and attractant is strong.
Nutrition needed for cinnamic acid can be degraded to body in enteron aisle, and the generation of energy stimulating lactic acid bacteria, are improved dynamic
Object humoral immunity and cellular immunity increase IgG level in serum, promote blood circulation, improves animal T lymphocyte conversion ratio
And phagocytic activity of leukocytes.
Test confirms that cinnamic acid has good effect to piglet gastrointestinal disturbances, the piglet of diarrhea occurs to bull with cinnamic acid
It is found after carrying out therapeutic test, cure rate illustrates that it has the effect of good treatment grice diarrhoea 75% or more.
Cinnamic acid has the bactericidal effect of wide spectrum because of it simultaneously, and dispensing can be killed most of bad into breeding environment
Strain cuts down the generation of waste water, has good effect to restoration of the ecosystem.
Eugenol has broad-spectrum antibacterial effect, can inhibit the life of staphylococcus aureus, Escherichia coli, ash arrhizus bacteria etc.
It is long.Eugenol is natural extract, and there is very high safety to have safe and non-toxic, environmentally protective compared with chemical preservative
The advantages of.
Manna oligosacchride is relatively stable under physiological ph conditions, is not easy to be decomposed by simple stomach animal alimentary canal enzyme, sweet, sugariness is low
In sucrose.
Manna oligosacchride can interfere the field planting of enteric pathogenic bacteria, and manna oligosacchride provides sweet dew sugar source abundant for bacterium, from
And can avoid the affine of bacterium and intestinal wall, pass through enteron aisle since mannan-oligosaccharides will not be digested enzyme and degrades and carry pathogen,
Therefore can play the role of that pathogen is prevented to be colonized in enteron aisle.Pathogen cannot be using mannan-oligosaccharides as its growth
Energy source, and beneficial bacteria can be activated by mannan-oligosaccharides, can promote the life of the beneficial bacteriums such as Bifidobacterium, lactobacterium acidophilus
It is long, regulate and control animal gastrointestinal tract micro-ecological environment.Also there is inhibition to make the harmful bacterias such as Escherichia coli, cholera bacteria, clostridium
With.
Feeding manna oligosacchride can improve piglet colon height of naps, enteron aisle muscle layer thickness, provide energy for intestinal epithelial cell
Amount maintains the normal structure of enteron aisle and function, prevents and treats grice diarrhoea.
Tributyrin is in neutrality, and chemical property is stablized, and can reach enteron aisle back segment by stomach, in big enteral by pancreas fat
Enzyme resolves into rapidly glycerol and butyric acid.Height of naps can be improved in tributyrin, reduces Crypt depth, increases duodenum
Fuzzy surface product；Pre- anti-diarrhea alleviates inflammation generation, improves immunity；Alleviate the enteron aisle as caused by extraneous factor, body oxidation
It stress；Improve the activity of related digestive ferment.
Butyric acid is the preferred energy matter of enteron aisle, and butyric acid does not need the effect by bile salt after entering in small intestine
It is directly absorbed, supplements energy, be a kind of energy source of quick noble cells, on the other hand, butyric acid can also significantly increase small intestine
Proliferation, differentiation and the maturation of epithelial cell, when intestinal cell is damaged, butyric acid preferentially decomposes energy supply as energy substance,
It repairs enteron aisle and improves gut barrier function.
Butyric acid has adjustment effect to Ions Absorption, and osmotic pressure in adjustable enteric cavity has serious diarrhea and alleviates
Effect.Butyric acid can stimulate absorption of the colon to sodium, to meet the needs of body storage moisture, maintain body stable state.
Butyric acid is adjustable intestinal flora balance, and butyric acid adjustable gastric enteron aisle acidity plays the role of acidulant, to reduce
The harmful bacterias such as acid nonfast Escherichia coli, salmonella and campylobacter, and colon beneficial microorganism can be stimulated to grow.
Lauryl sodium sulfate is dissolved in water, has good emulsification, infiltration and dispersion performance.
Polyethylene glycol has good water solubility, has good dispersibility, has good intermiscibility with organic matter component.
Polyethylene glycol and other emulsifiers share, and increase emulsion stability.Wherein, polyethylene glycol-4000 can also play excipient
Effect is conducive to liquid material and reduces flowing, promotes molding.Polyethylene glycol-4000 can increase osmotic pressure in enteric cavity, absorb water
Point, a large amount of dehydrations make body weak and death caused by avoiding because of diarrhea.
Poloxamer is soluble easily in water, can play the role of emulsifier, stabilizer, solubilizer and sorbefacient.It is husky to moor Lip river
Nurse can make enterocinesia slack-off, and the residence time increases in the gastrointestinal tract for moisture, food and drug, and degree of being absorbed and utilized increases.
Application method of the invention: the feed addictive for the prevention and treatment pig bloody flux that the present invention is prepared is added to
In pig complete feed, feed feeds pig, the feed for the prevention and treatment pig bloody flux that the present invention is prepared again after mixing
Additive is 0.04%~0.2% as adding proportion of the feed addictive in pannage.
The beneficial effects of the present invention are:
(1) high to the antibacterial activity of harmful bacteria, resultant effect is good.
Thymol, carvacrol, cinnamic acid, eugenol all have the stronger antibacterial activity for harmful bacteria, mitigate disease
Disease.
Manna oligosacchride can avoid the affine of bacterium and intestinal wall, play the role of that pathogen is prevented to be colonized in enteron aisle, also to big
The harmful bacterias such as enterobacteria, cholera bacteria, clostridium have inhibiting effect.
Tributyrin also can play the role of indirectly inhibiting harmful intestinal tract bacteria by decomposing obtained butyric acid.
(2) alleviate inflammatory reaction, preventing illness pig, sb.'s illness took a turn for the worse, and having shortened the course of disease facilitates illness pig health as early as possible
It is multiple.
It is anti-that carvacrol, Thymol and the tributyrin being added in feed addictive of the invention can alleviate inflammation
It answers, has antiphlogistic effects for colorectal mucosa Catarrhal, hemorrhagic and the gangrenous inflammation of suffering from bloody flux pig.Alleviate illness pig
The state of an illness only, having shortened the course of disease facilitates the rehabilitation as early as possible of illness pig.
(3) it adjusts osmotic pressure anti-dehydrating in enteric cavity and alleviates diarrhea.
Containing the raw material components for alleviating diarrhea with osmotic pressure anti-dehydrating in adjusting enteric cavity in additive of the invention, such as:
Osmotic pressure in the adjustable enteric cavity of tributyrin has relaxation effect to serious diarrhea.Butyric acid can stimulate colon to sodium
Absorption, thus meet body storage moisture needs, maintain body stable state；Such as: polyethylene glycol-4000 can increase in enteric cavity
Osmotic pressure absorbs moisture, and a large amount of dehydrations make body weak and death caused by avoiding because of diarrhea.
(4) immunity is improved, impaired enteron aisle is repaired, is beneficial to intestinal health, solve the problems, such as diarrhea.
Cinnamic acid can in enteron aisle can stimulating lactic acid bacteria generation, improve that animal body fluid is immune and cellular immunity, make serum
Middle IgG level increases, and promotes blood circulation, and improves animal T lymphocyte conversion ratio and phagocytic activity of leukocytes, also has good
The effect of good treatment grice diarrhoea.
Manna oligosacchride can improve pig colon height of naps, enteron aisle muscle layer thickness, energy is provided for intestinal epithelial cell, tieing up
The normal structure of enteron aisle and function are held, grice diarrhoea is prevented and treated.
Height of naps can be improved in tributyrin, reduces Crypt depth, increases Duodenal villi surface area；Prevention
Diarrhea alleviates inflammation generation, improves immunity.
(5) intestines peristalsis is reduced, moisture and nutriment is promoted preferably to absorb, improves growth performance.
Poloxamer can make enterocinesia slack-off, and the residence time increases in the gastrointestinal tract for moisture, food and drug, be absorbed and utilized
Degree increases.
Cinnamic acid has the stimulation of mitigation to stomach, can promote saliva and gastric secretion, moreover it is possible to increase pig bile
Secretion can stimulate the activity of intestinal mucosa and pancreas digestive ferment, enhance digestive function, and then increase animal appetite, natural peculiar
Fragrance can improve the feeding urges of pig, attractant is strong.
(6) intestine beneficial bacteria colony balance is adjusted.
What eugenol of plants essential oil of the present invention such as Thymol, carvacrol and cinnamic acid, manna oligosacchride,
Tributyrin all has the effect for adjusting intestine beneficial bacteria colony balance, is conducive to the impaired enteron aisle of illness pig and establishes as early as possible
Stable profitable strain state promotes enteron aisle to get well.
(7) attractant and palatability of feed can be improved.
Thymol, carvacrol, cinnamic acid all have significant good aroma in raw material components of the invention, for pig
Attractant it is good, can improve a poor appetite；On the other hand, manna oligosacchride is sweet, is suitble to the feeding habits hobby of pig.
Feed has good attractant and palatability, can allow the sick pig for suffering from bloody flux not anorexia, and can lure pig product into
Pole feeding maintains necessary nutrition intake, facilitates rehabilitation as early as possible.
(8) product homogeneity and quality are high.
Cosolvent emulsifying effectiveness is good, when the mixed solution of each component can be made to import high pressure homogenizer progress homogeneous, obtains steady
Fixed uniform liquid mixture is conducive to the homogeneity and quality that improve product.
(9) noresidue and withdrawal time, it is green safe.
The present invention noresidue in pig body in application process, also without withdrawal time, antibiotic etc. is not used in the present invention
Drug, used starting components are green safe product.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Heretofore described Thymol, carvacrol, cinnamic acid, eugenol, manna oligosacchride, tributyrin, 12
Sodium alkyl sulfate, polyethylene glycol, poloxamer, polyethylene glycol-4000, maltodextrin or beta-cyclodextrin are commonly to commonly use raw material
Or commodity, it is commercially available.
Embodiment 1
It is a kind of prevent and treat pig bloody flux feed addictive, including Thymol, carvacrol, cinnamic acid, eugenol, manna oligosacchride,
Tributyrin, cosolvent and carrier.
The component of the feed addictive of the prevention and treatment pig bloody flux matches in parts by weight are as follows: 12 parts of Thymol, Sheep's-parsley
18 parts of phenol, 20 parts of cinnamic acid, 7 parts of eugenol, 18 parts of manna oligosacchride, 15 parts of tributyrin, 4 parts of cosolvent and carrier 65
Part.The cosolvent is lauryl sodium sulfate.The carrier is maltodextrin.
A kind of preparation method of feed addictive that preventing and treating pig bloody flux, comprising the following steps:
Step (1): Thymol, carvacrol, cinnamic acid, eugenol, cosolvent and carrier are added in blending tank, are added one
Quantitative water simultaneously stirs evenly, and adjusts in blending tank that solid content is 35% in mixed solution, then by mixed solution obtained
It imports high pressure homogenizer and carries out homogeneous, obtain the liquid mixture A of stable uniform；
Step (2): uniformly introducing spray dryer for liquid mixture A obtained in step (1) and be spray-dried, and powder is made
Last mixture B；
Step (3): mixture of powders B obtained in step (2), manna oligosacchride, tributyrin are added to the mixer,
The feed addictive of prevention and treatment pig bloody flux is made after mixing.
As preferred further scheme, the machined parameters of the spray drying are that inlet air temperature is 160 DEG C, compressed air
Flow is 10L/min, inlet amount 6ml.
The present invention also provides the application of the feed addictive of above-mentioned prevention and treatment pig bloody flux, the feeding of the prevention and treatment pig bloody flux
Adding proportion of the feed additives in pannage is 0.04%.That is, being added on 0.04kg according in the pig adequate diet to 100kg
The weight ratio for stating the feed addictive of prevention and treatment pig bloody flux is prepared, and pig can be fed by being then uniformly mixed two kinds of materials.
Test situation
1.1 test groupings
Piglet 200 are selected, selected pig is randomly divided into two by selected pig weight, kind, physiological characteristic no significant difference
Group, it may be assumed that control group A and test group A, every group of 4 repetitions, 25 pigs of each repetition.
1.2 test feed
Full price basal diet: commercially available common pig full price basal diet is not added with the feed addition of the preparation of the embodiment of the present invention 1
Agent.
Additive tests daily ration: the feed addictive of the prevention and treatment pig bloody flux prepared by embodiment 1 and commercially available common pig
Full price basal diet is formulated, and is prevented and treated adding proportion of the feed addictive of pig bloody flux in pig full price basal diet and is
0.04%, i.e., according to the feed addictive for adding the above-mentioned prevention and treatment pig bloody flux of 0.04kg in the pig full price basal diet to 100kg
Weight ratio prepare, then by two kinds of materials be uniformly mixed can feed pig.
Above-mentioned full price basal diet is identical with pig full price basal diet used in additive test daily ration.
1.3 test method
First stage feeding experiment: control group A and test group A are raised on identical pig farm using identical management method
Hello, and control group A and test group A carry out feeding experiment simultaneously, feed 21 days.Control group A feeds above-mentioned full price basal diet.
Test group A feeds above-mentioned additive and tests daily ration.
Second stage feeding experiment: the first stage feed after, then by dysentery red in control group A fall ill pig pick out
Come, is randomly divided into two groups, i.e. control group B and experiment group B, on identical pig farm, use is identical for control group B and experiment group B
Management method is fed, and control group B and experiment group B carry out feeding experiment simultaneously, is fed 10 days.In control group B feeding
State full price basal diet.Experiment group B feeds above-mentioned additive and tests daily ration.
1.4 test effect
It is counted after the test, calculated result.
In first stage feeding experiment, the red dysentery pig disease incidence 67% of control group A, the red dysentery pig disease incidence 7% of test group A,
Test group A reduces 89% relative to control group A, pig disease incidence.
Test group A is relative to control group A, and pig average daily gain improves 26%, and pig average daily gain improves 9%, raises
Expect that conversion ratio improves 13%, improves the growth performance of pig.
In second stage feeding experiment, the red dysentery pig rehabilitation rate 0% of control group B, the red dysentery pig rehabilitation rate 100% of experiment group B,
Experiment group B has significant red dysentery illness pig curative effect relative to control group B.
The bloody flux of pig significantly can be prevented and treated and be cured to feed addictive of the present invention, and can also improve pig
Growth performance.
Embodiment 2
It is a kind of prevent and treat pig bloody flux feed addictive, including Thymol, carvacrol, cinnamic acid, eugenol, manna oligosacchride,
Tributyrin, cosolvent and carrier.
The component of the feed addictive of the prevention and treatment pig bloody flux matches in parts by weight are as follows: 20 parts of Thymol, Sheep's-parsley
9 parts of phenol, 16 parts of cinnamic acid, 14 parts of eugenol, 4 parts of manna oligosacchride, 10 parts of tributyrin, 9 parts of cosolvent and 55 parts of carrier.
The cosolvent is polyethylene glycol, and the polyethylene glycol is polyethylene glycol-4000.The carrier is β-ring paste
Essence.
A kind of preparation method of feed addictive that preventing and treating pig bloody flux, comprising the following steps:
Step (1): Thymol, carvacrol, cinnamic acid, eugenol, cosolvent and carrier are added in blending tank, are added one
Quantitative water simultaneously stirs evenly, and adjusts in blending tank that solid content is 20% in mixed solution, then by mixed solution obtained
It imports high pressure homogenizer and carries out homogeneous, obtain the liquid mixture A of stable uniform；
Step (2): uniformly introducing spray dryer for liquid mixture A obtained in step (1) and be spray-dried, and powder is made
Last mixture B；
Step (3): mixture of powders B obtained in step (2), manna oligosacchride, tributyrin are added to the mixer,
The feed addictive of prevention and treatment pig bloody flux is made after mixing.
As preferred further scheme, the machined parameters of the spray drying are that inlet air temperature is 155 DEG C, compressed air
Flow is 9.5L/min, inlet amount 7.5ml.
The present invention also provides the application of the feed addictive of above-mentioned prevention and treatment pig bloody flux, the feeding of the prevention and treatment pig bloody flux
Adding proportion of the feed additives in pannage is 0.2%.That is, above-mentioned according to 0.2kg is added in the pig adequate diet to 100kg
The weight ratio for preventing and treating the feed addictive of pig bloody flux is prepared, and pig can be fed by being then uniformly mixed two kinds of materials.
Test situation
1.1 test groupings
Piglet 200 are selected, selected pig is randomly divided into two by selected pig weight, kind, physiological characteristic no significant difference
Group, it may be assumed that control group A and test group A, every group of 4 repetitions, 25 pigs of each repetition.
1.2 test feed
Full price basal diet: commercially available common pig full price basal diet is not added with the feed addition of the preparation of the embodiment of the present invention 1
Agent.
Additive tests daily ration: the feed addictive of the prevention and treatment pig bloody flux prepared by embodiment 1 and commercially available common pig
Full price basal diet is formulated, and is prevented and treated adding proportion of the feed addictive of pig bloody flux in pig full price basal diet and is
0.2%, i.e., according to the feed addictive for adding the above-mentioned prevention and treatment pig bloody flux of 0.2kg in the pig full price basal diet to 100kg
Weight ratio is prepared, and pig can be fed by being then uniformly mixed two kinds of materials.
Above-mentioned full price basal diet is identical with pig full price basal diet used in additive test daily ration.
1.3 test method
First stage feeding experiment: control group A and test group A are raised on identical pig farm using identical management method
Hello, and control group A and test group A carry out feeding experiment simultaneously, feed 21 days.Control group A feeds above-mentioned full price basal diet.
Test group A feeds above-mentioned additive and tests daily ration.
Second stage feeding experiment: the first stage feed after, then by dysentery red in control group A fall ill pig pick out
Come, is randomly divided into two groups, i.e. control group B and experiment group B, on identical pig farm, use is identical for control group B and experiment group B
Management method is fed, and control group B and experiment group B carry out feeding experiment simultaneously, is fed 10 days.In control group B feeding
State full price basal diet.Experiment group B feeds above-mentioned additive and tests daily ration.
1.4 test effect
It is counted after the test, calculated result.
In first stage feeding experiment, the red dysentery pig disease incidence 69% of control group A, the red dysentery pig disease incidence 8% of test group A,
Test group A reduces 88% relative to control group A, pig disease incidence.
Test group A is relative to control group A, and pig average daily gain improves 36%, and pig average daily gain improves 15%, raises
Expect that conversion ratio improves 15%, improves the growth performance of pig.
In second stage feeding experiment, the red dysentery pig rehabilitation rate 0% of control group B, the red dysentery pig rehabilitation rate 85% of experiment group B,
Experiment group B has significant red dysentery illness pig curative effect relative to control group B.
The bloody flux of pig significantly can be prevented and treated and be cured to feed addictive of the present invention, and can also improve pig
Growth performance.
Embodiment 3
It is a kind of prevent and treat pig bloody flux feed addictive, including Thymol, carvacrol, cinnamic acid, eugenol, manna oligosacchride,
Tributyrin, cosolvent and carrier.
The component of the feed addictive of the prevention and treatment pig bloody flux matches in parts by weight are as follows: 16 parts of Thymol, Sheep's-parsley
13 parts of phenol, 24 parts of cinnamic acid, 11 parts of eugenol, 11 parts of manna oligosacchride, 4 parts of tributyrin, 7 parts of cosolvent and carrier 45
Part.
The cosolvent is poloxamer；The carrier is maltodextrin.
A kind of preparation method of feed addictive that preventing and treating pig bloody flux, comprising the following steps:
Step (1): Thymol, carvacrol, cinnamic acid, eugenol, cosolvent and carrier are added in blending tank, are added one
Quantitative water simultaneously stirs evenly, and adjusts in blending tank that solid content is 27% in mixed solution, then by mixed solution obtained
It imports high pressure homogenizer and carries out homogeneous, obtain the liquid mixture A of stable uniform；
Step (2): uniformly introducing spray dryer for liquid mixture A obtained in step (1) and be spray-dried, and powder is made
Last mixture B；
Step (3): mixture of powders B obtained in step (2), manna oligosacchride, tributyrin are added to the mixer,
The feed addictive of prevention and treatment pig bloody flux is made after mixing.
As preferred further scheme, the machined parameters of the spray drying are that inlet air temperature is 150 DEG C, compressed air
Flow is 9L/min, inlet amount 9ml.
The present invention also provides the application of the feed addictive of above-mentioned prevention and treatment pig bloody flux, the feeding of the prevention and treatment pig bloody flux
Adding proportion of the feed additives in pannage is 0.12%.That is, being added on 0.12kg according in the pig adequate diet to 100kg
The weight ratio for stating the feed addictive of prevention and treatment pig bloody flux is prepared, and pig can be fed by being then uniformly mixed two kinds of materials.
Test situation
1.1 test groupings
Piglet 200 are selected, selected pig is randomly divided into two by selected pig weight, kind, physiological characteristic no significant difference
Group, it may be assumed that control group A and test group A, every group of 4 repetitions, 25 pigs of each repetition.
1.2 test feed
Full price basal diet: commercially available common pig full price basal diet is not added with the feed addition of the preparation of the embodiment of the present invention 1
Agent.
Additive tests daily ration: the feed addictive of the prevention and treatment pig bloody flux prepared by embodiment 1 and commercially available common pig
Full price basal diet is formulated, and is prevented and treated adding proportion of the feed addictive of pig bloody flux in pig full price basal diet and is
0.12%, i.e., according to the feed addictive for adding the above-mentioned prevention and treatment pig bloody flux of 0.12kg in the pig full price basal diet to 100kg
Weight ratio prepare, then by two kinds of materials be uniformly mixed can feed pig.
Above-mentioned full price basal diet is identical with pig full price basal diet used in additive test daily ration.
1.3 test method
First stage feeding experiment: control group A and test group A are raised on identical pig farm using identical management method
Hello, and control group A and test group A carry out feeding experiment simultaneously, feed 21 days.Control group A feeds above-mentioned full price basal diet.
Test group A feeds above-mentioned additive and tests daily ration.
Second stage feeding experiment: the first stage feed after, then by dysentery red in control group A fall ill pig pick out
Come, is randomly divided into two groups, i.e. control group B and experiment group B, on identical pig farm, use is identical for control group B and experiment group B
Management method is fed, and control group B and experiment group B carry out feeding experiment simultaneously, is fed 10 days.In control group B feeding
State full price basal diet.Experiment group B feeds above-mentioned additive and tests daily ration.
1.4 test effect
It is counted after the test, calculated result.
In first stage feeding experiment, the red dysentery pig disease incidence 64% of control group A, the red dysentery pig disease incidence 9% of test group A,
Test group A reduces 86% relative to control group A, pig disease incidence.
Test group A is relative to control group A, and pig average daily gain improves 31%, and pig average daily gain improves 12%, raises
Expect that conversion ratio improves 14%, improves the growth performance of pig.
In second stage feeding experiment, the red dysentery pig rehabilitation rate 0% of control group B, the red dysentery pig rehabilitation rate 83% of experiment group B,
Experiment group B has significant red dysentery illness pig curative effect relative to control group B.
The bloody flux of pig significantly can be prevented and treated and be cured to feed addictive of the present invention, and can also improve pig
Growth performance.
Claims (8)
1. a kind of feed addictive for preventing and treating pig bloody flux, it is characterised in that: including Thymol, carvacrol, cinnamic acid, cloves
Phenol, manna oligosacchride, tributyrin, cosolvent and carrier.
2. a kind of feed addictive for preventing and treating pig bloody flux according to claim 1, it is characterised in that: the prevention and treatment pig
The component of the feed addictive of bloody flux matches in parts by weight are as follows: 12-20 parts of Thymol, 9-18 parts of carvacrol, cinnamic acid 16-
24 parts, 7-14 parts of eugenol, 4-18 parts of manna oligosacchride, 4-15 parts of tributyrin, 4-9 parts of cosolvent and 45-65 parts of carrier.
3. a kind of feed addictive for preventing and treating pig bloody flux according to claim 1 or 2, it is characterised in that: the hydrotropy
Agent is lauryl sodium sulfate, polyethylene glycol, any one in poloxamer.
4. a kind of feed addictive for preventing and treating pig bloody flux according to claim 3, it is characterised in that: the polyethylene glycol
For polyethylene glycol-4000.
5. a kind of feed addictive for preventing and treating pig bloody flux according to claim 1 or 2, it is characterised in that: the carrier
For maltodextrin or beta-cyclodextrin.
6. such as a kind of described in any item preparation methods for the feed addictive for preventing and treating pig bloody flux of claim 1~2, including with
Lower step:
Step (1): Thymol, carvacrol, cinnamic acid, eugenol, cosolvent and carrier are added in blending tank, and water is added
And stir evenly, solid content is 20%~35% in mixed solution in adjustment blending tank, then mixed solution obtained is led
Enter homogenizer and carry out homogeneous, obtains the liquid mixture A of stable uniform；
Step (2): uniformly introducing spray dryer for liquid mixture A obtained in step (1) and be spray-dried, and powder is made
Last mixture B；
Step (3): mixture of powders B obtained in step (2), manna oligosacchride, tributyrin are added to the mixer,
The feed addictive of prevention and treatment pig bloody flux is made after mixing.
7. a kind of preparation method of feed addictive for preventing and treating pig bloody flux according to claim 6, it is characterised in that:
In step (2), the machined parameters of the spray drying are that inlet air temperature is 150-160 DEG C, compressed air require 9-10L/
Min, inlet amount 6-9ml.
8. such as a kind of described in any item applications for the feed addictive for preventing and treating pig bloody flux of claim 1~2, feature exists
In: adding proportion of the feed addictive of the prevention and treatment pig bloody flux in pannage is 0.04%~0.2%.
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